Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats (1994)
    Springer
    Diabetologia 37 (1994), S. 225-231 
    Details
    ISSN: 1432-0428
    Keywords: Osmotic diuresis ; urea ; renal hypertrophy ; glomerular hyperfiltration ; diabetes ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the effects of chronic osmotic diuresis which were not associated with hyperglycaemia on the rat kidney, osmotic diuresis was induced by i. v. infusion of urea. A 5 mol/l urea solution was continuously infused at a rate of 100 ml · kg−1 · day−1 on the basis of body weight on day 0. Duration of infusion was 2, 6, 10 or 14 days. Control rats received continuously infused Ringer's solution. Urea-treated groups developed osmotic diuresis (urine flow = about 0.04 ml · min −1 · 100 g body weight−1) comparable to that in rats with experimental diabetes mellitus induced by i. v. streptozotocin (55 mg/kg), however urea-induced osmotic diuresis was not associated with blood glucose level increases. Compared with their controls, rats receiving urea for 2–14 days had markedly increased kidney weight. Rats receiving urea for 10 days showed greatest kidney weight increase, 0.565 ± 0.044 g/100 g body weight (mean ± SD), representing a 53% increase compared with the control (0.369 ± 0.034 g/100 g body weight). Kidney weight was associated with increases in kidney protein content. In contrast, none of control kidney weight values differed significantly from day 0 values (=normal rats; 0.387 ± 0.028 g/100 g body weight). Creatinine clearance values in urea-treated groups were also higher than those in controls. The maximum value, 0.65 ± 0.17.ml · min−1 · 100 g body weight−1, was recorded in the 14-day group and was significantly higher than the corresponding control value (0.34 ± 0.07 ml · min−1 · 100 g body weight−1) (p 〈0.001). Urea clearance values were also significantly higher in urea-treated groups than in respective controls. This study suggests that osmotic diuresis may induce renal hypertrophy/hyperplasia and glomerular hyperfiltration immediately after development of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398047
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats (1994)
    Springer
    Diabetologia 37 (1994), S. 225-231 
    Details
    ISSN: 1432-0428
    Keywords: Key words Osmotic diuresis, urea, renal hypertrophy, glomerular hyperfiltration, diabetes, rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the effects of chronic osmotic diuresis which were not associated with hyperglycaemia on the rat kidney, osmotic diuresis was induced by i. v. infusion of urea. A 5 mol/l urea solution was continuously infused at a rate of 100 ml·kg−1·day−1 on the basis of body weight on day 0. Duration of infusion was 2, 6, 10 or 14 days. Control rats received continuously infused Ringer's solution. Urea-treated groups developed osmotic diuresis (urine flow=about 0.04 ml·min−1·100 g body weight−1) comparable to that in rats with experimental diabetes mellitus induced by i. v. streptozotocin (55 mg/kg), however urea-induced osmotic diuresis was not associated with blood glucose level increases. Compared with their controls, rats receiving urea for 2–14 days had markedly increased kidney weight. Rats receiving urea for 10 days showed greatest kidney weight increase, 0.565±0.044 g/100 g body weight (mean±SD), representing a 53 % increase compared with the control (0.369±0.034 g/100 g body weight). Kidney weight was associated with increases in kidney protein content. In contrast, none of control kidney weight values differed significantly from day 0 values (=normal rats; 0.387±0.028 g/100 g body weight). Creatinine clearance values in urea-treated groups were also higher than those in controls. The maximum value, 0.65±0.17 ml·min−1·100 g body weight−1, was recorded in the 14-day group and was significantly higher than the corresponding control value (0.34±0.07 ml·min−1·100 g body weight−1) (p〈0.001). Urea clearance values were also significantly higher in urea-treated groups than in respective controls. This study suggests that osmotic diuresis may induce renal hypertrophy/hyperplasia and glomerular hyperfiltration immediately after development of diabetes. [Diabetologia (1994) 37: 225–231]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398047
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Nephrosialidosis: ultrastructural and lectin histochemical study (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 198-205 
    Details
    ISSN: 1432-0533
    Keywords: Nephrosialidosis ; Sialidosis ; α-neuraminidase deficiency ; Ultrastructure ; Lectin histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neuropathological findings in a Japanese male with nephrosialidosis are reported. Clinically, coarse face, psychomotor retardation, macular cherryred spot and proteinuria were noted at 1 year and 7 months. He was diagnosed to have nephrosialidosis on the basis of a deficiency of α-neuraminidase activity in both lymphocytes and cultured skin fibroblasts, and of severe glomerular and tubular involvement on renal biopsy. He died of multiple organ failure at 8 years and 6 months. There were numerous vacuoles and storage materials in visceral organs, particularly in the glomerular and tubular epithelial cells of the kidney and Kupffer cells as well as hepatocytes in the liver. Neuropathological examination revealed severe neuronal storage in the selected part of the central nervous system; lower motor neurons of the brain stem and spinal anterior horn cells, as well as neurons in the basal nucleus of Meynert. In the peripheral nervous system, sympathetic ganglia were severely affected. There was little or no neuronal storage in the basal ganglia, cerebral cortex or cerebellum, and demyelination was not found. Electron microscopic examination showed fine wavy multilamellar structures in the spinal anterior horn cells or Zebra body-like structures in the neurons of the Meynert's basal nucleus. Lectin histochemistry was positive for wheat germ agglutinin, Ricinus communis agglutinin-1 and peanut agglutinin within distended neurons. We conclude that the neuropathological feature in nephrosialidosis is not specific except for the selectiveness of the anatomical sites of involvement. It shares some aspects found in other types of sialidosis or galactosialidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334891
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A case of pigmentary type of orthochromatic leukodystrophy with early onset and globoid cells (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 427-433 
    Details
    ISSN: 1432-0533
    Keywords: Orthochromatic leukodystrophy (OLD) ; Globoid cell ; Proteolipid protein (PLP) ; Neuropathology ; Ceroid-lipofuscin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report herein a sporadic case of the pigmentary type of orthochromatic leukodystrophy with early onset and very rapid clinical course. The patient's development was normal until 2 years old, when he experienced visual disturbance. Rapid deterioration resulted in death 1.5 years after the onset. Metachromatic leukodystrophy, globoid cell leukodystrophy and adrenoleukodystrophy were excluded by biochemical assays. Autopsy findings were compatible with the diagnosis of the pigmentary type of orthochromatic leukodystrophy. However, there were unique findings of severe neuronal loss and the collection of globoid-like cells in the interface of the gray matter and the white matter. Immunohistochemical staining of myelin basic protein, proteolipid protein and galactocerebroside demonstrated that these myelin constituents were equally preserved in the posterior column, while absent in the lateral and anterior columns of the spinal cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713537
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Triplet exciton formation due to interaction between singlet excitons in polydiacetylene (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 7404-7416 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The time-resolved spectroscopy in polydiacetylene single crystals (PDA-MADF {poly-1-[3-(methylamino)phenyl]-4-[3,5-bis(trifluoromethyl)phenyl]-1, 3-butadiyne}) on femtosecond and picosecond time scales was performed. The time dependence of the photoinduced reflectance change in PDA-MADF exhibits three components with lifetimes ∼200 fs, 1–2 ps, and (very-much-greater-than)200 ps. These components are assigned to the free 1Bu excitons, self-trapped excitons, and triplet excitons. From the excitation intensity dependence of the reflectance change, a significant role of bimolecular interactions between singlet excitons for the formation of triplet excitons is clarified. A model of the mechanism of triplet exciton formation after the creation of singlet excitons is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465721
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Flux confinement measurements in large field-reversed configuration equilibria (1990)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 1706-1708 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The poloidal magnetic flux φ in large field-reversed configuration plasmas is examined experimentally. A wide range of initial equilibrium conditions, with 1≤φ≤8 mWb, is produced by varying the reverse bias magnetic field strength. The flux confinement time τφ at first improves with bias, albeit with field-null resistivities an order of magnitude larger than classical. A further increase in bias results in a reduction of τφ, which is inconsistent with either classical or anomalous diffusion theory. The data suggest the importance of nondiffusive processes such as instabilities or formation dynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859443
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Nucleation and growth mechanism of hemispherical grain polycrystalline silicon (1992)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 60 (1992), S. 2607-2609 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The formation of the nucleus [Watanabe et al., Extended Abstracts of the 22nd Conference on Solid State Devices and Materials (1990), p. 873] is performed at low O2 partial pressure during annealing and the density of HSG nuclei increases as the annealing time becomes longer. HSGs grow upward from the amorphous silicon surface, and twin formations are generated in almost all the HSGs. For approximately 50% of whole HSGs, polycrystalline silicon grows downward from the bottom of the HSG. A common heterogeneous material both for the nucleus formation of HSG and for that of polycrystalline silicon growing downward is thought to be formed at the interface between HSG and polycrystalline silicon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.106923
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    An experimental study of nerve regeneration through chemically treated allografts (1990)
    Springer
    International orthopaedics 14 (1990), S. 85-90 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons réalisé une expérimentation sur le lapin afin de déterminer s'il était possible de supprimer chez le receveur les réactions immunitaires aux allogreffes, ceci en traitant les transplantations nerveuses à l'aide de concentrations progresivement croissantes d'éthanol, d'éther et de ficine. Après traitement par l'éthanol l'échafaudage laminaire basal des gaines de Schwann reste intact et il se produit une repousse correcte des axones. Les résultats ne sont pas aussi bons après traitement par l'éther ou par la ficine. La préservation de la laminaire basale est donc le facteur essentiel qui permet, dans cette situation, la régénération nerveuse.
    Notes: Summary We carried out experiments in rabbits to determine whether treating nerve transplants with gradually increasing concentrations of ethanol, ether and ficin would inhibit the graft-host immune reaction to the allograft. After treatment with ethanol, the basal laminar scaffold of the Schwann cell remained intact and there was satisfactory axonal regeneration. The results after additional treatment with ether or ficin did not achieve such good results. Preservation of the basal lamina is considered to be the essential factor in allowing neural regeneration in these circumstances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183371
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    A case of chronic GM1 gangliosidosis presenting as dystonia: clinical and biochemical studies (1990)
    Springer
    Journal of neurology 237 (1990), S. 491-493 
    Details
    ISSN: 1432-1459
    Keywords: Chronic GM1 gangliosidosis ; Dystonia ; GM1 ganglioside metabolism ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical and biochemical studies are reported on a 32-year-old man with GM1 gangliosidosis who presented with a slowly progressive dystonia that began when he was aged 7 years and eventually became almost totally incapacitating at the age of 35. There was only mild intellectual deterioration, but myoclonus, seizures and macular cherry-red spots were never observed. Proton-density and T2-weighted MRI scans showed symmetrical hyperintense lesions of both putamina. No increase of GM1 ganglioside was found in plasma or cerebrospinal fluid, and the metabolism of GM1 ganglioside in cultured skin fibroblasts from the patient was also almost normal, although the residual activity of GM1 ganglioside β-galactosidase activity was only 10% of normal. These findings suggest that impaired GM1 ganglioside metabolism is not present systemically as it is in the infantile and juvenile types of the disorder, but is mainly confined to the central nervous system in chronic GM1 gangliosidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314770
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses (1991)
    Springer
    Archives of virology 117 (1991), S. 85-95 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven monoclonal antibodies (MAbs) with neutralizing activity against feline infectious peritonitis virus (FIPV) strain 79-1149 (type II) were prepared. When the polypeptide specificity recognized by these monoclonal antibodies (MAbs) was investigated by Western immunoblotting, all of the MAbs reacted with peplomer glycoprotein (S) of the virus. By competitive binding assay these MAbs were found to recognize at least 3 different epitopes. The reactivity of these MAbs with 6 viruses classified as FIPV type I (UCD-1, UCD-2, UCD-3, UCD-4, NW-1, and Black), feline enteric coronavirus (FECV) type II strain 79-1683, canine coronavirus (CCV) strain 1-71, and transmissible gastroenteritis virus (TGEV) strains TO-163 and SH was examined by neutralization tests. All MAbs neutralized FECV strain 79-1683, CCV strain 1-71, and TGEV strains TO-163 and SH, while they did not neutralize the 6 FIPV type I viruses. Moreover, the MAb against TGEV strain TO-163, which has strong neutralizing activity against 7 TGEV viruses, neutralized CCV strain 1-71, FECV strain 79-1683, and FIPV strain 79-1146, but did not neutralize the 6 FIPV type I viruses. These results demonstrated that there are at least 3 epitopes involved in the neutralization of FIPV type II strain 79-1146, and that these epitopes are not present in FIPV type I viruses but are present in FECV strain 79-1683 which does not induce feline infectious peritonitis, TGEV strains TO-163 and SH, and CCV strain 1-71. These results suggest the presence of 2 serotypes of FIPV which can be clearly distinguished by the neutralization test using MAbs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310494
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...