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  • 1
    Electronic Resource
    Electronic Resource
    Pre-eruptive varicella encephalitis: case report and review of the literature (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 814-815 
    Details
    ISSN: 1432-1076
    Keywords: Key words Varicella infection ; Neurology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Varicella-related neurological complications usually appear after the rash. Pre-eruptive neurological complications of primary varicella zoster virus infections have been rarely described. We report on a 5.5-year-old boy who developed encephalitis 4 days before the onset of a mild vesicular skin rash and 5 days after known exposure. Primary varicella zoster virus infection was confirmed serologically. Cranial magnetic resonance imaging revealed temporary inflammatory oedema in the right cerebellar peduncle. Conclusion Neurological complications of varicella may appear up to 2.5 weeks before the onset of the exanthema. Physicians treating patients with ataxia or encephalitis should inquire about exposure to varicella zoster virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050942
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  • 2
    Electronic Resource
    Electronic Resource
    A New Approach for Getting Refined X-Ray Diffraction Patterns by Using X-Ray Diffractometers with Energy Resolving Detectors (1998)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 278-281 (Apr. 1998), p. 221-226 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/03/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.278-281.221.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Cytokine Production and Serum Proteins in Depression (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 41 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One, as yet unemployed, approach to investigating immunology in depression is the assessment of the cytokine production by leucocytes, which would allow the determination of immune response under standardized conditions. Thus we measured the production of mitogen-induced cytokines (IL-1β, IL-2, IL-6, IL-10, interferon-7) and sIL-2R in a whole blood assay, and serum protein levels such as C-reactive protein (CRP), haptoglobin (Hp) and α2-macroglobulin (α2 M) in a longitudinal 6-week study in an attempt to assess leucocyte function during and after acute clinical stage of depression in 39 patients. Shortly after admission to hospital we found higher levels of all measured cytokines in the patients. Serum protein levels were significantly higher in the patients than in controls, and decreased over the study period. Whereas slightly elevated monokine levels in patients tended to reach control values, lymphokines showed a significant decrease over the 6 weeks as compared to baseline. These results suggest that the increase in immune activity seen at the beginning of the study may be followed by a suppressed cell-mediated immune function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03604.x
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  • 4
    Electronic Resource
    Electronic Resource
    Intracellular localization, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells (1995)
    Springer
    Virchows Archiv 426 (1995), S. 249-256 
    Details
    ISSN: 1432-2307
    Keywords: P-Glycoprotein ; Multidrug resistance ; Vesicle formation ; Daunorubicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the human gastric carcinoma cell line EPG85-257P (parent) induction of resistance to daunorubicin (DAU) was achieved by selection with stepwise increased concentrations of the drug. The new vairant was named EPG85-257DAU and was shown to overexpress the mdr1 gene product 170 kDa P-glycoprotein (P-Gp) as demonstrated by immunocytochemistry and mdr1-specific RT-PCR. To investigate the intracellular pathway of DAU the subcellular distribution of this autofluorescent drug was studied in the resistant cells and compared to its chemosensitive counterpart EPG85-257P. When sensitive cells were exposed to DAU the drug rapidly accumulated in the nucleus until cell death. No redistribution of DAU to the cytoplasm was observed. In resistant cells exposed to the drug DAU also accumulated in the nucleus but to a lesser extent than in parent cells. Following exposure, nuclear fluorescence was observed to decrease over a time period of up to 48 h. Six hours after DAU exposure formation of fluorescent vesicle formation started in the perinuclear region and increased continously. After 48 h nuclear fluorescence was no longer detectable and DAU was located exclusively in vesicles. During this period the vesicles moved from the region of origin to the cell periphery. A pulse chase experiment showed, that vesicles may contain DAU derived from the nucleus. Treatment of EPG85-257DAU cells with DAU in conjunction with the chemosensitizer cyclosporin A (CsA) increased nuclear fluorescence without impairing vesicle formation. Disruption of microtubules by nocodazole led to an accumulation of vesicles in the perinuclear region indicating that microtubules are involved in vesicular transport. Treatment of EPG85-257DAU cells with the actin disruptor cytochalasin B led to accumulation of vesicles in the cell periphery indicating that actin may be involved in exocytosis. Uptake and efflux of DAU and rhodamin (RH) were determined in sensitive and resistant cells using a fluorescence activated cell sorter. Uptake of both compounds was distinctly lower in resistant than in sensitive cells. When resistant cells preloaded for 2 h with RH subsequently were incubated in drug free medium the substance was rapidly released indicating transmembrane transport by P-Gp. In contrast, despite expression of P-Gp in resistant cells no considerable release of DAU was observed for up to 2 h under the same experimental protocol. This indicates that in resistant cells intracellular DAU at least in part may be inaccessible for P-Gp and that vesicular drug transport appears to contribute to DAU resistance by removing intracellular DAU via exocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191362
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  • 5
    Electronic Resource
    Electronic Resource
    Rezidivierende Parotitis Differentialdiagnose der Parotitisschwellung (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 467-470 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Rezidivierende Parotitis ; Mumps ; Parotisschwellung ; Sialographie ; Key words Recurrent parotitis ; Mumps ; Parotid swelling ; Sialogram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Apart from mumps, recurrent parotitis is the most common inflammatory salivary gland disease in childhood. The cause is still unknown. Case report: We present a ten-year-old boy with a recurrent swelling of the left parotid gland, who had difficulties in chewing and a sensation of tension on the left face. Since one year the child wore orthodontic appliances. There were no serological signs of viral infection or an autoimmune process. Ultrasound demonstrated an enlarged left parotid gland with multiple hypoechoic areas. The sialogramm revealed the typical image of multiple cystic ectasies and stenoses of the duct. Treatment of choice were saliva liberating measures. Four months later parotitis relapsed and orthodontic applicances were removed. Since then the patient was free of relapses. Discussion: Recurrent parotitis shoud be treated symptomatically, because of its favourable prognosis. An inflammation of the parotid gland secondary to trauma to Stensen’s duct caused by orthodontic applicances is suggested.
    Notes: Zusammenfassung Hintergrund: Die rezidivierende Parotitis stellt nach der Parotitis epidemica die häufigste entzündliche Speicheldrüsenerkrankung im Kindesalter dar, deren Pathogenese ungeklärt ist. Fallbericht: Wir stellen einen 10 Jahre alten, seit 1 Jahr orthodontisch versorgten Jungen mit einer rezidivierenden einseitigen Schwellung der Glandula parotis vor, dessen Hauptbeschwerden durch Kauschmerzen sowie ein uncharakteristisches Spannungsgefühl der betroffenen Gesichtsseite gekennzeichnet waren. Serologisch fanden sich keine Hinweise auf eine Virusinfektion oder Autoimmunerkrankung. In der Sonographie zeigte sich eine vergrößerte Parotis mit multiplen echoarmen Arealen. Die durchgeführte Sialographie erbrachte das typische Bild von multiplen zystischen Gangektasien und -stenosen. Therapeutisch verordneten wir speicheltreibende Maßnahmen. Nachdem es 4 Monate später zu einem Rezidiv gekommen war, wurde die orthodontische Versorgung entfernt. Seitdem ist der Patient rezidivfrei. Diskussion: Aufgrund ihrer guten Prognose sollte die rezidivierende Parotitis mit möglichst konservativen Maßnahmen behandelt werden. Ursächlich könnte die Parotitis durch Mikrotraumen am Ausführungsgangsystem infolge Manipulation durch die orthodontische Versorgung ausgelöst worden sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050286
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  • 6
    Electronic Resource
    Electronic Resource
    Zeolite ZnY catalysts prepared by solid-state ion exchange (1998)
    Springer
    Catalysis letters 51 (1998), S. 213-218 
    Details
    ISSN: 1572-879X
    Keywords: zeolite ZnY ; solid-state ion exchange ; salt inclusion ; 129Xe NMR spectroscopy ; adsorption of carbon monoxide and xenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Zeolites ZnY with various overall zinc contents were prepared from mixtures of zeolite NH4Y and crystalline zinc chloride by solid-state ion exchange. The obtained materials were investigated with carbon monoxide, xenon, and nitrogen adsorption as well as with 129Xe NMR and XRF spectroscopy. From the results of these measurements, the zinc cation distributions between the different types of cages of the faujasite framework as well as between the crystallographic positions SIII and SII within the large voids (supercages) were quantitatively determined. The concentrations of zinc cations in the supercages of the presently prepared zeolites are considerably higher than in materials obtained from NaY by conventional wet ion exchange using aqueous zinc salt solutions. Experimental evidence is provided for salt inclusion under certain conditions of preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019009706584
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  • 7
    Electronic Resource
    Electronic Resource
    Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones (1997)
    Springer
    Cell biology and toxicology 13 (1997), S. 155-165 
    Details
    ISSN: 1573-6822
    Keywords: cultured liver cells ; chromosomal aberrations ; structure-activity relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007302111081
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