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  • Polymer and Materials Science  (4)
  • Adenylate cyclase  (3)
  • Alzheimer's disease  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1093 (1991), S. 95-101 
    Details
    ISSN: 0167-4889
    Keywords: (Pig epidermis) ; Adenylate cyclase ; Agonist ; Desensitization ; Phorbol ester
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4889(91)90143-L
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5 (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 626-631 
    Details
    ISSN: 1432-0533
    Keywords: C-series gangliosides ; Microtubule-associated protein 5 ; Fetal antigen ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistological study of Alzheimer's brains was performed using antibodies to C-series gangliosides and microtubule-associated protein 5 (MAP5), and their staining patterns were compared with those of antibodies to tau and β-amyloid precursor protein. Antibodies to C-series gangliosides and MAP5, both of which are known to preferentially expressed in the fetal brains, immunostained dystrophic neurites of senile plaques, neurofibrillary tangles and neuropil threads abundant in 3rd and 5th layers in the cerebral cortex, all of which are considered to be pathological hallmarks of Alzheimer's disease. The immunostaining patterns of these structures by antibodies to C-series gangliosides and MAP5 were similar to those by the antibody to tau. These three antibodies also immunostained some neurons in Alzheimer's brain, although their staining patterns were slightly different from one another; i.e., both diffuse and granular patterns were seen by the antibody to tau, but only granular pattern by the antibodies to C-series gangliosides and MAP5. These neurons immunostained by these three types of antibodies appeared to be the precursors of the classical neurofibrillary tangles, as positively stained neurons were not seen in the brains of non-demented cases. The presence of fetal antigens such as the C-series gangliosides and MAP5 in Alzheimer's brain may suggest that regeneration or sprouting of neurons is ongoing in association with the re-induction of gene expression characteristic for the brain in the early stage of development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296372
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  • 3
    Electronic Resource
    Electronic Resource
    Establishment of a monoclonal antibody against senile plaques and its application for immunohistological and immunoelectron microscopical studies in the brain of the elderly (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 44-47 
    Details
    ISSN: 1432-0533
    Keywords: Monoclonal antibody ; Senile plaque ; Alzheimer's disease ; Senile dementia of Alzheimer type ; Congophilic angiopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A monoclonal antibody (Am-3) was produced against senile plaques in the brain of a patient with Alzheimer's disease. Am-3 was reactive with senile plaques of typical, primitive and diffuse type not only in the brain used as immunogen, but also those in the brain of 15 out of 25 autopsy cases of the aged people. Moreover, Am-3 was also reactive with granular materials of various sizes scattered in the 1st, 3rd and 4th layers of the cerebral cortices of the cases with severe dementia. Am-3 was also reactive with vessel wall of the congophilic angiopathy. By immunoelectron microscopic examination, Am-3 was positive with amyloid fibril in the core and crown of senile plaques, and in the congophilic angiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308956
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  • 4
    Electronic Resource
    Electronic Resource
    Protein kinase C-dependent modulation of stimulatory guanine nucleotide binding protein of fetal rat skin keratinocytes (1995)
    Springer
    Archives of dermatological research 288 (1995), S. 24-30 
    Details
    ISSN: 1432-069X
    Keywords: Key words G-protein ; Adenylate cyclase ; Phorbol ; esters ; Densensitization ; Keratinocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) has been known to induce heterologous desensitization of the epidermal adenylate cyclase, the precise mechanism of PMA action remains unknown. Effects of PMA on the receptor-G-protein-adenylate cyclase system of fetal rat skin keratinocytes (FRSK) were investigated. Choleratoxin catalysed the ADP ribosylation of 45 kDa and 52 kDa membrane proteins and islet activating protein (IAP) catalysed the ADP ribosylation of a 40 kDa membrane protein. Incubation of FRSK with PMA decreased the cholera toxin-catalysed ADP ribosylation of the membrane protein, but not the IAP-catalysed ADP ribosylation. The effect of PMA on the cholera toxin-catalysed ADP ribosylation was inhibited by the PKC inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methyl piperazine dihydrochloride). 1-Oleoyl-2-acetylglycerol (OAG), a membrane-permeable diacylglycerol analogue, also decreased the cholera toxin-catalysed ADP ribosylation, but 4- O -methyl PMA, a very weak PKC activator, had no effect. Keratinocytes are known to express the guanine nucleotide binding proteins, Gsα, Gi2α and Gi3α. Immunoblot analysis of the PMA-treated FRSK showed no detectable difference in the amount of Gsα, Gi2α, Gi3α or the β subunit of the G-protein. PMA significantly decreased the β-adrenergic adenylate cyclase response and cholera toxin-induced cyclic AMP accumulation, while it markedly increased forskolin-induced cyclic AMP accumulation. These results indicate that phorbol esters affect the stimulatory guanine nucleotide binding protein (Gs) of FRSK via a PKC-dependent pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050018
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  • 5
    Electronic Resource
    Electronic Resource
    Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with alzheimer's disease (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 94-97 
    Details
    ISSN: 1420-9071
    Keywords: Alzheimer's disease ; brain ; proteases ; kallikrein ; prolyl endopeptidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10−7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955428
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  • 6
    Electronic Resource
    Electronic Resource
    CRP down-regulates adenylate cyclase activity by reducing the level of phosphorylated IIAGlc, the glucose-specific phosphotransferase protein, in Escherichia coli (1998)
    Springer
    Molecular genetics and genomics 259 (1998), S. 317-326 
    Details
    ISSN: 1617-4623
    Keywords: Key words cAMP level ; Adenylate cyclase ; CRP ; Phosphorylation state ; IIAGlc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The cellular cAMP level is markedly down-regulated by cAMP receptor protein (CRP) in Escherichia coli. CRP regulates adenylate cyclase both at the level of transcription of its structural gene cya and at the level of enzyme activity. We established a method to determine the phosphorylation state of IIAGlc, the glucose-specific phosphotransferase protein, in intact cells. We found that IIAGlc exists predominantly in the unphosphorylated form in wild-type cells growing in LB medium, while it is largely phosphorylated in crp or cya cells. Disruption of the ptsG gene that codes for the membrane component of the major glucose transporter (IICBGlc), and/or the fruF gene coding for FPr (fructose-specific hybrid phosphotransferase protein), did not affect the phosphorylation state of IIAGlc. When IICBGlc was overproduced in the presence of glucose, the levels of both cAMP and phosphorylated IIAGlc in crp cells were concomitantly decreased to wild-type levels. In addition, when His-90 in IIAGlc was replaced by glutamine, both phosphorylation of IIAGlc and the overproduction of cAMP in crp cells were eliminated. We also found that extracts of crp + cells markedly stimulate dephosphorylation of IIAGlc-P in vitro. We conclude that CRP-cAMP down-regulates adenylate cyclase primarily by reducing the level of phosphorylated IIAGlc. The data suggest that unspecified proteins whose expression is under the control of CRP-cAMP are responsible for this regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050818
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  • 7
    Electronic Resource
    Electronic Resource
    Radical polymerization of 3-cyano-3-ethoxycarbonylpropyl vinyl ether via addition-abstraction mechanism (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 2839-2847 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080261020
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  • 8
    Electronic Resource
    Electronic Resource
    Phase separation in mixtures of poly(ethylene glycol monomethylether) and poly(propylene glycol) oligomers (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 29 (1991), S. 1419-1425 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Time-resolved light scattering was employed to investigate kinetics of phase separation in mixtures of poly (ethylene glycol monomethylether) (PEGE)/poly (propylene glycol) (PPG) oligomers. Phase diagrams for PEGE/PPG of varying molecular weights were established by means of cold point measurements. The oligomer mixtures reveal an upper critical solution temperature (UCST). Several temperature quench experiments were carried out with a 60/40 PEGE/PPG blend by rapidly quenching from a single phase (69°C) to two-phase temperatures (66-61°C) at 1°C intervals. As is typical for oligomer mixtures, the early stage of spinodal decomposition (SD) was not detected. The kinetics of phase decomposition was found to be dominated by the late stage of SD. Time-evolution of scattering intensity was analyzed in accordance with nonlinear and dynamical scaling theories. The time dependence of the peak intensity Im and the corresponding peak wavenumber qm was found to follow the power-law {Im(t)˜ tα, qm(t)˜ t-β} with the values of α = 3 ± 0.3 and β = 1 ± 0.2, which are very close to the values predicted by Siggia. This process has been attributed to a coarsening mechanism driven by surface tension. In the temporal scaling analysis, the structure function reveals university with time, suggesting self-similarity. Phase separation dynamics in 60/40 PEGE/PPG resembles the behavior predicted for off-critical mixtures.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1991.090291110
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  • 9
    Electronic Resource
    Electronic Resource
    Reverse osmosis with dynamically formed membranes from water-soluble polymers (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 22 (1978), S. 1607-1618 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Membranes were dynamically formed from poly(acrylic acid), poly(1-methyl-2-vinylpyridinium iodide), and methylcellulose on a Millipore filter. The effects of the conditions of membrane formation on reverse osmosis performances and the membrane structure were investigated. The primary factors that affect membrane performance were ascertained to be the kind and concentration of salts and the pH of the preparing solutions, the concentration and the polymerization degree of the membrane materials, the pore size of filters, and the pressure and circulation velocity during membrane formation. Two types of dynamically formed membranes, the membranes inside the filter and the membranes on the filter, were distinguished.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1978.070220612
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  • 10
    Electronic Resource
    Electronic Resource
    Permselectivities of some aromatic compounds in organic medium through cellulose acetate membranes by reverse osmosis (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 22 (1978), S. 2609-2620 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Reverse osmosis of some aromatic compounds in 1-propanol solution using porous cellulose acetate membranes and some factors which influence the organic solute permeability were investigated. Reverse osmosis data for a number of benzene derivatives showed that only phenol was rejected and the others were enriched. For the compounds with various substituent groups, the solute permeabilities have the following order; OH 〈 CH3 〈 H 〈 Cl 〈 NH2 〈 NO2. In the series of benzene, naphthalene, and anthracene, the permeability is related to the molar volume of solutes and varied as follows: benzene 〈 naphthalene 〈 anthracene. Generally speaking, there are two factors - a partition coefficient and a diffusion coefficient - for governing the permeation behavior through the membrane. Under the condition that no steric effect is exerted, the partition coefficient exclusively is a dominant factor. A good correlation between the partition coefficient of a particle and that of the membrane was pound. The partition coefficients are closely related to the dipole moment of solutes.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1978.070220917
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