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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the structure and biological effects of pyrotoxins purified from burned skin (1979)
    Springer
    World journal of surgery 3 (1979), S. 361-365 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Chez des souris, une brûlure cutanée a été réalisée dans des conditions contrôlées et avec un modèle standard de brûlure à haute température. Après homogénéisation à grande vitesse de la peau brûlée, une fraction toxique a été isolée par différentes techniques de purification. Nous avons démontré qu'une brûlure à température élevée produit des condensations chimiques et des aggrégats macromoléculaires dans la fraction protéinique de la peau. Les protéines plasmatiques jouent un rôle dans ces réactions. Après purification, les aggrégats macromoléculaires sont récoltés, non pas sous forme de protéines pures, mais sous forme de micelles lipo-protéiniques. Dans la fraction lipidique, on trouve des produits de décomposition thermique. Les effets biologiques de la fraction lipoprotéinique purifiée ont été étudiés sur une perfusion de foie de rat, 5 jours après injection intrapéritonéale du produit; plusieurs activités de biosynthèse du foie isolé ont été étudiées. Nous avons observé une nette réduction de la synthèse de l'urée et une dépression de la glyconéogenèse. Ces résultats biochimiques concordent avec des modifications de l'ultrastructure cellulaire: le complexe lipo-protéinique de la peau brûlée produit une vacuolisation des mitochondries des cellules hépatiques.
    Notes: Abstract Murine skin was thermally injured under controlled conditions in a standard high temperature burn model. After high-speed homogenization of the burned skin, a toxic fraction was isolated applying different purification procedures. It was demonstrated that high temperature burns produced chemical condensations and high molecular aggregates in the protein moiety of the skin. Plasma proteins were involved in these reactions. After the purification process, the high molecular aggregates were obtained not as pure proteins, but as lipid-protein micelles. In the lipid moiety itself, thermal decomposition products were detectable. The biological effects of the purified lipid-protein fraction were studied by aid of rat liver perfusions 5 days after intraperitoneal injection of the material measuring different biosynthetic activities of the isolated organ. Significantly reduced biosynthesis of urea and depressed gluconeogenesis were demonstrable. The biochemical results are paralleled by ultrastructural findings indicating that the lipid-protein complex from burned skin causes mitochondrial vacuolization in liver cells of treated animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556594
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  • 2
    Electronic Resource
    Electronic Resource
    Zeitschriften (1956)
    Springer
    Journal of molecular medicine 34 (1956), S. 657-662 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467939
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  • 3
    Electronic Resource
    Electronic Resource
    Zeitschriften (1956)
    Springer
    Journal of molecular medicine 34 (1956), S. 765-767 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346648
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1956)
    Springer
    Journal of molecular medicine 34 (1956), S. 163-166 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480311
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  • 5
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1959)
    Springer
    Journal of molecular medicine 37 (1959), S. 774-779 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478677
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  • 6
    Electronic Resource
    Electronic Resource
    Prediction of diuretic mobilization of cirrhotic ascites by pretreatment fractional sodium excretion (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 545-551 
    Details
    ISSN: 1432-1440
    Keywords: Ascites ; Liver cirrhosis ; Xipamide ; Spironolactone ; Furosemide ; Resistance to diuretics ; Fractional sodium excretion ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a randomized prospective study the efficacy and side effects of xipamide versus the combination spironolactone/furosemide in the treatment of cirrhotic ascites were studied. Out of 27 patients four responded to a basic treatment consisting of salt and water restriction and one had to be excluded because of deterioration of kidney function. The remaining 22 patients were randomized to additional treatment with either 20 mg xipamide/day (group I) or 200 mg spironolactone/ day combined with 40 mg of furosemide every other day (group II). A response to treatment during the first 4 days was seen in 7 of 11 patients of group I versus only 3 of 11 patients in group II. In the latter group 7 of 11 patients finally responded after 8 days of treatment. Responsiveness to either diuretic treatment strongly depended on pretreatment fractional Na excretion, FENa. The resistance to diuretic treatment can be predicted by a FENa〈0.2%, and could be overcome by additional strategies known to reduce avid proximal Na reabsorption. Xipamide frequently induced hypokalemia, whereas hyperkalemia was seen following treatment with spironolactone/furosemide. Kidney function remained stable during either diuretic treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667146
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  • 7
    Electronic Resource
    Electronic Resource
    Valid parameters for investigation of the pupillary light reflex in normal and diabetic subjects shown by factor analysis and partial correlation (1994)
    Springer
    Diabetologia 37 (1994), S. 414-419 
    Details
    ISSN: 1432-0428
    Keywords: Key words Pupillary autonomic function, pupillary parameters, factor analysis, pupillary unrest.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pupillary test data of 103 normal and 119 diabetic subjects (47 IDDM, 72 NIDDM) were evaluated by factor analysis. From a total of nine pupillary parameters three factors were extracted in the analysis. Factor 1 represents maximal pupillary area, contraction velocity at 1 s, dilation velocity at 6 s and minimal pupillary area – static and simple dynamic parameters; factor 2 amplitude of pupillary unrest, area under the detrended curve of pupillary unrest and period of pupillary unrest – parameters of pupillary unrest; factor 3 fusion frequency of pupillary response following flicker stimuli and latency time of pupillary light reflex – second order dynamic parameters. Factor analysis was then applied to investigate diabetic patients with a high percentage of autonomic neuropathic participants (about 39 % had pupillary and about 35 % had cardiorespiratory function disorders), which revealed the same three factors as those identified in normal subjects. Furthermore, an age-related database of parameters of pupillary unrest is given. It demonstrates that normal subjects and diabetic patients did not differ in the period of pupillary unrest (normal vs diabetic (mean ± SEM): 1550±29 vs 1536±27 ms; 2p〉0.5). The difference in amplitude (47.8±2.8 vs 41.0±2.6 % percentile; 2p =0.071) and area under the detrended curve of pupillary unrest (47.9±2.8 vs 40.8±2.6 % percentile, 2p =0.062) seems to show a trend but was not significant. In conclusion, factor analysis revealed three different pupillary test factors. From the comparison of normal and diabetic subjects factor 1 which accounts for the highest percentage of variance (≅ 43 %) and factor 3 (≅12 %) appear to be useful for investigating the pupillary light reflex. Factor 2 is not useful because of the insignificant differences between the normal and diabetic group. From factor analysis and partial correlation we believe that pupillary autonomic function in diabetic patients can be best assessed by using only two parameters, maximal pupillary area and latency time. [Diabetologia (1994) 37: 414–419]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408480
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  • 8
    Electronic Resource
    Electronic Resource
    Valid parameters for investigation of the pupillary light reflex in normal and diabetic subjects shown by factor analysis and partial correlation (1994)
    Springer
    Diabetologia 37 (1994), S. 414-419 
    Details
    ISSN: 1432-0428
    Keywords: Pupillary autonomic function ; pupillary parameters ; factor analysis ; pupillary unrest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pupillary test data of 103 normal and 119 diabetic subjects (47 IDDM, 72 NIDDM) were evaluated by factor analysis. From a total of nine pupillary parameters three factors were extracted in the analysis. Factor 1 represents maximal pupillary area, contraction velocity at 1 s, dilation velocity at 6 s and minimal pupillary area — static and simple dynamic parameters; factor 2 amplitude of pupillary unrest, area under the detrended curve of pupillary unrest and period of pupillary unrest — parameters of pupillary unrest; factor 3 fusion frequency of pupillary response following flicker stimuli and latency time of pupillary light reflex — second order dynamic parameters. Factor analysis was then applied to investigate diabetic patients with a high percentage of autonomic neuropathic participants (about 39 % had pupillary and about 35 % had cardio-respiratory function disorders), which revealed the same three factors as those identified in normal subjects. Furthermore, an age-related database of parameters of pupillary unrest is given. It demonstrates that normal subjects and diabetic patients did not differ in the period of pupillary unrest (normal vs diabetic (mean±SEM): 1550±29 vs 1536±27 ms; 2p〉0.5). The difference in amplitude (47.8±2.8 vs 41.0±2.6 % percentile; 2p=0.071) and area under the detrended curve of pupillary unrest (47.9±2.8 vs 40.8±2.6 % percentile, 2p=0.062) seems to show a trend but was not significant. In conclusion, factor analysis revealed three different pupillary test factors. From the comparison of normal and diabetic subjects factor 1 which accounts for the highest percentage of variance (≅43 %) and factor 3(≅12 %) appear to be useful for investigating the pupillary light reflex. Factor 2 is not useful because of the insignificant differences between the normal and diabetic group. From factor analysis and partial correlation we believe that pupillary autonomic function in diabetic patients can be best assessed by using only two parameters, maximal pupillary area and latency time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408480
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    205. Untersuchungen zur Pathophysiologie der Verbrennungskrankheit (1977)
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 645-645 
    Details
    ISSN: 1435-2451
    Keywords: Burn disease ; Toxin isolation ; Electromycroscopy of the liver ; Immunology ; Verbrennungskrankheit ; Toxinisolierung ; Elektronenmikroskopie der Leber ; Immunologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Bei der Verbrennung bilden sich toxische Substanzen in der Haut, die aus tierischer, menschlicher Haut und dem Serum schwerverbrannter Patienten isoliert wurden. Das „Toxin”, ein Lipid-Protein-Komplex, das als Vorstufe in der normalen Haut vorkommt, wirkt im Tierversuch bei i.p. Applikation letal, setzt die Infektionsresistenz herab, wird in allen Organen angereichert und schädigt die Zellen, wie Untersuchungen der Ultrastruktur und des Stoffwechsels der Leber nachwiesen. Ein Antitoxin wurde entwickelt, das im Tierversuch eine signifikante Schutzwirkung zeigte.
    Notes: Summary In high temperature burns a specific substance is formed in the skin that has been isolated from in vitro burned animal and human skin as well as from serum of serverely burned patients. This toxic lipid-protein complex derived from a naturally occurring precursor has a lethal effect when injected i.p. into recepient mice. It accumulates in all organs and reduces the animals' resistance to infection. Cell destruction was shown by ultrastructural and metabolic changes in the liver. An antitoxin was developed that protects against the lethal effect as well as the superimposed sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01305651
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  • 10
    Electronic Resource
    Electronic Resource
    Referatenteil (1955)
    Springer
    Journal of molecular medicine 33 (1955), S. 678-688 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01473003
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    Paper (German National Licenses)
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