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  • 1
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; MIBG scintigraphy ; Intraoperative staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metaiodobenzylguanidine (MIBG) imaging is a well-established method for locating intra-and extraadrenal pheochromocytomas. We investigated whether preoperative injection of 123-I-MIBG might be useful for intraoperative staging of chromaffine tumor cells. This was performed in a 46-year-old patient in whom the diagnosis of a malignant pheochromocytoma had been established by 123-I-MIBG imaging and enhanced catecholamine secretion. The rationale for intraoperative staging in this patient was a discrepancy between computed tomography (CI) of the abdomen and the radionuclide imaging, because scintigraphy revealed a mass with MIBG uptake in the right lower abdomen that could not be visualized by CT. We thus applied a preoperative dose of 4 mCi 123-I-MIBG and determined tissue activity by direct organ measurement. A right abdominal mass was thus identified with an activity of 10×104 impulses/s as compared to normal tissue (15×102). The left-sided tumor was found to be identified correctly by prior CT and MIBG imaging. We thus conclude that intraoperative application of this single probe measurement might help to identify chromaffine tumor cells that have not been located fully by CT.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 47 (1969), S. 382-383 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The serum of 64 woman, ages 18 to 39, who were metabolically normal were examined for total and free cholesterol, phospholipids, triglycerides, and cholesterol/phospholipid ratio. These determinations were performed serially in the early, mid-, and late menstrual phases. No significant differences were found in the three phases of the menstrual cycle.
    Notes: Zusammenfassung Bei 64 stoffwechselgesunden Frauen im Alter von 18–39 Jahren untersuchten wir das Gesamtcholesterin, das freie Cholesterin, die Phosphatide, die Triglyceride und den Cholesterin/Phosphatid-Quotienten im Serum am Anfang, in der Mitte und am Ende des Cyclus. Signifikante Unterschiede im Vergleich der einzelnen Cycluszeiten konnten nicht nachgewiesen werden.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Plasma von 41 gesunden Frauen im Alter von 18–31 Jahren untersuchten wir nach einer 12 bis 24monatigen oralen Behandlung mit verschiedenen Ovulationshemmern die Triglyceride, die Phosphatide, das gesamte und das freie Cholesterin sowie die freien Fettsäuren. Entsprechend der unterschiedlichen Zusammensetzung der Kontraceptiva wurden drei Gruppen gebildet: Gruppe I erhielt ein Präparat mit niedrigem Gestagen- und niedrigem Oestrogenanteil; Gruppe II Präparate mit wechselnden Oestrogenanteilen; Gruppe III Präparate mit niedrigen Gestagen- und niedrigen Oestrogenanteilen im Wechsel mit anderen Ovulationshemmern. Zusätzlich bildeten wir aus den drei Gruppen ein Gesamtkollektiv, in das auch ein 2-Phasenpräparat mit überwiegender Oestrogenwirkung aufgenommen wurde. Als Vergleich diente ein ovulationshemmerfreies Normalkollektiv. Die Triglyceride, das freie Cholesterin und die freien Fettsäuren zeigten keine signifikanten Änderungen. Die Triglyceride (besonders in der Gruppe I) weisen eine Tendenz zur Erniedrigung auf. Die Phosphatide waren in allen Gruppen entweder signifikant erhöht oder zeigten eine Tendenz zur Erhöhung. Für das Gesamtcholesterin konnte eine Erhöhungstendenz im Gesamtkollektiv nachgewiesen werden. Beim Vergleich der Gruppen I–III untereinander ließen sich statistisch keine Unterschiede sichern. Die Befunde lassen es notwendig erscheinen, die einzelnen Gruppen von Ovulationshemmern noch detaillierter und getrennt zu untersuchen.
    Notes: Summary 41 healthy women aged 18 to 31 years were treated with different contraceptive agents for 12 to 24 months. Triglyceride, phospholipid, total and free cholesterol, and free fatty acid levels were determined in the plasma of these subjects. The women were divided into three groups: Group I received a drug at low doses of gestagen and estrogen. In group II several drugs with changing doses of estrogen were combined. Women who received different drugs with low and high dosage of gestagen and estrogen are found in group III. The results of all these three groups were pooled and in addition, findings observed in women who received a sequential preparation with high estrogen dose have also been included.—A number of non-treated women served as controls. No significant changes were observed in triglyceride, free cholesterol and free fatty acid levels. Especially in group I, triglyceride levels showed a tendency to decrease. In all groups the phospholipids were either significantly increased or showed a tendency to increase. Total cholesterol tended to increase in the polled totals. No significant differences were found between groups I–III. The different types of contraceptives will have to be further examined in detail with respect to their varying amounts of gestagen and estrogen.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Triglycerides, free fatty acids, phospholipids, and total cholesterol in the plasma of 13 women aged between 18 and 30 were determined before and after a six months period of treatment with different oral contraceptives. These women had no important disturbances of metabolism. When plasma had been taken after this period treatment was continued after all. Lipids mentioned above were analysed at the beginning, middle, and the end of the cyclus. Neither triglycerides nor total cholesterol showed significant changes. Individually the findings decreased, increased, or showed no change. Phosphatide-level however showed during contraceptive treatment an increasing tendency in the beginning and middle of the cyclus. In the meantime no significant change was found in free fatty acids, whereas they had a decreasing tendency at the end of the cyclus. Further longtime studies are necessary to determine the effect of oral contraceptives on bloodlipid level. The different typs of contraceptives should be examined separately in bigger groups.
    Notes: Zusammenfassung Im Plasma von 13 Frauen ohne stärkergradige Störungen des Stoffwechsels im Alter von 18–30 Jahren untersuchten wir die Triglyceride, die freien Fettsäuren, die Phosphatide und das Gesamtcholesterin vor und nach einer 6monatigen oralen Behandlung mit verschiedenen Ovulationshemmern. Während der zweiten Untersuchungsserie wurde die kontrazeptive Behandlung nicht unterbrochen. Die Lipidanalysen führten wir am Anfang, in der Mitte und am Ende des Cyclus durch. In keiner Cyclusphase zeigten die Triglyceride und das Gesamtcholesterin signifikante Änderungen. Die Einzelwerte stiegen teils an, teils verringerten sie sich oder blieben konstant. Die Phosphatide ließen am Anfang und in der Mitte des Cyclus unter kontrazeptiver Behandlung eine Tendenz zur Erhöhung erkennen. Am Anfang und in der Mitte des Cyclus waren die freien Fettsäuren nicht signifikant verändert, am Ende zeigten sie unter Ovulationshemmern eine Tendenz zur Erniedrigung. Weitere langfristige Beobachtungen zur Klärung der oralen Wirkung von Ovulationshemmern auf den Blutfettspiegel sind notwendig. Die einzelnen Typen von Ovulationshemmern sollten in größeren Kollektiven getrennt beobachtet werden. Auch das wohl bisher größte Gesamtkollektiv von Wynn u. Mitarb. [26] läßt eine getrennte Betrachtung der einzelnen Typen vermissen.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Keywords: Cyclosporine ; Calcium ; Na-KATPase ; Vascular smooth muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cyclosporine A in enhancing vasconstrictor-induced calcium (Ca2+) mobilization in vascular smooth muscle cells may contribute to important side effects in cyclosporine therapy such as hypertension and nephrotoxicity. As we have previously shown, cyclosporine A stimulates transmembrane Ca2+ influx. Since Ca2+ efflux was not affected by cyclosporine A, we concluded that cyclosporine augments angiotensin II induced Ca2+ mobilization in vascular smooth muscle cells by an increased amount of Ca2+ in angiotensin II sensitive intracellular Ca2+ stores. The present study was therefore designed to examine the effect of cyclosporine A on cellular calcium content and on membrane calcium transport mechanisms. An important mechanism of Ca2+ extrusion from the cell is the Na-Ca exchanger. Its activity is closely related with that of the Na-ATPase. By increasing cellular sodium concentration the blockade of Na-ATPase would in turn activate cellular calcium uptake bx the Na-Ca exchanger. Therefore, we hypothesized that cyclosporine A might exert its effects in the same manner as a circulating Na-ATPase inhibitor. Total cell calcium was measured by atomic absorption and activity of Na-ATPase was estimated by an assay measuring phosphate production. Preincubation of the cells with cyclosporine (10 μg/ml) for 15 min increased total cell calcium from 31.4 ± 5.0 to 46.5 ± 5.3 nmol/mg protein (P 〈 0.05). Activity of Na-ATPase was not affected by cyclosporine A (3.9 ± 0.2 vs. 4.3 ± 0.2 μol Pi h−1 mg−1 protein). Therefore, cyclosporine A induced Ca2+ influx is not mediated by an inhibition of the Na-ATPase. Cyclosporine-stimulated accumulation of cellular calcium may be mediated, for example, by opening of calcium channels in the plasma membrane. Increased Ca2+ mobilization in the presence of cyclosporine A may be due to an increased amount of Ca2+ avaible from intracellular Ca2+ stores. These results are of substantial significance for understanding the pathophysiological mechanisms of cyclosporine A induced vasoconstriction.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing hormone ; Flush-blood flow-Doppler sonography ; Medial cerebral artery ; External carotid artery ; Extracerebral blood flow ; Intracerebral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study facial flush after systemic administration of human corticotropin-releasing hormone (hCRH) we injected 100 μg hCRH intravenously to ten healthy young men. The increase in facial temperature was measured by infrared camera. A significant increase in facial temperature of 1.39°C ± 0.3 was found within 7 min in all patients, which lasted up to 60 min, although facial flushing was visible in only 50% (5/10) of the probands. In a second experiment 100 μg hCRH was then administered to seven other healthy young men. Intra- and extracerebral blood flow velocity changes in the medial cerebral artery (MCA) and external carotid artery (ECA) were measured after hCRH administration by use of Doppler sonography. We found a decrease of intracerebral blood flow which was caused by hyperventilation and was reversible following 6% CO2 hyperventilation during a second injection of 100 μg hCRH. Blood flow velocity in the ECA increased by 111.5 ± 32.9% (compared to baseline level), lasted up to 60 min after hCRH injection, and was not reversible by 6% end-tidal CO2 ventilation. We thus demonstrated that the direct vasodilatory effect of hCRH involves the ECA-supplied vascular territory only. The intracerebral vasoconstrictory effect represents the result of hyperventilation following hCRH injection. The data thus clearly suggest an interaction of hCRH and the vascular endothelium of the ECA, causing a marked blood flow velocity increase and facial flushing.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 163 (1989), S. 458-465 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Psychophysiology 11 (1991), S. 22-23 
    ISSN: 0167-8760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Psychophysiology 11 (1991), S. 22 
    ISSN: 0167-8760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 961-972 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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