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  • 1
    Electronic Resource
    Electronic Resource
    3. Kongreß der Deutschen Diabetes-Gesellschaft (1969)
    Springer
    Diabetologia 5 (1969), S. 124-136 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212008
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gonadotropinsekretion nach Stimulation mit einem hochwirksamen Analogon des Gonadotropin-Releasing-Hormon (GnRH) bei gesunden Männern (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 363-364 
    Details
    ISSN: 1432-1440
    Keywords: Analog of LH-FSH Releasing Hormone ; LH ; FSH ; Analogon des LH-FSH-Releasing-Hormon ; LH ; FSH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Potente langwirksame GnRH-Analoga sind von besonderem Interesse für die Therapie des hypogonadotropen Hypogonadismus hypothalamischer Genese und des Kryptorchismus. Auf der Suche nach der geeigneten Dosierung einer solchen Substanz bei parenteraler Applikation wurde an 4 gesunden Männern der Serumspiegel von LH und FSH nach s.c. Injektion von D-Leu6-des-Gly10-GnRH-EA in unterschiedlicher Dosierung gemessen. 5 µg des Analogon waren nötig um eine Erhöhung der Gonadotropinspiegel über mindestens 8 h mit einem Maximum im Mittel 4 h nach Stimulation zu erzielen. Nach i.v. Bolusinjektion einer in Routine-GnRH-Tests verwandten Dosis von 25 µg originärem GnRH bei 3 Probanden traten vergleichbare Maximalspiegel auf. Gemessen an den Flächenintegralen der LH-Anstiege ergibt sich für das Analogon eine über 15 mal stärkere Wirksamkeit.
    Notes: Summary Potent long acting analogs of GnRH are of great interest especially in view of treatment of hypothalamic hypogonadotropic hypogonadism and of cryptorchidism. To find necessary parenteral doses of such a substance immunoreactive serum LH and FSH were measured in 4 normal adult human males after s.c. injection of various doses of D-Leu6-des-Gly10-GnRH-EA. 5 µg of the GnRH anlog were necessary to obtain increased serum gonadotropins over a period of at least 8 h. Comparable maximal levels were seen after i.v. bolus injection of 25 µg natural GnRH a dose as used in diagnostic routine tests in 3 probands. Comparing the areas under the curves of LH secretion an over 15 times greater effectiveness of the analog was calculated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477397
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma-cAMP bei primärem und sekundärem Hyperparathyreoidismus (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 1005-1006 
    Details
    ISSN: 1432-1440
    Keywords: Hyperparathyroidism ; Plasma cAMP ; Hyperparathyreoidismus ; Plasma-cAMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 3 Patienten mit operativ bestätigtem primären Hyperparathyreoidismus wurden normale Plasma-cAMP-Konzentrationen festgestellt, während bei 5 Dialysepatienten unabhängig vom Parathormonspiegel erhöhte Plasma-cAMP-Konzentrationen gefunden wurden. Diese Befunde sprechen gegen eine Regulation des Plasma-cAMP durch Parathormon bei diesen Krankheitsbildern.
    Notes: Summary 3 patients with operatively proven primary hyperparathyroidism showed normal plasma cAMP concentrations. 5 patients in chronic dialysis treatment independent of the level of parathyroid hormone had increased plasma cAMP concentrations. These observations suggest that there is under these circumstances no regulation of plasma cAMP by the parathyroid hormone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468953
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  • 4
    Electronic Resource
    Electronic Resource
    131-metaiodobenzylguanedine therapy of neuroblastoma in childhood (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 246-250 
    Details
    ISSN: 1432-1076
    Keywords: Neuroblastoma ; 131-metaiodobenzylguanedine treatment ; Therapeutic effect ; Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eleven children with neuroblastoma refractory to conventional therapy or relapse of neuroblastoma were treated with 131-metaiodobenzylguanedine (MIBG). The therapeutic results and the side effects were evaluated. In one patient with disseminated bone marrow involvement complete remission was obtained. Partial remission was observed in six patients and stable disease in another. Three patients did not respond to MIBG, in two of them the tumours did not accumulate a sufficient MIBG dose. Clinical and laboratory examinations revealed an excellent tolerance of MIBG in all patients. First attempts to continue cytostasis after MIBG therapy were made. MIBG has a good therapeutic efficacy is sufficiently incorporated into the tumour cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716467
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinktics of D-TRP^6-LH-RH after I.V. and S.C. application to male volunteers
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 172 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91601-3
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of decapeptyl-depot (DP-D)
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 77 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91325-2
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  • 7
    Electronic Resource
    Electronic Resource
    Serum LH-RH and LH patterns in men after pulsatile administration of LH-RH. comparison of different doses and routes of administration
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 20 (1984), S. 1394 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(84)90473-4
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  • 8
    Electronic Resource
    Electronic Resource
    Frozen shoulder: a sympathetic dystrophy? (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 84-87 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnostic and clinical features of the frozen shoulder syndrome and the Sudeck syndrome are similar in many aspects. Radioisotope bone scan shows an increased uptake in affected areas in both diseases, while native radiographs show a progressive demineralisation. Measurement of bone mineral density (BMD) by quantitative digital radiography objectified these local decalcification processes in an early stage of the frozen shoulder syndrome; 10 of 12 patients with primary frozen shoulder had BMD decreases greater 21% in the humeral head of the affected shoulder compared to the non-affected side. In the immobilised control group with degenerative changes of the rotator cuff, calcifying tendinitis and shoulder instability (n = 12) and in the group of healthy probands (n = 20), the difference between the affected and non-affected side (left and right humerus of the healthy probands) was only more than 21% in one case each. There are several references in the literature that assume frozen shoulder to be an algoneurodystrophic process; our observations support this hypothesis, possibly leading to earlier diagnoses and extended therapeutic management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050017
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  • 9
    Electronic Resource
    Electronic Resource
    Endokrinologische Vorhersage der Therapieansprechbarkeit depressiver Patienten auf Lofepramin (1979)
    Springer
    European archives of psychiatry and clinical neuroscience 227 (1979), S. 71-79 
    Details
    ISSN: 1433-8491
    Keywords: Depression ; Neuroendocrinology ; Thymoleptic drugs ; Depression ; Neuroendokrinologie ; Thymoleptika
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Pilotuntersuchung an 15 nosologisch heterogenen vitalisiert depressiven Patienten konnte nachgewiesen werden, daß einzelne neuroendokrinologische Funktionsgrößen in der Lage sind, das Therapieansprechen dieser Patienten auf Lofepramin vorherzusagen. In einem technisch einfach durchzuführenden globalen Stimulationstest (Insulinhypoglykämie in Kombination mit TRH- und LHRH-Injektion) wurden die Basalwerte und die Stimulationswerte von Prokalin, TSH, LH, Cortisol, HGH und Blutzucker erfaßt. Die Therapieansprecher unterschieden sich von den Therapieversagern durch höheren Nüchternblutzucker, höheren Hypoglykämiewert, größeren Blutzuckerabfall in Bezug auf den Ausgangswert, niedrigeres basales TSH, kleineren Stimulationsanstieg des HGH und kleineren Stimulationsanstieg des Cortisol. Die Zusammenfassung dieser Funktionsgrößen in einen einzigen Indikationswert erlaubte es, 14 der 15 über 3 Wochen mit 210mg Lofepramin pro Tag behandelten Patienten zutreffend der Gruppe der Therapieansprecher bzw. Therapieversager zuzuordnen.
    Notes: Summary In a pilot study of 15 depressive patients of the neurotic and endogenous type we could show that some neuroendocrinological parameters are apt to predict the thymoleptic efficacy of lofepramine. These parameters, which were measured with a simple global stimulation test (insulin hypoglycaemia combined with injection of TRH and LHRH), were as follows: high basal blood glucose; high hypoglycaemic blood glucose; high decrease of blood glucose in comparison to the basal level; low basal TSH; low increase of HGH and low increase of cortisol after hypoglycaemia. A synopsis of these parameters allowed a correct classification of 14 out of 15 patients according to therapy response and therapy resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585679
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    Paper (German National Licenses)
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