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  • 1
    Electronic Resource
    Electronic Resource
    A simple method to diagnose adrenoleukodystrophy using a dried blood spot on filter paper
    Amsterdam : Elsevier
    Clinica Chimica Acta 159 (1986), S. 77-82 
    Details
    ISSN: 0009-8981
    Keywords: Adrenoleukodystrophy ; Dried blood spot on filter paper ; Mass chromatography ; Very long chain fatty acids
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(86)90169-5
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Use of GC/MS/SIM for rapid determination of plasma levels of o, p'-DDD, o, p'-DDE and o, p'-DDA
    Amsterdam : Elsevier
    Clinica Chimica Acta 170 (1987), S. 305-314 
    Details
    ISSN: 0009-8981
    Keywords: GC/MS/SIM ; Plasma level monitoring ; o, p'-DDA ; o, p'-DDD ; o, p'-DDE
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(87)90141-0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Paraquat-resistant HeLa cells, with high catalase activity obtained by transfection of mouse catalase cDNA, as a useful tool for detection of cellular H2O2
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 537 
    Details
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90435-W
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Involvement of cell wall β-glucan in the action of HM-1 killer toxin
    Amsterdam : Elsevier
    FEBS Letters 348 (1994), S. 27-32 
    Details
    ISSN: 0014-5793
    Keywords: Cell wall ; HM-1 killer toxin ; KRE6 ; β-Glucan
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00575-3
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Emphysematous changes assessed by selective alveolobronchography and bronchodilator response in chronic airflow obstruction (1994)
    Springer
    Lung 172 (1994), S. 103-112 
    Details
    ISSN: 1432-1750
    Keywords: Selective alveolobronchography ; Chronic airflow obstruction ; Emphysema ; Airway reversibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the relationship between the emphysematous changes and bronchodilator responses in patients with chronic airflow obstruction (CAO), we studied the correlation between bronchodilator response to 10 mg inhaled metaproterenol and the extent of emphysema, using selective alveolobronchogram (SAB). Fifty-one patients with CAO were classified into 3 groups by the extent of emphysematous changes detected by SAB. In group 1, no or mild emphysematous change was observed on SAB (n = 9); in group 2, there were significant emphysematous changes but the involved area was less than 75% (n = 17); in group 3, emphysematous change was extensive and covered more than 75% (n = 25). The post-bronchodilator forced expiratory volume in 1 sec (FEV1) of patients in group 3 was significantly lower than in groups 1 and 2. The mean value of changes of FEV1 as a percentage of predicted FEV1 of patients in group 3 was significantly lower than in groups 1 and 2. These results indicated that the extent of emphysematous change correlated positively with the severity of fixed air-flow obstruction, and negatively with the bronchodilator response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185081
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  • 6
    Electronic Resource
    Electronic Resource
    Nilvadipine protects low-density lipoprotein cholesterol from in vivo oxidation in hypertensive patients with risk factors for atherosclerosis (2000)
    Springer
    European journal of clinical pharmacology 56 (2000), S. 35-41 
    Details
    ISSN: 1432-1041
    Keywords: Key words Nilvadipine ; Hypertension ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Nilvadipine, a calcium antagonist, has been shown to have antioxidant activity in vitro, but its effect on in vivo oxidation has not been assessed. The aim of this study was to investigate the antioxidant effect of this agent in vivo. The ratios of 7-keto cholestadien to cholesterol are believed to be an available marker of lipid peroxidation. Using these ratios, we have assessed the antioxidant effect of nilvadipine on low-density lipoprotein (LDL) in hypertensive patients with high risk of atherosclerosis. The risk factors of atherosclerosis may involve oxidation of LDL. Methods: Fifteen healthy subjects (seven females and eight males aged 35–72 years, mean ± SD=55.3 ± 13.8 years) and fifteen hypertensive patients (seven females and eight males aged 45–80 years, mean ± SD = 60.2 ± 11.8 years) were recruited. Patients were treated orally with nilvadipine (4 mg b.i.d.) for 4 weeks. Cholesterol oxidation levels of LDL in patients before and after nilvadipine therapy and healthy subjects were studied. Results: The ratios of 7-keto cholestadien to cholesterol in LDL of hypertensive patients before and 4 weeks after nilvadipine treatment and in healthy subjects were 6.5 ± 1.6% (mean ± SD), 3.8 ± 1.2%, and 0.2 ± 0.1%, respectively. There were significantly (P 〈 0.001) increased levels of cholesterol oxidation in LDL in patients with hypertension both before and after nilvadipine treatment compared with healthy subjects. However, there was a significantly (P 〈 0.001) decreased level of cholesterol oxidation in LDL in patients after nilvadipine treatment compared with patients before nilvadipine treatment. Conclusion: Our data showed that nilvadipine may protect LDL cholesterol from in vivo oxidation in hypertensive patients with high risk of atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050717
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    IL-4 and IL-13 Stimulate Human Bronchial Epithelial Cells to Release IL-8 (1999)
    Springer
    Inflammation 23 (1999), S. 545-555 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cytokine networks are important in regulating the traffic of inflammatory cells in the airways. Interleukin-8 (IL-8) released by human bronchial epithelial cells (HBECs) is thought to be of particular importance in attracting neutrophils and monocytes to sites of inflammation. Increased release of IL-8 by HBECs in response to Th-1 cytokines such as TNF alpha and IL-1 beta may be an important pathophysiologic pathway. The present study was designed to explore the role of the Th2 cytokine IL-4 and the functionally related interleukins IL-10, and IL-13 on the regulation of IL-8 release by HBECs. HBECs (passage 4–6) were cultured in LHC9/RPMI and when confluent cells were stimulated in unsupplemented medium LHCD/RPMI by IL-4, IL-10, and IL-13 at 10 ng/ml concentration for all cytokines. TNF alpha stimulation was used as a positive control. After 24 hours supernatants were collected and tested for IL-8 by a sandwich ELISA. Unstimulated HBECs spontaneously released limited amounts of IL-8 (11 ± 1 pM) and significantly increased cytokine production in response to IL-4 (42 ± 1 pM), IL-13 (30 ± 1 pM) and TNF (128 ± 11 pM). Stimulation with IL-10 (11 ± 1 pM) did not change basal production of IL-8. When HBECs were co-stimulated with IL-4 plus TNF, the production of IL-8 was further increased (204 ± 5 pM). In contrast, IL-10 attenuated the effect of TNF during co-stimulation (82 ± 5 pM). IL-13 did not affect the release of IL-8 induced by TNF (111 ± 9 pM). Northern blot analysis of IL-8 mRNA levels showed the highest induction of IL-8 mRNA in HBECs co-stimulated with TNF and IL-4. We conclude from our study that IL-4 directly induces IL-8 release from HBECs and amplifies the release of IL-8 in response to TNF alpha. IL-13 is less active and IL-10 has an inhibitory effect. Airway epithelial cells are able to interact, therefore, with products of both Th1 and Th2 cells with respect to modulating release of IL-8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020242523697
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