Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Indications for radioisotope bone scanning in staging of cervical cancer (1990)
    Springer
    Archives of gynecology and obstetrics 248 (1990), S. 21-23 
    Details
    ISSN: 1432-0711
    Keywords: Radioisotope bone scanning ; Staging examinations ; Cervical cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The total of 160 patients with newly diagnosed invasive cancer of the cervix had whole body radioisotope bone scanning during staging of their disease. 51 patients had cancer of the cervix stage I, 63 had stage II, 34 stage III and 12 stage IV (FIGO). Only in 8 of 160 patients did the bone scans indicate possible metastases and this was confirmed by X-ray examination in only one patient with stage IV disease and liver metastases. We conclude that patients with stage I and stage II carcinoma of the cervix do not need to have bone scans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389585
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibers: immunocytochemical and fine structural studies, with a note on unusual 18- to 20-nm filaments (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 406-414 
    Details
    ISSN: 1432-0533
    Keywords: Cytoplasmic body myopathy ; Immunohistochemistry ; Desmin ; Intermediate filaments ; Actin filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a fine structural and immunocytochemical study, the latter performed on semithin sections of epoxy resin embedded skeletal muscle fibers, three types of cytoplasmic bodies were identified in a case of cytoplasmic body myopathy: (1) The first type, the classical type, showed a central core and a light halo with radiating actin filaments at the periphery. (2) The second type, the spheroid body was characterized by irregularly arranged granular masses associated with intermediate filaments. Desmin immunoreactivity occurred in the central and peripheral parts, where filaments of intermediate size were visualized by electron microscopy. Desmin immunoreactivity was noted also at the Z-bands of striated annulets, within areas of disordered myofibrils, such as sarcoplasmic masses, and in atrophic muscle fibers. (3) The third type of the cytoplasmic body was composed mainly of large masses of uneven granularity and electron density. The center of this type reacted to anti-actin antibody suggesting that the 5- to 6-nm filaments, which ultrastructurally proved to be a major component, were of the actin type. By contrast, neither intermediate filaments nor actin microfilaments were found by electron microscopy in cytoplasmic bodies in a second case where no immunoreaction to desmin or actin occurred. Anti-vimentin antibody stained only the cytoplasm of endomysial cells, but not the inclusion bodies. Some other, unusual inclusions with 18- to 20-nm tubulo-filamentous structures have to be distinguished from the various types of filaments in cytoplasmic bodies. It is concluded, that pleomorphism and heterogeneity of “cytoplasmic bodies” have to be taken into consideration when classifying cytoplasmic body myopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307695
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 163-169 
    Details
    ISSN: 1432-1041
    Keywords: Ipsapirone ; CRF ; ACTH ; cortisol ; time series analysis ; hypothalamic-pituitary-adrenal axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5–30 mg per day were given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278478
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Low antithrombin III in neonatal shock: DIC or non-specific protein depletion? (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 500-503 
    Details
    ISSN: 1432-1076
    Keywords: Antithrombin III ; Albumin ; Shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low antithrombin III (AT III) levels in shock are usually ascribed to disseminated intravascular coagulation (DIC). However, decreased activities of clotting factors and their inhibitors could reflect a generalised fall in plasma proteins rather than DIC. AT III and albumin were compared in 48 asphyxiated and non-asphyxiated newborn rabbits (pH6.70–7.30). Both AT III and albumin were markedly decreased in the sickest animals and there was a direct linear relationship between the two proteins (P〈0.001). Similar results were obtained in ten newborn infants suffering from shock and haemorrhagic diathesis. In all cases AT III and albumin were decreased below the normal range and significantly correlated (P〈0.01). Our findings suggest that AT III is not a useful diagnostic marker of DIC. Further, a similar fall of clottable and non-clottable proteins in shock questions the general assumption that the ensuing coagulopathy is due to intravascular coagulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429051
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Modulation of short latency cutaneous excitation in flexor and extensor motoneurons during fictive locomotion in the cat (1989)
    Springer
    Experimental brain research 77 (1989), S. 57-68 
    Details
    ISSN: 1432-1106
    Keywords: Cutaneous EPSPs ; Fictive locomotion ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined modulation of transmission in short-latency, distal hindlimb cutaneous reflex pathways during fictive locomotion in 19 decerebrate cats. Fictive stepping was produced either by electrical stimulation of the mesencephalic locomotor region (MLR) or by administration of Nialamide and 1-DOPA to acutely spinalized animals. Postsynaptic potentials (PSPs) produced by electrical stimulation of low threshold afferents (〈 2.5 times threshold) in the superficial peroneal (SP), sural, saphenous or medial plantar nerves were recorded intracellularly from various extensor (n = 28) and flexor (n = 24) motoneurons and averaged throughout the step cycle, together with voltage responses to intrasomatic constant current pulses (in order to monitor relative cell input resistance). Each motoneuron studied displayed rhythmic background oscillations in membrane potential and correlated variations in input resistance. The average input resistance of extensor motoneurons was lowest during mid-flexion, when the cells were relatively hyperpolarized and silent. Conversely, average input resistance of flexor motoneurons was highest during mid-flexion, when they were depolarized and active. The amplitude of the minimum-latency excitatory components of PSPs produced by cutaneous nerve stimulation were measured from computer averaged records representing six subdivisions of the fictive step cycle. Oligosynaptic EPSP components were consistently modulated only in the superficial peroneal responses in flexor motoneurons, which exhibited enhanced amplitude during the flexion phase. With the other skin nerves tested (sural, saphenous, and plantar), no consistent patterns of modulation were observed during fictive locomotion. We conclude that transmission through some, but not all, oligosynaptic excitatory cutaneous pathways is enhanced by premotoneuronal mechanisms during the flexion phase of fictive stepping in several cat hindlimb motor nuclei. The present results suggest that the patterns of interaction between the locomotor central pattern generator and excitatory cutaneous reflex pathways depend on the source of afferent input and on the identity of the target motoneuron population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250567
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Phasic modulation of short latency cutaneous excitation in flexor digitorum longus motoneurons during fictive locomotion (1988)
    Springer
    Experimental brain research 71 (1988), S. 568-578 
    Details
    ISSN: 1432-1106
    Keywords: Fictive locomotion ; Cutaneous reflex pathways ; Flexor digitorum longus muscle ; Motoneurons ; Interneurons ; Reflex modulation ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined modulation of transmission of short-latency excitation produced by distal hindlimb cutaneous input, as well as fluctuations in motoneuron membrane potential and input resistance, in flexor digitorum longus (FDL) motoneurons during fictive locomotion. Fictive stepping was induced in unaesthetized, decerebrate cats either by repetitive stimulation of the mesencephalic locomotor region (MLR) or by administration of Nialamide and 1 DOPA after low spinal section. In the MLR preparations, brief depolarizing waves occurred in FDL cells during the early flexion phase of fictive stepping, immediately after cessation of activity in extensor muscles. In some FDL cells, plateau-like depolarizations also occurred during the extensor phase. Fictive stepping induced in acutely spinalized cats by administration of l-DOPA was slower and more variable; peak polarization in FDL motoneurons always occurred during the early flexion phase but there was usually no distinct depolarization during extension. In both types of preparation, the initial EPSP components in synaptic potentials (SP-EPSPs) produced by electrical stimulation of the cutaneous division of the superficial peroneal nerve (SP) were maximally facilitated during early flexion, coincident with the peak of background depolarization. This enhancement was manifested by an increase in the amplitude of initial SP-EPSP components or by decreased central latency of the initial EPSP components, or both. In most FDL motoneurons, input resistance decreased systematically during late flexion, coincident with relative membrane hyperpolarization. Correction of SP-EPSP amplitudes for changes in input resistance suggested that SP-EPSP facilitation persisted throughout the flexion phase These findings are discussed with reference to modulation of cutaneous reflexes during locomotion and the possibility that excitatory last-order interneurons in particular cutaneous reflex pathways may distribute excitatory drive from the central pattern generator for locomotion to FDL α-motoneurons
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248749
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    Afterhyperpolarization modulation in lumbar motoneurons during locomotor-like rhythmic activity in the neonatal rat spinal cord in vitro (1994)
    Springer
    Experimental brain research 99 (1994), S. 214-222 
    Details
    ISSN: 1432-1106
    Keywords: Afterhyperpolarization ; Motoneuron ; Locomotion ; In vitro ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Motoneuron afterhyperpolarization (AHP) amplitude and somatic input conductance were monitored during pharmacologically induced, locomotorlike ventral root activity using an isolated neonatal rat spinal cord preparation (transected at the C1 level). Nonspontaneously firing motoneurons were selected for study. Single spikes were evoked at regular intervals by brief depolarizing current pulse injections, while somatic input conductance was monitored by hyperpolarizing current pulses. The induction of rhythmic ventral root activity was associated with tonic depolarization of motoneurons as well as superimposed rhythmically alternating membrane depolarization and hyperpolarization (locomotor drive potentials, LDPs). In 9 of 13 trials (six of eight cells) the peak amplitude of AHPs following current-evoked action potentials was reduced during both the hyperpolarized and the depolarized phases of the LDP, compared with the pre-locomotor condition. The peak AHP amplitude increased during the depolarized phase of the LDP in 4 of 13 trials (three of eight cells); however, in 3 of these 4 trials measurement of the AHP later in the course of its trajectory, using a half decay time (HDt) reference point, demonstrated AHP amplitude reduction during rhythmic activity compared with the prelocomotor condition. In seven of eight motoneurons the induction of rhythmic activity was associated with a decrease in input conductance. The pattern of AHP amplitude and conductance modulation during the two phases of the LDP was consistent for individual trials; however, there was considerable intertrial variation. The results suggest that AHP modulation during locomotor-like activity in this preparation can be mediated independently of supraspinal influences by intrinsic spinal cord mechanisms, and the observed AHP suppression does not appear to be the passive result of an increase in background conductance. The discrepancy between peak and HDt-based AHP amplitude measurements during the depolarized phase of the LDP in some trials may be due to competing effects of passively enhanced potassium currents and a mechanism that actively reduces the calcium-dependent potassium conductance. The possibility that both the AHP amplitude and the input conductance changes observed during locomotor-like activity reflect a regulation of potassium channels is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239588
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Spezifische IgM-Teste in der Syphilis-Diagnose (1994)
    Springer
    Der Hautarzt 45 (1994), S. 685-689 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: 19S-IgM-FTA-ABS-Test – IgM-SPHA-Test – IgM-Captia-Test – Treponema pallidum-spezifische IgM-Teste – Syphilisserologie ; Key words: 19S-IgM-FTA-ABS-test – IgM-SPHA-test – IgM-Captia-test – Treponema pallidum-specific IgM-tests – Syphilis serology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. A total of 359 sera of untreated patients with syphilis were examined by three methods for the detection of Treponema pallidum specific IgM antibodies, the 19S-IgM-FTA-ABS test, the IgM solid phase haemadsorption assay (IgM-SPHA), and the IgM Captia assay. The results were compared and evaluated. In primary syphilis, the 19S-IgM-FTA-ABS and IgM-Captia yielded reactive results in all patients, whereas only 40% were positive in the IgM-SPHA; the corresponding values for early latent syphilis were 96.0%, 91.5% and 73.1%, respectively. In secondary syphilis, the reactivity of █ serum out of 27 was missed by IgM-Captia and that of another, by the IgM-SPHA. Mean values (ELISA units=extinction/cut-off) of IgM-Captia were higher in primary (2.25) than in secondary syphilis (1.70). In neurosyphilis, only the IgM-SPHA test detected reactivity in all sera, sensitivity for 19S-IgM FTA-ABS and IgM-Captia was 50.0% and 23.1%, respectively. Specificity of the IgM-Captia test results, determined in 386 sera, was 91.2%. The results of specific IgM tests are essential in the diagnosis of congenital syphilis as well as in the recognition of reinfection; they indicate the need for treatment and are useful in the assessment of the effectiveness of therapy.
    Notes: Zusammenfassung. Der Aussagewert von 3 Treponema-pallidum-spezifischen IgM-Testen, dem 19S-IgM-FTA-ABS-, dem 19S-IgM-Solid-Phase-Haemadsorption-Assay (IgM-SPHA) sowie dem IgM-Captia-Test wurde an 359 Sera von unbehandelten Patienten mit bekannter Syphilisinfektion untersucht und die Ergebnisse miteinander sowie mit den Befunden der Routineserologie (FTA-ABS-, TPHA-, VDRL-Test) verglichen. Im Primärstadium (n=38) waren die Proben sämtlicher untersuchter Patienten (37/37) im 19S-IgM-FTA-ABS- und im IgM-Captia-Test, jedoch nur 14/35 (40%) im IgM-SPHA-Test reaktiv. Der FTA-ABS zeigte bei 36/38 (94,7%), der TPHA bei 32/38 (84,2%), der VDRL bei 27/38 (71,1%) die Infektion an. Im Stadium der Frühlatenz (n=53) war der 19S-IgM-FTA-ABS-Test bei 48/50 (96%) reaktiv, der IgM SPHA bei 38/52 (73,1%), der IgM-Captia bei 44/49 (89,8%), der FTA-ABS bei 53/53 (100%), der TPHA bei 51/53 (96,2%) und der VDRL bei 48/53 (90,6%). Im Sekundärstadium (n=28) war der 19S-IgM-FTA-ABS-Test bei 28/28 (100%) reaktiv, der IgM-Captia bei 26/27 (96,3%), der 19S-IgM-SPHA bei 36/52 (69,2%), der FTA-ABS, der TPHA- und der VDRL-Test bei 28/28 (100%). Bei quantitativer Auswertung (ELISA-Einheiten – Absorptions-Grenzwert) des IgM-Captia-Testes lagen die Mittelwerte im Primärstadium deutlich höher (2,25) als im Sekundärstadium (1,7). Die Sera von Patienten mit Neurosyphilis (n=45) waren im 19S-IgM-FTA-ABS-Test in 19/38 (50%) der Proben, im IgM-SPHA-Test in 45/45 (100%), im IgM-Captia in 6/26 (23,1%), im FTA-ABS in 45/45 (100%), im TPHA in 45/45 (100%) und im VDRL in 43/45 (95%) reaktiv. Schließlich wurden die Sera von 195 Personen mit latenter Syphilis von unbekannter Dauer untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050150
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Purification and properties of a F420-nonreactive, membrane-bound hydrogenase from Methanosarcina strain Gö1 (1992)
    Springer
    Archives of microbiology 157 (1992), S. 505-511 
    Details
    ISSN: 1432-072X
    Keywords: Archaebacteria ; methanogenesis ; energy conservation ; membranes ; F420-dependent hydrogenase ; Methanosarcina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of the F420-reactive and F420-nonreactive hydrogenases from the methylotrophic Methanosarcina strain Gö1 indicated a membrane association of the F420-nonreactive enzyme. The membrane-bound F420-nonreactive hydrogenase was purified 42-fold to electrophoretic homogeneity with a yield of 26.7%. The enzyme had a specific activity of 359 μmol H2 oxidized · min-1 · mg protein-1. The purification procedure involved dispersion of the membrane fraction with the detergent Chaps followed by anion exchange, hydrophobic and hydroxylapatite chromatography. The aerobically prepared enzyme had to be reactivated anaerobically. Maximal activity was observed at 80°C. The molecular mass as determined by native gel electrophoresis and gel filtration was 77000 and 79000, respectively. SDS gel electrophoresis revealed two polypeptides with molecular masses of 60000 and 40000 indicating a 1:1 stoichiometry. The purified enzyme contained 13.3 mol S2-, 15.1 mol Fe and 0.8 mol Ni/mol enzyme. Flavins were not detected. The amino acid sequence of the N-termini of the subunits showed a higher degree of homology to cubacterial uptake-hydrogenases than to F420-dependent hydrogenases from other methanogenic bacteria. The physiological function of the F420-nonreactive hydrogenase from Methanosarcina strain Gö1 is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276770
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    Effects of tiflucarbine as a dual protein kinase C/calmodulin antagonist on proliferation of human keratinocytes and release of reactive oxygen species from human leukocytes (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 456-460 
    Details
    ISSN: 1432-069X
    Keywords: Tiflucarbine ; Protein kinase C ; Keratinocyte proliferation ; Reactive oxygen species ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Various studies have suggested that calmodulin (CaM) is involved in the pathophysiology of psoriasis. Protein kinase C (PKC) is also accepted as playing a regulatory role in cell proliferation as well as in inflammatory processes. Therefore, we investigated the effects of the known CaM antagonist tiflucarbine (BAY/TVX P 4495) on two cellular systems related to the major clinical symptoms of psoriasis: proliferation of cultured human keratinocytes (HaCaT cell line) and release of reactive oxygen species (ROS) from human polymorphonuclear leukocytes (PMNL). Tiflucarbine inhibited both cellular responses in a dose dependent manner. Furthermore, tiflucarbine directly affected PKC, and may thus be considered to be a dual PKC/CaM antagonist with putative antipsoriatic activity. The effects of tiflucarbine on the different parameters were compared with those of the structurally unrelated dual PKC/CaM inhibitor W-7 and those of the potent PKC inhibitor staurosporine. The potencies of all three compounds were found to be in the same range as their PKC-inhibiting potency. Our data indicate that PKC, rather than CaM, may play a regulatory role in the release of ROS as well as in keratinocyte proliferation. Therefore, inhibition of PKC in general might have a therapeutic benefit in psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371782
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...