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  • 11
    Electronic Resource
    Electronic Resource
    MR imaging enhancement with superparamagnetic iron oxidein chronic liver disease: influence of liver dysfunction andparenchymal pathology (1996)
    Springer
    Abdominal imaging 21 (1996), S. 318-323 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Superparamagnetic iron oxide—MR imaging, contrast agent—Liver cirrhosis, hepatocellular carcinoma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Purpose: To analyze the influence of liver dysfunction and parenchymal pathology on the accumulation of superparamagnetic iron oxide (SPIO). Methods: We evaluated MR images of 13 patients having small hepatic neoplasms before and after administration of SPIO (10 μmol/kg). Biopsy and laboratory data confirmed the presence of severe cirrhosis in two patients, mild cirrhosis in four, chronic hepatitis in five, and normal livers in two. Degrees of liver dysfunction or liver parenchymal pathology were correlated with reductions in signal intensity of the liver and spleen after administration of SPIO. Signal intensity reduction was evaluated using a 1.5 Tesla MR unit. Results: Response to SPIO of the liver and spleen did not correlate with liver parenchymal pathology, although reductions in signal intensity of the liver were somewhat small in severely cirrhotic livers. There were slight correlations between signal intensity alterations of the liver and laboratory data such as the indocyanine green retention rate (correlation coefficient 0.47), albumin (0.36), total bilirubin (0.36), and serum glutamic oxaloacetic transaminase (GOT) (0.46). Signal intensity reduction of spleen did not correlate with liver function tests except for serum GOT. In patients with cirrhosis, heterogeneous structures were detected in the nontumorous portions of the liver. However, these did not prevent the diagnosis of small hepatomas. Conclusion: The uptake of SPIO showed some correlation with liver function but not with chronic liver parenchymal pathology. SPIO provided sufficient contrast between tumor and surrounding liver parenchyma among patients with chronic liver disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900072
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  • 12
    Electronic Resource
    Electronic Resource
    Multilocular cystic renal cell carcinoma presenting as a solid mass: radiologic evaluation (1995)
    Springer
    Abdominal imaging 20 (1995), S. 164-168 
    Details
    ISSN: 1432-0509
    Keywords: Cystic renal cell carcinoma ; Cystic neoplasm ; CT ; Ultrasound ; MR imaging ; Angiography ; Small renal cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Multilocular cystic renal cell carcinomas (MCRCCs) are a recently described variety of renal cell carcinoma with characteristic pathological and clinical features. We found that the radiologic appearances of MCRCCs of smaller size did not fulfill the previously documented criteria of the MCRCCs. This study was conducted to analyze the radiologic characteristics of MCRCCs of smaller sizes. Methods: The radiologic findings of 13 multilocular cystic renal cell carcinomas of diameter ranging from 10–32 mm (average 22 mm) seen in nine patients were analyzed in correlation with pathologic findings. Results: On US, the tumors were predominantly hyperechoic (11 of 13 tumors) with or without small anechoic areas. Precontrast CT showed the lesions to be either hypodense or hyperdense depending on the presence of hemorrhage. Degree of contrast enhancement was usually slight. The mean increase in CT attenuation was 28 ±19 (mean±standard deviation) at dynamic phase and 12±10 at delayed phase. On MR imaging, signal intensities of the tumors were high both on T1- and T2-weighted images (7 of 9 tumors) due to proteinaceous fluid or hemorrhage. Dynamic enhanced MR imaging revealed irregular contrast enhancement within the tumor (5 of 6 tumors). Angiography failed to reveal neovascularity. Conclusion: Although multiple cysts were seen within the tumors pathologically, MCRCCs of smaller sizes appeared solid on radiologic examinations. However, contrast enhancement or neovascularity was very slight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201530
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  • 13
    Electronic Resource
    Electronic Resource
    Struma ovarii: MR appearances (1997)
    Springer
    Abdominal imaging 22 (1997), S. 100 -102 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Ovaries—Neoplasms—Struma ovarii—MR imaging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: Analysis of unenhanced and contrast-enhanced magnetic resonance (MR) images of struma ovarii, a rare benign neoplasm of the ovary, is the aim of this study. Methods: T2-weighted and Gd-DTPA-enhanced T1-weighted MR images of five histologically proven struma ovarii were evaluated retrospectively. Results: In all patients, unenhanced and contrast-enhanced T1-weighted MR images showed complex cystic masses composed of multiple cysts and a solid component, indicating the presence of large and small thyroid follicles. In four patients, the cyst fluid was hypointense on T1-weighted images and hyperintense on T2-weighted images. In one patient, the fluid was hyperintense on T1-weighted images and hypointense on T2-weighted images due to hemorrhage. Conclusion: A complex mass composed of multiple cysts and a solid component, indicating the presence of large and small thyroid follicles, appeared to be a characteristic MR finding of struma ovarii.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900150
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  • 14
    Electronic Resource
    Electronic Resource
    Clinical evaluation of gastric fundic gland polyps without familial polyposis coli (1995)
    Springer
    Abdominal imaging 20 (1995), S. 101-105 
    Details
    ISSN: 1432-0509
    Keywords: Stomach, polyposis ; Stomach, fundic gland polyp ; Stomach, cystic hamartomatous polyp ; X-ray examination, endoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Assessments were made of 63 cases of fundic gland polyposis (FGP) unassociated with adenomatosis coli. These cases were evaluated by radiological examination over 2 years follow-up. All polyps were pathologically confirmed by endoscopic biopsies. Methods: Most cases were asymptomatic when diagnosed during mass radiological surveys of the upper gastrointestinal tract. The majority of patients ranged in age from 40–60 years, and the polyps numbered fewer than 20 in 55 cases (87.3%). Polyps were detected in the fundic glands using the congo red test and by biopsies. Results: All serum gastrin values were within the normal range. During the course of this study, the polyps of 13 cases (20.6%) increased and those of three cases (4.8%) decreased or resolved completely. Conclusion: From these findings it is considered that FGP are observed in stomachs with less atrophy, and that polyps follow courses in which they increase, decrease, disappear, along with atrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201512
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  • 15
    Electronic Resource
    Electronic Resource
    Different expression of calreticulin and immunoglobulin binding protein in Alzheimer’s disease brain (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 153-160 
    Details
    ISSN: 1432-0533
    Keywords: Key words Calreticulin ; Immunoglobulin binding protein ; Immunohistochemistry/in situ hybridization ; Reverse transcription-polymerase chain reaction ; Alzheimer’s disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both calreticulin (CRT) and immunoglobulin binding protein (Bip) have a role in the folding and assembly of oligomeric membrane proteins in the endoplasmic reticulum (ER). Recent studies have demonstrated the generation of β-amyloid protein (Aβ) 1–42, a key peptide for amyloid deposits, in the ER. We, therefore, examined the localization and expression of CRT, Bip and their mRNA by immunohistochemistry, Western blot, in situ hybridization and semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in both neurologically normal and Alzheimer’s disease (AD) brains. Two polyclonal anti-CRT antibodies gave similar positive staining of CRT in neurons and glia. In neuronal cells, the cytoplasm, nucleoli and their processes were positive for CRT. In glial cells, perinuclear staining was frequently seen and the processes of some glial cells were also stained. In AD, these antibodies stained clearly damaged neurons but the number and the intensity of positive cells were decreased compared to controls. Processes of microglial cells were markedly positive in the AD white matter. Western blots using an anti-CRT antibody showed significantly lower immunoreactive bands in AD than control brains. By in situ hybridization, the number of neurons which express the CRT mRNA was less in AD than in controls. Using RT-PCR, the relative levels of the CRT mRNA in AD brains were also found to be significantly lower than those in controls. On the other hand, the number of Bip-positive cell, the production of Bip and the expression of mRNA for Bip did not differ between control and AD brains. These results suggest that CRT may be a multifunctional protein in human brain, and that the weak expression of CRT and the positive staining of microglial processes in AD brain may be part of the pathological processes in AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004019900165
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  • 16
    Electronic Resource
    Electronic Resource
    A case of cerebral composite ganglioneuroblastoma: an immunohistochemical and ultrastructural study (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 98-102 
    Details
    ISSN: 1432-0533
    Keywords: Composite ganglioneuroblastoma ; Electron microscopy ; Cerebrum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual cerebral tumor is reported in a 14-year-old boy. On light and electron microscopy, the constituent cells were very complex; the majority of the neoplastic cells were primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma. Neoplastic neuronal cells and hypertrophic astrocytes were also observed in these areas. The neuronal cells showed a continuous spectrum of differentiation from very primitive to mature ganglion cells. Furthermore, the tumor contained a highly cellular discrete area consisting of neuroblasts and their precursor cells. From these findings, a diagnosis of composite ganglioneuroblastoma was made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294230
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  • 17
    Electronic Resource
    Electronic Resource
    Angiomyolipoma of the liver: significance of CT and MR dynamic study (1998)
    Springer
    Abdominal imaging 23 (1998), S. 520-526 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Angiomyolipoma—Liver, US, CT, MRI, angiography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angiomyolipoma is a benign mesenchymal tumor that has been reported frequently in the kidney but rarely in the liver. In the present study, we present four cases of hepatic angiomyolipoma with different radiologic appearances, discuss differential diagnosis, and review previously reported cases. One of our cases was followed for 8 years. Computed tomography (plain, enhanced, and dynamic study), magnetic resonance imaging (T1-weighted spin echo, T2-weighted spin echo, and dynamic study), ultrasonography, and angiography were performed in all cases. Although different radiologic appearances were observed in the tumors, based on different proportions of fat, blood vessels, and muscle, three cases were diagnosed as angiomyolipoma. In one case, it was quite difficult to make radiologic diagnosis; hepatocellular carcinoma with fatty metamorphosis in part was most likely suspected, but histopathological examination revealed angiomyolipoma with few fat elements. In the present study, early and prolonged enhancement of the lesion with the special pattern of time density/intensity curve was significant for angiomyolipoma, and we suggest that preoperative radiologic diagnosis of the lesion is possible in most of the cases. However, it can be quite difficult to distinguish angiomyolipoma from some hepatocellular carcinomas with fatty metamorphosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900391
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  • 18
    Electronic Resource
    Electronic Resource
    CT differentiation between necrotic and nonnecrotic small bowel in closed loop and strangulating obstruction (1999)
    Springer
    Abdominal imaging 24 (1999), S. 120-124 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Small bowel—Closed loop—Strangulating obstruction—Intestinal necrosis—Computed tomography—Multivariate analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The purpose of this study was to evaluate computed tomographic (CT) findings for predicting the presence of intestinal necrosis in patients with closed loop and strangulating obstruction of the small bowel. Methods: Twenty-five patients with surgically confirmed closed loop and strangulating obstruction were divided into two groups with (n= 16) and without (n= 9) intestinal necrosis. By using univariate and multivariate statistical procedures, we evaluated the differences in CT findings between the two groups on the basis of the following six findings: bowel dilatation of strangulated loops (bowel dilatation), wall thickening of strangulated intestines (wall thickening), ascites, vascular dilatation of affected mesenteries (vascular dilatation), elevation of mesenteric attenuation (mesenteric attenuation), and radial distribution of the mesenteric vessels (radial distribution). Results: Of the six findings, ascites, vascular dilatation, mesenteric attenuation, and radial distribution provided significant discriminating findings between the two groups on univariate analysis. On multivariate analysis, mesenteric attenuation was the most important discriminative factor, followed by radial distribution and ascites. Using these three parameters, the CT was correlated with the surgical findings in 15 of the 16 patients in the necrosis group (sensitivity = 93.8%) and in eight of the nine patients in the nonnecrosis group (specificity = 88.9%). The overall accuracy was 92.0%. Conclusions: Mesenteric attenuation, radial distribution, and ascites, depicted on CT differentiate well between necrosis and nonnecrosis of the small bowelin patients with closed loop and strangulating obstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900458
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  • 19
    Electronic Resource
    Electronic Resource
    Synergistic effect of rabbit specific antiserum and amikacin on the treatment of mice with lethal infection due toKlebsiella pneumoniae (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 956-957 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A combination of rabbit specific antiserum and amikacin showed a synergistic effect on the treatment of mice with lethal infections due to a strain ofKlebsiella pneumoniae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971775
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  • 20
    Electronic Resource
    Electronic Resource
    Simulation study of phytoplankton photosynthesis and growth in the Fraser River estuary (1973)
    Springer
    Marine biology 19 (1973), S. 102-116 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phytoplankton photosynthesis was estimated by a simulation model of the Fraser River estuary (Canada). For this estimation, two kinds of information were considered; (1) the photosynthetic response of phytoplankton taken from the estuary to each environmental factor; (2) actual measurement of changes in each environmental factor in the estuary. As the major limiting factors, light intensity, temperature, and nitrate were taken into account. Variations in these parameters were combined together under the assumption of the “law of the minimum”; that is, only one of the environmental factors was considered to limit photosynthesis at any given time and place. From the results obtained, it could be shown which environmental factors actually limited phytoplankton photosynthesis in the Fraser River estuary at different times of the year and at different depths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00353581
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