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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 727-729 
    ISSN: 1432-1440
    Keywords: Knochenmark ; Histologie ; Bone marrow ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Histological sections of methacrylate-embedded bone marrow biopsies allow exact evaluation and classification of the cellular marrow components. We describe a simple method for preparation of sections of aspirated bone marrow particles following embedment in methacrylate. Comparison of histological sections from marrow particles and marrow biopsies demonstrated identical quality. Thus, preparation of methacrylate-embedded particle histologies will frequently abrogate the need for marrow biopsies performed in addition to a marrow aspiration. Routine preparation of both cytological and histological preparations from aspirated bone marrow allows more exact assessment of the bone marrow than cytological evaluation only.
    Notes: Zusammenfassung Histologische Schnitte methacrylat-eingebetteter Knochenmarksbiopsien erlauben wegen der hervorragend erhaltenen Zellstrukturen eine genaue Beurteilung des Knochenmarks. Wir haben eine einfache Methode entwickelt, um aspirierte Knochenmarksbröckel nach Methacrylateinbettung histologisch aufzuarbeiten. Die histologischen Präparate solcher Bröckelhistologien zeigen eine den üblichen Knochenmark-Nadelbiopsien vergleichbare Qualität. Methacrylat-eingebettete Bröckelhistologien machen so häufig eine zusätzlich zur Knochenmarkaspiration durchgeführte Knochenmarkbiopsie überflüssig. Routinemäßige Anfertigung zytologischer und bröckelhistologischer Präparate aus aspiriertem Mark erlaubt eine genauere Beurteilung des Markes als die zytologische Untersuchung alleine.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1335
    Keywords: Interferon plus MPA ; Advanced renal cell cancer ; Medroxyprogesterone acetate (MPA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFNα) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFNα 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFNα 2C (2MU) was given s.c. 5 times per week for 8–12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p. o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4%, corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
    Type of Medium: Electronic Resource
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