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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 1184-1188 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 102 (1980), S. 7441-7444 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 14 (1978), S. 325-328 
    ISSN: 1432-0428
    Keywords: Diabetes ; hypertrophy ; kidney ; nephrectomy ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney growth seen after the induction of experimental diabetes in rats has been compared to the compensatory renal growth after one-sided nephrectomy. After five days the kidney weight had increased from 650 ± 15 mg in a group of controls to 778 ± 21 mg in diabetic rats, and 764 ±17 mg in unilaterally nephrectomised rats. The increased weight was in both groups reflected in an increased DNA content and increased RNA/DNA and protein/DNA ratios. In a group of rats made diabetic and nephrectomised at the same time, kidney weight increased to 953 ± 22 mg after five days. When rats were unilaterally nephrectomised after 20 days of untreated diabetes, compensatory growth was much more pronounced than in non-diabetic rats, kidney weight rising from 780 ± 21 to 1144 ± 39 mg in five days. Similarly, in rats with established compensatory renal hypertrophy, diabetes induced a very rapid growth of the remaining kidney (1226 ± 46 mg after five days).
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 18 (1980), S. 501-505 
    ISSN: 1432-0428
    Keywords: Diabetes ; glomerulus ; hypertrophy ; kidney ; morphometry ; nephrectomy ; proximal tubule ; rats ; stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal hypertrophy in rats with streptozotocin diabetes or after unilateral nephrectomy was studied by sterological techniques. — After 4 days of diabetes total glomerular volume had increased by 30%, and after 47 days by 43%. Glomerular growth was more pronounced than whole kidney growth during the first 4 days, but subsequently whole kidney growth exceeded glomerular growth. In control rats glomerular volume was 4.9% of total kidney volume; after 4 days of diabetes it was 5.4% and after 47 days 4.1%. — Proximal tubule length increased from 366 m/kidney in control rats to 447 m/kidney after 47 days of diabetes; tubular luminal diameter increased from 26.8 μm to 31.4 μm in the same rats. Tubular length and luminal diameter were, however, not increased after 4 days of diabetes. — In unilaterally nephrectomised rats there was no early rapid glomerular growth. Glomerular fractional volume was 4.9% in controls, 4.4% at four days, and 4.2% at 24 days after nephrectomy. — The results indicate a disturbed glomerulo-tubular balance in the early phases of diabetic renal hypertrophy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Growth hormone ; diabetic microangiopathy ; basement membrane thickening ; experimental diabetes ; glomerular basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Injection of porcine growth hormone (200 μg) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p=0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 13 (1977), S. 141-143 
    ISSN: 1432-0428
    Keywords: Blood glucose ; diabetes ; DNA ; hypertrophy ; kidney ; rat ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116–340 mg/100 ml) the kidney weight, protein content and protein/DNA ratio were closely correlated with the glucose values.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: Diabetes ; growth hormone ; hypertrophy ; kidney ; rat ; streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Normal and diabetic rats were given daily injections of human growth hormone for four days (5 mg per rat per day). Injected rats showed no differences from uninjected controls with respect to kidney weight or renal content of protein, RNA or DNA. Kidney weight increased by 7% after two days of diabetes and by 20% after four days, but growth hormone caused no augmentation of the hypertrophy. It is concluded that growth hormone plays no role in the initiation of diabetic renal hypertrophy.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Extracts of the taste hair rich tarsi of the pro- and mesothoracic legs of the flyProtophormia terraenovae contain five chromatographically separable α-glucosidases (E.C. 3.2.1.20). These glucosidases were characterized according to their substrate specificities, their Michaelis constants and their pH optima. The enzymes GLU I, III and V show a broad specificity for several α-glucosides (sucrose, maltose, turanose, palatinose, melezitose and p-nitrophenyl-α-glucoside). The GLU II and IV split sucrose especially with extraordinarily high Michaelis constants (0.1–0.2 M). The properties of the fly enzymes were compared with those of other origine (intestine of mammals, yeast), but especially with those of the fly's taste hair rich labella (Morita and coworkers, 1972–1974). The enzyme GLU III exhibits properties indicating that it may be the sugar receptor protein in question.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 141 (1983), S. 122-126 
    ISSN: 1432-1076
    Keywords: Adducted thumb syndrome ; Congenital myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a female newborn baby with a “myopathic” stiff face, open mouth, high-arched palate, microgenia, generalized muscular hypotonia, limited extension of elbows, wrists and knees, flexed adducted thumbs, velopharyngeal insufficiency, and hypertrichosis. Death occurred at 3 months due to respiratory insufficiency. Muscular biopsy revealed myopathic abnormalities.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an investigation of 541 members of a hospital cleaning department, a prevalence rate of occupational skin diseases of 15.3% was found. During their hospital employment, 39.1% had it skin disease. Higher prevalence in the younger age groups can be explained by the selection of those with skin diseases for work away from the cleaning department. A large number developed their disease shortly after employment began. This was an indication that the observed prevalent conditions were irritant diseases. The distribution by diagnosis confirms this conclusion in as much as 75% of the occupational skin diseases were irritant dermatitis, 21% allergic contact dermatitis, and 4% monilia of the finger webs.The causes of allergic contact dermatitis were found to be formaldehyde, glutaraldehyde and chloramine in addition to nickel and rubber. Among the causes of irritant dermatitis were detergents, alkaline substances, acids and sodium perborate as well as hypochlorite, and hypobromite combinations.In order to reduce occupational skin diseases among cleaning personnel, it is necessary to extend both local and more general prophylactic measures.
    Type of Medium: Electronic Resource
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