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  • 11
    Electronic Resource
    Electronic Resource
    Quantitative Untersuchungen der regionalen Hirnperfusion mit 99mTechnetium Pertechnetat (1972)
    Springer
    Journal of neurology 203 (1972), S. 51-64 
    Details
    ISSN: 1432-1459
    Keywords: Cerebral Circulation ; Gamma Camera ; Intravenous Technique ; 99mTc-Pertechnetate ; Vascular Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde mit Hilfe neuerer technischer Möglichkeiten (Kamerasystem, freie Regionenauswahl) untersucht, inwieweit nach intravenöser Bolusinjektion eines radioaktiven Indicators (10–15 mCi 99mTc Pertechnetat) aus Zeitaktivitätskurven, die mit kurzer Zeitkonstanten (0,5 sec) extern über bestimmten Hirnregionen aufgenommen wurden, vergleichende quantitative Aussagen über Störungen der Hirnzirkulation möglich sind. Hierzu haben wir mehrere Parameter an 70 Patienten für 2 verschiedene Regionen geprüft (32 Kontrollpatienten und 38 nach klinischen Kriterien gruppierte Patienten mit und ohne Störungen der Hirnzirkulation). Den höchsten Informationsgehalt wiesen Parameter auf, die aus der ersten Hälfte der Zeitaktivitätskurve abgeleitet waren. In 70% der Fälle stimmten die Ergebnisse der Hirnperfusionsuntersuchung mit den klinischen, angiographischen und pathologisch anatomischen Befunden überein. Falsch negative Ergebnisse waren häufiger als falsch positive.
    Notes: Summary Cebral circulation was investigated by means of rapid sequential scintigraphy (0.5 sec per frame) after intravenous injection of a bolus of 10–15 mCi 99mTechnetium-pertechnetate using a multicrystal gamma camera (Autofluoroscope). The data were stored on a digital tape. Different areas of interest were flagged and time-activity curves were generated from these areas. The clinical significance of different parameters developed from the curves was tested in 70 patients grouped by clinical criteria (32 controls and 38 neurological patients with and without abnormal cerebral circulation). Parameters developed from the first half of the time activity curves were the most informative. In 70% of the neurological patients the result of the brain perfusion study was in keeping with the clinical, angiographic and anatomical findings. False negative results were more frequent than false positive ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316078
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  • 12
    Electronic Resource
    Electronic Resource
    Renale Clearance mit131J-markiertem Chlorjodpropyl-Inulin (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 264-266 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the 1st group of 10 patients inulin clearances were performed with J-131 labelled chlorjodpropyl-inulin and with inactive inulin simultaneously. The results were in good agreement. In the 2nd group of 11 patients only the clearance of J-131-inulin was measured. It is possible to reduce errors and time involved in the conventional method by using radioactive labelled inulin. The radioactive technique did not give identical results of the indirect clearance and the direct clearance calculated aftervan Slyke. The results of this investigation suggest that, at present, there is no simple and accurate method which could replace the method byvan Slyke. The uptake of free J-131 by the thyroid accounted for 5.6 to 7.6% of the dose injected. This uptake was reduced to 0.2% by prior treatment with Lugol's solution.
    Notes: Zusammenfassung Nachdem vergleichende Untersuchungen an 10 Patienten eine gute Übereinstimmung der Clearance mit inaktivem und131J-markiertem Chlorjodpropyl-Inulin ergeben hatten, wurden 11 weitere Patienten nur mit der131J-Inulin-Clearance untersucht. Die Verwendung von radioaktiv markiertem Inulin verringert die Fehlermöglichkeiten dieser Nierenfunktionsprobe und setzt den zeitlichen Aufwand für die Inulinbestimmung erheblich herab. Bei 11 Patienten wurde der Inulinverteilungsraum nicht wie bei der ersten Gruppe mit 5,0 g sondern mit 8,0 bis 10,0 g inaktivem Inulin aufgefüllt. Trotz dieser veränderten Technik konnten keine übereinstimmenden Ergebnisse zwischen der nachvan Slyke errechneten und der totalen Clearance erzielt werden. Für die klinische Anwendung ist nach unseren Untersuchungen die van Slykesche Methode noch nicht durch eine einfachere und genauere Methode ersetzbar. Die Aktivitätsaufnahme der Schilddrüse für abgespaltenes131J lag zwischen 5,6 und 7,6% der injizierten131J-Inulindosis. Durch Vorbehandlung mit Lugolscher Lösung ließ sie sich auf 0,2% herabsetzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01770884
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  • 13
    Electronic Resource
    Electronic Resource
    Osteoporose-Diagnostik mit einem125J-Profilscanner bei renaler Osteopathie (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 767-768 
    Details
    ISSN: 1432-1440
    Keywords: Osteoprosis ; Transmission profile scanning ; Renal insufficiency ; Chronic ; Osteoporose ; Profilscanner ; chronische Niereninsuffizienz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die quantitative Bestimmung der Absorption einer125J-Strahlenquelle durch die Mittelphalanx eines Fingers soll die frühzeitige Erkennung und Verlaufskontrolle von Skeletkalksalzminderungen gestatten. Der vorläufige Normalwertbereich von 86 Probanden deckt sich mit den Angaben in der Literatur, während die Reproduzierbarkeit der Einzel- als auch der wiederholten Messungen deutlich abweicht. Die radiologische Osteoporose bei chronisch niereninsuffizienten Patienten konnte nur in 33% durch die Messung der Absorption am Finger bestätigt werden.
    Notes: Summary Quantitative transmission profile scanning of the middle phalanx of the left forefinger was performed using the method of Börneret al. Normal ranges, different for sex and age, were established by the investigation of 86 patients showing no evidence of bone disease. The evaluation of this method's reproducibility in 5 normal subjects gave the following results: S. D. at five different days 7–35% S. D. at five continuous determinations 3.5–9.0%. Of 47 patients with severe chronic renal insufficiency, 33 showed signs of osteoporosis evidenced by radiological examination. Only in 13 of them were the absorption coefficients significantly decreased. Of the 14 patients without radiological evidence of osteoporosis 7 had normal and 7 other decreased values. It is concluded that the reproducibility of the method is not sufficient for follow-up studies and that the forefinger might not be representative for bone decalcification caused by chronic renal insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468283
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  • 14
    Electronic Resource
    Electronic Resource
    Schlußwort zur vorstehenden Diskussionsbemerkung (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 556-556 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468731
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  • 15
    Electronic Resource
    Electronic Resource
    Noctural myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration (1995)
    Springer
    European archives of psychiatry and clinical neuroscience 245 (1995), S. 8-10 
    Details
    ISSN: 1433-8491
    Keywords: Nocturnal myoclonus syndrome (NMS) ; Restless-legs syndrome (RLS) ; [123I]IBZM ; SPET ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nocturnal myoclonus syndrome (NMS) consists of stereotyped, repetitive jerks of the lower limbs that occur during sleep or wakefulness. NMS is often related with restless-legs syndrome (RLS) and can cause severe sleep disturbances and daytime sleepiness. The efficacy of dopamine agonists in the treatment points to a dopaminergic dysfunction in NMS. We investigated the central dopamine D2-receptor occupancy with [123I] labeled (S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl) benzamide (IBZM) (a highly selective CNS D2 dopamine receptor ligand) ([123I]IBZM) and single photon emission tomography (SPET) in 20 patients with NMS and in 10 healthy controls. In most of the patients with NMS there was a lower [123I]IBZM binding in the striatal structures compared to controls. The results indicate that NMS is related to a decrease of central D2-receptor occupancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191538
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  • 16
    Electronic Resource
    Electronic Resource
    Clinical value of dual-isotope fat absorption test system (FATS) using glycerol [125I]trioleate and glycerol [75Se]triether (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 822-828 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to delineate the clinical value of a dual-isotope fat absorption test system (FATS) using glycerol [75Se]triether as lipid-phase marker and glycerol [125I]trioleate as the test lipid, fecal isotope ratios from single stools (and a 72-hr stool homogenate) were compared to quantitative fecal fat excretion. The study included 11 patients without and 24 patients with steatorrhea. With a figure of 0.8% as the upper limit of normal, the test was a reliable indicator of steatorrhea with 87.5% sensitivity and 81.8% specificity; efficiency was 85.7%. Related to a prevalence of steatorrhea of 45.9% as the mean value of 1269 consecutive 72-hr specimens investigated for steatorrhea during 1978–1982, the positive (negative) predictive value of the FATS is 80.3% (87.2%). With 2% as the upper limit of normal, no false positive results ensued. It is concluded that a two-step interpretation of the FATS (0.8% limit and 2% limit) may be regarded a valid qualitative index for steatorrhea. The FATS isotope ratio using single stools correlated well with FATS ratios in the 72-hr stool homogenates (r=0.97). FATS therefore allows a convenient estimate of steatorrhea from measuring single stools. As a quantitative measure of fecal fat excretion, the FATS is unreliable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296050
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  • 17
    Electronic Resource
    Electronic Resource
    Zur Funktion des Ferritins bei der Eisenresorption (1957)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 230 (1957), S. 107-124 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Nach oraler Eisenzufuhr trateine Vermehrung des Ferritins im Magenund Darmtrakt , besonders aber im Duodenum ein. Die zur selben Zeit durehgefüihrten Bestimmungen des Ferritin- und Hämosiderineisens in anderen Organen machen deutlich, daβ diese Ferritinvermehrung im Magen-Darmtrakt nieht Ausdruck eines Blockmechanismus im Sinne vonGranick sein kann. Eine Resorptionssperre scheint erst dann einzutreten, wenn eine Absättigung des Organismus mit Eisen vorliegt. Die Tatsache, daβ sowohl beim Menschen wie beim Tier im Magen, Duodenum und Dünndarm immer Ferritin nachzuweisen ist, läβt vermuten, daβ die Eisenresorption in der Mucosazelle über das Ferritin verläuft und eine Durchwanderung yon Ferro-Ionen bei geringem Eisenbedarf, wie es yonGranick angenommen wurde, nicht wahrseheinlich ist. Bei plözliehem starkem Eisenangebot kann das Ferritin eine Auffangfunktion übernehmen, die eine kontinuierliche Abgabe yon Eisen an das Transferrin gewährleistet. Bei verstärkte Eisenbedarf kann die Ferritinvermehrung Ausdruck des Bestrebens eines an Eisen verarmten Organismus sein, aus der Nahrung vermehrt Eisen aufzunehmen. Bei verstärkter Eisenaufnahme konnte eine Speicherung yon Eisen in der lamina propria bzw. dem Interstitimnder Zotten nachgewiesen werden. Es wird daraus eine Funk-tionseinheit zwischen Ferritin und Hämosiderin bei der Eisenresorption angenommen. Eine verstgrkte Eisenresorption kann aber aueh mit einer Verminderung des Ferritins im Magen- und Darmtrakt einhergehen, wenn dureh reduzierende Substanzen wie das Cystein und die Aseorbinsäure vermehrt Eisen-Ionen yore Ferritin freigesetzt werden. Es tritt dann eine Ablagernng dieser Eisen-Ionen in der Form des Hämosiderins vor allem in der Milz ein. Eine Eisenresorption dureh den Magen konnte dureh gleiehzeitig durehüefiihrte Bestimmungen des Ferritin- und Hiimosiderineisens von Magen und Leber wahrseheinlieh gemaeht werden. Bei maximaler intramuskuläir herbeigeffiührter Eisenüberladung des Organismus wird ein Teil des zugeffihrten Eisens zu Ferritin aufgebaut. Sehlieβieh wird über eine neue histoehemisehe Eisendarstellung beriehtet. Es wird gezeigt, daβ aueh die Berlinerblau-und die Turnbullblau- Reaktion in geringem Ausmaβ in der Lage sind, das Ferritineisen darzu-stellen; vollständiger gelingt es mit der besehriebenen Methode. Fräulein I.Ehret danken wir für ihre Mitarbeit bei den durehgeführten Untersuehungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258514
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  • 18
    Electronic Resource
    Electronic Resource
    Significance of gated equilibrium radionuclide ventriculography in quantification and follow up of valvular regurgitation (1988)
    Springer
    European journal of nuclear medicine 14 (1988), S. 467-471 
    Details
    ISSN: 1619-7089
    Keywords: Radionuclide ventriculography ; Aortic regurgitation ; Mitral regurgitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to evaluate the significance of gated equilibrium radionuclide ventriculography (RNV) for non invasive quantification of valvular regurgitation and follow up, various approaches were tested concerning accuracy and reproducibility. By using in vitro labeling of red blood cells and extending the acquisition time, a clear reduction of dispersion was obtained in patients without valvular insufficiency. Quantification of regurgitation directly from functional images (ventricular amplitude or stroke volume image) was clearly superior compared to the variable region of interest method. Employing functional images, reproducibility between two observers and between two independent measurements was excellent. Correlation to regurgitation values determined by cardiac catheterization was only moderate with all RNV approaches tested. RNV is limited in the absolute quantification of valvular regurgitation due to the variable overlap of right atrium and right ventricle. However, because of its high reproducibility, RNV is a non invasive technique suitable for intraindividual follow up of patients with valvular insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252390
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  • 19
    Electronic Resource
    Electronic Resource
    Scintigraphic detection of inflammatory heart disease (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 666-674 
    Details
    ISSN: 1619-7089
    Keywords: Endocarditis ; Myocarditis ; Pericarditis ; Radionuclide imaging ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammatory diseases of the heart encompass myocarditis, endocarditis and pericarditis. This paper discusses the diagnostic potential of scintigraphy in these entities. In myocarditis, indium-111 antimyosin Fab imaging can visualize active myocyte damage and thus contribute substantially to the diagnosis. Antimyosin uptake is also seen in a large subset of patients with dilated cardiomyopathy, indicating ongoing myocyte injury in these cases. In endocarditis, immunoscintigraphy using monoclonal technetium-99m-labelled antigranulocyte antibodies provides useful diagnostic information in patients with equivocal echocardiographic findings. Immunoscintigraphy seems to indicate the floridity of the inflammatory process in endocarditis and may be used to monitor antibiotic therapy. In pericarditis, the clinical value of scintigraphy has not been convincingly demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285591
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  • 20
    Electronic Resource
    Electronic Resource
    Analysis of left ventricular regional motility: A comparison of different methods (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 205-208 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Multiple gated blood pool (MUGA) and contrast ventriculographic studies were performed within 24 h in 80 patients, 20 with 120 normokinetic wall segments and 60 with wall motion abnormalities in 239 of 360 wall segments. Three methods of evaluation of the radionuclide ventriculograms were compared with the results of the biplane contrast ventriculography which served as a standard: (1) qualitative analysis of the cine mode, (2) analysis of parametric scans (amplitude and phase images) and the phase histogram obtained by Fourier analysis, (3) quantitative determination of regional ejection fraction. Normal values were obtained from 20 patients with normal wall motion in the contrast angiogram. The overall sensitivity for the detection of wall motion abnormalities of high degree was 96% for method 1, 95% for method 2, and 90% for method 3, for those of low degree 72% for method 1, 63% for method 2, and 75% for method 3. Combining methods 2 and 3 the sensitivity was increased to 99% for high grade and to 81% for low grade wall motion abnormalities. The two methods showed a complementary effect because of different sensitivities in dependence of the localization of the wall motion abnormality. Although a high efficiency for the evaluation of left ventricular function was provided by the qualitative analysis of the cine mode the combination of Fourier analysis and the determination of regional ejection fraction should be preferred. It increases the sensitivity for the detection of wall motion abnormalities. Moreover, it offers quantitative data which improve the reproducibility and decrease the observer variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00448540
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