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  • 1
    Electronic Resource
    Electronic Resource
    Intraoperative localization of malignant pheochromocytoma by 123-i-metaiodobenzylguanidine single probe measurement (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 61-64 
    Details
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; MIBG scintigraphy ; Intraoperative staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metaiodobenzylguanidine (MIBG) imaging is a well-established method for locating intra-and extraadrenal pheochromocytomas. We investigated whether preoperative injection of 123-I-MIBG might be useful for intraoperative staging of chromaffine tumor cells. This was performed in a 46-year-old patient in whom the diagnosis of a malignant pheochromocytoma had been established by 123-I-MIBG imaging and enhanced catecholamine secretion. The rationale for intraoperative staging in this patient was a discrepancy between computed tomography (CI) of the abdomen and the radionuclide imaging, because scintigraphy revealed a mass with MIBG uptake in the right lower abdomen that could not be visualized by CT. We thus applied a preoperative dose of 4 mCi 123-I-MIBG and determined tissue activity by direct organ measurement. A right abdominal mass was thus identified with an activity of 10×104 impulses/s as compared to normal tissue (15×102). The left-sided tumor was found to be identified correctly by prior CT and MIBG imaging. We thus conclude that intraoperative application of this single probe measurement might help to identify chromaffine tumor cells that have not been located fully by CT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713012
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    RCBF-quantification with 99mTc-HMPAO-SPECT: Theory and first results (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 1-8 
    Details
    ISSN: 1619-7089
    Keywords: Cerebral blood flow ; 99mTc-HMPAO ; 195mAu ; SPECT ; Three compartment model ; Uptake kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity concentrations of 99mTc-HMPAO in brain after intravenous injection were evaluated in 25 patients using SPECT. With additional first pass studies of heart and brain with the short lived isotope 195mAu, the cardiac output and the mean cerebral transit times of the patients were measured a short time before the HMPAO injection. The time dependence of 99mTc-HMPAO activity in the brain was registered during the first 5 min after injection over both hemispheres. Using a simplified three compartment model it was possible to calculate the mean retention fraction of HMPAO in brain from the time activity curves. It could be shown that the regional cerebral blood flow in ml/min per 100 g can be calculated from the activity concentration of HMPAO in the brain, the cardiac output and the retention fraction. In 15 of the 25 cases the rCBF was measured using the planar 133Xe inhalation method as a reference. We found a significant correlation between the mean hemisphere CBF from our method and the mean hemisphere grey matter CBF from the Xenon method with a correlation coefficient of 0.73.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253591
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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