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  • 1
    ISSN: 1432-0533
    Keywords: Multiple sclerosis ; Schwann cell ; Remyelination ; Glial fibrillary acidic protein ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To extend earlier observations on Schwann cell remyelination in multiple sclerosis (MS) lesions (Itoyama et al. 1983) we immunostained spinal cord sections from eight Japanese MS patients with antiserum to Po glycoprotein, a major constituent of peripheral nervous system (PNS) myelin, myelin basic protein (MBP), and glial fibrillary acidic protein (GFAP). Spinal cord sections from six of the eight Japanese MS patients contained large clusters of peripheral myelin sheaths with anti-Po immunoreactivity. In lesions found in four of the six patients, thousands of Po-stained PNS myelin sheaths were present. Necrosis was prominent in these lesions which included more than half of the spinal cord's transverse area. The number and density of regenerating myelin sheaths of peripheral origin were much greater than we observed in MS spinal cord lesions of white people (Itoyama et al. 1983). Anti-GFAP immunoreactivity was present in most brain and spinal cord lesions. However, the areas in lesions that contained large groups of PNS myelin sheaths lacked anti-GFAP immunoreactivity. Our data suggest that spinal MS lesions that are large, severely demyelinated, and partially necrotic may contain factors that inhibit fibrous astrogliosis. These factors, other substances in the large lesions and/or the lack of astrocytic scarring could then promote Schwann cell invasion, multiplication, and remyelination of surviving axons.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Isoniazid neuropathy ; Axonal degeneration ; Axonal swelling ; Paranodal demyelination ; Ventral root
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphometric sequential studies of pathologic changes were carried out on myelinated fibers in the lumbar ventral root of Sprague-Dawley rats administered with isoniazid, 1,500 mg/kg body weight, in a single dose. Accumulation of axoplasmic organelles with secondary paranodal retraction of myelin sheath occurred in the middle part of the ventral root as early as day 2 after the administration. On day 3, axonal degeneration started to occur, distal to the middle part, where the accumulation of axoplasmic organelles is prominent. Such accumulation with the possible blockade of the fast axoplasmic transport in the proximal axon may be directly responsible for the distal axonal degeneration. Alternatively such accumulation may be secondary to the distal axonal degeneration. The morphological sequential findings described clearly reflects the pathological events in isoniazid neuropathy.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Cerebrovascular disease ; Micturition, frequency ; Hemiplegia ; Hemisphere specialization ; Micturition, urgency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine the individual contribution of the right and left cerebral hemispheres to micturition control, a clinical analysis was performed concerning frequency and urgency of micturition in 134 chronic hemiplegic patients. A mean frequency of urination, 9 times or more in 24h, was found more frequently in left than right hemiplegics. Left hemiplegics also complained more often of urgency than did right hemiplegics. A mean frequency of urination of 9 times or more in 24h and urgency co-existed more frequently in left hemiplegics than in right hemiplegics. In the present study, dealing with the chronic sequelae of stroke, frequency and urgency of micturition were found more commonly in patients with right hemisphere than left hemisphere lesions.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 5763-5765 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have found that Fe atoms in Fe/MgO multilayered films prepared in the UHV condition have a magnetic moment larger than that for bulk α-Fe. The magnetization of Fe atoms in Fe/MgO (10 A(ring)/15 A(ring)) film is about 240 emu/g at 4.2 K. The hyperfine field is 350 kOe at 4.2 K, which is also larger than that of bulk α-Fe.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1459
    Keywords: Electrocorticogram ; Epilepsia partialis continua ; Long loop reflex ; Myoclonus ; Somatosensory evoked potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a patient suffering from persistent myoclonic jerks in the right forearm without any definite EEG abnormality under routine recording conditions. By computer summation, using the jerk-locked averaging technique, a sharp spike was recognized as a precisely time-locked event in relation to myoclonic twitches. A cranial CT scan revealed a small cortical lesion, which was found very close to the sensorimotor cortex of the right arm. Cerebral blood flow study using the xenon inhalation method revealed a discrete focus of high flow, which corresponded well with the CT lesion. On electrical stimulation of the right median nerve, a large somatosensory evoked potential and an enhanced transcortical long loop reflex were observed. Electrocorticogram showed active focal spike discharges localized at the left precentral gyrus. We postulate that an epileptogenic focus in the motor cortex and an enhanced transcortical long loop reflex appear to be important for the occurrence of epilepsia partialis continua in this patient.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 232 (1985), S. 180-180 
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 233 (1986), S. 306-308 
    ISSN: 1432-1459
    Keywords: Adrenoleukodystrophy ; Beta-galactosidase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with adrenoleukodystrophy and his mother, a carrier, showed an elevated ratio of very long-chain fatty acids to long-chain fatty acids and decreased beta-galactosidase activity. Other lysosomal enzyme activities were normal except for the borderline level of arylsulfatase-A activity. However, the father and other patients with variant forms of adrenoleukodystrophy showed normal beta-galactosidase and other lysosomal enzyme activities.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 233 (1986), S. 373-375 
    ISSN: 1432-1459
    Keywords: Proteases ; Macrophages ; Lymphocytes ; Neurological diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies showed a significant decrease in the macrophage neutral protease and lymphocyte acid protease activities in patients with multiple sclerosis in remission, a significantly decreased neutral protease activity in macrophages in patients with myasthenia gravis and a significantly decreased acid protease activity in macrophages and lymphocytes in patients with polymyositis. No remarkable abnormalities were found in patients with myotonic dystrophy. These results suggest that multiple sclerosis, myasthenia gravis and polymyositis have an abnormality in immunological function.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 208 (1974), S. 17-25 
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Retrobulbar neuritis ; Optic nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 34 von 69 japanischen Patienten mit wahrscheinlicher multipler Sklerose (MS) zeigten Sehstörungen beim ersten Krankheitsschub. Bei 16 dieser 34 Patienten waren die Opticus-Symptome das einzige Symptom. Diese Fälle wurden als retrobulbäre Neuritis (RBN) diagnostiziert. Die klinischen Bilder dieser 16 Patienten wurden geschildert und analysiert. In dieser Serie überwogen weibliche Patienten im Verhältnis 4,3:1. Das Durchschnittsalter betrug bei Krankheitsbeginn 27 Jahre. Das Intervall zwischen dem Ende der ersten RBN zum nächsten Schub reichte von 1 Monat bis zu 13 Jahren. Seite und Art der Erkrankung, Schwere und Dauer der ersten Sehstörungen oder Grad der Besserung scheinen die folgende Entwicklung der anderen klinischen Symptome von MS nicht zu beeinflussen. Es ist bemerkenswert, daß 11 dieser 16 Patienten eine Sehstörung auch während des zweiten Schubes zeigten. Ein Vergleich der MS-Patienten, die eine Sehstörung als einziges Initialsymptom aufweisen, zwischen den östlichen und westlichen Ländern wäre in Zukunft wünschenswert.
    Notes: Summary Of 69 consecutive Japanese patients with probable multiple sclerosis (MS), 34 patients showed visual impairment at the initial bout. 16 out of these 34 patients manifested only the optic symptoms at the onset, without other clinical evidence of MS, and the condition was diagnosed as retrobulbar neuritis (RBN) initially. The clinical pictures of these 16 patients are described and analyzed. This series showed a female preference with the male-to-female ratio of 1 to 4.3. The age at onset was 27 years on the average, which is not significantly different from that of the whole MS series (31 years). The interval from the end of the initial RBN to the second bout ranged from 1 month to 13 years, but was less than 4 years in all cases but 2. The laterality, mode of onset, severity and duration of the initial visual impairment, or the degree of recovery from the initial bout did not seem to influence the subsequent occurrence of other clinical evidences of MS. It is noteworthy that in 11 out of the 16 patients the symptom at the second bout was, or at least also included, visual impairment. Comparison of MS patients, who started with visual impairment as the sole initial symptom, between the Oriental and Western countries is warranted.
    Type of Medium: Electronic Resource
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