Bibliothek

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] All properties of molecules—from binding and excitation energies to their geometry—are determined by the highly correlated initial-state wavefunction of the electrons and nuclei. Details of these correlations can be revealed by studying the break-up of these systems into their ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    ISSN: 1432-041X
    Schlagwort(e): F9 cells ; Differentiation ; Retinoic acid ; mRNA ; Cytokeratins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary We have identified a cDNA coding for the murine keratin D from a collection of clones representing F9 teratocarcinoma stem cell mRNA sequences. These sequences are synthesized specifically after the addition of retinoic acid and cAMP to the culture medium. The clone is 1,382 nucleotides long and contains the entire information for the active polypeptide, the complete 3′ end and most, if not all, of the 5′ non-coding region. The mRNA is found in hepatocytes, in PYS-2 cells (an endodermal cell line) and in differentiated (retinoic-acid-treated) F9 cells, but not in untreated F9 cells. The length of the mRNA is 1.4 kb, as estimated by Northern blot hybridization. Southern hybridization performed under very stringent conditions detects a single fragment hybridizing strongly with the cloned cDNA, suggesting that the mouse genome contains only one or very few copies of this gene. We present the first complete sequence of a keratin expressed in simple epithelia, i.e. keratin D, and discuss its structural features.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Diabetologia 32 (1989), S. 831-838 
    ISSN: 1432-0428
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Digitale Medien
    Digitale Medien
    Springer
    International archives of occupational and environmental health 30 (1972), S. 23-30 
    ISSN: 1432-1246
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In Modell- und In vivo-Untersuchungen wird die Frage studiert, welchen Schutz gegenüber den verschiedenen Pestiziden das Tragen von Schutzhandschuhen bietet. Die Autoren kommen zu der Feststellung, da\ zahlreiche Pflanzenschutzmittel das Handschuhmaterial in verschiedenem Grade durchdringen; der Grad der Penetration ist eine Funktion mannigfaltiger Faktoren. Die Ergebnisse deuten darauf hin, da\ die Exposition aller Wahrscheinlichkeit nach beim Mensch nicht die zur Hervorrufung akuter Vergiftungen erforderliche Konzentration erreicht, doch darf das Faktum der Mikroexposition — vor allem im Falle persistenter und kumulierender Mittel — nicht au\er acht gelassen werden. Im Spiegel der Untersuchungen ist es angebracht, eine Versorgung mit optimalem Schutz gewÄhrenden Handschuhen anzustreben.
    Notizen: Summary Many countries have legislation on the wearing of the necessary protective clothing by people working with pesticides, for the toxicity of different pesticides is an important issue in occupational safety. In this kind of work the part of the body most exposed is the hand. Our investigations were designed to find out what protection safety gloves give against different pesticides. For our investigations we used a model device and laboratory animals. The results show that safety gloves do not give complete protection in every case. The degree of permeability depends on various factors; the effects of exposure may vary according to the material and the thickness of the gloves, the concentration of the pesticide used, the temperature and the length of time the gloves have already been in use. The higher the concentration is, for instance, the greater the permeation will be. Therefore weaker solutions are less harmful. The higher the temperature, the more intensive the diffusion of the toxic substances will be. Nor can climatic factors be ignored. If contact between the chemicals and the surface of the gloves is continues over a long period harmful exposure becomes more likely. For this reason long working hours should to be avoided and facilities should be installed for the workpeople to wash their gloves frequently. According to the investigations using the model device, exposure is unlikely to result in acute intoxication. In most eases exposure results in a subtoxic process. Subtoxic exposure should be treated with caution, especially where persistent and cumulative chemicals are concerned. These investigations indicate that every effort should be made to attain maximum protection. The results are presented in figures and tables. The following pesticides were used for these investigations: Novenda (DNOC), Kresonit (DNOC), Sevtox (DNBP), Aretit (DNBP-acetate).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 29 (1973), S. 1140-1141 
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Nach der Wirkung auf die Überlebenszeit von Transplantaten bei Mäusen zu schliessen, besitzt Leucoagglutinin ausPhaseolus vulgaris extrahiert, eine nur schwache immunosuppressive Aktivität. Sie ist nicht deutlich mit der lymphozytenstimulierenden oder agglutinierenden Aktivität verknüpft. Eine starke akute Toxizität von Leukoagglutinin wurde festgestellt.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 29 (1973), S. 863-865 
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Es wurde die Kinetik der Reaktion zwischen Lymphozyten und Leukoagglutinin ausPhaseolus vulgaris untersucht.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Journal of statistical physics 52 (1988), S. 1429-1445 
    ISSN: 1572-9613
    Schlagwort(e): Nonlinear optimization ; hypersurface deformation ; ant-lion method ; irregular graphs ; graph partitioning ; global minima ; simulated annealing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract A general strategy is advanced for simplifying nonlinear optimization problems, the “ant-lion” method. This approach exploits shape modifications of the cost-function hypersurface which distend basins surrounding low-lying minima (including global minima). By intertwining hypersurface deformations with steepest-descent displacements, the search is concentrated on a small relevant subset of all minima. Specific calculations demonstrating the value of this method are reported for the partitioning of two classes of irregular but nonrandom graphs, the “prime-factor” graphs and the “pi” graphs. We also indicate how this approach can be applied to the traveling salesman problem and to design layout optimization, and that it may be useful in combination with simulated annealing strategies.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 66 (1988), S. 21-25 
    ISSN: 1432-1440
    Schlagwort(e): Acquired immune deficiency syndrome (AIDS) ; Cerebrospinal fluid ; HIV encephalitis ; HIV-specific antibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To establish a reliable procedure for the early detection of central nervous system involvement in HIV infection, paired cerebrospinal fluid and serum samples of 59 patients were analysed. Fifteen were HIV antibody positive without clinical symptoms (stage I), 12 had lymphadenopathy syndrome or AIDS-related complex (stage II), and 32 had AIDS (stage III). Intrathecal synthesis of HIV antibodies was determined by a modified ELISA. Antibodies in CSF and serum were evaluated at identical immunoglobulin G levels to correct for the actual blood-CSF-barrier permeability. A CSF/serum quotient above 1.5 is indicative of intrathecal antibody synthesis, which was found in 47% of the patients in stage I, 67% in stage II, and 84% in stage III. These findings indicate an early and frequent invasion of the CNS.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 66 (1988), S. 26-31 
    ISSN: 1432-1440
    Schlagwort(e): AIDS ; Dementia ; HIV encephalitis ; Neuropsychiatric symptomatology ; Psychological testing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Combined medical, neurological, and serological investigations were carried out in 59 patients infected with human immunodeficiency virus (HIV). In stage I clinical and neuropsychiatric testing did not reveal evidence for HIV encephalitis as diagnosed by local antibody production in CSF. Neuropsychiatric abnormalities, brain atrophy, memory and cognitive impairment reliably indicated HIV encephalitis in later stages. The commonest symptoms were cerebellar and brainstem signs, followed by dementia. Epileptic fits and hemipareses always were associated with cerebral toxoplasmosis. A polyneuropathy was frequently found but other causes have to be considered.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Journal of neurology 234 (1987), S. 308-314 
    ISSN: 1432-1459
    Schlagwort(e): Facial nerve palsy ; CSF ; Immunoglobulins ; Enzyme-linked immunosorbent assay ; Virus-specific antibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sixty-two patients with acute idiopathic peripheral facial nerve palsy (AIPFP) and 31 patients with lymphocytic meningoradiculitis (Garin-Bujadoux or Bannwarth's syndrome) are described. Results of cerebrospinal fluid (CSF) analysis, including the measurement of immunoglobulins (Ig) G, A, and M, indicate that pleocytosis and/or disturbance of the blood-CSF barrier (BCB) and/or local immunoglobulin synthesis within the central nervous system (CNS) do occur in about 25% of patients with AIPFP. The commonest finding is a slight to moderate breakdown of BCB function without evidence of intrathecal immunoglobulin synthesis. In only about 10% of patients, further support for an inflammatory process within the CNS is found by intrathecal synthesis of oligoclonal IgG and/or localized synthesis of IgG and/or IgA. The majority of cases (75%) do not show any signs of an inflammatory process within the CNS. In contrast, lymphocytic meningopolyradiculitis (LMR) has a characteristic CSF profile with early impairment of BCB permeability as well as with rapid and predominant intrathecal IgM synthesis, which helps to distinguish monosymptomatic LMR from AIPFP. By applying a sensitive enzyme-linked immunosorbent assay to identical concentrations of IgG in serum and CSF, evidence of intrathecal synthesis of virus-specific antibodies was found only in 2 of 13 patients with AIPFP. In contrast, all 4 patients with herpes zoster oticus and peripheral facial palsy (Ramsay Hunt syndrome) showed an intrathecal IgG synthesis to varicella zoster virus lasting for up to 4 months after onset of disease.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...