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  • 11
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of the newly synthesized ruthenium derivative imidazolium-bis(imidazole)tetrachlororuthenate (III) [ImH(RuIm2Cl4)] was compared with that of 5′-deoxy-5-fluorouridine (5′dFUR) in autochthonous acetoxymethyl-methylnitrosamine (AMMN)-induced colorectal cancer in SD rats. Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period. ImH(RuIm2Cl4) exhibited considerable antitumoral efficacy compared with 5′dFUR (20 T/C % and 60 T/C %, respectively) against the growth of AMMN-induced colorectal adenocarcinoma in SD rats. The mortality rates with ImH(RuIm2Cl4) were dose-related, but its efficacy did not vary in all doses administered.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 61 (1956), S. 55-64 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. 49 Ratten erhielten verschiedene Gummisorten in Erbsen-, Folien- und Röhrenform subcutan und intraperitoneal implantiert. Der Gummi stammte aus schwarzen Pessaren, von transparenten Gummisaugern und von rotem Draingummi. In allen Versuchen entstanden lokale Sarkome, und zwar bei insgesamt 16 von 35 Tieren. 2. 10 Ratten wurden Scheibchen aus einem Celluloidpessar implantiert. In keinem Falle entstand eine Geschwulst.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1964), S. 125-137 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Various nitrosamines and nitrosamides cause renal tumors in the rat (Table 1), if these agents are administered in high single doses once, or only for a short time. Histologically the tumors are both epithelial and mixed tumors of the nephroblastoma type. The tumors are compared with those renal tumors reported in the literature occurring either spontaneously or induced experimentally.
    Notes: Zusammenfassung Verschiedene Nitrosamine und Nitrosamide erzeugen Nierentumoren bei der Ratte (Tabelle 1), wenn sie in hohen Einzeldosen einmalig oder nur für kurze Zeit zugeführt werden. Histologisch handelt es sich um epitheliale Geschwülste und um Mischtumoren vom Typ der Nephroblastome. Die Tumoren werden mit den in der Literatur beschriebenen spontanen und experimentell erzeugten Nierengeschwülsten verglichen.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1964), S. 291-296 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After repeated subcutaneous injection of tobacco smoke condensates in rats, 27.5% of the animals developed sarcomas locally at the site of injection after a mean induction period of 22±1 months. In a control series, in which the solvent for the smoke condensate was injected subcutaneously, no tumors developed locally. After the prolonged administration of tobacco smoke condensates orally no tumors could be induced. The cancerogenic effect of tobacco smoke condensates is strictly localized; that is, resorptive distant effects were not demonstrable.
    Notes: Zusammenfassung Nach wiederholter subcutaner Injektion von Tabakrauchkondensaten bei Ratten entwickelten 27,5% der Versuchstiere nach einer mittleren Induktionszeit von 22±1 Monaten lokal an der Injektionsstelle Sarkome. In einer Kontroll-Serie, bei der die Lösungsmittel der Rauchkondensate subcutan injiziert wurden, entstanden keine lokalen Geschwülste. Nach wiederholter oraler Zufuhr von Tabakrauchkondensaten konnten keine Tumoren erzeugt werden. Die cancerogene Wirkung von Tabakrauchkondensaten ist also streng lokaler Natur, resorptive Fernwirkungen sind nicht nachweisbar.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1964), S. 297-302 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Droplet application of urethan to the skin of C 57 black mice (single dose: 11.2 mg; total dosage: 1560 mg/animal) led chiefly (84%) to hepatic “blood cysts”, and in one animal (2%) to a squamous cell carcinoma locally at the site of application. The cutaneous droplet application of 9,10-dimethyl-1,2-benzanthracene (single dose: 0.0018 mg; total dosage: 0.0504 mg/animal) caused skin carcinomas in 9.5% of the animals. When both substances were applied together to the skin in the same dosage as above, the number of tumors induced was not increased. No “syncarcinogenesis” existed.
    Notes: Zusammenfassung Hauttropfungen bei C 57 black-Mäusen mit Urethan (Einzeldosis: 11,2 mg; Gesamtdosis: 1560 mg/Tier) führten vorwiegend (84%) zu “Blutcysten” in der Leber und bei einem tier (2%) zu einem Plattenepithelcarcinom lokal an der Applikationsstelle. Hauttropfungen mit 9,10-Dimethyl-1,2-benzanthracen (Einzeldosis: 0,0018 mg; Gesamtdosis: 0,0504 mg/Tier) ergaben in 9,5% der Fälle lokale Hautcarcinome. Wurden beide Substanzen in der gleichen Dosierung kombiniert auf die Haut aufgebracht, dann erhöhte sich die Tumorausbeute nicht. Es liegt also keine “Syncarcinogenese” vor.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1964), S. 125-137 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Various nitrosamines and nitrosamides cause renal tumors in the rat (Table 1), if these agents are administered in high single doses once, or only for a short time. Histologically the tumors are both epithelial and mixed tumors of the nephroblastoma type. The tumors are compared with those renal tumors reported in the literature occurring either spontaneously or induced experimentally.
    Notes: Zusammenfassung Verschiedene Nitrosamine und Nitrosamide erzeugen Nierentumoren bei der Ratte (Tabelle 1), wenn sie in hohen Einzeldosen einmalig oder nur für kurze Zeit zugeführt werden. Histologisch handelt es sich um epitheliale Geschwülste und um Mischtumoren vom Typ der Nephroblastome. Die Tumoren werden mit den in der Literatur beschriebenen spontanen und experimentell erzeugten Nierengeschwülsten verglichen.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1965), S. 549-551 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 16α, 17α-Epoxyoestratrienol was injected subcutaneously to rats in a total dose of 90 mg/animal. Tumors did not develop in the animals.
    Notes: Zusammenfassung 16α, 17α-Epoxyoestratrienol wurde bei Ratten in einer Gesamtdosis von 90 mg/Tier subcutan injiziert. In keinem Falle entwickelten sich bei den Versuchstieren Tumoren.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 67 (1965), S. 11-15 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After subcutaneous injections of dinitrosopiperazine weekly (10 mg/kg body weight) into mice of the DBA strain, all animals surviving long enough (receiving a total dose of 1120±140 mg/kg) developed pulmonary (alveolar cell adenomata and carcinomata) and hepatic tumors (liver cell carcinomata, hemangioendotheliomata). The organotropy of the cancerogenic action of the nitrosamines is not only dependent on the chemical structure and the mode of application of the compounds, but is also dependent on the animal species.
    Notes: Zusammenfassung Nach subcutanen Injektionen von wöchentlich 10 mg/kg Körpergewicht Dinitrosopiperazin an Mäusen des DBA-Stammes entwickelten alle lange genug überlebenden Tiere nach Aufnahme einer Gesamtdosis von 1120±140 mg/kg Lungen- und Lebertumoren. Die Organotropie der cancerogenen Wirkung bei Nitrosaminen ist nicht nur von der chemischen Struktur und der Applikationsart der Substanzen abhängig, sondern auch von der Tierart.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 67 (1965), S. 135-140 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The simultaneous oral administration of the hepatic carcinoma-inducing di-ethylnitrosamine and the auditory canal carcinoma-inducing 4-dimethyl-aminostilbene in rats did not effect the development of the auditory canal carcinoma. The development of the liver carcinoma, however, was significantly accelerated if both substances were given together in relatively high daily doses. With the reduction of the daily dose this syncarcinogenic action was not demonstrable.
    Notes: Zusammenfassung Die gleichzeitige orale Applikation des Leberkrebs erzeugenden Diäthylnitrosamins und des Gehörgangkrebs erzeugenden 4-Dimethylamino-stilbens an Ratten beeinflußte die Gehörgangskrebsentstehung nicht. Die Leberkrebsentstehung wurde signifikant beschleunigt, wenn beide Substanzen in relativ hohen Tagesdosen zusammen gegeben wurden. Diese syncarcinogene Wirkung war bei der Reduktion der Tagesdosen nicht mehr nachweisbar.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 67 (1965), S. 141-144 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After the intravenous injection of the Yoshida ascites sarcoma all inoculated rats died after 17±3 days with tumors that were localized primarily in the adrenals, lungs and lymphatics. Growing liver metastases appeared only extremely seldom. The growth of the metastases in the liver was not enhanced by treating the recipient animal with the liver poison, diethylnitrosamine. Bodily stress or immobilization of the inoculated rats failed to change the localization or frequency of the metastases.
    Notes: Zusammenfassung Nach intravenöser Injektion des Yoshida-Ascites-Sarkoms starben alle geimpften Ratten nach 17±3 Tagen mit Tumoren, die hauptsächlich in den Nebennieren, Lungen und im Lymphsystem lokalisiert waren, während wachsende Lebermetastasen nur extrem selten auftraten. Durch Behandlung der Empfängertiere mit dem Lebergift Diäthylnitrosamin konnte das Metastasenwachstum in der Leber nicht gesteigert werden. Körperliche Belastung oder Ruhigstellung der geimpften Ratten änderten die Metastasenlokalisation und-frequenz nicht.
    Type of Medium: Electronic Resource
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