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  • 1
    ISSN: 1432-055X
    Schlagwort(e): Schlüsselwörter Hemihepatektomie ; Hämodynamik ; Oxygenierung ; Lebervenenkatheter ; Key words Hemihepatectomy ; Hemodynamic ; Oxygenation ; Liver venous catheter
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Abstract Objective: The aim of this study was to compare low dose dopamine and dopexamine with respect to of liver-venous oxygen saturation, oxygen delivery and – demand, liver function tests and cardiocirculatory effects in the reperfusion period during a hemihepatectomy operation with occlusion of the liver hilus. Methods: Twenty patients were studied in a randomised, doubleblind setting. They either received 2 µg/kg per min dopamine or 0.5 µg/kg per min dopexamine perioperatively. For monitoring purposes a pulmonary artery and a liver venous catheter were placed. At four different time points hemodynamic parameter were assessed and blood samples were drawn. Results: Significant changes between groups were found 5 min after opening the liver hilus for the cardiac index and the systemic oxygen delivery, as well as at the end of the operation for pulmonary shunt volume, which had increased more in the dopexamine group. No significant difference between liver venous oxygen saturation and liver function tests was found. Conclusion: Until more detailed studies concerning the influence of dopamine on the hepatic-splanchnic region during liver surgery are performed, dopexamine can not be considered superior to dopamine during these operations.
    Notizen: Zusammenfassung Fragestellung: Gibt es einen Unterschied bezüglich der leber-venösen Sauerstoffsättigung, des Sauerstoffangebots und -verbrauchs, der Leberfunktion sowie der kardiozirkulatorischen Effekte während der Reperfusion zwischen niedrig dosiertem Dopamin und Dopexamin bei Leberteilresektionen mit Leberhilusokklusion? Methodik: 20 Patienten wurden randomisiert, doppelblind in zwei Gruppen eingeteilt und erhielten entweder 2 µg/kg/min Dopamin oder 0,5 µg/kg/min Dopexamin. Für das perioperative Monitoring wurden ein pulmonalarterieller- und ein Lebervenenkatheter gelegt. Zu vier Meßzeitpunkten wurden Parameter der Hämodynamik erhoben und Blut abgenommen. Ergebnisse: Ein signifikanter Unterschied zwischen den Gruppen bestand 5 min nach Eröffnung des Leberhilus in einem stärker angestiegenen Cardiacindex und systemischen Sauerstoffangebot sowie am OP-En-de in einem stärker angestiegenen pulmonalen Shuntvolumen in der Dopexamingruppe. Es gab keinen Unterschied bezüglich der leber-venösen Sauerstoffsättigung und der Leberfunktionsparameter. Schlußfolgerung: Bis weiterführende Untersuchungen mit differenzierter Betrachtung der Wirkung von Dopexamin bei leber-chirurgischen Eingriffen vorliegen, ist Dopexamin bei diesen Operationen gegenüber Dopamin nicht als überlegen zu betrachten.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Intensive care medicine 22 (1996), S. 1466-1467 
    ISSN: 1432-1238
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-1238
    Schlagwort(e): Key words Transportation of patients ; Critical illness ; Mechanical ventilation ; Critical care ; Predictors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objectives: Critically ill patients are often transferred due to the growing number of diagnostic procedures required to be performed outside the intensive care unit. These transfers have proved to be very critical. The aim of this study was to evaluate predictors for the deterioration of respiratory function in critically ill patients after transfer. Design: Prospective, clinical, observational study. Setting: 1800-bed university teaching hospital. Subjects: 98 mechanically ventilated patients were investigated during transfer. Measurement and main results: Before transfer, all patients were classified according to the Acute Physiology and Chronic Health Evaluation (APACHE) II score and the Therapeutic Intervention Scoring System (TISS). Haemodynamics and arterial blood gases were measured at 11 different times. Arterial oxgen tension (PaO2), fractional inspired oxygen (FIO2), PaO2/FIO2 ratio, lowest PaO2/FIO2 ratio, minimal PaO2 and maximal FIO2, APACHE II score, TISS before transfer, age and duration of transfer were analysed as potential predictors for deterioration of respiratory function after transfer. Variables were analysed using Classification and Regression Trees and Clustering by Response. In 54 transports (55 %) there was a decrease in the PaO2/FIO2 ratio, and a decrease of more than 20 % from baseline was noted in 23 of the transferred patients (24 %). Age 〉 43 years and FIO2 〉 0.5 were identified as predictors for respiratory deterioration. Conclusions: Our predictors were able to indicate deterioration after transfer correctly in 20 of 22 patients (91 %), combined with a false-positive rate in 17 of 49 (35 %).
    Materialart: Digitale Medien
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  • 4
    ISSN: 1432-1238
    Schlagwort(e): Key words C1-esterase inhibitor ; Complement system ; Sepsis ; Liver transplantation ; Caroli's disease ; Colloid osmotic pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The extent of complement and contact activation is related to outcome in sepsis. A low functional index of their main blocker C1-esterase inhibitor (C1-INH) is considered as a relative deficiency of C1-INH and might contribute to the development of fatal complications in the intensive care unit. The first results of therapeutic intervention with C1-INH concentrate in septic shock are promising. We report on our experience of C1-INH concentrate administration in a young woman with Caroli's disease as ultimate rescue therapy for septic shock with capillary leakage syndrome after combined liver and kidney transplantation. No focus of infection was detectable and thus surgical intervention was not indicated. Antibiotic therapy at that time included vancomycin, tobramycin, meropenem and fluconazol. Hemodynamic stabilization occurred within hours after administration of C1-INH concentrate. Simultaneously a reduction in vasopressor medication was possible and negative fluid balance was achieved.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    ISSN: 1432-1238
    Schlagwort(e): Key words Alcohol withdrawal syndrome ; Ethanol kinetics ; Ethanol dosage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: Alcohol withdrawal syndrome (AWS) is a severe complication during postoperative treatment of alcohol-dependent patients. Besides the use of clomethiazole, clonidine, and benzodiazepines, there is another possible way to prevent AWS by deliberate administration of ethanol. The appropriate dosage of ethanol has not been known up to now and it could be defined according to the average ethanol elimination rate (EER) which, from forensic analysis, is known to be 15 mg/dl per h in a normal population. However, it is questionable whether these data are suitable for the calculation of the correct dosage in alcohol-dependent patients. Design: Preliminary retrospective descriptive study. Setting: Intensive care unit of a university teaching hospital. Patients: 11 alcohol-dependent patients (9 males, 2 females, mean age 50.8 years, range 33 to 60 years). Interventions: Ethanol substitution (ES) by parenteral application. Measurements and results: Ethanol kinetics were evaluated by repeated measurement of the blood ethanol concentration (BEC) over a period of at least 6 h parallel to the administration of ethanol. The average EER was found to be 28 mg/dl per h with a standard deviation of 11 mg/dl per h. The minimum value was 18 mg/dl per h and the maximum 50 mg/dl per h. These EERs were significantly higher than the EERs known from forensic analysis. AWS was prevented in all 11 patients. Conclusions: Close control of BEC and precise adjustment of ethanol administration are necessary prerequisites for ES. The standard EER is not sufficient to define the appropriate ethanol dosage due to enormous variations in the ethanol metabolism of alcohol-dependent patients.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1432-1238
    Schlagwort(e): Capillary leak syndrome Critical illness Sepsis Blood volume determination Bioelectric impedance Osmotic pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Objective: Capillary leakage syndrome (CLS) is a frequent complication in sepsis, characterized by loss of intravasal fluids leading to generalized edema and hemodynamic instability despite massive fluid therapy. In spite of its importance no standardized diagnostic criteria are available for CLS. Design: Prospective clinical study. Setting: 1800-bed university hospital Patients: Six septic shock patients with CLS were compared to six control patients. Measurements and results: CLS was clinically determined by generalized edema, positive fluid balance, and weight gain. Plasma volume was measured by indocyanine green, red blood cell volume by chromium-51 labeled erythrocytes, and colloid osmotic pressure before and 90 min after the administration of 300 ml 20% albumin. Extracellular water (ECW) was measured using the inulin distribution volume and bioelectrical impedance analysis. Red blood cells averaged 20.2±1.0 ml/kg body weight in CLS patients and 23.3±4.1 in controls. ECW was higher in CLS patients than in controls (40.0±6.9 vs. 21.7±3.7 l; p〈0.05). ECW of inulin was correlated with that measured by bioelectrical impedance analysis (r=0.74, p〈0.01). The increase in colloid osmotic pressure over the 90 min was less in CLS patients than in controls (1.1±0.3 vs. 2.8±1.3 mmHg; p〈0.05). Conclusion: These results suggest that measurements of an increased ECW using bioelectrical impedance analysis combined with a different response of colloid osmotic pressure to administration of albumin can discriminate noninvasively between patients with and those without CLS.
    Materialart: Digitale Medien
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