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  • 1
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    Efficient hybrid method for the modal analysis of optical microcavities and nanoresonators (2021)
    Details
    Publication Date: 2022-06-13
    Language: English
    Type: article , doc-type:article
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    OPUS
  • 2
    Electronic Resource
    Electronic Resource
    A Radial Basis Function Neural Network Multicultural Factors Evaluation Engine For Product Concept Development (2001)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Expert systems 18 (2001), S. 0 
    Details
    ISSN: 1468-0394
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Computer Science
    Notes: In recent years, new product development (NPD) has become more and more competitive and globalized. In order to succeed in the global marketplace, it is imperative to take multicultural factors into serious consideration during the stage of product concept development. Generally, the voice of customers has been treated as a starting point to downstream product definition and design metrics determination in developing new product concepts. As a result, the elicitation, representation and management of customer requirements will determine the success level of an organization's NPD efforts. Therefore, multicultural factors, also known as the ‘macro’ perspective in the business environment, are the most significant imperatives for organizations to handle, especially in the current trend of globalization. In practice, there are few holistic and promising systems for multicultural factor evaluation in customer requirements. This work aims at realizing a prototype system that combines the strengths of the laddering technique and the radial basis function neural network for customer requirements acquisition and multicultural factor evaluation. The performance of the prototype system is illustrated by using a case study on the design of a refrigerator. The results obtained from the case study are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1468-0394.00177
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A Web-enabled product definition and customization system for product conceptualization (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Expert systems 22 (2005), S. 0 
    Details
    ISSN: 1468-0394
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Computer Science
    Notes: Abstract: Owing to rapidly changing customer needs and much shorter product life cycles, for developing a successful product it is imperative to employ more efficient and flexible approaches for product conceptualization. To meet this demand, a Web-enabled product definition and customization system (PDCS) is proposed, from a design-knowledge-handling viewpoint, in this paper. It comprises two phases, namely product definition based on the laddering technique and a novel design knowledge hierarchy, and product customization based on an integrated methodology of conjoint analysis and Kohonen association techniques. Basically, this system is a method of conducting design decision-making via customer involvement, i.e. a strategy for transforming customer preference into a specific product concept. A case study on wood golf club design is used to illustrate and validate the proposed Web-enabled PDCS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-0394.2005.00315.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A Prototype Recombinant Vaccine Against Respiratory Syncytial Virus and Parainfluenza Virus Type 3 (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 813-818 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have produced a genetically-engineered chimeric protein composed of the external domains of the respiratory syncytial virus (RSV) fusion (F) protein and the parainfluenza virus type 3 (PIV-3) hemagglutinin-neuraminidase (HN) protein in insect cells using the baculovirus expression system. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0894-813
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Biological and Biomechanical Behavior of Titanium Implants with Fluoridated Hydroxyapatite Coatings (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1087-1090 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: For dental/orthopedic implants to achieve better bone apposition and bone-implantbonding, various approaches to improve titanium surfaces have been developed. Recently, afluoridated hydroxyapatite (FHA) coating on titanium (Ti) implants was made by sol–gel methodand shown to be a possible applicative bone implant. The purpose of the current study was toevaluate biological responses and biomechanical bonding strength of FHA coated Ti implants ascompared with that of the conventional Ti alloys and hydroxyapatite (HA) coated Ti implants. Invitro assays were made using human osteoblast-like cell (MG63) culture on different implants withcell attachment, morphology and differentiation evaluations. The implant plates were alsoimplanted into the proximal metaphysis of New Zealand White rabbit tibiae. After 8 and 16 weeksimplantation, mechanical and histological assessments were performed to evaluate biomechanicaland biological behavior in vivo. The results showed that the cell adhesion and cell growth rate onthe FHA and HA surface was higher than that on cp Ti surface (p〈0.01), and insignificantdifference was observed between two coated groups. Mechanical test demonstrated that the FHAimplants had a higher interface shear strength than the both controls at 8 and 16 wks, with nosignificant difference with HA-Ti. Histologically, the coated implants revealed a significantlygreater percentage of bone-implant contact when compared with the uncoated implants. Resultsdemonstrated that the new FHA surface improved cell adhesion and proliferation. The coatingexhibited a bioactive mechanical and histological behavior at bone-implant interface, suggestingthat a useful approach by combined coating processes could optimize implant surfaces for bonedeposition and early implant fixation
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1087.pdf
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Functional Behaviour of Human Periodontal Ligament Cells around Various Dental Implants (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 837-840 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In the present investigation, four titanium (Ti) surfaces of dental implants were comparedthrough in vitro systems. The surface roughness of Ti was measured by TR240 mobile surfaceroughmeter. The Ti implants were seeded with human periodontal ligament cells (hPLDCs) andmaintained for a period of 0-7 days. The adhesion, proliferation, and differentiation of hPLDCswere observed by using Cell morphology, cell counting and Osteocalcin (OC) immunofluorescentstaining. Results suggest that surface roughness of titanium favors hPDLCs behavior and improvescell adhesion, proliferation, and differentiation
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.837.pdf
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Pressureless Sintering the Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉/SiC Nanocomposites in Deoxidized Atmosphere (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1093-1096 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Many significant improvements have been shown in mechanical properties of ceramic nanocomposites with ceramic matrix being dispersed with second sub-micro sized (or nano-sized) phase. This study designed and fabricated Al2O3/SiC nanocomposites with a raw material used for 85% alumina as matrix andSiC grits in submicro-scale as dispersion phase via a controlled pressureless sintering in air. With coarse SiC powder as bed powder, both C and SiC powder making deoxidized atmosphere, 85Al2O3/SiC nanocomposites with different SiC contents were densified by pressureless sintering at low temperature. Fracture surface investigation indicated that dense nanocomposites with small grain size were produced. General material properties and microstructure were measured and characterized. The results showed that composites sintered in deoxidized atmosphere had better mechanical properties than those sintered in flowing argon
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1093.pdf
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Processing of Calcium Phosphate Porous Materials by 'Self-Setting' (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1563-1566 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Macroporous biomaterials based on a-tricalcium phosphate (a-TCP) bone cement with porous structures suitable for implantation purposes were prepared in the present work. According to the reversible swelling/deswelling behavior of gelatin at a single temperature or pH, a “self-setting” method that uses gelatin granules as pore formers was developed to process the porous microstructure. By mixing gelatin powder and bone cement powder (BCP), and adding water (1% solution of NaH2PO4×HO) to form pastes which set within 15 to 30 min, this setted cement was then immerged in deionized water of temperature 25°C or 32°C for hydration. During the hydration, the pH of deionized water after cement pastes were introduced at 32°C changed from 8.6 to 7.2 which caused by the transformation of a-TCP to hydroxyapatite (HA). Meanwhile, gelatin particles will swell by water uptake to form large size spheres in cementmatrix. This swelling behavior is sensitive to the variation of pH value. After hydration for 4 day, a body containing gelatin gel spheres was obtained. Then heating the deionized water to temperature 50°C, gelatin spheres in cement matrix were solved and porous microstructure composed of larger pore sizes corresponding approximately to the average size ofthe swelling gelatin granules was obtained. The porous bodies by this technique were found to have tractable and interconnected porosity in the range of 60~84%, with typical pore sizes ranging from 100~300 microns. This new processing technique can be used in the manufacture of unsintered biomaterials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1563.pdf
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    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 401 (1999), S. 670-677 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Id proteins may control cell differentiation by interfering with DNA binding of transcription factors. Here we show that targeted disruption of the dominant negative helix–loop–helix proteins Id1 and Id3 in mice results in premature withdrawal of neuroblasts from the cell cycle and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/44334
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    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    In vitro Investigation of Mesenchymal Stem Cells with Nanophase PLGA/HA Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1153-1156 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone grafts have been used to fill bone defects caused by disease or trauma. The amount ofautografts is limited and allogenic bone grafts may transmit diseases and cause immune responses.Numerous materials have been proposed and used as scaffolds for bone tissue reconstruction. In thisstudy, we tested nanophase PLGA/HA composite with mesenchymal stem cells in vitro to examineits biological response and cellular activity. The nanophase composite was compared toconventional polystyrene on cytocompatibility by cell attachment, proliferation, alkalinephosphotase activity test and scanning electron microscopy (SEM) analysis. The resultsdemonstrated that human mesenchymal cells showed more cell attachment and higher cellproliferation rate when growing on nanophase PLGA/HA composite than those growing onpolystyrene alone. And the composite also promoted MSC cells differentiate to osteoblast cells ascompared with control. It was suggested that the combination of bone marrow mesenchymal cellswith artificial materials or differentiation factors may enhance bone formation and regeneration,nanophase PLGA/HA composite might therefore be a promising scaffold material for bone tissuesubstitute in clinical application
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1153.pdf
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    Paper (German National Licenses)
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