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  • 1
    Electronic Resource
    Electronic Resource
    Increased blood pressure responses to central angiotensin II in spontaneously hypertensive rats (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 47-49 
    Details
    ISSN: 1432-1440
    Keywords: Blutdruck ; Angiotensin II ; Propranolol ; Spontan hypertensive Ratten ; Gehirn ; Blood pressure ; Angiotensin II ; Propranolol ; Spontaneously hypertensive rats ; Brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The blood pressure responses following infusions of angiotensin II (ANG II) into the brain ventricles (i.v.t.) have been tested in spontaneously hypertensive (SH) rats and in normotensive Wistar Kyoto (WK) rats. The mean arterial blood pressure increases were significantly higher in SH rats than in WK rats. Propranolol treatment reduced blood pressure increases to i.v.t. ANG II in WK, but not in SH rats. The higher sensitivity to i.v.t. ANG II in SH rats supports a role of central ANG II in the maintenance of high blood pressure in SH rats.
    Notes: Zusammenfassung Angiotensin II (ANG II) wurde spontan hypertensiven (SH) Ratten und normotensiven Wistar Kyoto (WK) Ratten in den lateralen Hirnventrikel (i.v.t.) infundiert. Der mittlere arterielle Blutdruck stieg bei den SH Ratten signifikant höher an als bei den normotensiven WK Ratten. Propranolol-Vorbehandlung reduzierte die Blutdruckanstiege nach i.v.t. ANG II Infusionen bei WK Ratten, nicht aber bei SH Ratten. Die höhere ANG II Empfindlichkeit der SH Raten bestätigt frühere Ergebnisse, die darauf hinweisen, daß zentrales ANG III an der Aufrechterhaltung des hohen Blutdruckes von SH Ratten beteiligt sein kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477452
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Kationenfluxe am Erythrozyten bei Patienten mit essentieller Hypertonie (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 517-521 
    Details
    ISSN: 1432-1440
    Keywords: Essential hypertension ; Erythrocytes ; Rubidium influx ; Na — K-cotransport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 86Rubidium influx and Na — K-cotransport have been investigated in erythrocytes of mild essential hypertensives and normotensives devoid of familial hypertension. For measurement of cotransport Na-loaded/K-depleted erythrocytes were used while rubidium influx (with and without ouabain) was determined under physiological conditions. Both transport systems were linear in time, the interassay variances in a range of about 10%. The patients with essential hypertension exhibited a decreased rubidium influx compared to the normotensive controls. Ouabain-sensitive fluxes were not significantly different between the two groups, whereas ouabain-resistent rubidium influx was diminished in the group of the patients. Na — K-cotransport was also found to be decreased in essential hypertension. There was no correlation between cotransport and Rb-influx. The results indicate changes in cation fluxes in erythrocytes of essential hypertensives, the Na — K-cotransport being rather more altered than rubidium influx. It is speculated that hypertensive persons with reduced rubidium flux rates may represent a subpopulation of essential hypertension and that their high blood pressure may be additionally influenced by exogeneous factors e.g. enhanced sodium uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488719
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Peripheral effects of thyroid hormones: Alteration of intracellular Na-concentration, ouabain-sensitive Na-transport, and Na-Li countertransport in human red blood cells (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 598-601 
    Details
    ISSN: 1432-1440
    Keywords: Hyperthyroidism ; Erythrocytes ; Na-K ATPase ; Na-Li countertransport ; Intracellular sodium concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the effect of thyroid hormones on erythrocyte cation transport systems and intracellular electrolyte content we have measured the activity of Na-K ATPase, Na-Li countertransport, as well as red cell sodium and potassium contents in patients with hyperthyroidism and in euthyroid controls. Intracellular Na- and K-concentrations were determined in erythrocytes washed three times in isotonic MgCl2 solution. Ouabain-sensitive Na-transport was estimated as the increase of Na before and after addition of ouabain in an erythrocyte suspension in isotonic Na-free medium. Na-Li countertransport was measured according to the method described by Canessa et al. [2]. The patients with hyperthyroidism exhibited a significantly elevated intracellular sodium content as well as a highly increased Na-K ATPase activity. Intracellular potassium content was not altered in the hyperthyroid subjects, but Na-Li countertransport was markedly decreased as compared to the controls. The results indicate that different ion transport systems of the erythrocyte membrane are influenced by thyroid hormones. We suggest that the elevation of Na-K ATPase activity might be due to the increased intracellular sodium concentration which is caused by the diminished countertransport pathway. Furthermore, the activity of Na-K ATPase, Na-Li countertransport, and intracellular sodium content in erythrocytes might be a useful peripheral indicator of thyroid hormone excess.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728180
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    Paper (German National Licenses)
    Fulltext
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