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  • 1
    Electronic Resource
    Electronic Resource
    Postoperative recovery of mitochondrial function of the human liver graft procured and preserved with University of Wisconsin (UW) solution (1990)
    Springer
    Transplant international 3 (1990), S. 128-132 
    Details
    ISSN: 1432-2277
    Keywords: Liver preservation, UW solution ; Mitochondrial function, in liver preservation ; Preservation, liver UW solution ; Ketone body ratio, liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in arterial blood ketone body ratio (KBR) were investigated in 47 human liver transplantations. Of the 20 grafts preserved with University of Wisconsin (UW) solution, 10 had a cold preservation period of less than 10 h (UWS group) and 10 of more than 10 h (UWL group). In 27 other cases, grafts were preserved with EuroCollins (EC) solution for less than 10 h (EC group). In the EC group, KBR increased over 0.7 within 6 h after reperfusion of the graft in 17 cases (63%) and within 24 h in 7 cases (26%). In the 3 other cases, KBR failed to recover, and these patients underwent retransplantation. In the UW group, KBR recovered within 6 h in 13 cases (65%) and within 24 h in 7 cases (35%). There were no significant differences between the UWS and UWL groups. It is shown that the mitochondrial function of liver grafts preserved with UW solution can be well maintained even after extended preservation periods of more than 10 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355457
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  • 2
    Electronic Resource
    Electronic Resource
    Pre- and post-transplant assessment of liver function in paediatric liver transplantation (1992)
    Springer
    European journal of pediatrics 151 (1992), S. S39 
    Details
    ISSN: 1432-1076
    Keywords: Liver transplantation ; Liver function tests ; Prognostic tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pre-operative risk of paediatric liver transplantation candidates (n=41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subjected as covariates to a survival analysis in the Cox proportional hazards model. There was a significant relationsship between the results of mono-ethylglycinexylidide (MEGX) formation and ICG test and the 365-day survival rate. In the stepwise analysis, none of the remaining parameters improved the predictive ability when added to the dynamic liver function test results. The assessment of post-transplantation liver function was studied in 27 patients during the first 28 postoperative-day period. In addition, liver function was studied in a cross-sectional study 1–7 years after successful liver transplantation in children with complete or partial rehabilitation. In the early postoperative period severe organ damage was indicated by both static and dynamic liver function tests. In the later course after transplantation no deterioration of liver function measured with MEGX formation was to be observed. These findings demonstrate the usefulness of dynamic liver function tests in the pre- and post-transplant assessment of liver function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02125801
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of a fragment of the c-erbB-2 translational product p185 in serum of breast cancer patients (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 249-252 
    Details
    ISSN: 1432-1335
    Keywords: Breast cancer ; c-erbB-2 oncogene ; ICA ; p185 fragment ; Serum determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer patients showed serum concentrations up to 578 kU/l. All 9/70 patients with serum concentrations higher than 30 kU/l had clinical evidence of metastatic disease and the serum levels of all 35/70 patients without metastasis lay within the normal range. From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l. In all, 6/9 patients without metastasis serum levels were below 30 kU/l. The data of the present study suggest that determination of serum p185 fragment concentrations may be useful as a diagnostic tool in postoperative follow-up of breast cancer patients with c-erbB-2 overexpression of the primary tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212719
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of the liver graft before procurement (1990)
    Springer
    Transplant international 3 (1990), S. 78-81 
    Details
    ISSN: 1432-2277
    Keywords: Liver graft viability ; Ketone body ratio, in brain-dead patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatic energy metabolism was assessed by measuring the blood ketone body ratio (KBR), that is, the ratio of acetoacetate to β-hydroxybutyrate in the arterial blood, in 31 brain-dead patients in an intensive care unit (ICU) in Japan and in 25 donors just before procurement of the liver for transplantation in Germany. In the study in Japan, 7 of the 12 brain-dead patients treated with highdose catecholamine showed significantly decreased KBRs, revealing the detrimental effect of catecholamine on livermmetabolism. In contrast, 8 of the 9 untreated patients with blood pressure below 80 mm Hg showed almost normal KBRs. In the 25 donors in Germany, KBR was maintained within the normal range. Based upon conventional criteria, 21 livers were selected for use and the other 4 were discarded. Nineteen of the grafts were able to normalize KBR within 24 h after reperfusion, while 2 failed to function and required a second transplantation. It was suggested that a KBR in the normal range in donors is a prerequisite to immediate recovery of metabolic function of the liver graft after transplantation, and that hypotensive donors as a potential source of liver grafts may warrant further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336208
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  • 5
    Electronic Resource
    Electronic Resource
    Receiver operating characteristic (ROC) analysis of the ability of arterial ketone body ratio to predict graft outcome after liver transplantation — its sensitivity and specificity (1992)
    Springer
    Transplant international 5 (1992), S. 23-26 
    Details
    ISSN: 1432-2277
    Keywords: Liver transplantation ; graft prognosis test — Prognosis ; liver transplantation ; ketone body ratio — Arterial ketone body ratio ; prognosis liver graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the ability of arterial ketone body ratio (AKBR; acetoacetate/3-hydroxybutyrate) to predict graft prognosis after liver transplantation, the diagnostic value as a predictive index was compared between AKBR and conventional liver function tests using receiver operating characteristic (ROC) analysis. The ROC curves were determined for AKBR, GOT, GPT, total bilirubin, serum lactate level, and prothrombin time, all of which were measured on the 1st and 2nd postoperative days in 88 cases of liver transplantation. Comparisons of the areas under the ROC curves between AKBR and other tests revealed the significant superiority of AKBR to other tests in predicting graft death within 1 month after transplantation. The present study suggests that AKBR can be used as an accurate index to predict graft prognosis after liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337185
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  • 6
    Electronic Resource
    Electronic Resource
    Veränderungen der leberfunktion und -morphologie nach anlage verschiedener portokavaler bypassoperationen (1992)
    Springer
    Langenbeck's archives of surgery 377 (1992), S. 144-151 
    Details
    ISSN: 1435-2451
    Keywords: Portal blood supply ; Liver function ; Portocaval shunt ; Arterialization of a portocaval shunt ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand eines tierexperimentellen Modells werden die Folgen operativ veränderter Perfusionsbedingungen auf die Leberfunktion aufgezeigt. Drei Gruppen mit je 5 Versuchstieren (deutsches Hausschwein) werden folgenden Operationen unterzogen: Gruppe 1 erhielt einen portokavalen Shunt. Zusätzlich zu einem portokavalen Shunt wurde Gruppe 2 mit einem venösen Interponat zwischen V cava und Pfortaderstumpf versehen. Bei den Tieren der Gruppe 3 wurde neben den beiden genannten Operationen noch eine Arterialisation des Interponats durchgeführt. Im Verlauf wurden zu definierten Zeitpunkten klinische, laborchemische und histologische Daten erfaßt. Die Tiere der Gruppen 2 und 3 wiesen im Verhalten and ebenfalls hinsichtlich aller erhobener Leberfunktionsparameter normale Werte auf. Die Tiere der Gruppe 1 zeigten in allen genannten Funktionen erheblich schlechtere Ergebnisse. In dieser Arbeit konnte demonstriert werden, daß fur eine normale Leberfunktion die direkte portale Perfusion entbehrlich ist und letztere durch kavalvenöses bzw. arterialisiertes kavalvenoses Blut voll kompensiert werden kann.
    Notes: Summary Using an experimental animal model consequences of operatively changed modes of liver perfusion on hepatic function could be demonstrated. Three groups of 5 animals each (swine) had the following operations: Group I received a portocaval shunt. In group II in addition to the portocaval shunt a vein graft was interposed between the vena cava and the portal vein. In group III an arterialization of this graft was performed in addition to the two operations mentioned above. Follow-up at defined time intervals included clinical, laboratory and histological data. It could be demonstrated that animals in group II and III showed normal parameters as far as behavior and controlled lab data are concerned. Animals of group I had significantly poorer results in all tests. In this study we found that direct portal perfusion was not necessary for a normal liver function and could be fully compensated both by caval venous blood and by arterialized caval venous blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184371
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  • 7
    Electronic Resource
    Electronic Resource
    012 Lipid hydroperoxide determination in serum by HPLC and iodometry (1992)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 343 (1992), S. 62-63 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332006
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Drug monitoring and pharmacokinetics (1990)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 337 (1990), S. 121-124 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00325732
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    Paper (German National Licenses)
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