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  • 1
    Electronic Resource
    Electronic Resource
    Strain-related differences in Sephadex bead-induced airway hyperresponsiveness and inflammation in rats (1997)
    Springer
    Inflammation research 46 (1997), S. 299-305 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Sephadex beads — Rat — Strain — Airway hyperresponsiveness — Airway inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: The aim of this study was to compare Sephadex G-200 (Sephadex)-induced airway hyperresponsiveness (AHR) and pulmonary eosinophilia among some rat strains.¶Materials: Sprague-Dawley (SD), Brown-Norway (BN), Fischer 344 (Fischer), Lewis and Wistar-Kyoto (WKY) rats were used.¶Methods: Sephadex (0.5 mg/animal) was intravenously administered on days 0, 2 and 5. Measurement of AHR using serotonin and bronchoalveolar lavage (BAL) was performed on day 7.¶Results: The Lewis strain exhibited significant AHR to Sephadex but the BN, Fischer and WKY strains did not. Additionally, the degree of AHR in Lewis rats was smaller than in SD rats throughout the study. Eosinophils in BAL fluid, however, increased in each strain, and the magnitude of the response was BN 〉 Lewis 〉 WKY 〉 Fischer. Both the AHR and pulmonary eosinophilia in Lewis rats were inhibited by dexamethasone (0.1 mg/kg, p.o. × 3).¶Conclusion: These results indicate that the Lewis rat is a useful strain for analysis of the mechanism of Sephadex-induced AHR and airway inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050191
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 138-144 
    Details
    ISSN: 1432-0533
    Keywords: Myositis ; Animal model ; Immunoglobulin G ; Complement ; Class II antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental allergic myositis (EAM) was produced in SJL/J mice by inoculation with the myosin B fraction of the rabbit skeletal muscle, and the pathological changes were quantified. The myosin B fraction contains actin, myosin, tropomyosin and many other proteins, and has been known to induce severe EAM in guinea pigs. In the present model, macrophages and CD4+ lymphocytes predominated among the infiltrating cells. On the surface of muscle fibers and in the regions of cell infiltration deposition of the immunoglobulin G (IgG) and complement factor 3 was observed. EAM was transferred to normal mice by injecting the serum IgG of EAM. Depleting the recipients of complement before the transfer resulted in less-severe pathological changes. Morphologically, the EAM IgG showed an affinity for the nuclei, myofilaments, sarcolemma and blood vessels of mouse skeletal muscle. Biochemically EAM IgG contained antibodies against myosin, actin, troponin, M protein and other muscle proteins. These results indicated that IgG and complement play important roles in this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227760
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  • 3
    Electronic Resource
    Electronic Resource
    Acute toxoplasma myositis: an immunohistochemical and ultrastructural study (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 223-227 
    Details
    ISSN: 1432-0533
    Keywords: Myositis ; Toxoplasmosis ; Macrophages ; T lymphocytes ; Major histocompatibility complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly CD4+ T cells and the inflammatory cells in and around the muscle fibres were chiefly macrophages. Expression of major histocompatibility complex class I and II antigens was observed in the infiltrating cells and endothelial cells of the blood vessels. A small proportion of the infiltrating cells expressed interferon-γ. A possible role of the immune mechanism in the evolution of myositis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334513
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  • 4
    Electronic Resource
    Electronic Resource
    Dexamethasone Increases Growth Hormone (GH)-Releasing Hormone (GRH) Receptor mRNA Levels in Cultured Rat Anterior Pituitary Cells (1996)
    Oxford : Blackwell Science Ltd.
    Journal of neuroendocrinology 8 (1996), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To examine the effects of glucocorticoid (GC) on growth hormone (GH)-releasing hormone (GRH) receptor gene expression, a highly-sensitive and quantitative reverse-transcribed polymerase chain reaction (RT-PCR) method was used in this study. Rat anterior pituitary cells were isolated and cultured for 4 days. The cultured cells were treated with dexamethasone for 2, 6, and 24 h. GRH receptor mRNA levels were determined by competitive RT-PCR using a recombinant RNA as the competitor. Dexamethasone significantly increased GRH receptor mRNA levels at 5 nM after 6- and 24 h-incubations, and the maximal effect was found at 25 nM. The GC receptor-specific antagonist, RU 38486 completely eliminated the dexamethasone-induced enhancement of GRH receptor mRNA levels. Dexamethasone did not alter the mRNA levels of β-actin and prolactin at 5 nM for 24 h, whereas GH mRNA levels were significantly increased by the same treatment. The GH response to GRH was significantly enhanced by the 24-h incubation with 5 nM dexamethasone. These findings suggest that GC stimulates GRH receptor gene expression through the ligand-activated GC receptors in the rat somatotrophs. The direct effects of GC on the GRH receptor gene could explain the enhancement of GRH-induced GH secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.1996.04779.x
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  • 5
    Electronic Resource
    Electronic Resource
    Epitaxial relations between in situ superconducting YBa2Cu3O7−x thin films and BaTiO3/MgAl2O4/Si substrates (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 1772-1776 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In situ superconducting YBa2Cu3O7−x films with Tc0 up to 87 K and Jc, 77 K up to 6×104 A/cm2 were prepared on Si substrates with MgAl2O4 and BaTiO3 double-buffer layers. The epitaxial relations between various layers were established by transmission electron microscopy. The MgAl2O4 layer is heavily faulted. The subsequent BaTiO3 layer stops most of the faults, provides a template for the YBa2Cu3O7−x growth, and partially screens off the stress due to different thermal expansion coefficients. The microstructure of the YBa2Cu3O7−x layer is very similar to that of the films deposited directly on SrTiO3, exhibiting a homogeneous heavily faulted single-crystal-like structure free from secondary phases and grain boundaries. The slight degradation of the transport properties is attributed to residual thermal stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346607
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  • 6
    Electronic Resource
    Electronic Resource
    Determination of electric field profiles in amorphous silicon solar cells (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 478-480 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Time-resolved photoconductivity measurements with subnanosecond time resolution are applied to study the electric field profile in amorphous silicon solar cells in the range from 0.3 V forward to 0.8 V reverse bias. The method is used for a comparison of state-of-the art devices with different junction design. Optical and electrical contributions to the device performance are discussed and the limitations in improving the performance by use of a-SiC:H window layers are pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103672
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  • 7
    Electronic Resource
    Electronic Resource
    Space-charge distribution and trapping kinetics in amorphous silicon solar cells (1992)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 60 (1992), S. 1120-1122 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Using electron time-of-flight experiments we have determined the electric field profile and the electron transport efficiency in amorphous silicon solar cells. In optimized devices we find a correlation between the space-charge distribution and the trapping behavior at the p-i junction, indicating that charged defects in the space-charge region determine both, the electric field distribution and the trapping kinetics. From their capture cross section the charged states are identified as positively charged dangling bonds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.106435
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  • 8
    Electronic Resource
    Electronic Resource
    Cytokine secretion of periodontal ligament fibroblasts derived from human deciduous teeth: effect of mechanical stress on the secretion of transforming growth factor-β1 and macrophage colony stimulating factor (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 34 (1999), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The periodontal ligament may play an important role in tooth eruption, root development and resorption. The tissue physiologically receives mechanical force during mastication. We focused on the effects of intermittent mechanical strain on the cytokine synthesis of periodontal ligament (PDL) fibroblasts in vitro. The cells were derived from human periodontal ligament of deciduous teeth (HPLF-Y) and permanent teeth (HPLF). The two kinds of PDL cells and human gingival fibroblasts (HGF) were cultured in flexible bottomed culture plates. The cells were mechanically stretched at 5% elongation. 3-cycles/min for 24 h on d 7 in culture using a Flexercell® strain unit. After the stretching, we measured DNA content and alkaline phosphatase activity in the cell layer, transforming growth factor beta 1 (TGF-β1) and macrophage colony stimulating factor (M-CSF) contents in the conditioned medium. The TGF-β1 level in the conditioned medium of HPLF was significantly higher than that of HPLF-Y and HGF. It was stimulated by mechanical stretching only on HPLF, whereas no significant effect was observed on HPLF-Y and HGF. M-CSF secretion was inhibited by the stretching on all of HPLF, HPLF-Y and HGF. Lα,25 dihydroxy vitamin D3 (D3) stimulated M-CSF secretion into the culture medium of both HPLF and HPLF-Y, but the stretching inhibited M-CSF secretion and completely blocked the enhancement by D3. These data suggest that periodontal ligament cells synthesize and secrete the molecules as autocrine or paracrine factors that affect bone remodelling and root resorption and the level of those factors change in response to mechanical stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1999.tb02249.x
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  • 9
    Electronic Resource
    Electronic Resource
    New compositional and optical data for antimonian and bismuthian varieties of hemusite from Japan (1991)
    Springer
    Mineralogy and petrology 45 (1991), S. 11-17 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Neue chemische und optische Daten für antimon- und bismuthführende Hemusite auf epithermalen Au-Ag-Cu Lagerstätten in Japan werden vorgelegt. Die empirische Formel für die antimon-führende Varietät aus der Iriki-Mine ist: (Cu5.83Fe0.14Ag0.01)Σ5.98Mo1.03(Sn0.54Sb0.41Te0.03Bi0.02)Σ1.00 (S7.85Se0.15)Σ8.00, und die der Sb-Bi Varietät aus der Kawazu Mine ist: (Cu5.84Fe0.14Ag0.01)Σ5.99M01.03(Sn0.82Sb0.11Bi0.l0Te0.04)Σ1.07 (S7.80Se0.12)Σ7.92. Die theoretische Formel von Hemusit ist Cu+ 4Cu2+ 2Mo4+Sn4+S8, während die wahrscheinlichere Formel für den Hemusit von Iriki Cu+ 4Cu2+ 1.5Mo4+Sn4+ 0.5Sb5+ 0.5S8, mit Sb5+ an der Stelle von Sn4+, das(SbS4)3− Tetraeder bildet, wie zu erwarten ist, unter der Voraussetzung, da♭ das Metall zu Schwefelverhältnis 1 und die Struktur sphaleritähnlich ist. Bi3+ kann jedoch nicht in dieser Weise untergebracht werden, und das führt zu einem Mangel an (S + Se) für den Hemusit von Kawazu. Die Reflektions-Spektren beider Minerale werden mit denen des Wolfram-Equivalents von Hemusit (Kiddcreekit) verglichen. Die Beziehung zwischen Hemusitsensu stricto und diesen jetzt beschriebenen Varietäten wird auf der Basis einfacher und gekoppelter chemischer Substitution diskutiert. Auf dieser Basis werden Schlüsse auf die Valenz von Sb, Bi Mo und Cu in der Hemusit-Struktur gezogen.
    Notes: Summary New compositional and optical data are reported for antimonian and antimonianbismuthian varieties of hemusite from epithermal Au-Ag-Cu deposits in Japan. The empirical formula for the antimonian variety, from the Iriki mine is: (Cu5.83Fe0.14Ag0.01)Σ5.98Mo1.03(Sn0.54Sb0.41Te0.03Bi0.02)Σ1.00(S7.85Se0.15)Σ8.00, and that of the Sb-Bi variety from the Kawazu mine is: (Cu5.84Fe0.14Ag0.01)Σ5.99Mo1.03(Sn0.82Sb0.11Bi0.l0Te0.04)Σ1.07(S7.80Se0.12)Σ7.92. The theoretical formula of hemusite is Cu+ 4Cu2+ 2MO4+Sn4+S8, whilst the most probable formula of the Iriki hemusite is Cu+ 4.5CU2+ 1.5Mo4+Sn4+ 0.5Sb5+ 0.5S8, with Sb5+ substituting for Sn4+ and forming (SbS4)3− tetrahedra as might be expected, given that the metal to sulphur ratio is 1, and given the sphalerite-like structure of the mineral. However Bi3+ cannot be so accommodated, resulting in a deficiency in (S + Se) for Kawazu hemusite. Reflectance spectra for both are compared with those of the tungsten analogue (compositional) of hemusite, kiddcreekite. The relationship between hemusitesensu stricto and these newly reported varieties is discussed in terms of simple and coupled chemical substitutions, and inferences are drawn on the valency of Sb, Bi, Mo and Cu in the hemusite structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01164499
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of [3H]clozapine binding sites in rat brain (1995)
    Springer
    Journal of neural transmission 101 (1995), S. 51-64 
    Details
    ISSN: 1435-1463
    Keywords: [3H]clozapine binding ; serotonin 5-HT2 receptor ; dopamine D4 receptor ; frontal cortex ; limbic area
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the characteristics of [3H]clozapine binding sites in four rat brain regions (frontal cortex, limbic area, hippocampus and striatum) in order to elucidate the pharmacological profile of this unique atypical antipsychotic drug. The specific [3H]clozapine binding was found to be saturable and reversible in all these brain regions. Scatchard analysis of the saturation data indicated that the specific binding consisted of high- and low-affinity components. Displacement experiments showed that the muscarinic cholinergic receptor represented about 50% of [3H]clozapine binding in each brain area. Serotonin 5-HT2 and dopamine D4 receptor binding sites could also be detected by displacement experiments using ketanserin and nemonapride, respectively, in frontal cortex and limbic area, but not in hippocampus or striatum. Alpha-1, alpha-2, histamine H1, dopamine D1, D2, or D3 receptor components could not be determined within the high-affinity [3H]clozapine binding sites in any brain region. It is possible that the atypical property of clozapine may depend on the modulatory effect on dopaminergic function via 5-HT2 receptor blockade and/or may be mediated via D4 receptor blockade in the mesocortical and mesolimbic area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271545
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