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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 5440-5441 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 5610-5617 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 186 (1992), S. 137-143 
    ISSN: 1432-0568
    Keywords: Human ; Hippocampus ; Limbic system ; Computer graphics ; Stereotactic surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A statistical method is described to show the distribution of neuroanatomical structures within a Cartesian coordinate system from any given number of examinations. The algorithm is based on polygons derived from the outlines of neuroanatomical structures in parallel canthomeatal-orientated cutting planes. These polygons are transformed in virtual voxels, rotated into the bicommissural coordinate system, and projected onto the three main planes of this coordinate system. Areas with the same probability for the structures examined are given in these planes. As an example this method is applied to the hippocampal formation and the results attained are shown.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 79 (1996), S. 335-341 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Description / Table of Contents: Contents The paper describes a new 50 V BiCMOS smart power process. The development includes the monolithic integration of dielectrical isolated 1.5 μm CMOS devices, NPN/PNP bipolar transistors, 50 V vertical and quasivertical DMOS power transistors, poly-n + capacitors, Zener diodes, implanted resistors and double metal wiring. The process will be used to fabricate efficient and self protected circuits with integrated diode or DMOS full bridges. Based on an industrial 1.5 μm CMOS, circuit robustness is achieved by adding dielectric isolation and high voltage transistors. Vertical trenches, 1.2 μm wide, filled with oxide and polysilicon, yield lateral isolation between devices. Vertical isolation is given by SIMOX technology (Separation by IM-planted OXygen). An additional ion implant optimises a vertical or quasivertical DMOS power transistor with low on resistance. Bipolar transistors are integrated without extra masking steps. The circuit layout is compatible to existing CMOS standard cell libraries. Beyond SIMOX, wafer bonded substrates may be used as starting material. Efficient design and fabrication characterise this process suited for automotive applications.
    Notes: Übersicht Im vorliegenden Artikel wird die Entwicklung eines neuen 50 V-BiCMOS-Smart-Power-Prozesses beschrieben. Dieser beinhaltet die monolithische Integration von dielektrisch isolierten 1.5 μm CMOS-Transistoren, NPN/PNP-Bipolartransistoren, 50 V vertikalen/quasivertikalen DMOS-Leistungstransistoren (VDMOS, QVDMOS), Poly-n +-Kondensatoren, Zener-Dioden, implantierten Widerständen sowie Zweilagen-Metallisierung. Dieser Prozeß ermöglicht die Herstellung eigensicherer und effizienter Dioden- und DMOS-Vollbrückenschaltungen. Ausgehend von einem industriellen Niedervolt−1.5 μ-CMOS-Prozeß wird die Robustheit durch den Einsatz der dielektrischen Isolation und die Integration von spannungsfesten Transistoren erhöht. Die laterale dielektrische Isolation der Bauelemente wird durch Trenches, d.h. nahezu senkrecht geätzte, 1.2 μ breite Gräben, die oxidiert und aufgefüllt werden, hergestellt. Die vertikale dielektrische Isolation geschieht mittels SIMOX-Technologie (Separation by IMplanted OXygen). Eine Zusatzimplantation dient der Optimierung eines DMOS-Transistors als vertikales oder quasivertikales Leistungsbauelement mit niedrigem Einschaltwiderstand. Die Bipolartransistoren, hergestellt ohne zusätzliche Masken, sind für den Einsatz im Automobilsektor geeignet. Dabei bleibt das Layout kompatibel zu existierenden CMOS-Standardzellenbibliotheken. Dieses ist für industrielle Hersteller hinsichtlich Kontinuität in Entwurf und Produktion bedeutsam. Der Herstellungsprozeß ist gleichermaßen für SIMOX- und für SDB-(Silicon Direct Bonded) Substrate geeignet.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 17 (1938), S. 1148-1151 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Untersuchungen am isolierten Kaninchenohr nachKrawkow-Pissemski ergaben bei 30 Normotonen (in 30 Bestimmungen) eine durchschnittliche Durchflußverminderung von 7,4%, bei 36 Patienten mit essentieller Hypertonie (46 Bestimmungen) von 11,4%; in den Fällen mit einem Blutdruck über 200 mm Hg betrug sie 13,4%. Diese Resultate lassen auf eine Zunahme der vasoconstrictorisch wirkenden Stoffe bei der Hypertonie schließen. Eine Adrenalinwirkung dabei war nach dem Ausfall der Untersuchung am parallellaufenden gynergenvergifteten Präparat nicht anzunehmen. 2. Bei Hunden, die durch intrazisternale Kaolininjektion eine Blutdruckerhöhung erfahren hatten, ließ sich zeigen, daß bei dieser Hochdruckform, bei der so lange eine rein nervöse Entstehungsursache angenommen wurde, vasopressorische Stoffe eine Rolle spielen. 3. Da bei epinephrektomierten Tieren eine stärkere pressorische Gefäßwirkung nach Kaolininjektion nicht eintrat, ist mit Wahrscheinlichkeit die Nebenniere als Ursprungsort dieser Stoffe anzunehmen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Medullary thyroid carcinoma ; Prognostic factors ; Sporadic and familial form ; Age ; Sex ; Tumor stage at diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 741 patients with medullary thyroid carcinoma diagnosed between 1967 and 1991 was carried out by members of the German Medullary Thyroid Carcinoma Study Group to evaluate prognostic factors. A total of 559 patients (75%) were considered to have sporadic disease, and 182 (25%) had the familial type. The sex ratio (male to female) was 1:1.4 in sporadic disease patients, and the mean age at diagnosis was 45.9 years (range 5-81 years). For familial disease patients the sex ratio was 1:1.1, and the mean age at diagnosis was 33.4 (range 5–77 years). The follow-up time for 630 patients ranged from 1 month to 20.8 years (mean 13.0 years). The overall adjusted survival rate was 86.7% at 5 years and 64.2% at 10 years. In a univariate analysis the stage of disease at diagnosis, age, sex, and type of disease (sporadic, familial) were relevant prognostic factors, with a better prognosis for young female patients with familial disease and diagnosed at an early stage. In a multivariate proportional hazards analysis, the difference in the survival rate of patients with familial disease versus those with the sporadic form disappeared, while prognostic information provided by age and sex was still significant. The poorer prognosis of patients with sporadic medullary thyroid carcinoma may be related to the patients' older age at detection and more advanced tumor stage at diagnosis. There seems to be no difference in biological behavior between tumors of the sporadic and those of the familial type.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 11 (1923), S. 957-962 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 276 (1984), S. 209-215 
    ISSN: 1432-069X
    Keywords: 13-cis-Retinoic acid ; Isotretionoin ; Conglobate acne ; Seborrhoea ; Serum lipids ; Acne treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A follow-up was done on the patients of the German multicenter study with severe conglobate acne who had been treated with different dosages of 13-cis-retinoic acid. Eighty-seven patients were monitored from 12 to 21 months. Optimal long-term therapeutic effects were obtained with an initial dose of 1.0 mg/kg body weight, for 3 months, followed by another 3-month-treatment period with 0.2 mg/kg body weight. Six months after the termination of therapy 96% of the patients were still in remission and 81% after 12 months. Comparative figures for the administration of doses were 84% as opposed to 47% (0.5 → 0.2 mg/kg body wt.) and 74% as opposed to 37% (0.2 → 0.2 mg/kg body wt.), respectively. It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects. Transiently elevated lipid levels as well as other tolerable side effects return to normal within 3 months at the latest after discontinuation of treatment.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 276 (1984), S. 297-302 
    ISSN: 1432-069X
    Keywords: Psoriasis ; Selective ultraviolet phototherapy ; DNA antibodies ; Antinuclear antibodies ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sera of 21 psoriatics treated by selective ultraviolet phototherapy (SUP) for 1–7 months were screened for IgG- and IgM-anti-DNA antibodies and antinuclear antibodies (ANAs) by standardized ELISA and the indirect immunofluorescence technique. No patients developed IgG-antibodies against native DNA under SUP, but two patients increased their IgM-antibody titers five- and tenfold, respectively. The IgG- and IgM-anti-single-stranded-(ss)DNA antibody titers remained unaltered in 38% and 57% of the patients. In 43% and 24%, respectively, they rose to a maximum of three times their original; and in 20% they decreased to a minimum of 40% of their pretherapeutic titers. After 1 month therapy no patient had produced ANAs, but all three patients showing ANAs before therapy had increased titers (one titer step). These remained on the elevated level or were even further increased by one-titer step during progressive therapy. Two patients out of 14 developed low titers of IgM-(1:20) or IgA-(1:40)ANAs against deoxyribonucleoprotein (DNP), initially after 3 months of irradiation; in one of them IgG-ANAs (titer 1:10) against DNP were additionally formed after 6 months of therapy. Our results suggest that lesions in DNA and DNP generated by SUP trigger an immune response to nuclear antigens.
    Type of Medium: Electronic Resource
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