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  • Granulocyten  (3)
  • ITP in pregnancy  (2)
  • chemotaxis  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 1057-1060 
    ISSN: 1432-1440
    Keywords: Chemotaxis ; Diabetes ; Granulocyten ; intracelluläre Abtötung ; NBT-Index ; Phagocytose ; Chemotaxis ; Diabetes ; Granulocytes ; intracellular killing ; NBT-index ; Phagocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Granulocyte function of 10 diabetic children has been investigated. At the time of testing the diabetes was in poor control. Five children were retested one week later after adjustment of diet and insulin dose. In contrast to some reports we did not find a phagocytic defect in the ingestion of particles, but the capacity of intracellular killing of Staphylococcus aureus was impaired. Chemotaxis was also reduced whereas the NBT-index and intracellular killing of Candida albicans were normal. Better control of the diabetes led to an improvement of bactericidal killing capacity.
    Notes: Zusammenfassung Bei 10 Kindern mit Diabetes wurde die Funktion der Granulocyten getestet. Zum Zeitpunkt der Untersuchung waren die Patienten schlecht eingestellt. Fünf Kinder wurden nach Korrektur der Insulindosis und der Diät eine Woche später erneut getestet. Im Gegensatz zu Berichten aus der Literatur fanden wir keine verringerte Ingestion von Partikeln. Dagegen war die intracelluläre Abtötung von Staphylococcus aureus gestört. Die chemotaktische Aktivität war ebenfalls verringert, während der NBT-Index und die intracelluläre Abtötung von Candida albicans normal waren. Optimale Einstellung des Diabetes führte zu einer Verbesserung der Abtötungsfähigkeit gegenüber Bakterien.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 643-652 
    ISSN: 1432-1440
    Keywords: Granulocytes ; function ; inborn defects ; chemotaxis ; opsonisation ; phagocytosis ; intracellular microbicidal activity ; Granulocyten ; Funktion ; angeborene Defekte ; Chemotaxis ; Opsonierung ; Phagocytose ; intracelluläre Keimabtötung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Funktion der Granulocyten und deren Störungen findet zunehmend Beachtung. Die vorliegende Übersicht soll den augenblicklichen Stand des Wissens zusammenfassen. Im ersten von zwei Teilen wird ein Überblick über die molekulare Basis der Granulocytenfunktion gegeben und die wesentlichsten angeborenen Störungen der Chemotaxis, Opsonierung, Phagocytose und intracellulären Abtötung von Keimen werden referiert.
    Notes: Summary The insight in the function and dysfunction of granulocytes lately arouses more and more interest. This report summarises our present knowledge. In the first of two chapters the authors review the molecular basis of granulocyte function and the inborn defects of chemotaxis, opsonisation, phagocytosis and intracellular killing of bacteria and fungi.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 739-746 
    ISSN: 1432-1440
    Keywords: Granulocytes function ; secondary defects ; chemotaxis ; opsonisation ; phagocytosis ; intracellular microbicidal activity ; Granulocyten ; Funktion ; sekundäre Defekte ; Chemotaxis ; Opsonierung ; Phagocytose ; intrazelluläre Keimabtötung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im ersten Teil dieser Übersicht haben wir einen Überblick über die molekulare Basis der Granulocytenfunktion und deren wesentlichsten angeborenen Störungen gegeben. Der vorliegende zweite Teil soll das gegenwärtige Wissen über die sekundären Störungen der Chemotaxis, Opsonierung, Phagocytose und intracellulären Keimabtötung zusammenfassen.
    Notes: Summary In the first part we reviewed both the molecular basis of granulocyte function and the inborn defects. The present chapter summarizes our knowledge of the secondary defects of chemotaxis, opsonisation, phagocytosis and intracellular microbicidal activity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0584
    Keywords: ITP ; ITP in pregnancy ; High-dose immunoglobulin therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ITP in pregnancy may lead to fetal thrombocytopenia caused by the transplacental passage of maternal antiplatelet antibody. The most hazardous complication in the infant is intracranial hemorrhage. In addition ITP in pregnancy is reported to be associated with an increased abortion rate and an elevated fetal morbidity and mortality. Therefore obstetric management must aim at increasing maternal and fetal platelets. Severel therapeutic approaches to the treatment of ITP in pregnancy are evaluated. Two cases of ITP in pregnancy are reported. Administration of high-dose intravenous immunoglobulin is introduced as a new therapy for ITP in pregnancy. The rapid reversal of thrombocytopenia following immunoglobulin G administration suggests that it is useful especially as emergency treatment for ITP in pregnancy.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 48 (1984), S. 409-413 
    ISSN: 1432-0584
    Keywords: Acute postinfectious ITP ; Chronic idiopathic thrombocytopenic purpura ; Immunoglobulin therapy ; Steroid therapy ; ITP in pregnancy ; Neonatal thrombocytopenia ; Neonatal isoimmune thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute ITP following infection in children has a high rate of spontaneous remission. Since the platelet count is not uncommonly profoundly depressed, ITP is associated with a mortality of around 1%. The aim of treatment in ITP is to prevent bleeding. As a rule, this can only be achieved by normalizing the platelet count. Intravenous immunoglobulin offers certain advantages over conventional steroid therapy. Moreover, two out of three patients with chronic ITP respond to IgG i.v. The characteristic features of ITP in pregnancy, thrombocytopenia in babies born to mothers with ITP and neonatal isoimmune thrombocytopenia are discussed.
    Type of Medium: Electronic Resource
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