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  • 1
    Electronic Resource
    Electronic Resource
    Collision-induced state-to-state energy transfer in the ν2+3ν3 rovibrational manifold of gas-phase acetylene (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 100 (1994), S. 2398-2401 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Time-resolved infrared-ultraviolet double resonance spectroscopy is used to measure collision-induced rovibrational energy transfer in the ν2+3ν3 region (∼11 600 cm−1) of gas-phase acetylene. Of particular interest is rotationally resolved V–V transfer between the Fermi-coupled 2133 and 11234351 levels, for which the rate is relatively high (approximately 13% of the Lennard-Jones collision rate) and the relevant rovibrational states markedly perturbed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.466487
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  • 2
    Electronic Resource
    Electronic Resource
    Dose-related healing of duodenal ulcer with the proton pump inhibitor lansoprazole (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 5 (1991), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lansoprazole (AG 1749) is a novel substituted benzimidazole which inhibits gastric acid secretion by blocking H+, K+-ATPase. This randomized, double-blind multicentre trial studied the dose–response relationship of lansoprazole on ulcer healing and compared it with ranitidine in 314 out-patients with endoscopically assessed, symptomatic duodenal ulcer. Cumulative healing rates with Lansoprazole 7.5, 15, and 30 mg o.m. were 48, 59, and 74% at 2 weeks and 75, 84, and 95 % at 4 weeks, respectively (intention-to-treat); the difference of the healing rates between 7.5 and 30 mg groups was significant (P 〈 0.001).Corresponding healing rates for 300 mg ranitidine nocte were 51 and 89 %. Pain relief was similar in all treatment groups. Lansoprazole was well tolerated. During a follow-up of 6 months relapse rates after lansoprazole 7.5, 15, and 30 mg were 21, 29, and 22%, respectively; the relapse rate after ranitidine 300 mg was 20%. In conclusion, lansoprazole provides faster healing of duodenal ulcer than ranitidine and a similar relapse pattern. For further trials in peptic ulcer disease a daily dose of lansoprazole 30 mg o.m. is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1991.tb00025.x
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Untersuchung mitogenetischer Strahlung mit dem Zählrohr (1935)
    Springer
    Naturwissenschaften 23 (1935), S. 688-688 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489116
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  • 4
    Electronic Resource
    Electronic Resource
    Histamine storage and metabolism of human liver in disorders of the biliary tract (1980)
    Springer
    Inflammation research 10 (1980), S. 101-104 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In three clinical-biochemical trials (all prospective, two balanced but only the last one randomized) histamine methyltransferase (HMT) activity and histamine content were determined in liver tissue of patients being operated for an epigastric tumour or a chronic duodenal ulcer (control group) and of those suffering from disorders of the biliary tract (test group). With median HMT-activities between 361 and 427 pmol/(min×mg protein) in the control and the test groups the human liver showed the highest histamine methylation capacity of all organs of all species hitherto investigated. This explained the well-known high elimination rate from the portal plasma by a single passage through the liver. Whereas patients of the control groups showed median hepatic histamine values between 1.4 and 1.9 μg/g tissue, the corresponding values in patients suffering from cholelithiasis lay between 2.6 and 2.8 μg/g tissue. The observed increase was only 37% in the first (unbalanced and non-randomized) trial (p=0.100;n=50), but was 100% both in the second (balanced) and third (randomized) trial (p〈0.03;n=44 resp.n=24). The results show, that performing a randomized controlled clinical-biochemical trial including only 24 patients and running only for two months (trial 3) led to the same results at the same level of significance as a balanced but non-randomized trial (trial 2) with 44 patients and a four-month investigation period. A prospective but unbalanced trial (trial 1), however, did not show any significant result at all, nevertheless comprising a great number of patients (n=50).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024187
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  • 5
    Electronic Resource
    Electronic Resource
    Gastric histamine methyltransferase: Different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified enzyme preparation (1984)
    Springer
    Inflammation research 14 (1984), S. 346-350 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibitor/activator and substrate properties of enantiomers of two methylated histamines (MH) were investigated using a histamine methyltransferase preparation which was purified 1207-fold from pig fundic mucosa by ultracentrifugation, ion-exchange chromatography on DEAE-cellulose and preparative electrofocusing. In 1–100 μM concentrations,S-α-MH andR-α-MH were acceptor substrates as good as histamine itself. When substrate concentrations were increased to 1 mM these substances were methylated to an even greater extent than histamine, since they did not exert substrate inhibition on HMT. Introduction of a further methyl-group into the Nα-position reduced acceptor substrate properties drastically. A difference in methylation was then seen sinceR-α,N α-DMH was a better substrate thanS-α,N α-DMH, Whereas α-MH's could not activate HMT the α,N α-DMH's did. The poorer the substrate affinity of the investigated substances was, the better they were able to activate HMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973824
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  • 6
    Electronic Resource
    Electronic Resource
    Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model (1993)
    Springer
    Inflammation research 39 (1993), S. C169 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Protein kinase C (PKC) mediates a number of intracellular signal transduction pathways implicated in the pathogenesis of inflammation, including phospholipase A2-dependent arachidonic acid release and eicosanoid production. Recent studies demonstrate that the PKC inhibitor GF109203X significantly reduces a number of inflammatory processes resulting from PKC activation by the topical application of phorbol myristate acetate (PMA) to mouse ears. In this model, GF109203X significantly reduced edema at doses similar to the PKC inhibitor staurosporine, and more effectively than indomethacin, zileuton, or sodium meclofenamate. Histological and biochemical analysis of biopsies from control and drug-treated ears revealed a marked reduction in edema, infiltrating neutrophils, and levels of the neutrophil-specific marker, myeloperoxidase, in GF109203X-treated mice. Prostaglandin E2 levels were also reduced in ears treated with GF109203X. These data suggest that GF109203X is an effective antiinflammatory agent as evaluated in the PMA model of edema, and implicates PKC as a potential target in the development of novel anti-inflammatory agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972756
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  • 7
    Electronic Resource
    Electronic Resource
    Assay and identification of histamine in human gastric aspirate by a fluorometric-fluoroenzymatic technique. Its application in patients with chronic duodenal ulcer (1982)
    Springer
    Inflammation research 12 (1982), S. 17-25 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine assays can be unreliable in individual subjects or samples even though the particular method is in general working very well. Therefore the specificity and accuracy of histamine determination in the gastric aspirate of individual duodenal ulcer patients was thoroughly examined and shown to be satisfactory. Pitfalls of the fluorometric assay were investigated. A native (non-histamine) fluorescence in gastric aspirate which occurs before the addition of OPT was not removed by the original Shore procedure. In the combined assay (Dowex 50+ butanol extraction) this fluorescence no longer interferes with the assay. For the identification of histamine in a single gastric aspirate of an individual duodenal ulcer patient, the reversed blank (3M HCl added to the reaction mixture before OPT instead after OPT), excitation and fluorescence spectra, the heating test with spectra recorded and the HMT test were found to be reliable. The formaldehyde test and the heating test without recording the spectra were useless since they gave false negative results. Since the HMT test was regarded as a reference method it was thoroughly investigated both by theoretical considerations (enzyme kinetics) and by a series of measurements in a single patient as well as in a group of nine subjects. Samples from the period of peak acid output in response to pentagastrin showed an average histamine concentration of about 8 ng/ml and a histamine output of 1.5 μg/30 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965100
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  • 8
    Electronic Resource
    Electronic Resource
    Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: Fact or fictions? (1984)
    Springer
    Inflammation research 14 (1984), S. 325-334 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To understand the role of histamine in the aetiology and pathogenesis of human diseases reliable data are urgently needed for the histamine content and for the activities of histamine-forming and-inactivating enzymes in human tissues. In order to make a substantial progress toward this aim a tissue-sampling programme during surgical interventions was carefully conceived and conducted. From March 1982 until January 1983 106 tissue specimens were taken from 56 patients who underwent surgery. Only healthy tissues, not injured or oedematous, and without adherent structures were taken by only one surgeon who was interested in this research and experienced in tissue preparation procedures in biochemistry. The times of ‘warm’ ischaemia during the operative procedures were visually estimated, the times between resection of the organs or specimens and deep-freezing of the tissues were precisely recorded. Compared to previous work in the literature and especially to our own work using the same assays for determination higher histamine contents were found in this study in most of the tissues, in particular in the gastrointestinal tract. Also the diamine oxidase activities were considerably higher in many organs, e.g. 3–4 times higher in the gastrointestinal tract when compared with those in publications of our group who used always the same analytical test. However, the histamine methyltransferase activities in this study were not at variance to those determined in previous investigations. Many of them were reported in this communication for the first time. Since the methods for histamine determination and those for measuring enzymic activities were not different in this study and in previous communications of our group we are convinced that the optimized tissue-sampling and-preparation techniques were responsible for the higher values in this communication. But the problem of the ‘warm’ ischaemia period could not be solved by sample-taking procedures of this type during operations. There are good reasons to prefer biopsy specimens for the analysis of histamine storage and metabolism in human tissues in health and disease, but — unfortunately — they are not always available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973821
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of taprostene, a stable prostacyclin analogue, on haemodynamics, platelet function and arachidonate metabolism in healthy volunteers (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 347-350 
    Details
    ISSN: 1432-1041
    Keywords: taprostene (CG 4203) ; PGI2 analogue ; platelet function ; arachidonate metabolism ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to assess the effect of taprostene on haemodynamics, platelet function and arachidonate metabolism in 4 healthy volunteers an intravenous infusion of 25 ng · kg−1 · min−1 was given for 6 h. During the infusion period systolic blood pressure dropped from 130 to 111 mm Hg and diastolic blood pressure from 77 to 69 mm Hg. The heart rate rose from 77 to 84 beats/min. During the taprostene infusion the slope and height of the ADP and collagen induced platelet aggregation curves were significantly inhibited and the sensitivity of platelets to PGI2 and PGE1 was increased. Plasma and serum thromboxane B2, conversion of exogenous radiolabelled arachidonic acid, WU-test, circulating endothelial cell count, concentration of platelet factor 4, β-thromboglobulin, malondialdehyde and the PGI2-synthesis stimulating plasma factor did not show any clear drug-related alteration. It is concluded that infusion of taprostene 25 ng · kg−1 · min−1 caused measurable inhibition of platelet function ex vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315573
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  • 10
    Electronic Resource
    Electronic Resource
    New tools (1990)
    Springer
    Surgical endoscopy and other interventional techniques 4 (1990), S. 124-124 
    Details
    ISSN: 1432-2218
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591276
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