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  • Calcium  (2)
  • Methoxyisobutylisonitrile  (2)
  • Adenylate cyclase  (1)
  • Colonic adenoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion
    Amsterdam : Elsevier
    FEBS Letters 222 (1987), S. 327-331 
    Details
    ISSN: 0014-5793
    Keywords: Adenylate cyclase ; Membrane fusion ; Opiate receptor ; Reconstitution
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(87)80395-2
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epidermal growth factor receptors and epidermal growth factor-like activity in colorectal mucosa, adenomas and carcinomas (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 518-523 
    Details
    ISSN: 1432-1440
    Keywords: Epidermal growth factor ; EGF ; Transforming growth factor ; EGF-receptor ; Carcinogenesis ; Colon ; Rectum ; Colonic adenoma ; Colonic carcinoma ; Familial polyposis coli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The epidermal growth factor (EGF) and alpha-tumor growth factor are mitogenic proteins which bind to the EGF-receptor and may play a role in carcinogenesis or tumor progression. Our study investigated whether colorectal carcinomas and adenomas express altered levels of EGF-receptors or overproduce EGF-like activity by comparing histologically normal mucosa to carcinomas resected from the same patients. EGF-receptors were characterized by radioligand binding studies. Carcinomas contained unchanged or decreased levels of EGF-receptors in 13/16 and moderately increased levels in 3/16 patients as compared to normal mucosa. Adenomas obtained from 2 patients with familial polyposis coli and from a third patient with a coincident carcinoma had similar numbers of EGF-receptors as normal mucosa. EGF-like growth factors, in contrast, were significantly elevated in carcinoma extracts as compared to extracts from normal mucosa of the same patients. Adenomas did not contain elevated levels of EGF-like activity. We conclude that increased expression of EGF-receptors is infrequent in colonic adenocarcinomas. Increased production of EGF-like growth factors may frequently occur but seems to be associated with tumor progression rather than with premalignant lesions as represented by adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719776
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Muscarinic inhibition of potassium-induced noradrenaline release and its dependence on the calcium concentration (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 291 (1975), S. 1-15 
    Details
    ISSN: 1432-1912
    Keywords: Heart ; Noradrenaline release ; Potassium ; Calcium ; Methacholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Noradrenaline release from the isolated rabbit heart was evoked by perfusion with a medium containing 135 mM potassium and 17 mM sodium ions (high K+-low Na+). 2. The noradrenaline output in response to high K+-low Na+ was dose-dependently decreased by methacholine (0.625–320 μM) and this effect was reserved by atropine 1.44 μM. 3. Lowering the calcium concentration of high K+-low Na+ from 1.8–0.1125 mM decreased the noradrenaline output by 85%. The effect of methacholine, expressed as % inhibition of noradrenaline release, was potentiated by lowering of the calcium concentration. 4. Both at normal and lowered calcium concentrations the inhibitory action of methacholine was larger from 0–5 than from 5–10 min after perfusion with high K+-low Na+. 5. Perfusion of hearts with media containing high K+-high Na+ or normal K+-low Na+ caused noradrenaline outputs somewhat smaller than those after high K+-low Na+. The release from 0–5 min was both calcium-dependent and inhibited by methacholine. 6. High K+ and/or low Na+ solutions caused an increase in coronary perfusion pressure which was little affected by the noradrenaline released simultaneously. 7. It is concluded that activation of muscarine receptors at the terminal adrenergic fibre decreases the availability of calcium for transmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510816
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  • 4
    Electronic Resource
    Electronic Resource
    Perioperative myocardial perfusion scintigraphy at rest with technetium 99m methoxyisobutylisonitrile before and after coronary bypass operations (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 99-105 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m ; Methoxyisobutylisonitrile ; Myocardial perfusion scintigraphy ; Coronary bypass operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen patients were examined at rest by technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial scintigraphy 1 day before and 1 week after aorto-coronary bypass operation with planar and single photon emission tomography (SPET) imaging. One day postoperatively, a planar scintigraph in the intensive care unit (ICU) was done. Inter-observer variability was 3.8% for all examinations and for SPET alone, 3.9%. The quality of the planar images taken under emergency conditions in the ICU was quite comparable with those taken under routine conditions. The postoperative myocardial infarction in a patient who died 6 days later could clearly be demonstrated. In 16.2% of all segments which were hypoperfused at rest on preoperative scintigraphy, an amelioration of perfusion could be shown in the 1 st week after the bypass operation.99Tc-MIBI proved to be a useful agent to assess perioperative perfusion, in the ICU as well as under standard conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00950754
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Perioperative myocardial perfusion scintigraphy at rest with technetium 99m methoxyisobutylisonitrile before and after coronary bypass operations (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 99-105 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m ; Methoxyisobutylisonitrile ; Myocardial perfusion scintigraphy ; Coronary bypass operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen patients were examined at rest by technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial scintigraphy 1 day before and 1 week after aorto-coronary bypass operation with planar and single photon emission tomography (SPET) imaging. One day postoperatively, a planar scintigraph in the intensive care unit (ICU) was done. Inter-observer variability was 3.8% for all examinations and for SPET alone, 3.9%. The quality of the planar images taken under emergency conditions in the ICU was quite comparable with those taken under routine conditions. The postoperative myocardial infarction in a patient who died 6 days later could clearly be demonstrated. In 16.2% of all segments which were hypoperfused at rest on preoperative scintigraphy, an amelioration of perfusion could be shown in the 1 st week after the bypass operation. 99Tc-MIBI proved to be a useful agent to assess perioperative perfusion, in the ICU as well as under standard conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175912
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Novel and uncommon isoforms of the calcium sensing enzyme calcium/calmodulin dependent protein kinase II in heart tissue (1995)
    Springer
    Basic research in cardiology 90 (1995), S. 372-379 
    Details
    ISSN: 1435-1803
    Keywords: Calcium ; calmodulin ; protein kinase ; calmodulin dependent protein kinase ; isoform
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcium/calmodulindependent protein kinase type II (CaM kinase II) is an intracellular enzyme discovered several years ago in the brain which is obviously involved in intracellular signal transmission. Meanwhile it was detected in virtually every mammalian tissue. Several isoforms have been found to exist. Most recently the tissue distribution and the molecular structure of these isoforms have suggested that each form entails a particular function. In the present study we describe the identification, cloning, and nucleotide sequencing of two novel CaM kinase II isoforms which we discovered in rat heart. The presence of these additional subtypes makes the heart the organ which possesses the greatest number of different and unusual CaM kinase II isoforms throughout the body except for the brain. The importance of this finding is underscored by the fact that calcium is involved in the regulation of many crucial cardial parameters. The deduced amino acid sequence that we have obtained from the new CaM kinase II isoforms indicates a molecular organization which could make the design of subtype-specific inhibitory drugs for CaM kinase II possible. Such compounds would act similarly to but much more selectively than digitalis glycosides and would be likely to possess less side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788498
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