Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-0428
    Keywords: Calcium ; EDTA ; glucose tolerance ; insulin ; uraemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of calcium infusion on the intravenous glucose tolerance was tested in hypocalcaemic patients suffering from renal insufficiency. It was shown that the delayed glucose disappearance rate in uraemics could be improved (p 〈 0.005) by the infusion of calcium gluconolactobionate despite the fact that the serum concentrations of potassium, urea nitrogen, and the blood pH were not altered. The basal insulin concentration was significantly depressed by the calcium infusion (p 〈 0.02). The serum calcium concentration was significantly correlated to the glucose assimilation coefficient in the uraemic patients (p 〈 0.01). — 3 hypocalcaemic patients without renal failure had a normal glucose tolerance and a normalization of the serum calcium concentration had no discernable effect. — A slight but significant decrease of the serum calcium concentration (p 〈 0.01) by EDTA-Na2 in normocalcaemic patients did not change the intravenous glucose tolerance. — It is concluded that hypocalcaemia may be one of the causes for the abnormal glucose tolerance in chronic renal failure.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0428
    Keywords: Key words ; Glucose ; fructose ; insulin ; isolated fat cells ; re-esterification of free fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In isolated human fat cells of the greater omentum and the mammary gland, the effect of glucose, fructose, and/or insulin was tested on the re-esterification rate of FFA measured by the balance method. It could be shown that in the absence of glucose no re-esterification activity was demonstrable. Glucose alone or fructose alone stimulated the re-esterification of FFA dose-dependently in isolated fat cells of the greater omentum, and to a minor degree in fat cells of the mammary gland. Insulin had no effect on the re-esterification rate of FFA in the presence or absence of glucose or fructose, whereas it significantly stimulated the incorporation of glucose-C into CO2 and lipids. It is concluded that the re-esterification of FFA in human adipose tissue, at least in vitro, is mainly controlled by glucose without need for insulin.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1440
    Keywords: Lymphocytes ; Subpopulations ; Chronic lymphocytic leukaemia ; Lymphocyten ; Subpopulationen ; Chronische Lymphadenose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zirkulierende Lymphocyten setzen sich aus funktionell heterogenen Zellen zusammen, welche mit morphologischen Methoden allein nur ungenügend differenziert werden können. Unter Verwendung immunologischer und autoradiographischer Methoden wurden Lymphocyten mit Determinanten leichter (kappa) Ketten, Lymphocyten mit Membranreceptoren für Immun-Komplement-Komplexe, lymphatische Zellen mit cytoplasmatischem Immunglobulingehalt und Lymphocyten in DNS-Synthese bestimmt. Gegenüber Normalpersonen waren bei Patienten mit chronischer Lymphadenose Abweichungen an mehreren dieser Lymphocytenpopulationen nachweisbar. Die Ergebnisse werden im Hinblick auf das Konzept thymus- und knochenmarkabhängiger Lymphocyten diskutiert, deren Differenzierung mit immunologischen Methoden erleichtert wird.
    Notes: Summary Circulating lymphocytes consist of a heterogenous cell population. Employing immunological and autoradiographic methods lymphocytes with Ig (kappa) determinants, those with membrane receptors for immune-complement complexes, lymphocytes containing Ig intracellularly and those in DNA synthesis were evaluated in normals and in patients with chronic lymphocytic leukaemia (CLL). The concept of functionally defective lymphocytes in CLL was further substantiated. The use of immunological markers for identifying thymus (T)- and bone marrow (B) derived human lymphocytes is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-1440
    Keywords: Lymphocytes ; Lymphocytes ; Ig determinants ; subpopulations ; Hypogammaglobulinaemia ; Lymphocyten ; Lymphocyten-Ig-Determinanten ; Lymphocyten-Subpolulationen ; Hypogammaglobulinämien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter Verwendung125I markierter monospezifischer Antiseren gegen menschlicheμ-,γ-,α-,κ-undλ-Ketten bestimmten wir den Prozentsatz Ig-tragender Blutlymphocyten bei Patienten mit primären und symptomatischen Hypogammaglobulinämien. Zwei Patienten mit geschlechtsgebundenen Hypogammaglobulinämien, 2 mit IgA-Defekten, 4 mit transitorischen Hypogammaglobulinämien und 13 mit symptomatischer. Hypogammaglobulinämien (7 multiple Myelome, 2 M. Waldenström und 4 chronische Lymphadenosen) wurden untersucht. Bei erwachsenen Kontrollen fanden wir im Mittelκ-Ketten an 18,5%,λ-Ketten an 2,8%,μ-Ketten an 12,1%,γ-Ketten an 10,5% undα-Ketten an 3,9% der Blutlymphocyten. Prinzipiell ähnliche Ergebnisse wurden bei gesunden Kindern, bei Patienten mit transitorischen Hypogammaglobulinämien und solchen mit IgA-Defekten erhalten. Im Gegensatz dazu fehlten Ig-tragende Lymphocyten in beiden Fällen mit geschlechtsgebundener Hypogammaglobulinämie weitgehend. Normale Werte wurden bei ihren Eltern und bei den untersuchten Geschwistern erhalten. Trotz einer deutlichen Verminderung zumindest eines der Serum-Ig fanden sich bei Patienten mit multiplen Myelomen normale oder lediglich leicht herabgesetzte Zahlen Ig-tragender Lymphocyten. Bei Kranken mit M. Waldenström waren IgM-tragende Lymphocyten stark vermehrt. Trotz verminderter Serum-Ig Spiegel waren die anderen Ig-Klassen an der Zelloberfläche in etwa normaler Häufigkeit nachzuweisen. Diese Diskrepanz war bei Patienten mit chronischer Lymphadenose besonders ausgeprägt, bei denen eine extreme Vermehrung Ig-tragender Lymphocyten mit normalen oder verminderten Serum-Ig-Spiegeln einherging. Die Ergebnisse werden im Hinblick auf eine Störung der B-Zellreifung diskutiert.
    Notes: Summary Using125I labelled monospecific antisera against human,μ-,γ-,α-,κ- andλ-chains we investigated the percntage of surface Ig-bearing lymphocytes in patients suffering from primary or acquired hypogammaglobulinaemias. Two patients with sex-linked hypogammalobulinaemia, 2 with IgA defects, 4 with transitory hypogammaglobulinaemia and 13 patients with secondary hypogammaglobulinaemia (7 with multiple myeloma, 2 with M. Waldenström, 4 with chronic lymphocytic leukaemia) were studied. In healthy adult controlsκ-chains were found in the average on 18.5%.λ-chains on 2.8%,μ-chains on 12.1%,γ-chains on 10.5% andα-chains on 3.9% of blood lymphocytes. Comparable results were obtained in children, in patients suffering from transitory hypogammaglobulinaemia and in those with IgA-defects. In contrast, lymphocytes bearing Ig-determinants were almost absent in both cases with sex-linked hypogammaglobulinaemia (normal values were obtained in both parents and the siblings investigated). In patients with multiple myeloma, despite a low level of at least one immunoglobulin in the serum, normal or only slightly reduced numbers of lymphocytes with Ig-determinants were observed. In patients with M. Waldenström IgM-bearing lymphocytes were markedly increased, but the other Ig classes were represented in normal numbers despite reduced serum levels. In patients with chronic lymphocytic leukaemia the disagreement between very high numbers of lymphocytes bearing at least L-chain determinants on their surfaces and the Ig serum levels was striking. The results are discussed in regard to a maturation defect of B-lymphocytes in hypogammaglobulinaemias.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...