ISSN:
1432-0428
Keywords:
Pancreatic duct ligation
;
fasting blood glucose
;
glucose tolerance
;
serum IRI
;
effect of glucagon
;
diabetes model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The present studies on duct ligated dogs and rabbits are an attempt to demonstrate functional alterations in glucose metabolism: 1. In rabbits the insulin reserve in the pancreatic gland was reduced to about one fifth of its normal value. 2. In dogs, as well as in rabbits, the values of fasting blood glucose remained normal for a period of 12 months following the operation. In rabbits the intragastric, but in dogs both the intragastric and the intravenous glucose tolerance were impaired. 3. In duct ligated dogs, the increase in serum IRI was diminished after intra-gastric and i.v. glucose load, as well as after injection of glucagon. Attempts are being made to adapt the model for special studies concerning the early state of diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00423033
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