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  • 2000-2004  (15)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes (2000)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Ceramides produced by sphingomyelin hydrolysis activate a cycle that is followed by three different major cellular responses: downregulation of cell proliferation, induction of cell differentiation and apoptosis. In the skin, the generation of intracellular ceramide may also provide a link between an extracellular signal and the induction of the apoptosis programme for the elimination of damaged cells. Objectives We investigated the effect of ceramides capable of entering cells on cultured keratinocytes. Methods Human keratinocytes from neonatal skin were cultured in serum-free medium with or without increasing concentrations of ceramide 2 (CER-2; N-acetyl sphingosine) (5, 10, 20 and 40 µmol L−1). Proliferative effects were studied either by cell counts or by 3H-thymidine incorporation and flow cytometric analysis. Apoptosis was studied by TUNEL staining and Western blot analysis of Bcl-2 protein. Results Cell counts and DNA synthesis were reduced in a dose-dependent manner following CER-2 treatment. TUNEL staining showed CER-2-induced apoptosis at 48, 72 and 96 h. Western blot analysis showed that CER-2 induces downregulation of Bcl-2 at 24–96 h. Conclusions These results demonstrate that CER-2 inhibits cell proliferation and induces apoptosis, possibly via a Bcl-2-dependent mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2000.03700.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    FC02.2
Patch tests with gluten and gliadin in children with coeliac disease (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Atopy patch tests (ATPs) are believed to be a useful diagnostic procedure for atopic dermatitis (AD), aiming at the detection of delayed reactions to aeroallergens and food allergens. Our aim was to investigate immune responses to gluten and gliadin in children affected by coeliac disease by performing APTs, and to compare these data to the ones observed in AD patients. 31 children, 15 males and 16 females (mean age ± s.d. = 5,5 ± 3,8 years) affected by coeliac disease underwent APTs with gluten and gliadin. Among these, 15 children were on gluten-free diet at the moment of our examination and 3 patients were affected by AD. 83 AD children not affected by celiac disease, were used as controls. 19,4% and 12,9% of children with coeliac disease proved positive to APTs with gluten and gliadin, respectively. No difference in the frequency and intensity of APT responses were present between the patients on gluten-free diet and the children not on diet. Among AD patients 12% reacted to gluten, whereas no positive reactions to gliadin were observed. Going on these findings, the cellular-mediated reactivity to gliadin in patients with coeliac disease may show a clinical expression by positive APT reactions to gliadin. These represent a specific finding in subjects with coeliac disease when compared to AD children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309ay.x
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  • 3
    Electronic Resource
    Electronic Resource
    Monitoring levels of preservative sensitivity in Europe (2002)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 46 (2002), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2002.460404.x
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  • 4
    Electronic Resource
    Electronic Resource
    Patch testing with corticosteroid mixes in Europe (2000)
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 42 (2000), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents, each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0%) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10%, budesonide 0.002%, and tixocortol pivalate, both concentrations (1.0 and 0.10%) tracing the same number. With the mixes, 53.2–59.6% of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25% of these only to 1.0% and another 25% only to 0.10%. Testing with mix I and tixocortol pivalate 0.10% picked up 98/110, testing with tixocortol pivalate 1.0% and 0.10% and budesonide 0.10% picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30% of contact allergy to corticosteroid markers was missed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2000.042001027.x
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  • 5
    Electronic Resource
    Electronic Resource
    Reproducibility of APT (2002)
    Oxford, UK : Munksgaard International Publishers
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2002.23836_3.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    P24
Increasing prevalence of sensitization to preservatives in children (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to evaluate the frequency of contact sensitization to preservatives in a pediatric population and to compare the data to our previous findings referring to the period 1988–1994. From January 1995 to December 2002, 1255 patients aged 7 months-12 years, 583 boys and 672 girls, with suspected allergic contact dermatitis underwent patch testing with our pediatric series of 30 allergens including 5 different preservatives: methyldibromoglutaronitrile, methyl(chloro)isothiazolinone, imidazolidinyl urea, paraben mix, and formaldehyde. Of the 1255 children tested, 108 (8.6%), 52 boys and 56 girls, showed positive reactions to 1 or more of the preservatives listed above. In particular, 55 subjects reacted to methyl(chloro)isothiazolinone, 22 to methyldibromoglutaronitrile, 20 to paraben mix, 17 to formaldehyde, and 13 to imidazolidinyl urea. Among our preservative-positive children, 77% of patients reacted to other haptens of the series, and 44% were affected by atopic dermatitis. In comparison with our previous data referring to the period 1988–1994, a significant increase has been observed in the frequency of positive reactions to methyldibromoglutaronitrile, paraben mix, and formaldehyde. Our findings confirm the importance of patch testing children with preservatives since the wider and wider use of cosmetics in the pediatric age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309ff.x
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  • 7
    Electronic Resource
    Electronic Resource
    Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 48 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0·01%, 0·033% and 0·1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0·35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2003.00077.x
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  • 8
    Electronic Resource
    Electronic Resource
    FC04.2
Sensitization to propolis in 1255 children undergoing patch testing (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Propolis is an ancient remedy well known for its beneficial properties. The aim of our study was to estimate the frequency of sensitization to propolis in our pediatric patch test population. 1255 children, 583 boys and 672 girls, aged from 7 months to 12 years, were patch tested for suspected allergic contact dermatitis with our pediatric series of 30 allergens including propolis. Out of these, 37% were affected by atopic dermatitis. Among the 1255 children tested, 113 (9%), 60 boys and 53 girls reacted to propolis. In subjects reacting to propolis the dermatitis involved the face in 4% of cases, the trunk in 3%, the hands in 2,2%, and the flexural skin folds of the limbs in 1,7%. The wider and wider use of propolis in “natural products” and biocosmetics, even in the pediatric age, could explain the high frequency of positive patch test responses to propolis we observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309dn.x
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  • 9
    Electronic Resource
    Electronic Resource
    Evaluation of eugenol allergy in a patch-test population (2001)
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 44 (2001), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2001.440107-4.x
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  • 10
    Electronic Resource
    Electronic Resource
    Urticaria after topical immunotherapy with diphenylcyclopropenone (2002)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 47 (2002), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2002.4705102.x
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