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  • 1
    Electronic Resource
    Electronic Resource
    Drug-induced toxic epidermal necrolysis (Lyell's syndrome) in a 4-year-old girl (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 91-93 
    Details
    ISSN: 1432-1076
    Keywords: Drug-induced toxic epidermal necrolysis ; Lyell's syndrome ; Cryostat section ; Bulla formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Toxic epidermal necrolysis (Lyell's syndrome) with erythematous skin lesions and bulla formation developed in a 4-year-old girl. An accurate diagnosis using the cryostal technique on the top of a bulla was available within 1 h of hospital admission. The course was unusually mild, probably because of early treatment with corticosteroids. Skin prick tests revealed salicylamide as the agent responsible for inducing the disease. The patient was advised to avoid this substance for the rest of her life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491939
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  • 2
    Electronic Resource
    Electronic Resource
    European multicenter study of the TRUE Test™ (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 19 (1988), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new, standardized, ready-to-apply patch test, the TRUE Test™, has been evaluated on 698 consecutive patients with suspected contact dermatitis. The patients were tested with 12 different allergens. Simultaneously, the same 12 allergens in pet. (Trolab®) were applied symmetrically to the opposite side of the upper back using the conventional Finn Chamber® technique. There were positive test reactions to all 12 allergens lusted in the patient group. The concordance of positive reactions between the TRUE Test™ and the Finn Chamber® test was 67%; 13% of all positive reactions were recorded only for the TRUE Test™ and 20% only for the Finn Chamber® method. The frequency of questionable and irritant reactions was of the same low order of magnitude for both tests methods; such reactions were recorded an around 2% of all test patches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1988.tb05504.x
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  • 3
    Electronic Resource
    Electronic Resource
    Anaphylactoid reactions to infusions of plasma protein and human serum albumin Role of aggregated proteins and of stabilizers added during production (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 9 (1979), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Six patients suffering from anaphylactoid reactions after infusion of pasteurized plasma (PP) or human serum albumin (HSA) were investigated. Clinical symptoms ranged from urticaria and hypotension to cardiac arrest. Immunoglobulin levels, especially of IgA, were normal, as were concentrations of complement factors C3, C4 and factor B. In skin and lymphocyte transformation tests patients, with the exception of one severely allergic to protein, did not react to the monomeric pure HSA. Five out of six patients reacted against HSA aggregates and three patients to the HSA modified by caprylate added as stabilizer during commercial HSA production. It is concluded that the anaphylactoid reactions developing after PP or HSA infusion result from a non-specific reaction to protein aggregates and in some cases possibly from a specific immune response to the caprylate-modified HSA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1979.tb01527.x
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  • 4
    Electronic Resource
    Electronic Resource
    Intragastral provocation under endoscopic control (IPEC) in food allergy: mast cell and histamine changes in gastric mucosa (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 15 (1985), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In fourteen patients with food allergy, intragastral provocation under endoscopical control (IPEC) was performed. In all patients positive immediate-type reactions of the gastric mucosa were observed consisting of oedema, erythema and petechial bleeding. Microscopically, mast cell degranulation was observed and measured by mast cell counts using the o-phthaldialdehyde technique. Concomitantly, tissue histamine content in gastric mucosa decreased significantly after allergen provocation, while there was no change in normal volunteers. Plasma histamine concentration increased in most patients; the increases were most evident in four patients showing mild systemic reactions (urticaria and bronchospasm). The technique described might prove to be useful in establishing the diagnosis in doubtful cases of food allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1985.tb02273.x
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  • 5
    Electronic Resource
    Electronic Resource
    Anaphylactoid reaction after injection of anti-rhesus-D-hyperimmunoglobulin (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 18 (1988), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1988.tb02902.x
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of different methods for enumeration of Langerhans cells in vertical cryosections of human skin (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 118 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have quantified Langerhans cells (LC) in cryosections of normal human skin and lesional skin from patients with atopic eczema and psoriasis vulgaris using six different methods. The results from the different methods varied considerably and were sometimes contradictory, for example when LC numbers in psoriatic skin were compared with those in normal skin. Thus, in addition to the staining technique used and the selection of the dendritic cell type to be counted, the enumeration method used can also influence the quantitation of LC in normal and pathological skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb02432.x
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  • 7
    Electronic Resource
    Electronic Resource
    T4/T8 ratio and absolute T4 cell numbers in different clinical stages of Kaposi's sarcoma in AIDS (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-seven men (36 homosexual or bisexual and one heterosexual) with epidemic Kaposi's sarcoma and underlying HIV infection were followed up over a period of up to 32 months. Fourteen patients (38%) died, with a median survival time of 7.2 months after the diagnosis of AIDS. Seventeen patients (46%) presented with one or more opportunistic infections, mostly Pneumocystis carinii pneumonia. Eighteen patients (49%) had lymphadenopathy syndrome according to the definition of the CDC. Using the Laubenstein-classification of Kaposi's sarcoma, all patients either remained stable or deteriorated, improvement was never observed. Absolute T4 lymphocyte counts and the T4/T8 ratio were not related to the disease stage. With the onset of B symptoms (systemic symptoms), however, the absolute T4 numbers and the T4/T8 ratio markedly decreased. Delayed type hypersensitivity also showed no relationship to the clinical stages of Kaposi's sarcoma. Thus, the clinical progression of Kaposi's sarcoma lesions seems to be largely independent of the immunological parameters investigated. However, the onset of B symptoms was observed to be related to changes in immune status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb07095.x
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  • 8
    Electronic Resource
    Electronic Resource
    Keratinocytes in lesional skin of atopic eczema bear HLA-DR, CD1a and IgE molecules (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apparently normal, and lesional skin from patients with atopic eczema were investigated immunohistochemically with anti-HLA-DR, -CD1a and -IgE antisera. A CD1a + intercellular pattern was observed in uninvolved skin in the majority of the patients whereas an HLA-DR +/CD1a+ network, mostly localized in basal and supra-basal areas, was shown in lesional skin of virtually all of them. Moreover, an HLA-DR +/CD1a + IgE + intercellular pattern was observed in some of the patients only and was predominantly localized in those areas characterized by lymphocyte exocytosis, spongiosis or vesicle formation. Whether keratinocytes are able to synthesize CD1a antigen and FcɛR or if these molecules are only produced and shed by CD1a +/IgE + epidermal dendritic cells remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb00880.x
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  • 9
    Electronic Resource
    Electronic Resource
    Bullous amyloidosis (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 113 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A patient with a 12-year history of a relapsing bullous dermatosis is presented. Unusual clinical features included urticarial erythema, conspicuous mottled hyper- and depigmentation, lichenification and ichthyosiform hyperkeratosis. Serum immunoglobulin E levels were elevated. Histological examination showing deposits of amyloid in the uppermost dermis confirmed the diagnosis of bullous amyloidosis. Ultrastructurally, blister formation occurred at the level of the lamina lucida. The amyloid did not react with a panel of antibodies directed against amyloid fibril proteins. No underlying systemic disease was found. The bullous eruption responded to prednisolone therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb02047.x
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  • 10
    Electronic Resource
    Electronic Resource
    Humorale und zelluläre Immunphänomene im klinischen Verlauf der chronischen posttraumatischen Osteomyelitis (1976)
    Springer
    Infection 4 (1976), S. 84-89 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The humoral and cell-mediated immune response was investigated in 90 patients suffering from chronic posttraumatic osteomyelitis. In 10–20% of the patients the serum IgG and IgM was increased, in 5–10% the levels were decreased. The values were compared with those of a control group of 35 normal healthy volunteers. Of 55 patients with staphylococcal infection only 25 had a positive antistaphylolysin titer. Eleven out of 25 patients with staphylococcal osteomyelitis showed a positive in vitro lymphocyte transformation after stimulation with α-staphylolysin (mean transformation rate 5.4 ± 0.9). The phytohemagglutinin and the pokeweed-mitogen response were normal. A comparison of the immunological reactivity of the patients and the clinical severity of the disease showed that patients with established delayed-type hypersensitivity phenomena suffered a significantly worse clinical course of the disease.
    Notes: Zusammenfassung Neunzig Patienten mit chronischer post-traumatischer Osteomyelitis wurden immunologisch untersucht. Die Ergebnisse wurden mit einer Kontrollgruppe von 35 gesunden Freiwilligen verglichen. In 10–20% der Patienten fanden sich erhöhte Serum-IgG- und IgM-Konzentrationen; in 5–10% waren diese erniedrigt. Unter 55 Patienten mit Staphylokokkeninfektion zeigten nur 25 einen positiven Antistaphylolysintiter. Elf von 25 untersuchten Patienten mit Staphylokokken-Osteomyelitis zeigten eine positive in-vitro-Lymphozytentransformation nach Stimulation mit α-Staphylolysin (durchschnittliche Transformationsrate 5,4 ± 0,9). Dabei war die Phytohämagglutinin- sowie die Pokeweed-Mitogen-Antwort normal. Ein Vergleich der immunologischen Reaktionslage der Patienten mit dem Schweregrad der klinischen Erkrankung ergab, daß die schwersten Verläufe in der Gruppe der Patienten mit nachweisbarer zellulärer Überempfindlichkeit gefunden wurden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01638722
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