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  • 1
    Electronic Resource
    Electronic Resource
    Nitrogen Metabolizing Enzyme Activities In the Free-Living Soil Amoebae Acanthamoeba Castellanii, Acanthamoeba Polyphaga and Hartmannella Vermiformis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 40 (1993), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . Free-living soil amoebae consume a wide variety of food, including algae, yeast, small protozoa and especially bacteria, which they digest to fulfil their nutritional requirements. Amoebae play an active role in the nitrogen mineralization in soils due to their nitrogen metabolizing capacities. However, little is known about nitrogen metabolizing enzyme activities in these free-living soil amoebae. In this study a number of key enzymes involved in the nitrogen metabolism of the axeaically cultivated free-living soil amoebae Acanthamoeba castellanii, Acanthamoeba polyphaga and two different strains of Hartmannella vermiformis were determined. the specific enzyme activities for exponential growth phase ceils were calculated and it appeared that the species tested possessed urate oxidase, glutamine synthetase, NADH-dependent glutamate dehydrogenase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase activity. Glutamate synthase activity could not be detected in any of these species. the levels of specific activities varied depending on the enzymes tested. For all species the highest activities were detected for the transaminase reactions yielding glutamate, and for glutamate dehydrogenase. A general conclusion is that the pathway of nitrogen assimilation in free-living soil amoebae is similar to the one observed for other eukaryotes. Differences in specific activities were detected between the species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1993.tb04912.x
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  • 2
    Electronic Resource
    Electronic Resource
    Unusual Sequence of Immunoglobulin L-Chain Rearrangements in a Gamma Heavy Chain Disease Patient (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 36 (1992), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients with gamma heavy chain disease (γ-HCD) generally produce incomplete immunoglobulin (Ig) γ-heavy chains (yγ-HCD protein) which cannot associate with light chains (IgL). In most patients Bence Jones proteins (BJP) are not observed. However, in the 61-year-old patienl WIN we found γl-HCD proteins and λ BJP in serum and urine. WIN -γl-HCD protein does not carry the Ig Fd region, has a molecular weight of 33.5 kDa, and the seven N-terminal amino acid residues are not translated from any of the known immunoglobulin heavy chain (IgH) gene sequences. These residues are followed by the Cγl-hinge region. In DNA from peripheral blood lymphocytes of patient WIN we found bands representing dominant rearrangements in one ofthe two alleles of the IgH, IgK and Igλ locus. Taken together, the data from protein and DNA analysis strongly suggest, albeit do not formally prove, that one dominant B-cell clone which carries it rearranged and a non-rearranged allele of each Ig locus produces γ-HCD protein and λ BJP. The productive λ-gene rearrangement in this clone thus has not been preceded by abortive rearrangements in both γ-locus alleles. Lymphocytes with an unusual sequence of IgL-chain gene activation seem to be involved in the case of γ-HCD described here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1992.tb02961.x
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  • 3
    Electronic Resource
    Electronic Resource
    New Orally Effective Iron Chelators (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 612 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb24322.x
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  • 4
    Electronic Resource
    Electronic Resource
    Primary antiphospholipid syndrome (PAPS) (1991)
    Springer
    Rheumatology international 10 (1991), S. 255-260 
    Details
    ISSN: 1437-160X
    Keywords: Anticardiolipin antibodies ; Primary antiphospholipid syndrome ; Antiphospholipid antibodies ; Lupus anticoagulant ; Thrombosis ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antiphospholipid antibodies (aPL) interfere with the coagulation system and can cause thrombosis and other clotting disorders. The combination of recurrent venous thrombosis, arterial embolism and recurrent fetal loss is nowadays considered to be primary antiphospholipid syndrome (PAPS), provided an underlying systemic lupus erythematosus (SLE) has been excluded and aPL have been detected. We report on two patients with PAPs, and show the course of their IgG- and IgM-anticardiolipin antibody (aCL) titers during immunosuppressive therapy with prednisone and azathioprine or cyclophosphamide. Over a period of 18 months this therapy was effective in preventing relapses of thrombo-embolism and other complications. Therapy with cyclophosphamide resulted in normalization of the aCL titers in one of the two reported cases. Azathioprine treatment reduced the aCL titer in the other patient, without fully normalizing it. Based on our observation, we propose to treat PAPS-associated severe and recurrent thrombo-embolic complications by aggressive immunosuppression, including azatioprine and cyclophosphamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274889
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  • 5
    Electronic Resource
    Electronic Resource
    MHC associations of autoantibodies against recombinant Ro and La proteins in systemic lupus erythematosus (1992)
    Springer
    Rheumatology international 12 (1992), S. 169-173 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Genetics ; Ro and La antibodies ; Recombinant autoantigens ; MHC ; Multicenter study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies against recombinant 52 kD-Ro, recombinant 60 kD-Ro and recombinant La protein were determined by ELISA in over 300 central European patients with systemic lupus erythematosus (SLE). A strong association with HLA-DR3 was found for antibodies against 52 kD-Ro and La, but not for recombinant 60 kD-Ro antibodies in the absence of antibodies against 52 kD-Ro or La. Ro/La negative SLE patients still showed an increased frequency of HLA-DR3 as compared to healthy controls. These results indicated that the preferential formation of Ro and La antibodies was not due to an unspecific stimulatory effect of HLA-DR3 but that the antibody response to certain defined proteins (52 kD-Ro and La) was influenced by MHC genes in SLE. Furthermore, the association of SLE with HLA-DR3 was independent of the effects of DR3 on the formation of 52 kD-Ro and La antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302148
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  • 6
    Electronic Resource
    Electronic Resource
    Palmar fascial thickening and contractures of fingers resembling arthritis — a paraneoplastic symptom? (1992)
    Springer
    Rheumatology international 12 (1992), S. 79-80 
    Details
    ISSN: 1437-160X
    Keywords: Finger contractures ; Palmar fasciitis ; Ovarian carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 59-year-old women presented with contractures of the fingers of both hands 11 months before a diagnosis of an ovarian carcinoma with paraaortic lymph node metastases was made. We suggest that the contractures, which were associated with palmar fascial thickening and which clinically resembled arthritis, might have been a paraneoplastic sign.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300982
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  • 7
    Electronic Resource
    Electronic Resource
    HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus (1994)
    Springer
    Rheumatology international 14 (1994), S. 63-69 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Recombinant U1-nRNP proteins ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate a possible involvement of HLA-class II alleles in the genetic predisposition for the formation of anti-U1-nRNP antibody in systemic lupus erythematosus (SLE), genomic DNA of 178 patients was typed for the DRB1, DQA1 and DQB1 alleles using a polymerase chain reaction (PCR) and non-radioactive-oligonucleotide typing. Antibodies against recombinant U1-nRNP proteins (U1-A- U1-C-and 70K-protein) were determined by ELISA. Anti-U1-C antibody was found in 26 (14.7%), anti-U1-A in 34 (19.2%) and anti-70K in 17 (9.6%) patients. A joint occurrence was observed for these antibodies against the recombinant U1-nRNP proteins: anti-U1-C and anti-U1-A antibodies occurred together more frequently than alone and than together with anti-U1-70K antibodies. The frequency of DRB1 * 04 was slightly increased in the patients with anti-U1-C as compared to the patients without anti-U1-C (P〈0.05, Pcorr=n.s., RR=2.4). The DQA1 * 0301 allele, which is in linkage disequilibrium with DRB1 * 04, is found more frequently in anti-U1-C-positive than in antibody-negative patients. The DQB1 * 0303 allele, detected in 12 of 176 SLE patients, was absent in the patients with any of the antibodies against the U1-nRNP proteins. All these deviations may be due to chance alone. We concluded that the presence of antibodies against recombinant U1-nRNP proteins was not significantly associated with any HLA DRB1, DQA1 and DQB1 allele in our group of SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300249
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  • 8
    Electronic Resource
    Electronic Resource
    HLA-DR1 and DRw6 association in DR4-negative rheumatoid arthritis patients (1990)
    Springer
    Rheumatology international 10 (1990), S. 171-175 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; HLA-DR antigens ; Conformational equivalence hypothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study of 110 seropositive rheumatoid arthritis (RA) patients confirms the significant association of susceptibility to RA with HLA-DR4 specificity (P〈0.001). The DR1 frequency is elevated in the entire seropositive patient group, reaching marginal significance (P〈0.025). The DR4-negative patients, however, have a much higher prevalence of DR1 (P〈0.001). Surprisingly, the DRw6 specificity is significantly increased in the remaining DR4- and DR1-negative patients (P〈0.01). These results demonstrate that RA is not associated with a single HLA-specificity, but to various degrees with DR4, DR1, and DRw6. These findings, and particularly the newly recognized association with DRw6, support the hypothesis that functionally equivalent shared epitopes or conformations on otherwise distinct MHC molecules may confer risk for developing RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274843
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  • 9
    Electronic Resource
    Electronic Resource
    A long-term longitudinal isotypic study of anti-topoisomerase I autoantibodies (1992)
    Springer
    Rheumatology international 12 (1992), S. 231-234 
    Details
    ISSN: 1437-160X
    Keywords: Scleroderma ; Anti-topoisomerase I autoantibodies ; CREST ; Raynaud's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this first retrospective longitudinal study of anti-topoisomerase I autoantibodies (anti-topo I) we examined the isotypic expression in 13 patients with scleroderma by enzyme-linked immunosorbent assay. Titers were stable for up to 16 years. However, one patient lost the antibody, while another developed high levels of IgM with myositis and another, high levels of IgA with cardiac disease. For the first time the de novo development of anti-topo I was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301007
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  • 10
    Electronic Resource
    Electronic Resource
    Intravascular lymphoma simulating vasculitis (1994)
    Springer
    Rheumatology international 14 (1994), S. 131-133 
    Details
    ISSN: 1437-160X
    Keywords: Intravascular lymphoma ; Vasculitis Systemic disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case history of a patient with intravascular lymphoma (IL) is reported. Signs of a systemic illness including fever, muscular weakness, telangiectasias, nephrotic syndrome, and neurologic manifestation suggested vasculitis. Cyclophosphamide treatment produced almost complete remission, but the patient died of respiratory failure 13 months after presentation due to lung involvement. The diagnosis was not revealed until postmortem examination. The differential diagnosis of IL is provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300816
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