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  • 1
    Electronic Resource
    Electronic Resource
    Hämolysediagnostik und Differentialdiagnose hämolytischer Anämien (1998)
    Springer
    Der Internist 39 (1998), S. 1273-1289 
    Details
    ISSN: 1432-1289
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die pathogenetische Klassifikation der Anämien erfolgt primär auf der Basis ihrer Erythrozytenkinetik (Tabelle 1). Eine große Gruppe verschiedener Anämieformen ist auf eine gestörte Produktion von Erythrozyten zurückzuführen. Die andere große Gruppe umfaßt Anämien durch Blutverlust oder verminderte Erythrozytenlebensdauer. Diagnostik und Differentialdiagnose der letztgenannten Formen sind Gegenstand dieses Beitrags.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050300
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  • 2
    Electronic Resource
    Electronic Resource
    Ausbildung in Onkologie (1999)
    Springer
    Der Onkologe 5 (1999), S. 637-641 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die onkologischen Erkrankungen gehören wegen ihrer Häufigkeit und ihrer Bedeutung für Morbidität und Mortalität zu den wesentlichen Herausforderungen, denen sich Absolventen des Medizinstudiums heute und in der Zukunft zu stellen haben. Die altersstandardisierte krebsspezifische Mortalität liegt in Deutschland bei 280/100.000 Einwohner jährlich; dies entspricht 250.000 Krebstodesfällen pro Jahr. Da etwa jede zweite Krebserkrankung geheilt wird, ist die Zahl der jährlich neudiagnostizierten Fälle etwa doppelt so hoch. Aufgrund des steilen Anstiegs des Krebsrisikos nach dem 60. Lebensjahr ist, trotz aller Bemühungen um eine verbesserte Primärprävention, mit weiter steigender Lebenserwartung eine weitere Zunahme wahrscheinlich. Globale Angaben zur Prävalenz sind nicht verfügbar und sagen wegen der unterschiedlichen natürlichen Prognose verschiedener Krebsformen wenig aus. Zweifellos ist unabhängig von der Inzidenzentwicklung jedoch auch hier mit einem weiteren Anstieg zu rechnen, da die Zahl der für viele Jahre erfolgreich palliativ behandelbaren, aber nicht geheilten Krebspatienten zunimmt. Die Onkologie ist weltweit ein Schwerpunktthema und bedarf der. Gestaltung eines onkologischen Curriculums in der ärztlichen Ausbildung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050419
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  • 3
    Electronic Resource
    Electronic Resource
    Kongenitale dyserythropoetische Anämien (1999)
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 992-999 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Kongenitale dyserythropoetische Anämie ; Ineffektive Erythropoese ; Erythrozytenmembran ; Eisenüberladung ; Key words Congenital dyserythropoietic anemia ; Ineffective erythropoiesis ; Iron overload ; Red cell membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The congenital dyserythropoietic anemias represent a group of rare inborn errors with ineffective erythropoiesis as the predominant mechanism of anemia. They are primarily classified into three types on the basis of characteristic abnormalities of the erythroblasts as shown by light and electron microscopy. There are distinct associated features such as pattern of heredity, cell kinetics and abnormalities of the cell membrane. In addition, patients with apparent CDA of heterogenous phenotype are observed, that cannot be attributed to any of the three types. Recently variant genes have been localized to different regions on chromosome 15 or 22. Cases of CDA were reported from many ethnics, in particular in families of meditarranean origin. Many patients load iron necessitating iron depletion. Gallstones are a frequent complication and are observed in childhood or adolescence. Therapeutic measures such as splenectomy, treatment by Interferon α or allogeneic bome marrow transplantation depend on the type and the severity of clinical expression, which shows large variations both within and between affected kindreds.
    Notes: Zusammenfassung Unter dem Begriff der kongenitalen dyserythropoetischen Anämien (CDA) wird eine geno- und phänotypisch heterogene Gruppe seltener angeborener Erkrankungen der Erythropoese zusammengefaßt. Sie sind durch eine Ineffektivität der Erythropoese und charakteristische morphologische Veränderungen der Erythroblasten gekennzeichnet, die eine Einteilung in 3 Typen erlauben. Damit assoziierte Merkmale betreffen den Erbgang, die Zellkinetik, Veränderungen der Erythrozytenmembran und die unterschiedliche Lokalisation des varianten Gens. Die Pathogenese ist nur teilweise bekannt. Bei dem meisten Patienten kommt es, teilweise bereits im Kindesalter, zur Gallensteinbildung und zur sekundären Hämochromatose, die eine Eisenentzugsbehandlung erfordert. Therapeutische Maßnahmen wie Splenektomie, Interferon-α-Behandlung oder allogene Knochenmarktransplantation richten sich nach dem CDA-Typ und der sehr unterschiedlichen Schwere der Erkrankung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050529
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  • 4
    Electronic Resource
    Electronic Resource
    Chronic myelogenous leukemia in blast crisis: retrospective analysis of prognostic factors in 90 patients (1996)
    Springer
    Annals of hematology 73 (1996), S. 225-230 
    Details
    ISSN: 1432-0584
    Keywords: Key words Chronic myelogenous leukemia ; Blast crisis ; Prognosis ; Karyotypic findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the analysis 89 patients had died, with a median survival of 11 weeks from diagnosis of blast crisis. Patient characteristics demonstrated in the univariate analysis to have significant association with shorter survival were: thrombocythemia, leukocyte count above 20×109, Karnofsky index 〈50%, nonlymphoid blast cell morphology, cytogenetic clonal evolution, the presence of a double Philadelphia chromosome or trisomy 8, and no response to therapy. In 17 of 59 patients (29%) evaluable for response to therapy a complete or partial remission was achieved. These responders had a significantly longer median survival (25 weeks) as compared with nonresponders (9 weeks). Response to therapy was significantly better in lymphoid blast crisis and in patients without clonal evolution. In a multivariate analysis containing all significant variables of the univariate analysis two parameters retained their prognostic significance: response to therapy and trisomy 8. In spite of the short overall survival in blast crisis, the determination of prognostic factors may be a useful tool for the clinician planning therapy, especially new therapeutic approaches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050233
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  • 5
    Electronic Resource
    Electronic Resource
    The abundant presence of Söderström bodies in cytology smears of fine-needle aspirates contributes to distinguishing high-grade non-Hodgkin's lymphoma from carcinoma and sarcoma (1997)
    Springer
    Annals of hematology 74 (1997), S. 175-178 
    Details
    ISSN: 1432-0584
    Keywords: Key words Söderström bodies ; Cytology smears ; Non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Söderström bodies, also termed lymphoglandular bodies (LGB) and detectable in fine-needle aspiration cytology smears, have long been accepted as indicative of lymphoid tissues. To investigate the validity of this association, we examined 588 cytologic smears from high-grade non-Hodgkin's lymphoma (NHL), carcinoma, and sarcoma. Slides with lymphocytes in the vicinity of carcinoma and sarcoma cells had been excluded. Two independent observers scored smears to number, size, color, form, and smear background of the LGB. In 68 of 359 (19%) nonlymphoid malignancies rare (defined as 〈1 LGB per high-power field) or occasional LGB (defined as 1–20 LGB per high-power field) were detectable. Half of these tumors consisted of melanomas, small cell lung carcinomas, and teratomas; the other half encompassed undifferentiated sarcomas. However, none of the smears obtained from carcinoma or sarcoma tissue had abundant LGB (defined as 〉20 LGB per high-power field). When number of LGB was estimated to be abundant, the sensitivity for diagnosing a lymphoma was 54%; however, specificity was 100%. The difference in showing LGB between high-grade NHL and carcinoma/sarcoma was highly significant (p=0.0001). The presence of abundant LGB in cytologic smears strongly suggests the diagnosis of lymphoma, while the absence of LGB nearly excludes this diagnosis. No trends were observed with the other criteria which were tested. LGB in aspiration cytology smears from malignant tumors thus represent a useful tool to distinguish high-grade NHL from carcinoma and sarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050278
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  • 6
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia Long-term follow-up of a prospective multicenter trial (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: Key words De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n = 26), were not considered, the median relapse-free-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n = 44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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  • 7
    Electronic Resource
    Electronic Resource
    Autologous platelet transfusion in alloimmunized patients with acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 169-173 
    Details
    ISSN: 1432-0584
    Keywords: Autologous transfusion ; Platelets ; Immunization ; Acute leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-eight transfusions of autologous platelets were given to eight alloimmunized patients receiving curative chemotherapy for acute leukemia. Platelets were collected at regeneration of hematopoiesis after a chemotherapy cycle, cryopreserved with 5% dimethylsulfoxide in liquid nitrogen, and retransfused during bone marrow aplasia following the next treatment cycle. The in vitro platelet recovery after freezing, thawing, and washing was 85 ±4%. The in vivo corrected count increment 1 h after autologous platelet transfusions was 11±5×109/l. With the exception of moderate urticaria and slight nausea each after one transfusion, no immediate or chronic side effects occurred. The bleeding time was shortened and hemorrhage during bone marrow aplasia was prevented in all alloimmunized patients by autologous platelet transfusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910313
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  • 8
    Electronic Resource
    Electronic Resource
    Obituary — Jan Neuwirt (1995)
    Springer
    Annals of hematology 71 (1995), S. 205-205 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910320
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  • 9
    Electronic Resource
    Electronic Resource
    Autologous platelet transfusion in alloimmunized patients with acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 169-173 
    Details
    ISSN: 1432-0584
    Keywords: Key words Autologous transfusion ; Platelets ; Immunization ; Acute leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Seventy-eight transfusions of autologous platelets were given to eight alloimmunized patients receiving curative chemotherapy for acute leukemia. Platelets were collected at regeneration of hematopoiesis after a chemotherapy cycle, cryopreserved with 5% dimethylsulfoxide in liquid nitrogen, and retransfused during bone marrow aplasia following the next treatment cycle. The in vitro platelet recovery after freezing, thawing, and washing was 85±4%. The in vivo corrected count increment 1 h after autologous platelet transfusions was 11±5×109/l. With the exception of moderate urticaria and slight nausea each after one transfusion, no immediate or chronic side effects occurred. The bleeding time was shortened and hemorrhage during bone marrow aplasia was prevented in all alloimmunized patients by autologous platelet transfusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910313
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  • 10
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n=26), were not considered, the median relapsefree-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n=44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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    Paper (German National Licenses)
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