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  • 1
    Electronic Resource
    Electronic Resource
    Energetics of fission of Th^2^3^2 induced by 27.8 MeV helium ions
    Amsterdam : Elsevier
    Physics Letters 8 (1964), S. 263-265 
    Details
    ISSN: 0031-9163
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0031-9163(64)91573-2
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of interferon-α on DOI-induced wet-dog shakes in rats (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 947-955 
    Details
    ISSN: 1435-1463
    Keywords: Serotonin ; interferon ; wet-dog shake ; opioid receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute (1h) intraperitoneal (ip) treatment with interferon (IFN)-α-2a (300IU/g) significantly inhibited wet-dog shakes (WDS) induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-α did not affect spontaneous locomotion. The inhibition of DOI (0.5mg/kg)-induced WDS by IFN-α was dose (90–300 IU/g)- and time (1–6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0mg/kg, ip), an opioid receptor antagonist. Acute (1h) intracerebroventricular (icv) treatment with IFN-α (1,500IU/rat) also inhibited DOI (0.5mg/kg)-induced WDS, and the effect was blocked by NLTX (50μg/rat, icv). These results suggest that IFN-α may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291785
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of acute and chronic administration of dehydroepiandrosterone on (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced wet dog shaking behavior in rats (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 23-33 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Wet dog shaking behavior (WDS) ; dehydroepiandroste-rone (DHEA) ; dexamethasone ; (±)-1-(2 ; 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) ; serotonin-2A (5-HT-2A) receptor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. It has been reported that dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEA-S) is associated with affective disorders and that pathology of affective disorders are related with dysfunction of serotonin(5-HT)-2A receptor-mediated responses. In this study, we investigated the effect of DHEA on (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI), 5-HT-2A receptor agonist, -induced wet dog shaking behavior (WDS) in rats. Acute treatment with DHEA inhibited the DOI-induced WDSs dose dependently. This inhibition was recovered by opioid receptor antagonist, naltrexone. 5-HT-2A receptor-mediated WDSs were desensitized after chronic treatment with DOI, however chronic treatment with DHEA had no effect on this desensitization. Chronic treatment with DHEA had no facilitating effect of chronic dexamethasone treatment on DOI-induced WDSs. These findings may lead the possibility that DHEA has the inhibitory effect of 5-HT-2A mediated signaling pathway via non-genomic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050138
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  • 4
    Electronic Resource
    Electronic Resource
    Heterologous supersensitization between serotonin2 and alpha2-adrenergic receptor-mediated intracellular calcium mobilization in human platelets (1992)
    Springer
    Journal of neural transmission 88 (1992), S. 25-36 
    Details
    ISSN: 1435-1463
    Keywords: Serotonin2 receptor ; α2-adrenergic receptor ; calcium mobilization ; heterologous supersensitization ; human platelets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent reports suggest that serotonin (5-HT)2 receptor-mediated second messenger systems are enhanced in platelets of affective disorders. To make the mechanism of the enhanced response clear, we investigated 5-HT2 and alpha (α)2-adrenergic receptor-induced intracellular calcium (Ca2+) mobilization in platelets of healthy volunteers, using fura-2. 5-HT2 and α2-adrenergic receptor-mediated Ca2+ mobilization was enhanced by prior exposure to the other type of agonist, so called “heterologous supersensitization”. The supersensitization was due to the enhancement of maximal response without change in agonist affinity. Chelating extracellular Ca2+ did not diminish the supersensitization. This enhancement of Ca2+ mobilization was not inhibited by H-7, an inhibitor of protein kinase C. However, this supersensitization was inhibited by pretreatment with sodium fluoride which directly activates guanine nucleotide binding regulatory proteins (G proteins). These results suggest that the supersensitization was caused from intracellular Ca2+ storage sites through a G protein-coupled pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245034
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  • 5
    Electronic Resource
    Electronic Resource
    Prognostic value of P-glycoprotein expression in bone and soft-tissue sarcoma (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 164-170 
    Details
    ISSN: 1437-7772
    Keywords: Key words P-glycoprotein ; Osteosarcoma ; Soft-tissue sarcoma ; Prognosis ; Immunohistochemistry ; RT-PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The purpose of this study was to investigate the correlation between P-glycoprotein status and outcome in adult patients with high-grade osteosarcomas and soft-tissue sarcomas. Methods. P-glycoprotein status was determined im-munohistochemically in specimens from 28 patients with osteosarcoma and 34 patients with soft-tissue sarcoma. The polyclonal antibody mdr(Ab-1) was used for either decalcified or undecalcified tissue samples which were formalin-fixed and paraffin-embedded. The expression of P-glycoprotein mRNA was also determined by the polymerase chain reaction in 23 fresh sarcoma specimens. P-glycoprotein status was analyzed in relation to the duration of event-free survival. Results. Positivity for P-glycoprotein was found in 29% of the osteosarcomas and 34% of the soft-tissue sarcomas. Consistent results were obtained at both the immunohistochemical and reverse transcriptase-polymerase chain reaction (RT-PCR) levels in 19 of 23 sarcomas (83%). In patients with osteosarcoma, the presence of increased levels of P-glycoprotein was significantly associated with a decreased probability of event-free survival after diagnosis (P = 0.022). In contrast, in patients with soft-tissue sarcoma there was no correlation between the level of P-glycoprotein and prognosis. Conclusions. In patients with high-grade osteosarcomas, the presence of increased levels of P-glycoprotein detected by polyclonal antibody mdr(Ab-1) was associated with a significantly increased risk of adverse events. This association was not found in patients with soft-tissue sarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012032
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  • 6
    Electronic Resource
    Electronic Resource
    The relationship of the platelet 5-HT-induced calcium response to clinical symptoms in eating disorders (1999)
    Springer
    Psychopharmacology 142 (1999), S. 289-294 
    Details
    ISSN: 1432-2072
    Keywords: Key words Platelet ; Intracellular calcium concentration ; 5-HT2A receptor ; Eating disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical observations indicate that persons with eating disorders exhibit many psychopathologic symptoms such as difficulty with impulse control and depressed mood associated with impaired regulation of serotonin (5-HT) synaptic function in the central nervous system. In this study, we focused on the relationship between the 5-HT-induced calcium response in platelets and the clinical symptoms. While age, body weight, and severity of depressive symptoms were not correlated with 5-HT-induced response, there was an enhanced response in patients with bulimic symptoms or other impulsive behaviors. Moreover, patients with multi-impulsive behaviors had a significantly higher maximal increase than patients with uni-impulsive behavior, i.e., those who had only bulimic symptoms, as well as non-impulsive patients, and controls. Considering these results, the 5-HT-induced response may be related to difficulty with impulse control in general rather than bulimic eating attitudes specifically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050891
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  • 7
    Electronic Resource
    Electronic Resource
    Involvement of the α2-adrenergic system in polydipsia in schizophrenic patients: a pilot study (1997)
    Springer
    Psychopharmacology 130 (1997), S. 382-386 
    Details
    ISSN: 1432-2072
    Keywords: Key words Schizophrenia ; Polydipsia ; Drinking behavior ; Mianserin ; Clonidine ; α2-Adrenoceptor ; Adrenergic system ; Body weight change
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Animal studies have suggested the involvement of the adrenergic system in drinking behavior. The present study investigated the involvement of the α2-adrenergic system in the polydipsia of patients with chronic schizophrenia by use of an α2 agonist and an antagonist. Four patients with schizophrenic disorders accompanied by intermittent hyponatremia and polydipsia were the subjects of, and completed, this study. Drinking behavior was assessed by calculating the percent of maximum weight gain [PMWG: (maximum diurnal weight – standard weight) × 100/standard weight]. Standard weight was defined as body weight after 8 h of water restriction. Clonidine (75, 150, and 225 mg/day) increased the PMWG in a dose-dependent manner in the four subjects. In contrast, in three of the subjects, mianserin (30, 60, and 90 mg/day) decreased PMWG, and the severe polydipsia disappeared almost completely. These findings indicate clearly that the α2-adrenergic system is involved in the drinking behavior of schizophrenic patients. Mianserin appears to be clinically useful in treating such patients with polydipsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050254
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  • 8
    Electronic Resource
    Electronic Resource
    The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma (1988)
    Springer
    International orthopaedics 12 (1988), S. 305-308 
    Details
    ISSN: 1432-5195
    Keywords: Osteosarcoma ; Pulmonary metastasis ; Adjuvant chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a étudié les modifications de l'aspect des métastases pulmonaires chez des malades porteurs d'un ostéosarcome et traités par chimiothérapie complémentaire. Trente-deux malades traités à la fois par chirurgie radicale et chimiothérapie ont été examinés (groupe avec chimiothérapie). Soixante-deux malades traités seulement par chirurgie radicale (groupe sans chimiothérapie) ont également été suivis, constituant un groupe de contrôle. Le groupe avec chimiothérapie a présenté une diminution du nombre ainsi qu'un retard à l'apparition des métastases. Le temps de doublement de ces tumeurs ne diffère pas entre les deux groupes. La localisation initiale des métastases dans le groupe avec chimiothérapie est le plus souvent la base du poumon, tandis que dans le groupe sans chimiothérapie c'est habituellement la partie moyenne du poumon. Après apparition des métastases pulmonaires la durée de survie est plus importante dans le groupe avec chimiothérapie que dans l'autre. L'examen histologique montre que les foyers métastatiques sont identiques à la localisation initiale de la tumeur.
    Notes: Summary Alterations in the pattern of pulmonary metastasis of patients with osteosarcoma treated with adjuvant chemotherapy were studied. Thirty two patients who were treated with both radical surgery and adjuvant chemotherapy were observed (chemotherapy group). As a control, sixty two patients treated with radical surgery alone were also assessed (non-chemotherapy group). The chemotherapy group demonstrated a reduction in the number and a delay in the appearance of metastases. The tumour doubling time did not differ between the chemotherapy and non-chemotherapy groups. The initial site of metastasis among the chemotherapy group was most commonly in the lower lung field, whereas among the non-chemotherapy group it was usually to the middle lung field. The chemotherapy group survived longer than the non-chemotherapy group after developing pulmonary metastases. Histological examination showed that the metastatic foci simulated the primary sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317829
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of magnetic resonance imaging and computed tomography in the local assessment of osteosarcoma (1992)
    Springer
    International orthopaedics 16 (1992), S. 285-290 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de cette étude est d'évaluer la capacité de l'imagerie par résonance magnétique (IRM) à préciser le siège et le degré d'extension des ostéosarcomes et d'en comparer les résultats à ceux de la tomodensitométrie (TDM). Nous avons examiné 20 patients atteints d'ostéosarcome par IRM (Siemens MRI scanner 1.5 tesla) ainsi que par TDM (CT/T CT scanner Yokokawa). Un examen anatomopathologique de la pièce chirurgicale a été effectué et ses résultats comparés à ceux de l'IRM et de la TDM. La taille de la tumeur mesurée par l'IRM était très comparable à celle de la pièce opératoire: la différence était en moyenne de 3.3 mm±1.6. L'appréciation par la TDM de l'atteinte corticale a été la même que celle de l'IRM dans 15 cas, mais supérieure dans les 5 autres. L'IRM a été supérieure à la TDM chez 5 patients dont les lésions atteignaient l'articulation et identique chez les 12 autres. L'IRM a été supérieure à la TDM en ce qui concerne l'évaluation de l'extension dans les parties molles dans 9 cas et égale dans les 11 autres. L'IRM s'est montrée supérieure à la TDM pour estimer l'atteinte neuro-vasculaire dans 9 cas et égale dans les 11 autres. Ces résultats montrent que l'IRM définit mieux le degré d'extension locale des ostéosarcomes que la TDM.
    Notes: Summary We have compared the value of magnetic resonance imaging (MRI) with computed tomography (CT) in assessing the extent and the localization of osteosarcomas. Twenty patients were examined by both systems, and the results related to the clinical and histological findings. While both investigations are valuable, MRI may be more useful for defining the local extent of an osteosarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182713
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  • 10
    Electronic Resource
    Electronic Resource
    Cyclic GMP generation mediated by 5-HT-2 receptors via nitric oxide-dependent pathway and its effect on the desensitization of 5-HT-2 receptors in C6 glioma cells (1995)
    Springer
    Journal of neural transmission 100 (1995), S. 27-38 
    Details
    ISSN: 1435-1463
    Keywords: 5-HT-2 receptors ; cGMP generation ; nitric oxide ; desensitization ; C6 glioma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serotonin (5-HT)-2 receptor-mediated cGMP generation was investigated in comparison with calcium (Ca2+) mobilization in C6 glioma cells. 5-HT enhanced cGMP generation, and risperidone and ketanserin potently blocked the response. These results indicate that 5-HT-2 receptors are responsible for the cGMP generation. 5-HT-induced cGMP production was completely abolished by BAPTA, an intracellular Ca2+ chelating agent, or N g -monomethyl-L-arginine (NMMA), a nitric oxide synthase (NOS) inhibitor, suggesting that 5-HT-induced cGMP generation was through nitric oxide (NO)-dependent pathway. 5-HT (10 μM)-elicited Ca2+ mobilization and cGMP generation were reduced to 40 and 15 % after pretreatment with 10 μM 5-HT for 4 hours. NMMA did not modify 5-HT-induced desensitization of either Ca2+ mobilization or cGMP generation, suggesting that NO pathway is independent of the desensitization. The present study has demonstrated the nature of 5-HT-2 receptormediated cGMP generation in C6 glioma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276863
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