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  • 1
    Electronic Resource
    Electronic Resource
    Precipitation of icosahedral phase from a supercooled liquid region in Zr65Cu7.5Al7.5Ni10Ag10 metallic glass (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 75 (1999), S. 3497-3499 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The formation of an icosahedral phase from the rapidly quenched Zr65Cu7.5Al7.5Ni10Ag10 metallic glass was confirmed and the kinetics of the precipitation upon isothermal annealing in the supercooled liquid region were examined by differential scanning calorimetry. Based on the kinetic analysis, it is clarified that the precipitation in the supercooled liquid region takes place by an interfacial controlled growth with a nearly steady-state nucleation rate. The Arrhenius plot between effective time lag, τ, of nucleation and isothermal annealing temperature yields a single linear relation, in which the activation energy for nucleation is evaluated to be 366 kJ/mol. It is concluded that the transformation of amorphous to quasicrystal proceeds by a homogeneous nucleation mode, which is different from those of Pd–U–Si and Al–Cu–V quasicrystals arising from an inhomogeneous distribution of quenched-in nuclei. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.125367
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  • 2
    Electronic Resource
    Electronic Resource
    Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To elucidate the physiological role of Fyn, we analysed the properties of synaptic transmission and synaptic plasticity in hippocampal slices of mice overexpressing either wild-type Fyn (w-Fyn) or its constitutively active mutant (m-Fyn). These fyn-transgenes were driven by the calcium/calmodulin-dependent protein kinase IIα promoter which turned on in the forebrain neurons including hippocampal pyramidal cells and in late neural development. In the hippocampal slices expressing m-Fyn the paired-pulse facilitation was reduced and the basal synaptic transmission was enhanced. A weak theta-burst stimulation, which was subthreshold for the induction of long-term potentiation (LTP) in control slices, elicited LTP in CA1 region of the slices expressing m-Fyn. When a relatively strong stimulation was applied, the magnitude of LTP in m-Fyn slices was similar to that in control slices. By contrast, the basal synaptic transmission and the threshold for the induction of LTP were not altered in the slices overexpressing wild-type Fyn. To examine the effect of expression of m-Fyn on GABAergic inhibitory system, we applied bicuculline, a GABAA receptor blocker, to the hippocampal slices. The ability of bicuculline to enhance excitatory postsynaptic potentials was attenuated in slices expressing m-Fyn, suggesting that the overexpression of m-Fyn reduced the GABAergic inhibition. The enhancement of synaptic transmission and the reduction of GABAergic inhibition may contribute to the enhanced seizure susceptibility in the mice expressing m-Fyn. Thus, these results suggest that regulation of Fyn tyrosine kinase activity is important for both synaptic transmission and plasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00407.x
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  • 3
    Electronic Resource
    Electronic Resource
    A new staining method of astrocytes for paraffin section (1980)
    Springer
    Acta neuropathologica 49 (1980), S. 67-69 
    Details
    ISSN: 1432-0533
    Keywords: Staining method for paraffin sections ; Astrocyte ; Silver impregnation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new method of staining astrocytes in formalin-fixed, paraffin-embedded sections was devised: (1) fix them in 5% mercuric chloride solution for 30 min to 1 h at 56°C, (2) then place in 0.5% iodine alcohol for 5 min followed by placing in 0.5% sodium thiosulfate for 5 min, (3) immerse in 0.25% potassium permanganate for 3 min, (4) place in 2% oxalic acid for 2 min, (5) mordant in 2% iron alum for 45 s, and (6) place in 2% silver nitrate solution for 30 min. The next step is impregnation in ammoniacal silver solution for 10–15 min at 56°C, followed by reduction in neutral formalin and 2% iron alum, toning in 0.2% gold chloride, and fixing in 5% sodium thiosulfate. Pathological astrocytes of fibrillary and protoplasmic types were distinctly demonstrated, although nerve cells and nuclei of oligodendrocytes and microglial cells were also faintly stained. Thus, the staining for paraffin sections is fairly selective for astrocytes in pathological states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692222
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  • 4
    Electronic Resource
    Electronic Resource
    Nasu-Hakola's disease (membranous lipodystrophy) (1981)
    Springer
    Acta neuropathologica 54 (1981), S. 89-93 
    Details
    ISSN: 1432-0533
    Keywords: Nasu-Hakola's disease ; Membranous lipodystrophy ; Sclerosing leukodystrophy ; Axonal neurofilamentous spheroid ; Neuroaxonal leukoencephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of Nasu-Hakola's disease (membranous lipodystrophy) was reported. A 29-yearold Japanese woman whose younger sister had been affected with typical Nasu-Hakola's disease with skeletal and neuropsychiatric sysdromes and membranocystic lesions in the bones developed forgetfulness and lack of initiative. The clinical features were characterized by diminished drive, apathy, euphoria, disturbance of attention, amnestic syndrome, and gait disturbance. The elinical course of her illness was 8 years. The neuropathologic examination revealed marked symmetrical gliosis of the cerebral white matter (sclerosing leukodystrophy) predominantly in the frontal and temporal lobes with slight or moderate demyelination (dissociation glio-myelinique) and widespread axonal changes such as fragmentation and spheroid in the white matter of the cerebral hemisphere, cerebellum, basal ganglia, and brain stem. The ultrastructure of spheroids showed neurofilamentous accumulation. We discussed the importance of axonal changes with regard to the pathogenesis and etiogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689400
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  • 5
    Electronic Resource
    Electronic Resource
    Pallido-nigro-luysial atrophy with massive appearance of corpora amylacea in the CNS (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 169-172 
    Details
    ISSN: 1432-0533
    Keywords: Pallido-nigro-luysial atrophy ; Combined system degeneration ; Progressive supranuclear palsy ; Corpora amylacea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of pallido-nigro-luysial atrophy, characterized by symptoms typical of progressive supranuclear palsy, presented (1) severe symmetrical abiotrophic degeneration of the globus pallidus, substantia nigra, and subthalamic nucleus and (2) widespread accumulations of corpora amylacea in the CNS. The former is thought to be consistent with pallidonigro-luysial atrophy and we regard it as a combined system degeneration of both the pallido-nigral and the pallido-luysial systems. The significance of the latter is quite obscure. As far as we know, only three cases of pallido-nigro-luysial atrophy have been reported. However, there is no reported case of this disorder with such widespread and massive accumulations of corpora amylacea as in our case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689999
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  • 6
    Electronic Resource
    Electronic Resource
    Rattan bamboo blind (Japanese sudare)-like profiles of neurofibrillary tangles in Alzheimer’s disease (1996)
    Springer
    Acta neuropathologica 91 (1996), S. 448-450 
    Details
    ISSN: 1432-0533
    Keywords: Key words Neurofibrillary tangles ; Alzheimer’s ; disease ; Ultrastructure ; Rattan bamboo blind-like ; arrangement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual ultrastructure for neurofibrillary tangles, which has not been described so far, is presented in a case of Alzheimer’s disease. This profile consists of parallelly arranged paired helical filaments and criss-cross tubular profiles that are arranged at regular interval of 300–500 nm, resembling rattan bamboo blind or Japanese sudare-like profiles. Coexistence of Hirano bodies in the same neuron is infrequently encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050451
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  • 7
    Electronic Resource
    Electronic Resource
    Distribution and morphology of brain stem plaques in Alzheimer's disease (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 131-136 
    Details
    ISSN: 1432-0533
    Keywords: Senile plaque ; Alzheimer's disease ; Brain stem ; Distribution ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology, incidence and distribution of senile plaques in the brain stem were examined in 15 cases of Alzheimer's disease, using mainly the Methenamine-Bodian method. The plaques were found in all cases and were grouped into three types according to their morphology. They were not randomly scattered in the brain stem, but had a distribution common to all cases. There were numerous plaques in the periaqueductal gray, superior colliculus, fourth-ventricle floor and superior central nucleus. The plaques were also found less abundantly in the reticular formation, substantia nigra, pontine nucleus and inferior olivary nucleus. There was a tendency for certain plaque types to be associated with specific regions. In the familial cases, the plaques tended to occur even in the regions where they were rare in other cases. The capillaries with plaque-like degeneration were observed not infrequently in the brain stem. The distribution of plaques did not always coincide with that of neurofibrillary tangles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688200
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  • 8
    Electronic Resource
    Electronic Resource
    Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM) (1986)
    Springer
    Acta neuropathologica 72 (1986), S. 124-129 
    Details
    ISSN: 1432-0533
    Keywords: Aging ; PAS-positive granular structures ; Learning disturbance ; Senescence accelerated mouse (SAM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Abnormal granular structures, which stained positively with periodic acid-Schiff (PAS-positive granular structures; PGS), were observed in the brain of senescence accelerated mouse (SAM). They were small, round to ovoid, homogenous structures measuring up to 5 μm in diameter and usually grouped in clusters. PGS were localized in the hippocampus, piriform cortices, olfactory tubercle, nucleus of the trapezoid body, and cerebellar cortices. Quantitative analysis revealed that PGS remarkably increased in the hippocampus of SAM-P/8, a substrain of SAM, with advancing age, although a few PGS also appeared in the aged control mice, SAM-R/1 and DDD. Their histochemical nature, morphological features and distribution pattern were different from those of corpora amylacea and other similar bodies. A close anatomical relationship between PGS and glial fibrillary acidic protein-positive astrocytes was inferred from immunohistochemical studies. PGS is considered to be one of the morphological manifestations of senescence in mice brains, and are found to occur more numerously in the brains of learning or memory deficit mice, SAM-P/8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685973
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibitory effects of JTE-522, a novel prostaglandin H synthase-2 inhibitor, on adjuvant-induced arthritis and bone changes in rats (1998)
    Springer
    Inflammation research 47 (1998), S. 187-192 
    Details
    ISSN: 1420-908X
    Keywords: Key words: JTE-522 — Adjuvant arthritis — Prostaglandin H synthase-2 (PGHS-2) — Bone change — Non-steroidal anti-inflammatory drugs (NSAIDs)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To investigate the effect of JTE-522, a novel selective prostaglandin H synthase (PGHS)-2 inhibitor, on adjuvant-induced arthritis and bone changes.¶Subjects: Male Lewis rats at 8 weeks old were immunized with heat-killed mycobacteria.¶Treatment: JTE-522 (0.1–30 mg/kg) and indomethacin (0.1–3 mg/kg) were administered orally once-daily after immunization.¶Methods: Paw swelling, bone changes in arthritic paws and vertebrae, urinary levels of deoxypyridinoline and pyridinium crosslinks, and the incidence of gastric lesions were determined in arthritic rats.¶Results: JTE-522 (from 0.3 mg/kg) suppressed the development of paw swelling, and also reduced bone damage (score and bone mineral density) in arthritic paws and the urinary excretion of deoxypyridinoline and pyridinium crosslinks. However, JTE-522 did not cause gastric lesions even at 30 mg/kg in arthritic rats.¶Conclusions: These results suggest that JTE-522 possesses potent anti-arthritic activities and suppressive activity on inflammatory bone resorption without gastric side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050316
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats (1997)
    Springer
    Inflammation research 46 (1997), S. 461-466 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Prostaglandin H synthase-2 — Anti-inflammatory agent — JTE-522 — Indomethacin — Gastric ulcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: The antinociceptive, antipyretic, and anti-inflammatory effects of JTE-522, a novel selective prostaglandin H synthase (PGHS)-2 inhibitor, were examined in rats.¶Materials: Sheep seminal vesicle PGHS-1 and placenta PGHS-2 were used for in vitro assay, while for in vivo experiments, male rats (4–8 weeks old) were used.¶Treatment: JTE-522 and reference compounds (0.01–100 μM) were subjected to enzyme assay. JTE-522 (0.3–30 mg/kg) and indomethacin (0.3–10 mg/kg) were administered orally.¶Results: JTE-522 inhibited PGHS-2 (IC50: 0.64 μM) without affecting PGHS-1 activity at 100 μM. In rats with yeast-induced hyperalgesia, JTE-522 showed a dose-dependent antinociceptive effect (ED50: 4.4 mg/kg). In rats with yeast-induced pyrexia, JTE-522 significantly reversed the pyrexic response (ED50: 3.9 mg/kg). Orally administered JTE-522 dose-dependently inhibited carrageenin-induced rat paw edema (ED30: 4.7 mg/kg). In rats with adjuvant-induced arthritis, JTE-522 showed a significant inhibitory effect at daily doses of 0.3–3 mg/kg. JTE-522 did not cause severe gastric lesions at oral doses up to 300 mg/kg.¶Conclusions: Our results indicate that the selective PGHS-2 inhibitor JTE-522 may represent a novel type of anti-inflammatory drug without adverse effects on the gastrointestinal tract. JTE-522 may thus be a promising agent for treating both acute inflammatory diseases and chronic inflammatory diseases such as rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050225
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