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  • 1
    Electronic Resource
    Electronic Resource
    Identification of the DNA damage-responsive elements of therhp51 + gene, arecA andRAD51 homolog from the fission yeastSchizosaccharomyces pombe (1996)
    Springer
    Molecular genetics and genomics 251 (1996), S. 167-175 
    Details
    ISSN: 1617-4623
    Keywords: Schizosaccharomyces pombe ; DNA-damage inducibility ; Damage-responsive element ; Upstream activating sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract TheSchizosaccharomyces pombe rhp51 + gene encodes a recombinational repair protein that shares significant sequence identities with the bacterial RecA and theSaccharomyces cerevisiae RAD51 protein. Levels ofrhp51 + mRNA increase following several types of DNA damage or inhibition of DNA synthesis. Anrhp51::ura4 fusion gene was used to identify the cis-acting promoter elements involved in regulatingrhp51 + expression in response to DNA damage. Two elements, designated DRE1 and DRE2 (fordamage-responsiveelement), match a decamer consensus URS (upstream repressing sequence) found in the promoters of many other DNA repair and metabolism genes fromS. cerevisiae. However, our results show that DRE1 and DRE2 each function as a UAS (upstream activating sequence) rather than a URS and are also required for DNA-damage inducibility of the gene. A 20-bp fragment located downstream of both DRE1 and DRE2 is responsible for URS function. The DRE1 and DRE2 elements cross-competed for binding to two proteins of 45 and 59 kDa. DNase I footprint analysis suggests that DRE1 and DRE2 bind to the same DNA-binding proteins. These results suggest that the DRE-binding proteins may play an important role in the DNA-damage inducibility ofrhp51 + expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02172915
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  • 2
    Electronic Resource
    Electronic Resource
    Lamellar structure and morphology of nylon 46 crystals: a new chain folding mechanism for nylons (1992)
    s.l. : American Chemical Society
    Macromolecules 25 (1992), S. 917-924 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00028a063
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  • 3
    Electronic Resource
    Electronic Resource
    Design of potent and specific inhibitors of carboxypeptidases A and B (1979)
    s.l. : American Chemical Society
    Biochemistry 18 (1979), S. 1427-1430 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00575a006
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  • 4
    Electronic Resource
    Electronic Resource
    Transrectal color Doppler ultrasonography for postejaculation hematuria (1996)
    Springer
    Abdominal imaging 21 (1996), S. 551-553 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Postejaculation hematuria—Transrectal color Doppler ultrasonography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A case involving an adult man with postejaculation hematuria (PEH) is described. We used transrectal color Doppler ultrasonography to evaluate periprostatic or intraprostatic vascular anomalies. We confirmed a vascular anomaly by angiography and embolized it. Periprostatic vascular anomaly may be a cause of PEH, and color Doppler ultrasonography is helpful for the initial studies of this entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900125
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  • 5
    Electronic Resource
    Electronic Resource
    Dysplastic nodules of the liver: imaging findings (1999)
    Springer
    Abdominal imaging 24 (1999), S. 250-257 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver—Neoplasms—US—CT—MR.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To verify characteristic features of hepatic dysplastic nodules at different imaging modalities. Methods: Twenty-eight patients with 37 dysplastic nodules of the liver (0.8–3.0 cm) underwent sonography (28 patients), computed tomography (CT; 24 patients), magnetic resonance (MR; 11 patients), and angiography (12 patients). Each nodule was analyzed for echogenicity, attenuation, signal intensity, and vascularity. Results: Echogenicity of nodules was high in 16 (43%), homogeneous in two (6%), and low in 19 (51%) of 37 nodules. Attenuation of nodules was high in one (7%), homogeneous in four (26%), and low in 10 (67%) of 15 nodules on the arterial-phase CT images; homogeneous in five (33%) and low in 10 (67%) of 15 nodules on the portal-phase CT images; and high in four (17%), homogeneous in six (26%), and low in 13 (57%) of 23 nodules on the delayed-phase CT images. Signal intensity of nodules was high in 15 (94%) and homogeneous in one (6%) of 16 nodules on T1-weighted MR images and was homogeneous in seven (44%) and low in nine (56%) of 16 nodules on T2-weighted MR images. Vascularity of nodules was avascular in 14 (88%) and slightly vascular in two (12%) of 16 nodules. Conclusions: Hepatic dysplastic nodules show diverse imaging characteristics with different imaging techniques; however, common imaging findings of hepatic dysplastic nodules are low echo, low attenuation, and high, low, or homogeneous intensity on T1- and T2-weighted MR, and avascularity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900490
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  • 6
    Electronic Resource
    Electronic Resource
    Focal eosinophilic infiltration of the liver: a mimick of hepatic metastasis (1999)
    Springer
    Abdominal imaging 24 (1999), S. 369-372 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver, eosinophilic infiltration—Liver, CT.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present three cases of focal eosinophilic infiltration in the liver that mimicked hepatic malignancy on computed tomography during hepatic arteriography (CTHA) and computed tomography during arterial portography (CTAP). In all patients, focal eosinophilic liver infiltration appeared as a solitary nodule or as two nodules without hepatosplenomegaly and showed homogeneous hyperattenuation on CTHA and hypoattenuation on CTAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900516
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  • 7
    Electronic Resource
    Electronic Resource
    Larval development of the euphausiid Euphausia pacifica in the Yellow Sea (1993)
    Springer
    Marine biology 115 (1993), S. 625-633 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The complete larval development of Euphausia pacifica in the Yellow Sea is described and the stages are compared with larvae of E. nana. Euphausiid larvae examined in the present study were collected at 30 stations in the Yellow Sea in 1989. During the stages of Calyptopis III to Furcilia II, E. pacifica larvae are smaller than E. nana larvae but they are larger from Furcilia III onward. There are geographical variations in body size of Calyptopis III among the southern California waters, the eastern Japan waters, the Japan Sea, and the Yellow Sea; body size is smallest in the Yellow Sea and Japan Sea, while it is largest in southern California waters and intermediate in eastern Japan waters. Segmentation of antennal endopods was observed in the 5″6 to 5″1 furcilia forms in the Yellow Sea population, suggesting that this characteristic is not as reliable for identification of furcilia stages as the pleopods and terminal telson spines. Thus, we propose here that there are six furcilia stages of E. pacifica, instead of the seven previously reported by Boden (1950).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349370
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular design of novel metal-binding oligomeric human metallothioneins (2000)
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 84-89 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Genes for dimeric and tetrameric human metallothionein (hMT) were designed and successfully overexpressed in Escherichia coli to generate functional oligomeric hMTs. An hMT synthesized with prokaryotic codons, a linker encoding a gly-gly-gly tripeptide, and Met-deficient hMT-II was ligated to create a dimeric hMT, from which a tetrameric hMT was then constructed. The increased molecular size of the constructs resulted in improved stability and productivity in E. coli. The oligomeric proteins formed inclusion bodies which were dissolved with dithiothreitol, and the purified apo-metallothioneins were reconstituted with Cd or Zn ions in a reducing condition. The oligomeric hMT proteins incubated with Cd ions showed a typical Cd-thiolate absorbance peak at 245–255 nm. The dimeric and tetrameric hMT proteins exhibited both Cd and Zn binding activities that were respectively two and four times higher than those of the hMT-II monomer protein. These novel oligomeric hMTs may be useful in bioremediation for heavy metals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530000360
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  • 9
    Electronic Resource
    Electronic Resource
    Development of Efficient Cardiac Differentiation Method of Mouse Embryonic Stem Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 25-28 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To obtain an enhanced population of cardiomyocytes from differentiating mouseembryonic stem (ES) cells, we confirmed the role of noggin treatment during the cardiacdifferentiation of mouse ES cells. ES cells were cultured in ES medium containing both noggin andLIF for 3 days on the mouse embryonic fibroblast feeder layer, followed by dissociated andsuspension culture without LIF to form the embryoid body (EB). The next day, noggin waseliminated and EBs were cultured continuously. Noggin treated ES cells showed a relatively rapidincrease of cardiac marker genes, while the vehicle (PBS) treated group showed no significantcardiac marker expression at 4 days after the EB formation. Furthermore, Noggin treated ES cellsshowed 68.00±9.16% spontaneous beating EBs at 12 days after the EB formation. To develop amore efficient cardiomyocyte differentiation method, we tested several known cardiogenic reagents(ascorbic acid, 5’-Azacytidine, LiCl, oxytocin, FGF2 and PDGF-BB) after noggin induction or wecultured noggin treated ES cells on various extracellular matrixes (collagen, fibronectin andMatrigel). Quantitative RT-PCR and immunocytochemistry results showed a significantly increasedcardiac differentiation rate in the FGF2 treated group. Differentiation on the collagen extracellularmatrix (ECM) could slightly increase the cardiac differentiation efficiency. These results show thepossibilities for the establishment of selective differentiation conditions for the cardiacdifferentiation of mouse ES cells
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.25.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Generalized pustular psoriasis following withdrawal of short-term cyclosporin therapy for psoriatic arthritis (2005)
    sOxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2005.01195.x
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