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  • 1
    Electronic Resource
    Electronic Resource
    Dolichos biflorus agglutinin binding to intracranial germ-cell tumors: detection of embryonal components in germinomas (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 347-351 
    Details
    ISSN: 1432-0533
    Keywords: Lectin ; Dolichos biflorus agglutinin ; Human germ-cell tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dolichos biflorus agglutinin (DBA) binding was examined in 32 cases of intracranial human germcell tumors. In embryonal carcinomas, intense DBA binding sites were found on the free surface and cytoplasm of embryonal cells. In teratomas, glandular structures often had positive DBA binding sites. Yolk sac carcinomas and choriocarcinomas showed negative DBA affinity. Of 19 cases of germinomas, 10 showed no DBA-positive cells, while sporadically and/or collectively distributed-DBA positive cells were found in the other 9 cases. Common brain tumors such as gliomas, neurinomas and meningiomas were negative for DBA staining. Considering the cellular carbohydrate structure, these findings suggest that DBA-positive cells in germinoma might be evidence of differentiation into embryonal or some somatic components. In addition, because of the absence of DBA binding sites in the common brain tumors, the identification of such binding sites in brain tumors might act as a marker for embryonal or somatic components, especially among germ-cell tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713524
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  • 2
    Electronic Resource
    Electronic Resource
    The value of EEG and cerebral evoked potentials in the assessment of neonatal intracranial hemorrhage (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 177-184 
    Details
    ISSN: 1432-1076
    Keywords: EEG ; Evoked potentials ; Newborn ; Intracranial hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The EEG, visual and auditory evoked potentials (VEP, AEP) were evaluated in 16 full-term newborn infants who had intracranial hemorrhage documented by computerized tomography (CT). Three of them had supratentorial, three, supra- and infratentorial hemorrhage, while the other ten had infra- or peri-tentorial bleeding. Three died during the neonatal period. Eight of the 13 surviving infants were neurologically normal and five were abnormal at the time of the follow-up. Those who had normal or mildly abnormal background EEGs all developed normally, while those whose neonatal EEG was severely abnormal subsequently developed neurological sequelae irrespective of the extent of intracranial hemorrhage. The EEG, VEP or AEP is of little value in the diagnosis of intracranial bleeding but the EEG is valuable in assessing the degree of associated parenchymatous damage and is of great prognostic significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441313
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  • 3
    Electronic Resource
    Electronic Resource
    Preventive therapy against delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage: Trials of thromboxane A2 synthetase inhibitor and hyperdynamic therapy (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 15-19 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; cerebral vasospasm ; hyperdynamic therapy ; thromboxane synthetase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of thromboxane A2 synthetase inhibitor and hyperdynamic therapy on delayed cerebral ischaemia following aneurysmal subarachnoid haemorrhage were evaluated in a series of twenty eight patients, who underwent aneurysmal clipping with 72 hours after subarachnoid haemorrhage. Postoperatively, 13 patients were treated with thromboxane A2 synthetase inhibitor, Xanbon® {sodium (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoate}. Hyperdynamic therapy with dobutamine was given to the remaining 15 patients. Of the 13 patients treated with Xanbon®, nine patients (69%) developed delayed cerebral ischaemia and cerebral infarcts occurred in eight patients (62%). On the other hand, of the 15 patients treated with hyperdynamic therapy, only three patients (20%) manifested delayed cerebral ischaemia and two patients (13%) developed cerebral infarcts. In the present study, the patients treated with hyperdynamic therapy met an expected incidence of ischaemic events after subarachnoid haemorrhage by today's standards, while those treated with thromboxane A2 synthetase inhibitor did not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401822
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  • 4
    Electronic Resource
    Electronic Resource
    Nucleolar organizer region score and Ki-67 labelling index in high-grade gliomas and metastatic brain tumours (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 37-41 
    Details
    ISSN: 0942-0940
    Keywords: Glioma ; metastatic brain tumour ; Ki-67 ; nucleolar organizer regions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of malignant brain tumours comprising 6 anaplastic astrocytomas, 3 glioblastoma multiforme, 1 medulloblastoma and 6 metastatic brain tumours were investigated independently by a silver colloid method for nucleolar organizer regions (NORs) and an immunohistochemistry using a monoclonal antibody against a nuclear antigen, Ki-67, in proliferating cells. The correlation between the mean number of NORs and the percentage of Ki-67 labelled cells (Ki-67 labelling index) was examined. In addition, four normal brain tissue samples without neoplastic cells were stained for NOR. The mean number of NORs in these malignant brain tumours was significantly greater than that in normal astrocytes (p〈0.001). Moreover, both the mean number of NORs and the Ki-67 labelling index in metastatic brain tumours were significantly greater than those in high-grade gliomas (p〈0.001). The Ki-67 labelling index and the mean number of NORs in malignant brain tumours including metastatic brain tumours were found to be linearly related (r=0.86). These results suggest that the proliferative potential of malignant brain tumours could be evaluated by NOR score as well as Ki-67 labelling index and that such indices provide clear discrimination between high-grade gliomas and metastatic brain tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405695
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  • 5
    Electronic Resource
    Electronic Resource
    Cranioplasty utilizing a preserved autogenous bone flap coated with acrylic resin (1980)
    Springer
    Acta neurochirurgica 52 (1980), S. 273-280 
    Details
    ISSN: 0942-0940
    Keywords: Cranioplasty ; acrylic resin ; coating method ; skull bone defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cranioplasty utilizing a resin-coated preserved autogenous skull flap was devised and used in 36 cases, 14 of them being followed up radiologically. It has been confirmed that this method is advantageous in that it repairs the skull defect satisfactorily both from surgical and cosmetic points of view. Furthermore this method causes no anxiety to the patient because of the autogenous origin of the bone flap. We recommend this method for cranioplasty when an autogenous bone flap is preserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402082
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  • 6
    Electronic Resource
    Electronic Resource
    Cytochemical changes in lactate dehydrogenase isoenzymes in human brain tumours (1984)
    Springer
    Acta neurochirurgica 71 (1984), S. 243-253 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumours ; LDH isoenzyme ; cytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lactate dehydrogenase (LDH) isoenzyme patterns in benign and malignant brain tumours were determined by means of electrophoresis of the cell extracts and selective cytochemical stain of the smears. The LDH isoenzyme distribution of the cell extracts showed a pronounced cathodal shift in the malignant gliomas and metastatic carcinomas. Normal brain tissues and histologically benign gliomas, however, showed an anodal pattern with a dominance of the H-type LDH. Schwannomas and meningiomas had a midzone isoenzyme pattern with a dominant LDH3 fraction. Pituitary adenomas usually showed the LDH pattern similar to that of the normal cerebrum. The LDH M fraction could be cytochemically verified using an inhibitory effect by 2.6 M urea in staining. Astrocytomas grades 3–4 and metastatic carcinomas were characterized by loss or marked reduction of stainability by urea treatment, while astrocytomas grades 1–2 and oligodendrogliomas were resistant to urea inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401319
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  • 7
    Electronic Resource
    Electronic Resource
    Surgical treatment of cavernous angioma involving the brainstem and review of the literature (1991)
    Springer
    Acta neurochirurgica 113 (1991), S. 138-143 
    Details
    ISSN: 0942-0940
    Keywords: Cavernous angioma ; MR imaging ; brainstem ; radical surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five cases of symptomatic cavernous angioma involving the brainstem are reported. Magnetic resonance (MR) imaging is of greatest value in the diagnosis and for surgical indication. All cases were treated by radical extirpation. All of them improved postoperatively. The surgical indications for this lesion of the brainstem are briefly discussed with a review of the literature, including 28 previous cases, operated on directly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403199
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  • 8
    Electronic Resource
    Electronic Resource
    Prognosis of intracranial germ cell tumours: Effectiveness of chemotherapy with cisplatin and etoposide (CDDP and VP-16) (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 111-117 
    Details
    ISSN: 0942-0940
    Keywords: Germ cell tumour ; chemotherapy ; CDDP ; VP-16
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A co-operative study for patients with intracranial germ cell tumours was performed to analyze their prognosis and the effectiveness of Cisplatin/Etoposide (CDDP/VP-16) chemotherapy. A total of 46 patients; 30 primary and 16 recurrent cases were registered from 15 participating neurosurgical institutions in Japan. Based on histological criteria and tumour markers, they were classified into three groups; germinoma, germinoma with syncytiotro-phoblastic giant cell (STGC), and non-germinomatous malignant tumour. Sixteen patients were treated with CDDP/VP-16 chemotherapy alone and the other 30 patients were treated by a combination of surgery and/or radiation in addition to chemotherapy. Eleven out of 13 patients (85%) with germinoma showed a complete (n=10) or partial (n=1) response to CDDP/VP-16 chemotherapy even if their tumours were recurrent and there was evidence of CSF dissemination. For the germinoma with STGC and non-germinomatous malignant tumour, a high response rate; 100% for the former and 78% for the latter, could also be achieved in both the primary and the recurrent cases except in those cases of immature teratoma. Their survival times were still different between them. Two-year survival was 50% in germinoma with STGC and 48% in non-germinoma, while it was 88% in germinoma cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112027
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructural Changes of Cochlea in Mice with Hereditary Chondrodysplasia (cho/cho) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 630 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb19598.x
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  • 10
    Electronic Resource
    Electronic Resource
    Regiochemistry of Cytochrome P450 Isozymes (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 34 (1994), S. 251-279 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.34.040194.001343
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