Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Investigation of nimodipine pharmacokinetics in Chinese patients with acute subarachnoid haemorrhage (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 363-366 
    Details
    ISSN: 1432-1041
    Keywords: Nimodipine ; pharmacokinetics ; Chinese patients ; acute subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nimodipine pharmacokinetics was investigated in 12 Chinese patients with acute subarachnoid haemorrhage receiving an IV infusion of 1.6 or 2 mg/h (based on estimated body weight) for 10 days. Peripheral venous blood samples were collected for up to 4 days and plasma nimodipine was assayed by GC/ECD. The mean value was taken as the steady state concentration (Css) and Clearance (CL) (hourly dose/Css) was calculated. Eight survivors were given oral nimodipine (60 or 90 mg) every 6h (based on body weight), blood was sampled over 6 h and the plasma nimodipine level determined. The values for Css, CL and CL·kg−1 were 33.5 μg·l−1, 58 l·h−1 and 1.0 l·h−1·kg−1 respectively; in survivors receiving the drug orally, bioavailability of the 30 mg tablet was 9%. In one very sick patient given crushed tablets by naso-gastric tube, the AUC was very low; in vitro studies indicated that adsorption of nimodipine by the tubing was unlikely to have been the cause. The pharmacokinetic findings in Chinese patients are comparable to previously reported values in Caucasians.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265956
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    MHC Association Between Antistriational Antibody-Negative Myasthenia Gravis in the Chinese (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27155.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Influence of gonadal hormones on sexual differences in sensitivity to methamphetamine-induced neurotoxicity (1994)
    Springer
    Journal of neural transmission 8 (1994), S. 215-221 
    Details
    ISSN: 1435-1463
    Keywords: Methamphetamine ; estrogen ; testosterone ; Parkinson's
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The administration of high doses of methamphetamine to mice causes long-lasting depletions of striatal dopamine to a greater extent in males than in females. Likewise, the incidence of Parkinson's disease is higher in males than in females. The present study investigated the roles of estrogen and testosterone in mediating the dopamine depletion induced by methamphetamine. Male and female mice received four cumulative SC doses of methamphetamine (10 mg/kg) at two hour intervals and were sacrificed two weeks later for HPLC analysis of striatal monoamines. Intact male mice were found to have a 76% dopamine depletion, which was significantly greater than the 37% depletion exhibited by the intact female mice. Neither removal of the ovaries nor removal of the testes one month prior to the methamphetamine treatment significantly changed the magnitude of the methamphetamine-induced dopamine depletion. Thus, the reduced sensitivity of female mice to methamphetamine may be independent of physiological gonadal hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260942
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The morphologic changes of endometrial spiral arterioles in IUD-induced menorrhagia (1994)
    Springer
    Advances in contraception 10 (1994), S. 213-222 
    Details
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumé Pour explorer la relation entre la ménorragie provoquée par les DIU et la fonction des artérioles spiralées, nous avons examiné l'endomètre aux microscopes polarisant et électronique sur des échantillons obtenus 24 heures après le début de la microrragie prémenstruelle. Ces échantillons provenaient d'un groupe d'utilisatrices de DIU présentant un écoulement sanguin (24 cas), d'un groupe sans écoulement sanguin (20 cas) et d'un groupe témoin n'utilisant pas de DIU (20 cas). Une comparaison avec le groupe témoin a permis de constater que la dégénérescence des parois des artérioles spiralées était plus accentuée et que la dilatation du lumen de ces artérioles était plus prononcée, particulièrement dans le tissu spongieux. Dans le groupe témoin, ces altérations étaient légères, ce qui laisse penser que la ménorragie provoquée par les DIU pourrait fort bien être associée à une faible contractilité des artérioles spiralées dans le tissu spongieux.
    Abstract: Resumen A los efectos de investigar la relación existente entre la menorragia inducida por DIU y la función arteriolar espiral, examinamos el endometrio bajo microscopio óptico y electrónico en muestras obtenidas dentro de las 24 horas de iniciado el sangrado premenstrual. Estas muestras comprendían un grupo de sangrado con DIU (20 casos), un grupo de no sangrado con DIU (20 casos) y un grupo de no usuarias de DIU (10 casos) como control. En comparación con el grupo de no usuarias de DIU, los cambios degenerativos de la pared arteriolar espiral fueron más acentuados y la dilatación del lumen arteriolar espiral más evidente, especialmente en la capa esponjosa. Estos cambios fueron leves en el grupo de no usuarias de DIU, característica que sugiere que la menorragia inducida por DIU podría estar correlacionada con la contractilidad deficiente de las arteriolas espirales de la capa esponjosa.
    Notes: Abstract To investigate the relationship between IUD-induced menorrhagia and spiral arteriolar function, we examined the endometrium under light and electron microscope on samples obtained within 24 hours after the onset of premenstrual spotting. These samples included an IUD bleeding group (20 cases), an IUD non-bleeding group (20 cases) and an IUD non-user group (10 cases) as controls. Compared with the IUD non-user group the degenerative changes of spiral arteriolar wall were more severe and dilation of the spiral arteriolar lumen was more obvious, especially in the spongeous layer. In the IUD non-user group these changes were mild, suggesting that IUD-induced menorrhagia might be correlated with poor contractility of spiral arterioles in the spongeous layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983353
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Computed tomography in cervical spondylotic myelopathy and radiculopathy: visualisation of structures, myelographic comparison, cord measurements and clinical utility (1986)
    Springer
    Neuroradiology 28 (1986), S. 221-236 
    Details
    ISSN: 1432-1920
    Keywords: Cervical spinal cord ; Cervical spondylosis ; Computed tomography ; Computer-assisted myelography ; Metrizamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixty-nine patients with cervical spondylotic myelopathy (CSM), radiculopathy (CSR), or both (CSMR) were studied with computed tomography (CT). Computer-assisted myelography (CAM) accurately determines the site and nature of spondylotic protrusions and provides good visualisation of the subarachnoid space and cord deformities even in areas with dilute metrizamide. However, excessive vertebral movement and bulging ligamenta flava with their effects on cord deformity, so easily visualised in myelograms, are completely or partially missed. In the assessment of CSM, metrizamide myelography (MM) followed by CAM should be performed, particularly when the myelographic images are unsatisfactory due to contrast dilution or blockage, when cord compression cannot be ascertained with MM and when cord atrophy is suspected. In CSR, the diagnostic information from MM and CAM is comparable. The diagnostic criteria in CAM are, however, less direct and since MM is adequate in uncomplicated cases, CAM is generally not necessary. The APD, APD/TD ratio, area and circularity are sensitive indices of cord deformity and the first two should be used more often to assist visual assessment of cord deformity. The relation between cord parameters and treatment response is better reflected in CSM cases managed conservatively and the results suggest that the degree of cord deformity is helpful in determining the outcome and hence the choice between surgical and conservative treatment. In plain CT, the osteophytes and calcified discs are adequately visualised and canal dimensions measured with accuracy, but the cervical cord and roots cannot be properly assessed and the diagnosis of CSM or CSR cannot be ascertained. At present, its role in cervical spondylosis is therefore limited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548196
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography (1986)
    Springer
    Neuroradiology 28 (1986), S. 339-343 
    Details
    ISSN: 1432-1920
    Keywords: Water soluble contrast medium ; Side effects ; Metrizamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although metrizamide is now being superseded by other contrast media, the mechanisms of its side effects may be of fundamental importance. One hundred and four consecutive patients with suspected cervical cord or root lesion were studied prospectively for factors which might influence the side effects of metrizamide myelography. Elderly patients were more prone to develop mental confusion. An earlier onset of dizziness and/or vertigo was associated with the lumbar route of intrathecal injection. Perhaps surprisingly, phenobarbitone prophylaxis shortened the duration of confusion and delayed the onset of headaches. Other factors, viz. sex, excess intracranial flow of metrizamide and myelographic blockage were not shown to have a significant influence on the adverse reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333441
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Is there an increased risk of early side effects of metrizamide in post-myelogram computed tomography? (1984)
    Springer
    Neuroradiology 26 (1984), S. 399-403 
    Details
    ISSN: 1432-1920
    Keywords: Metrizamide ; myelography ; risks ; complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The safety of post-myelogram computed tomography (PMCT) as an additional diagnostic procedure to metrizamide myelography was evaluated. One hundred and four consecutive patients with suspected cervical cord lesions were studied prospectively; 50 had both myelography and PMCT, and the 54 acting as controls had only myelography. PMCT did not increase the incidence, severity or duration of common side effects and the majority of patients accepted this additional procedure. It is concluded that as long as care is taken to avoid the occurrence of excessive contrast in the intracranial subarachnoid space, PMCT is a safe procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327494
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Morphology and measurements of the cervical spinal cord in computer-assisted myelography (1985)
    Springer
    Neuroradiology 27 (1985), S. 399-402 
    Details
    ISSN: 1432-1920
    Keywords: Cervical spinal cord ; computer-assisted myelography ; computed tomography ; metrizamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-six control subjects had computer assisted myelography (CAM) using the EMI CT 5005 scanner. The normal cervical cord is elliptical, more circular at the upper and lower ends and flatter in the mid-segments. Asymptomatic cord deformities, usually mild, were present in nine subjects (25%). Four measurements, namely, sagittal diameter (APD), transverse diameter (TD), area (a) and circumference (c) were made and two more parameters calcultted i.e. APD/TD ratio and circularity (=4 π a/c2). These control values form the basis of qualitative and quantitative assessment of cord deformity. When cord measurements are to be used, control values should be obtained for each scanner and procedures should be standardized
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327602
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Syringomyelia and cervical spondylosis: a clinicoradiological investigation (1987)
    Springer
    Neuroradiology 29 (1987), S. 143-151 
    Details
    ISSN: 1432-1920
    Keywords: Syringomyelia ; spondylosis ; plain radiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighty eight patients with proven syringomyelia have been studied retrospectively to explore the relationship between syringomyelia and spondylotic degeneration of the cervical spine. When compared with age and sex matched control subjects, they showed no significant increase in incidence or severity of spondylosis or of vertebral subluxation. Duration of symptoms, degree of disablity, and the pattern of analgesia or lower motor neurone lesions in the arms did not appear to be related to the development of spondylosis. The onset of moderate spondylosis was, however, earlier than in the controls, and individual cases with a remarkably early onset or unusual site and/or severity of spondylosis and subluxation were encountered, particularly following laminectomy. It was also noted that in a small number of patients the concomitant development of spondylosis contributed to clinical deterioration. It is concluded that while syringomyelia does not have a consistent, major role in the development of cervical spondylosis or vertebral luxation, it may contribute to progression of spinal degenerative disease in some patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327539
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Some dynamic factors in compressive deformity of the cervical spinal cord (1987)
    Springer
    Neuroradiology 29 (1987), S. 136-142 
    Details
    ISSN: 1432-1920
    Keywords: Computed myelography ; Spinal cord compression ; Cervical spondylosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An investigation into the relative elastic and non-elastic components of compressive deformity of the cervical spinal cord has been made. Sixteen patients were examined by computed myelography with the neck flexed and extended, and one fresh specimen of a human spinal cord was studied under reversible transverse compression with the specimen in a stretched and shortened state. In conditions of transverse compression cord tissue undergoes an alteration in viscoelastic properties, manifesting itself as reduced expansion of the compressed segment as the cord shortens, which in some cases is independant of whether the agent is seen to actually contact the cord. The presence of degenerative changes in cord substance probably accentuates this alteration in mechanical properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327538
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...