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  • 1
    Electronic Resource
    Electronic Resource
    Segment by Segment Linear Ablation with an Articulated Bilimb Catheter: Initial Experimental Results (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 21 (1998), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Transcatheter radiofrequency (RF) ablation of atrial fibrillation or flutter requires the creation of linear lesions. However, conventional catheters are not predictably effective because of poor endocardial contact, and limited lesion size and penetration. The purpose of the study was to assess, in the right atrium, the efficacy and safety of a new catheter designed to create long myocardial tissue lesions using RF energy. The main characteristics of this 8 Fr deflectable RF ablation catheter were: (1) a perpendicularly contacting articulated bilimb electrodes ensuring stable and firm endocardial firm contact; and (2) an irrigated planar interface. Three different electrode prototypes were tested. Fourteen anesthetized sheep weighing 61 ± 7 kg underwent RF ablation in the right atrium using three incremental power levels (25 to 45, 50, 55 to 75 W) with the aim of creating fully transmural (FT) lesions, defined as continuous and complete epicardial and endocardial lesion imprints. The animals were euthanized 1 hour later for macroscopic and histologic examinations. Forty-three of the 80 right atrial lesions created, in smooth as well as in trabeculated areas, were FT. The percentage of FT lesions increased with the applied power from 37% with 25–45 W, to 49% with 50 W, and up to 86% for 55–75 W. In all but two cases, histologic examination showed no discontinuity between FT lesions produced by both limbs resulting in 19 coalescent linear lesions with an average size of 25 × 6 × 4 mm (length × width × depth). In situ bipolar electrograms after ablation in the FT group showed split potentials and/or a marked decrease in amplitude from 2.85 ± 1.79 to 0.33 ± 0.14 mV (P = 0.001) accompanied by near complete disappearance of unipolar electrograms. There was no perforation due to RF ablation. In conclusion, continuous and FT lesions can be achieved in various areas of sheep atria, including the trabecular right atrium, with a perpendicularly contacting bilimb electrode catheter. It represents a promising tool for catheter ablation of atrial fibrillation and flutter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.1998.tb01215.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dural arteriovenous shunt involving the superior petrosal sinus: presentation and treatment by transvenous embolisation via the occipital and transverse sinuses (1997)
    Springer
    Neuroradiology 39 (1997), S. 67-70 
    Details
    ISSN: 1432-1920
    Keywords: Key words Dural arteriovenous shunt ; Superior petrosal sinus ; Endovascular treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a dural arteriovenous shunt on the superior petrosal sinus at the origin of the petrosal vein, and its treatment. This is the first report of transvenous embolisation of such a shunt through the contralateral occipital and transverse sinuses. It was possible to achieve complete obliteration of the superior petrosal sinus shunt by coils and polyvinyl acetate liquid embolisation, in a combined venous and arterial approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050369
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  • 3
    Electronic Resource
    Electronic Resource
    Acrylamide-induced peripheral neuropathy in normal and neurofilament-deficient Japanese quails (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 17-22 
    Details
    ISSN: 1432-0533
    Keywords: Acrylamide ; Peripheral neuropathy ; Neurofilament ; Pathology ; Quail
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Morphological effects of acrylamide (AC) on the peripheral nerves in normal and neurofilament (NF)-deficient (Quv) Japanese quails were investigated. AC (100 mg/kg) was injected intraperitoneally every other day. After the birds manifested neurological signs, they were necropsied (after 10 ∼ 21 AC injections) and the sciatic and tibial nerves were examined. In both normal and Quv qualis, AC produced axonopathy with a distal-proximal progression. In AC-intoxicated normal quails, the nerve fiber pathology was characterized by typical Wallerian-like degeneration, consisting of axonal degeneration, myelin breakdown, macrophage migration, Schwann cell proliferation and regeneration of nerve fibers. Ultrastructurally, AC-induced NF accumulation was detected in the axon of myelinated nerve fibers. In AC-intoxicated Quv qualis, axonal degeneration with accumulation of membranous organelles occurred; however, sequential events of Wallerian-like degeneration were not as prominent as in AC-intoxicated normal qualis. These results demonstrated that NF-deficient Quv quails are sensitive to neurotoxic effects of AC. On the other hand, the different pathology of AC-intoxicated normal and Quv qualis indicates the presence or absence of NFs influences the appearance and extent of AC axonopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294254
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  • 4
    Electronic Resource
    Electronic Resource
    Intra-Operative Premature Rupture of the Cerebral Aneurysms. Analysis of the Causes and Management (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1255-1263 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Premature rupture; cerebral aneurysm; microsurgery; temporary clipping.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The causes and management of intra-operative premature rupture are analysed and discussed.  During the past 6 years, the authors, performed 398 consecutive direct surgical interventions for ruptured cerebral aneurysms. Intra-operative premature rupture is defined as a rupture which occurs before the securing of the parent arteries or the neck of the aneurysm and is out of control, at least temporarily. The causes and management were retrospectively analysed by reviewing video tape recordings.  Intra-operative premature ruptures which met the above definition occurred in 24 cases (6.0%). The causes were as follows: 1.) dural opening and arachnoid opening (8.3%), 2.) haematoma removal (12.5%), 3.) brain retraction (16.7%), 4.) aneurysm dissection (62.5%). A double suction technique was used to control bleeding and haemostasis with a small piece of cotton or a temporary clip, performed in 20 cases (83.3%). However, in cases with premature rupture immediately after the dural or arachnoid opening, the extension of the haematoma into the subarachnoid space resulted in severe brain swelling and partial resection of the brain had to be done to secure temporary clipping. The double suction technique and primary haemostasis using a small piece of cotton or temporary clip resulted in good outcome even in cases with premature rupture. However, very early premature rupture also occurred although its incidence was extremely rare. The removal of part of the brain can secure the working space but the outcome was poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050428
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  • 5
    Electronic Resource
    Electronic Resource
    Surfactant proteins and stable microbubbles in tracheal aspirates of infants with respiratory distress syndrome: relation to the degree of respiratory failure and response to exogenous surfactant (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 131-138 
    Details
    ISSN: 1432-1076
    Keywords: Key words Pulmonary surfactant  ;  Respiratory distress syndrome  ;  Tracheal aspirate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Surfactant proteins (SP-A and SP-BC), albumin (ALB), and stable microbubble (SM) count were measured in tracheal aspirates from infants with respiratory distress syndrome (RDS) receiving single-dose Surfactant-TA (surfactant group, n = 32) or no surfactant (control group, n = 12), and those without RDS (non-RDS group, n = 8) to determine biochemical and biophysical status of surfactant in the course of RDS after surfactant replacement. Surfactant therapy resulted in immediate and sustained elevations of SP-BC/ALB and SM count with a rapid fall in ventilatory index to levels measured in the non-RDS group, whereas these indices improved slowly in the control group. The SP-A/ALB was initially low in both RDS groups and increased to levels measured in the non-RDS group by age 48 h. Multiple regression analysis showed that SP-BC/ALB, postnatal age, SM count, SM count/SP-A plus SP-BC, and surfactant therapy were independently associated with the severity of RDS as assessed by ventilatory index (r = 0.75, P 〈 0.0001; number of samples = 256). Infants with a relapse response to surfactant (n = 9) had levels of SP-A/ALB and SP-BC/ALB similar to those measured in the sustained group (n = 23), but had significantly lower SM count and SM count/SP-A plus SP-BC between 24 and 96 h of age. Conclusion Surfactant therapy normalizes the sur factant and respiratory status of infants with RDS. Surfactant dysfunction rather than depletion may explain the relapse response seen in some surfactant recipients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050571
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  • 6
    Electronic Resource
    Electronic Resource
    Development of a testicular haemangioma after interferon therapy for hepatic haemangiomas: a case report (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 784-786 
    Details
    ISSN: 1432-1076
    Keywords: Key words Juvenile haemangioma ; Hepatic haemangioma ; Testicular haemangioma ; Interferon alfa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 2-month-old Japanese boy presenting with large multiple haemangiomas invading his liver. He was treated with daily subcutaneous injection of interferon alfa (IFN-α)-2a with progressive reduction of the hepatic haemangioma. He developed a scrotal mass 2 months after discontinuation of IFN, and this mass eventually required surgical management. Resected tumour was a juvenile haemangioma. The escape of this haemangioma from IFN therapy may be correlated to the quite low level of injected IFN in testis. Conclusion IFN therapy may not be curative for testicular haemangioma although it is effective in shrinking haemangiomas of the liver and skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050712
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  • 7
    Electronic Resource
    Electronic Resource
    Thomson-scattering diagnostics of Kr/Ne and Kr/He plasmas using a picosecond laser (1995)
    Springer
    Applied physics 61 (1995), S. 165-168 
    Details
    ISSN: 1432-0649
    Keywords: 42.55.Gp ; 52.80. - s ; 52.70. - m
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Thomson scattering from plasmas in high-pressure discharges for rare-gas-halide excimer-laser pumping was observed using a frequency-doubled 300 ps Nd: YAG laser. A temporal resolution of 1 ns was realized for the Thomson-scattering measurement, and detailed temporal changes of the electron density and temperature were measured in Kr/Ne and Kr/He plasmas. Calculations using a computer simulation showed good agreement with the experimental results, implying that the plasma dynamics is properly treated in the simulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01090938
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  • 8
    Electronic Resource
    Electronic Resource
    Orbital degrees of freedom and electron correlation in optical absorption of metallic La Sr MnO (1998)
    Springer
    The European physical journal 5 (1998), S. 413-417 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 71.27.+a Strongly correlated electron systems; heavy fermions - 71.30.+h Metal insulator transitions and other electronic transitions - 78.20.-e Optical properties of bulk materials and thin films
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The optical absorption in ferromagnetic metal La1-xSrxMnO3 is anomalous; it has a wide-range absorption up to about 1 eV even at zero temperature. Since 3d electrons in La1-xSrxMnO3 partially fill doubly degenerate eg orbitals, the orbital degrees of freedom are crucial to understand this metallic system. We argue that the interband transition within eg orbitals is important in the optical absorption. The optical spectrum is modified also by the inter-orbital Coulomb interaction. We have examined perturbatively the effect of the Coulomb interaction on the spectrum. Available experiments are discussed by comparing with the present results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050461
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  • 9
    Electronic Resource
    Electronic Resource
    End-stage renal disease and coronary artery bypass grafting (1999)
    Springer
    The international journal of angiology 8 (1999), S. 171-171 
    Details
    ISSN: 1615-5939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01616448
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  • 10
    Electronic Resource
    Electronic Resource
    Relationship between respiratory failure and plasma noradrenaline levels in amyotrophic lateral sclerosis (1997)
    Springer
    Clinical autonomic research 7 (1997), S. 173-177 
    Details
    ISSN: 1619-1560
    Keywords: amyotrophic lateral sclerosis ; plasma noradrenaline ; head-up tilt test ; sympathetic hyperactivity ; respiratory failure ; chemoreceptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated plasma noradrenaline (NA) levels at rest and during head-up tilt test in 20 patients with sporadic amyotrophic lateral sclerosis (ALS). Their fasting plasma NA levels ranged from 195 to 4227 pg/ml. The average plasma NA level was 483 pg/ml in five ambulatory patients, 341 in two wheelchair-bound patients, 1264 in 11 bedridden patients, and 208 in two respirator-dependent patients whose disability grading was the worst among the four groups. Arterial carbon dioxide (PCO2) was evaluated as a measure of respiratory function. The coefficient of correlation between PCO2 and plasma NA wasr=0.654 (p〈0.01). Either respiratory failure or lower motor neuron dysfunction may relate to the elevation of plasma NA levels. In the two bedridden patients, plasma NA levels and heart rate at rest increased significantly as the disease progressed. Cardiovascular responses to head-up tilting were normal. These data suggest that the elevation of plasma NA levels may be related to progression of respiratory failure and lower motor neuron dysfunction. In conclusion, sympathetic hyperactivity in ALS is considered to be not primary, but secondary to somatic motor disabilities and respiratory failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267978
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