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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 26 (1993), S. 1060-1064 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 2493-2495 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have fabricated a Si metal-oxide-semiconductor field-effect transistor with a 20-nm channel length using a novel step/edge technique. An Al gate is evaporated onto a step in the SiO2 gate oxide. A second Al gate, separated from the first by a plasma-enhanced chemical-vapor-deposited SiO2 layer, provides inversion layer extensions of the source and drain contacts. Electrical conductance measurements indicate a channel length approximately equal to the fabricated gate length.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 5559-5562 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We present an improved design for far-infrared (FIR) circular polarizers used in a lightpipe transmission system for magneto-optical experiments. A peak efficiency of nearly 100% is achieved for FIR laser radiation by reducing the multiple reflections within the polarizer system, as well as scattering from the walls of the lightpipe. Broadband low-resolution measurements are less susceptible to errors due to multiple reflections, but incorporation of these improvements is still found to reduce systematic errors due to the reflection from the sample. Also, we have measured the low temperature index of refraction of quartz and find significant disagreement with published values for frequencies below 100 cm−1. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have demonstrated a new planarized all-refractory technology for low Tc superconductivity (PARTS). With the exception of the Nb-AlOx-Nb trilayer preparation, the processing is done almost exclusively within an advanced Si technology fabrication facility. This approach has allowed us to leverage highly off of existing state-of-the-art lithography, metal etching, materials deposition, and planarization capabilities. Using chemical-mechanical polish as the planarization technique we have fabricated Josephson junctions ranging in size from 0.5–100 μm2. Junction quality is excellent with the figure of merit Vm typically exceeding 70 mV. PARTS has yielded fully functional integrated Josephson devices including magnetometers, gradiometers, and soliton oscillators.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1803
    Keywords: myocardial ischemia ; revascularization ; laser ; systolicperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Laser-induced intramyocardial revascularization (LIR) has been used to promote direct communications between blood within the ventricular cavity and that of the existing myocardial vasculature in an attempt to increase perfusion in patients with ischemic heart discase. This study was conducted to measure the effects of LIR channels on regional myocardial flood flow (microspheres), cardiac mechanics (sonomicrometers), and myocardial tissue pressures in 18 dogs. Under baseline hemodynamic conditions (mean HR=165.2±11.4 bpm, LVP=123.6±22.9/4.0±1.8 mmHg, AoP=112.8±27.1/77.0±22.5 mmHg), myocardial blood flow in laser-treated tissue (mean =1.11±.10 cc/min/gm before laser; .71±.19 cc/min/gm after laser) was reduced as compared to blood flow in control tissue (mean=1.12±.15 cc/min/gm before laser; 1.25±.22 cc/min/gm after laser). Regional myocardial systolic shortening (11.32%±3.82% before laser; 7.49%±2.86% after laser) was decreased by 33%. During simultaneous reversible ligation of the LAD and LCCA for 2 min, when intramyocardial channels represented the only tissue access for the injected microspheres, blood flow in laser-treated tissue was not increased above that of the control non-lasered tissue. However, regional blood flow was greater in laser-treated ischemic tissue (mean=.61±.12 cc/min/gm) than in untreated ischemic areas (mean=.04±.03 cc/min/gm) when left ventricular pressure (LVP) was acutely elevated (mean SLVP=207.0±16.1 mmHg). Using these measurements, a model is proposed to predict regional systolic pressure gradients between the left ventricular cavity and coronary intramyocardial vasculature required to permit restoration of blood flow to ischemic myocardium. We conclude that improved perfusion via laser-induced intramyocardial channels does not occur in otherwise normal myocardium exposed to acute coronary ligation and only small improvements in perfusion are noted when LVP is significantly elevated. Consideration of further clinical application of this approach is seriously cautioned awaiting additional experimental studies.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Infection 22 (1994), S. 233-237 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The presence of resistant pneumococcal organisms has become a major problem in the world today. These organisms are responsible for changing the methodology required for susceptibility testing and for the newly proposed guidelines for resistance. These newly proposed MICs are still under consideration because of the limited data used for their establishment. The treatment of resistant pneumococcal infections outside of the central nervous system is not yet well standardized. Central nervous system infections should be approached with care and a knowledge of current recommendations for their therapy. We expect changes in the recommendations for therapy over the coming years until a standardized approach can be established.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0827
    Keywords: Key words: Methotrexate — Bone loss — Rheumatoid arthritis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Because previous studies of high-dose methotrexate usage have demonstrated an effect on bone formation and resorption, this study was done to determine whether long-term, low-dose use of methotrexate for the treatment of rheumatoid arthritis causes bone loss. Bone mineral density (BMD) of the lumbar spine and hip was measured in 10 Caucasian postmenopausal women who had never received methotrexate and 10 Caucasian postmenopausal women who had received the drug for 3 or more years. There were no significant differences in BMD at the lumbar spine (L2–L4) between patients who had used long-term methotrexate compared with patients never treated with methotrexate (1.08 ± 0.08 g/cm2 versus 0.98 ± 0.14 g/cm2, respectively; P= 0.08). Similarly, there were no significant differences in BMD at the femoral neck between methotrexate users and nonusers (0.81 ± 0.08 g/cm2 versus 0.76 ± 0.15 g/cm2, respectively; P= 0.42). These results suggest that long-term low-dose methotrexate treatment for rheumatoid arthritis is not associated with accelerated bone loss.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1569-8041
    Keywords: JM216 ; lung cancer ; non-small cell ; oral chemotherapy ; platinum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: JM216 is a new oral platinum complex with dose-limitingtoxicity myelosuppresssion, now undergoing phase II evaluation. Patients and methods: JM216 was evaluated as first line therapy innon-small-cell lung cancer. 17 patients received 120 mg/m2/dayfor five days repeated every three weeks. Results: Toxicity was manageable, the commonest side-effects being nausea,vomiting, diarrhoea, constipation and asthenia. Myelososuppression wasgenerally grade 〈2 and there were no cases of neutropenic sepsis orbleeding. Thirteen patients were fully evaluable for response. No sustainedobjective responses were reported. One patient was reported as stable diseasehad a partial response after three courses but was progressing again afterfour. An additional five patients had stable disease (46.2%). Conclusions: Although some patients may have had useful palliation, JM216did not appear to have significant antitumour activity in non-small-cell lungcancer.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 20 (1993), S. 331-336 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The virtues of chemical inertness and low surface energy which make polytetrafluoroethylene (PTFE) a valuable engineering polymer also account for the difficulty in achieving structural adhesive bonds. While plasma surface treatment has proven to be the most effective means of maximizing strength and permanence of adhesive bonds with the most inert of engineering polymers, a simple plasma treatment has proven elusive for PTFE. The following studies evaluate two very different plasma processes, activation and deposition, as a means to achieve reliable and high-strength structural adhesive bonds. Sodium naphthalene-etched PTFE is used as a control. Presented are ESCA data which support a theory that improvement is limited by a weakened boundary layer of the PTFE.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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