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  • 1
    Electronic Resource
    Electronic Resource
    Therapieprobleme der Hyperlipoproteinämie Typ I (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 415-422 
    Details
    ISSN: 1432-1440
    Keywords: Hyperlipoproteinemia type I ; Familial hyperlipidemia ; Diet therapy in hyperlipoproteinemias ; Lipoprotein lipase ; Medium chain triglycerides ; Essential fatty acids ; Hyperlipoproteinämie Typ I ; Familiäre Hyperlipidämie ; Diättherapie bei Hyperlipoproteinämie ; Lipoproteinlipase ; Mittelkettige Fettsäuren ; Essentielle Fettsäuren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der therapeutische Effekt verschiedener Diäten mit unterschiedlichen Relationen von lang- und mittelkettigem Fett, Kohlenhydraten und Eiweiß wurde bei zwei Geschwistern mit Hyperlipoproteinämie Typ I untersucht. Eine Normalisierung der TG-Werte konnte trotz extrem fettarmer Kost (〈5 g täglich) nicht erreicht werden, da es infolge der relativ kohlenhydratreichen Diät und wahrscheinlich auch wegen der Gabe von MCT zu einer starken Vermehrung der prä-β-Lipoproteine kam. Da es sich um eine lebenslange Therapie handelt, müssen die Risiken einer normal fetthaltigen Kost — vor allem rezidivierende Pankreatitiden durch die exzessiven Chylomikronenspiegel — gegen die einer fettreduzierten und kohlenhydrat-und MCT-reichen Kost — erhöhtes Atheroskleroserisiko durch Hyperpräbetalipoproteinämie — abgewogen werden. Daher erscheinen uns folgende diätetische Richtlinien sinnvoll: 1. Reduktion des langkettigen Fetts auf weniger als 30 g pro Tag, wobei besonders auf eine genügende Linolsäurezufuhr (4–6 g täglich) zu achten ist. 2. Der Kohlenhydratanteil sollte 50 Kalorienprozent nicht überschreiten und vor allem aus Stärke bestehen. 3. Das so entstehende Kaloriendefizit sollte vor allem durch Protein gedeckt werden, was durch spezielle Eiweißanreicherung einzelner Nahrungsmittel möglich ist. 4. Nur bei Schwierigkeiten bei der Einhaltung der eiweißreichen Kost sollte der Einsatz mittelkettigen Fetts erwogen werden.
    Notes: Summary The therapeutic effect of different diets varying in long chain and medium chain triglycerides, carbohydrate, and protein was tested in two siblings with type I hyperlipoproteinemia. Despite administration of an extremely fat reduced diet (〈5 g daily), a normalization of plasma TG could not be obtained because—as a consequence of its high carbohydrate and/or its MCT content—it resulted in a considerable increase in pre-β-lipoproteins. As life long dietary therapy has to be maintained, the risks of a normal fat containing diet (mainly bouts of pancreatitis) and those of a carbohydrate and MCT rich diet (premature atherosclerosis) are to be carefully considered. On the basis of our data we therefore suggest the following dietary regimen: 1. Reduced intake of long chain triglycerides (less than 30 gms per day), but with sufficient amounts of essential fatty acids (4–6 gms linoleate daily). 2. The carbohydrates should not exceed 50% of total calories and ought to consist mainly of starch. 3. The caloric deficit thus generated should be balanced by a high protein intake. This is facilitated by applying a specially protein-enriched food. 4. Medium chain triglycerides may be necessary when adherence to the protein-rich diet turns out to be bad.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01470927
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  • 2
    Electronic Resource
    Electronic Resource
    Wirkung von Bezafibrat bei primären Hyperlipidämien (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 97-105 
    Details
    ISSN: 1432-1440
    Keywords: Hyperlipidemia ; Lipoproteins ; Bezafibrate ; Lipoprotein-Lipase ; Hyperlipidämie ; Lipoproteine ; Bezafibrat ; Lipoprotein-Lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung von Bezafibrat auf Lipid- und Lipoproteinspiegel wurde in einer Langzeitstudie über 40 Wochen bei 27 Patienten mit primären Hyperlipoproteinämien untersucht (12 Patienten mit HLP Typ IV n.F., 7 Patienten mit Typ IIb, 3 Patienten mit Typ IIa, 4 Patienten mit Typ V und 1 Patient mit Typ III). Bezafibrat senkte in diesem Kollektiv das Gesamtcholesterin um 16%, während das HDL-Cholesterin um 28 bzw. 36% anstieg (p〈0,05). Die Serumtriglyzeride fielen um 59% (450 mg Bezafibrat/die) bzw. 66% (600 mg Bezafibrat/die) statistisch signifikant ab (p〈0,05). Bei Hyperlipidämien vom Typ IV, IIb, IIa und V waren Anstiege des HDL-Cholesterins feststellbar. Das LDL-Cholesterin verhielt sich typenspezifisch. Die Aktivität der Lipoproteinlipasen (postheparin) wurde durch Bezafibrat von 10,5±0,7 auf 14,7±0,7 bzw. 15,5±0,8 µmol FFA/ml/Stunde um ca. 30% gesteigert (p〈0,05). Die Nebenwirkungen während Bezafibrat-Behandlung waren gering.
    Notes: Summary The effect of long-term treatment over 40 weeks with Bezafibrate on lipids and lipoproteins was investigated in 27 patients with primary hyperlipoproteinemias (hlp) (12 patients with hlp type IV, 7 patients with type IIb, 3 patients with type IIa, 4 patients with type V and 1 patient with type III). Bezafibrate reduced total cholesterol by 16%, whereas HDL-cholesterol increased by 28% and 36% (p〈0.05). Serumtriglycerides decreased by 59% (450 mg Bezafibrate daily) and by 66% (600 mg Bezafibrate daily) statistically significant (p〈0.05). In hyperlipidemias type IV, IIb, IIa and V increases of HDL-cholesterol could be observed. The course of LDL-cholesterol was different in the various types of hlp. The postheparin-lipoprotein-lipase (PHLA) was activated by treatment with Bezafibrate from 10.5±0.7 to 14.7±0.7 and 15.5±0.8 µmol FFA/ml/h or by 30% (p〈0.05). Only few side-effects during treatment with Bezafibrate could be ascertained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716387
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  • 3
    Electronic Resource
    Electronic Resource
    Polymorphisms of apolipoproteins A-IV and E in a Turkish population living in Germany (1996)
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 285-290 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Human apolipoproteins (apo) E and apo A-IV are polymorphic with significantly different allele frequencies among different ethnic groups. Whereas the variation at the apo E gene locus affects plasma cholesterol levels in all populations studied so far and is associated with longevity in Caucasians, the influence of the common apo A-IV polymorphism on plasma lipoproteins has not been unanimously accepted. We have therefore determined the common apo E and apo A-IV polymorphisms by isoelectric focusing, calculated the respective allele frequencies and studied their effects on plasma lipoproteins in a random sample of 240 nonrelated Turkish subjects (141 males, 99 females) living in Germany and originating from central and eastern Anatolia. When compared with the German population and other Caucasians in Europe a prominence of the apo ɛ3 allele frequency (0.885) was accompanied by a decrease in the frequencies of both the apo ɛ2 allele (0.048) and the apo ɛ4 allele (0.067). Thus, the Turkish population studied here clustered with populations mainly from southern Europe and Japan, which have low ɛ2 and ɛ4 allele frequencies. Also, the frequency of the A-IV-1 allele was higher (0.967) and that of the A-IV-2 allele lower (0.033) in the Turkish subjects studied than in other populations. At an average level of total cholesterol of 194.5 ± 45 mg/dl, no significant influence of the A-IV alleles on plasma lipoproteins was seen. However, apo E and apo B differed significantly between apo E phenotypes, with high levels of apo E and low levels of cholesterol and apo B in carriers of the ɛ2 allele, and vice versa for the ɛ4 allele. The average cholesterol excess for the ɛ2 allele was –7.95 mg/dl, for the ɛ3 allele, –1.34, and for the ɛ4 allele, +14.15 mg/dl. Thus, despite the unusual frequency distribution of the apo E alleles, their effects on plasma lipoproteins are within the range reported for other populations in Europe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050208
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  • 4
    Electronic Resource
    Electronic Resource
    Frequency of pancreatitis after endoscopic retrograde cholangiopancreatography with iopromid or iotrolan: a randomized trial (2000)
    Springer
    European radiology 10 (2000), S. 677-680 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Iopromide – Iotrolan – Endoscopic retrograde cholangiopancreatography – Pancreatitis – Contrast media toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Blood isotone contrast media is considered to be less toxic to vascular and pancreatic duct endothelium than high-osmolar contrast media. In this study we assessed the impact of a low-osmolar contrast agent compared with a blood isotone product on pancreatic damage induced by endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic retrograde sphincterotomy (EST). In a prospective trial 42 consecutive ERCP/EST patients were randomized to receive either iopromid, a low-osmolar non-ionic contrast agent (770 mosmol/kg H2O), or iotrolan, a blood-isotone non-ionic product (320 mosmol/kg H2O). The endoscopies were performed by two experienced endoscopists. Forty patients were included in the study. Blood samples were collected before and 40 min, 2, 4, 6 and 24 h after the endoscopic procedure. Samples were analysed for pancreatic serum enzymes, acute-phase proteins and blood counts. A clinical pain score was investigated. Post-ERCP pancreatitis was diagnosed in 2 patients in the iopromid group and in 5 patients in the iotrolan group. There was no significant difference between groups in the time course of pancreatic serum enzymes, acute-phase proteins or in the pain score. Due to the small number of patients in this study, only stronger differences caused by the two contrast media could have led to statistically significant results. We did not observe statistically significant differences in comparing iotrolan and iopromid concerning ERCP/EST-induced pancreatic damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050983
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  • 5
    Electronic Resource
    Electronic Resource
    CI-924 Effects on plasma lipids in patients with Type II and Type IV hyperlipoproteinaemia (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 477-481 
    Details
    ISSN: 1432-1041
    Keywords: hyperlipoproteinaemia (Type II/Type IV) ; gemfibrozil ; CI-924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary CI-924 (CI), 5,5′-[[1,1′-biphenyl]-2,5-diylbis(oxy)]bis[2,2-dimethylpentanoic acid] is chemically similar to gemfibrozil. Patients with Type II (n=13) and Type IV (n=22) hyperlipoproteinaemia (HLP) were maintained 12 weeks on a baseline diet containing 55% sugar, 15% protein 30% fat and 〈300 mg cholesterol daily to stabilize weight and lipids. They were then entered in a parallel group double-blinded protocol and received 0, 300, 600, or 1200 mg CI p.o. daily for 12 weeks. CI consistently elevated anti-atherogenic HDL and lowered VLDL at 600 mg/day in both Type II and Type IV HPL at 8 weeks. In Type II patients, CI lowered cholesterol, decreased LDL/HDL and increased ApoA-I. In Type IV patients, CI also lowered TC while elevating LDL and ApoA-II. CI had no effect on Apo-B, LDL-ApoB, or Apo-E.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558127
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  • 6
    Electronic Resource
    Electronic Resource
    Determination of apolipoprotein variants by isoelectric focusing in agarose
    Amsterdam : Elsevier
    Analytical Biochemistry 163 (1987), S. 182-187 
    Details
    ISSN: 0003-2697
    Keywords: agarose/urea ; apolipoproteins A-I, A-II, and E ; isoelectric focusing
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(87)90110-2
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  • 7
    Electronic Resource
    Electronic Resource
    Purification of human lysozyme from milk and pancreatic juice
    Amsterdam : Elsevier
    Analytical Biochemistry 139 (1984), S. 224-227 
    Details
    ISSN: 0003-2697
    Keywords: heparin-Sepharose affinity chromatography ; human milk lysozyme ; human pancreatic lysozyme
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(84)90409-3
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetic properties of human pancreatic carboxylesterase
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 754 (1983), S. 142-149 
    Details
    ISSN: 0005-2760
    Keywords: (Human pancreas) ; Carboxylesterase ; Fluorescence ; Kinetics ; Substrate specificity ; Taurocholate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(83)90155-8
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  • 9
    Electronic Resource
    Electronic Resource
    Doubling the omeprazole dose (40 mg b.d. vs. 20 mg b.d.) in dual therapy with amoxycillin increases the cure rate of Helicobacter pylori infection in duodenal ulcer patients (1997)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several studies have shown that dual therapy with omeprazole and amoxycillin may cure Helicobacter pylori infection. However, the optimum dose of omeprazole has still to be established.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:An international, randomized, double-blind multicentre trial was conducted in patients with duodenal ulcers to compare the H. pylori cure rates obtained by dual therapy consisting of either omeprazole 20 mg b.d. plus amoxycillin 750 mg b.d. or omeprazole 40 mg b.d. plus amoxycillin 750 mg b.d. for 2 weeks. Dual therapy was followed by omeprazole 20 mg once daily for 2 weeks. Before entering the trial and 4 weeks after cessation of treatment H. pylori infection was assessed by histology and a 13C-urea breath test.〈section xml:id="abs1-3"〉〈title type="main"〉Results:381 patients were randomized into the study, of whom 345 were evaluable for the all-patients-treated analysis of efficacy and 378 were valid for the evaluation of safety. Histology results showed that H. pylori infection was cured in 64 out of 174 patients treated with omeprazole 20 mg b.d. plus amoxycillin and in 102 out of 171 patients treated with omeprazole 40 mg b.d. plus amoxycillin (37% vs. 60%; P 〈  0.001). Both treatment regimens were well tolerated, with adverse events reported by 29 (15.2%) and 35 patients (18.7%), respectively.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:This study has shown that dual therapy with amoxycillin 750 mg b.d. and omeprazole 40 mg b.d. is superior to dual therapy with amoxycillin and omeprazole 20 mg b.d. in patients with H. pylori-positive duodenal ulcers. Thus, a true dose–response relationship exists between omeprazole and treatment success. However, a combination of omeprazole with two of amoxycillin, clarithromycin and a nitroimidazole is a preferable alternative for routine clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00169.x
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  • 10
    Electronic Resource
    Electronic Resource
    Reliable separation of cis and trans fatty acids by gas liquid chromatography on glass capillary columns (1975)
    Springer
    Chromatographia 8 (1975), S. 507-510 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Because of the recent progress in lipid research, the availability of an excellent separation method for fatty acid methyl esters has become more and more important. A speical need exists for a good separation of cis and trans isomers, and of isomers with different positions of double-bonds. This goal was achieved by applying a 50 m glass-capillary column with an inner diameter of 0.33 mm, installed in a Carlo Erba Fractovap 2301 AC. The GC was equipped with FID, linear temperature programmer and automatic injection-system. The main characteristics of the system were a separation number of 47 and a theoretical plate number of 227052. The reproducibility of relative retention time and of weight %, expressed as maximum percent deviation of the mean values of 10 chromatograms was 0.26% and 1.53%, respectively. Preliminary results of the quantitative analysis of free cholesterol with a short OV-17 glasscapillary column, indicate a precision better than 0.8%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267593
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