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  • 1980-1984  (3)
  • 1960-1964  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier (1981)
    Springer
    Acta neuropathologica 54 (1981), S. 55-61 
    Details
    ISSN: 1432-0533
    Keywords: Blood-brain barrier ; Dye-protein tracers ; Pathophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Sodium fluorescein and Evans Blue, commonly used tracers in the study of blood-brain barrier disturbances, revealed considerable differences in their respective protein binding capacity in the plasma, passage through the barrier and in the rate of their elimination from the brain parenchyma. 2. In the plasma a considerable portion of the sodium fluorescein remains free and behaves like a micromolecular barrier tracer. On the other hand, almost complete binding of the Evans Blue to albumin confers to it properties of a protein tracer. 3. Following the extravasation of the tracers, the sodium fluorescein is relatively soon eliminated, whereas Evans Blue remains in the cellular elements of the brain parenchyma for a considerable time, although the protein moiety of the tracer is removed much sooner from the cytoplasm of glial cells, presumably by the lysosomal digestion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691332
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glycogen changes in X-Irradiated rat brain (1963)
    Springer
    Acta neuropathologica 2 (1963), S. 482-490 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Röntgenbestrahlung des Rattenkopfes hatte im Gehirn die Anhäufung von histochemisch nachweisbaren PAS-positiven Granula zur Folge, die sich als Glykogen erwiesen. Die Glykogen-Granula fanden sich hauptsächlich in Gliazellen; sie traten nicht in Nervenzellen auf. Die Anzahl der Glykogen-Granula war ungefähr proportional der verabreichten Strahlendosis. Obgleich das Vorkommen derartiger Veränderungen unter den Bedingungen von ionisierenden Teilchenbestrahlungen bekannt ist, stellt dies den ersten Nachweis nach Röntgenbestrahlung dar. Quantitative chemische Analysen des Gehirnes mittels der Glucose-Oxydase-Methode zeigten — 24 Std nach Applikation von 3.000 r — einen Anstieg des Glykogengehaltes um ca. 40%.
    Notes: Summary X-irradiation of the head of rats resulted in the accumulation of histochemically demonstrable PAS-positive granules in the brain, which were identified as glucogen. The glycogen granules were confined predominantly to the neuroglial cells; they did not appear in neurons. The amount of glycogen granules was approximately proportional to the dose administered. Although such changes are known to occur under conditions of ionizing particle radiation, this is the first demonstration that they appear following X-irradiation. Quantitative chemical analysis of the brains by the glucose oxydase method demonstrated an increase of glycogen of approximately 40%, 24 hours after exposure to 3.000 r. The biochemical change responsible for the glycogen accumulation may consist in an impairment of the enzymes mediating the incorporation and release of glucose from glycogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685758
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Enzyme histochemistry of the chick choroid plexus (1964)
    Springer
    Acta neuropathologica 3 (1964), S. 480-489 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Mittels histochemischer Methoden wurden Aktivität und Lokalisation von oxoreduktiven und gewissen hydrolytischen Enzymen im Plexus chorioideus des Hühnerembryo zwischen dem 35. und 46. Entwicklungsstadium untersucht. 2. Ein Anstieg der Enzymaktivität mit zunehmendem Alter wurde im Plexus chorioideus gefunden; eine Ausnahme bildete die Cytochrom-oxydase, die eine ungefähr gleichbleibende Aktivität zeigte. 3. Auffallend war die Lokalisation der oxoreduktiven und hydrolytischen Enzyme im Bürstenbesatz der Epithelzellen des Plexus chorioideus,-vornehmlich im 40. Entwicklungsstadium. 4. Die Lokalisation verschiedener Enzymsysteme könnte mit den Phänomenen des aktiven Transportes im Plexus chorioideus in Verbindung stehen.
    Notes: Summary 1. By use of histochemical methods the activity and localization of oxo-reductive enzymes and certain hydrolytic enzymes in chick embryo choroid plexus in between the 35 to 46th stage of development was studied. 2. An increase of enzyme activity with increasing age was found in the choroid plexus with the exception of cytochrome oxidase, which revealed activity of a fairly constant level. 3. The localization of oxoreductive and hydrolytic enzymes on the brush borders of epithelial cells of the choroid plexus especially at the 40th stage of development was prominent. 4. The localization of the various enzyme systems may be related to the active transport phenomena in the choroid plexus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688456
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 217-222 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal activity ; Ischemia ; Hippocampus ; Gerbil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous neuronal activity was recorded in the cerebral cortex and the CA1 sector of the hippocampus in gerbils during and after 5-min ischemia, produced by bilateral clamping of the common carotid arteries. It was found that spontaneous activity in both cortical and CA1 neurons ceased within 60 s after the onset of ischemia and that it began to reappear 10–20 min after the recirculation. During the next 24 h most CA1 neurons which were recorded showed hyperactivity. This was evident primarily by an increase in spike discharges, whereas recordings from the cerebral cortex were within the preocclusion ranges. On the 2nd day after ischemia, functioning CA1 neurons could not be found, as if they were in a state of functional death, although histological sections showed a general preservation of their cellular structure at that time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691869
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of 5-minute ischemia in mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 207-216 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Blood-brain barrier ; Cerebral blood flow ; Glucose utilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in Mongolian gerbils following 5 min cerebral ischemia, produced by bilateral clamping of the common carotid arteries. The morphological changes were confined to the hippocampus and revealed a conspicuously delayed destruction of the CA1 neurons, occurring after 3 days. Following release of carotid occlusions, there were two separate openings of the BBB. One, occurring shortly after recirculation, was associated with focal hyperemia in the cerebral cortex, hippocampus and basal ganglia; the second opening was observed after several days and was associated with severe neuronal destruction in the CA1 sector. Correlation of quantitative and qualitative rCBF assays with14C-deoxyglucose autoradiographic observations indicated an uncoupling between blood flow and glucose metabolism, observed in the hippocampus at 10 min after recirculation. The described changes provide a further insight into the post-ischemic events which determine the outcome of ischemic injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691868
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    Paper (German National Licenses)
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