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  • 1
    Electronic Resource
    Electronic Resource
    Pattern formation in a ts-cell-lethal mutant ofDrosophila: The range of phenotypes induced by larval heat treatments (1977)
    Springer
    Development genes and evolution 183 (1977), S. 41-59 
    Details
    ISSN: 1432-041X
    Keywords: Imaginal discs ; Pattern formation ; Cell death ; Duplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We describe the range of phenotypes caused by cell death when larvae of the heat-sensitive cell-lethal mutant,l(1)ts726 ofDrosophila, are subjected to heat treatment at different stages of development. When the treatment extends into the pupal period, certain bristles fail to develop but the disc derivatives are otherwise normal. Earlier treatments cause the replacement of sets of leg and eye-antennal markers by mirror image duplications of neighbouring sets. The results are compared in detail with those expected under a gradient model proposed earlier to account for the phenotype. It is found that although the results for the second leg are in excellent agreement with the predictions of the model, a more elaborate hypothesis is necessary to account for the eye-antennal disc data. Abnormal head patterns fall into several distinct categories, any one of which could be explained by postulating the existence of a gradient, if other categories did not also occur. The markers affected in each case belong to overlapping sets, and each category of pattern can be induced by heat treatments administered throughout the temperature-sensitive period. The statistical distribution of the data is such that only one category of pattern would be detected in a small scale experiment. The possible implications relative to pattern formation in normal development are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00849033
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  • 2
    Electronic Resource
    Electronic Resource
    An ultrastructural study of spontaneous mineralization in the brains of aging mice (1982)
    Springer
    Acta neuropathologica 58 (1982), S. 120-124 
    Details
    ISSN: 1432-0533
    Keywords: Mouse ; Thalamus ; Mineralization ; X-ray microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous mineralization observed in the thalamus, and meninges of the median longitudinal fissure, of several strains of mice was studied by light and electron microscopy. The mineralized deposits were closely associated with blood vessels, were periodic acid-Schiff positive, and contained variable amounts of calcium. The thalamic deposits were found to be in an extra-cellular location, and consisted of a randomly arranged mass of fine fibrils or spicules, with laminations of varying electron density in larger deposits. The deposits appeared to develop on the surface of subendothelial and medial, vascular basement membranes. Energy dispersive, X-ray microanalysis demonstrated the presence of both calcium and phosphorus in small and large deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691652
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of a new neuroleptic in the pituitary gland of the rat (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1485-1486 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: summary The14C-labelled, substituted benzamide neuroleptic Tiapride has been found to accumulate transiently in the pituitary gland of the rat following a single dose, and a prolonged retention of the drug was observed in the pars intermedia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01918823
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  • 4
    Electronic Resource
    Electronic Resource
    Pentobarbital: Presynaptic effect in the squid giant synapse (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 487-488 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In concentrations that produced synaptic blockade in the squid giant synapse, sodium pentobarbital produced a dose-related, reversible decrease of the ‘calcium spike’ of the presynaptic terminal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922226
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  • 5
    Electronic Resource
    Electronic Resource
    Peroxidase and leucine-aminopeptidase in diploidMedicago species closely related to alfalfa: Multiple gene loci, multiple allelism, and linkage (1981)
    Springer
    Theoretical and applied genetics 60 (1981), S. 221-228 
    Details
    ISSN: 1432-2242
    Keywords: Allozymes ; Peroxidase ; Leucine-aminopeptidase ; Linkage ; Lucerne ; Medicago
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The genetics of peroxidase and leucine-aminopeptidase isozymes was studied utilizing starch gel electrophoresis in the diploidsMedicago sativa L. (M. coerulea Less.) andM. falcata L. Three anodal and one cathodal sets of peroxidase isozymes identify four linked loci. In addition, two anodal sets of leucine-aminopeptidase isozymes identify two loci that may be linked. The allozymes at each of the loci segregated as expected for monomeric enzymes. However in several crosses there were deficiencies in the number of progeny in particular genotypic classes. This could result from the segregation of recessive deleterious genes linked to some of the allozyme alleles. This is the first report of multiple loci and multiple alleles determining isozymes inMedicago.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342543
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of loprazolam and of triazolam on psychological functions (1984)
    Springer
    Psychopharmacology 82 (1984), S. 386-388 
    Details
    ISSN: 1432-2072
    Keywords: Loprazolam ; Triazolam ; Residual effects ; Psychological functions ; Rebound insomnia ; Accidents ; Spontaneous complaints ; Manual dexterity ; Visual analogue scales
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve poor sleepers of mean age 52 years performed 2 h of laboratory tests three times on 1 day during each week of nightly intake of loprazolam 0.5 mg, loprazolam 1 mg, triazolam 0.5 mg, or continued placebos. Only in the mornings did loprazolam 1 mg cause impairment in manual dexterity and card-sorting, and triazolam 0.5 mg in manual dexterity. Using difference from baseline, withdrawal of either drug after 3 weeks was associated with poorer subjective quality of sleep than following continuing placebos. The rate of spontaneous complaints (including accidents) associated with the drugs was as informative as formal testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427691
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  • 7
    Electronic Resource
    Electronic Resource
    Segregation of allozymes in megagametophytes of viable seed from a natural population of jack pine, Pinus banksiana Lamb. (1984)
    Springer
    Theoretical and applied genetics 69 (1984), S. 145-151 
    Details
    ISSN: 1432-2242
    Keywords: Segregation distortion ; Allozymes ; Pinus banksiana Lamb. ; Lethal allelism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Segregation ratios of allozymes in haploid female gametophytes obtained from viable seed were studied in a natural population of jack pine, Pinus banksiana. Stability of these ratios was assessed for three levels of the sexually reproductive crown as well as for four years of natural fertilization. Analyses of observed segregation ratios of four of five polymorphic isozyme loci showed good correspondence to the overall 1∶1 ratios expected for simple Mendelian inheritance. Allozymes of glucose-6-phosphate dehydrogenase did not segregate in the expected 1∶1 ratio. In addition, there were significant deviations from the expected segregation ratio for all the loci at some sampling positions on individual trees. Heterogeneity of segregation among trees, strata and years could be the result of pollen pool heterogeneity, segregation distortion and/or recessive lethal and semi-lethal gene combinations resulting in early embryo abortion. These types of segregation deviations in viable seed can affect the estimation of allele frequencies from bulked samples of a small number of individuals, the inference of heterozygosity/homozygosity of parental trees, and estimates of selfing rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00272888
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  • 8
    Electronic Resource
    Electronic Resource
    Estimation of mating system parameters in plant populations using the EM algorithm (1983)
    Springer
    Theoretical and applied genetics 65 (1983), S. 157-161 
    Details
    ISSN: 1432-2242
    Keywords: Maximum-likelihood estimation ; Mating systems ; Incomplete data ; EM algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An EM algorithm procedure is presented for the maximum-likelihood estimation of mating system parameters of mixed mating system models for both angiosperms and gymnosperms. One advantage of the procedure is the ability to accommodate any number of alleles in the mature population and pollen pool. Estimates of the outcrossing rate ( $$\hat t$$ ) derived from the model are bounded strictly within the natural biological range (i.e., 0 ≦ $$\hat t$$ ≦1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264884
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of inoculum density, nitrogen source and saprophytic fungi on Fusarium wilt of Mexican lime (1984)
    Springer
    Plant and soil 79 (1984), S. 203-210 
    Details
    ISSN: 1573-5036
    Keywords: Aspergillus ochraceus ; Citrus ; Fungal antagonism ; Pencillium funiculosum ; pH effect ; Trichoderma harzianum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Mexican lime seedlings were inoculated with 0, 500, 1000, 2000, 4000 and 8000 microconidia ofFusarium oxysporum f. sp.citri per gram of potting media. The percent infection and mean disease severity rating increased with increasing inoculum density of the pathogen. In potting mix infested withAspergillus ochraceus, Penicillium funiculosum andTrichoderma harzianum at 5000 conidia per gram 2 weeks prior to infestation withF. oxysporum f. sp.citri at 0, 1000, 4000, and 8000 microconidia per gram,A. ochraceus reduced,P. funiculosum increased andT. harzianum had no effect on disease severity or pathogen population. OnlyP. funiculosum showed antagonistic activityin vitro against the pathogen. Disease severity and pathogen propagule densitites were greater and pH was lower in potting media fertilized with NH4−N than in media fertilized with NO3−N.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182342
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  • 10
    Electronic Resource
    Electronic Resource
    A re-examination of the fracture mechanics energy balance for elastic-perfectly plastic materials (1977)
    Springer
    International journal of fracture 13 (1977), S. 553-555 
    Details
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00034262
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