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  • 1
    Electronic Resource
    Electronic Resource
    Hydroxy1 driven reconstruction of the polar NiO(111) surface
    Amsterdam : Elsevier
    Surface Science 315 (1994), S. L977-L982 
    Details
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-6028(94)90529-0
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  • 2
    Electronic Resource
    Electronic Resource
    Tierexperimentelle hypothalamische Fettsucht und Magersucht (1962)
    Springer
    Journal of neural transmission 24 (1962), S. 541-544 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Bilateral destruction within the area of the ventromedial hypothalamic nucleus, without injuring the lateral part of the nucleus, led in rats, checked against control animals, to an increased consumption of food with a strong increase in body weight. Bilateral destruction within the area of the lateral hypothalamus resulted in a stoppage of food consumption with a considerable loss of weight and finally, in the course of 16 days, in exit. By unilateral irritation in the dorsal lateral hypothalamus food consumption could be restored. This was possible, however, only when the points of the electrodes were localized in the strictly limited area in which the fibers of the Fasciculus medialis telencephali pass into the Nucleus lateralis hypothalami. Presumably, this releases way-making impulses which activate the reflexes directing food consumption.
    Abstract: Résumé La destruction bilatérale au dedans de l'aire du noyau hypothalamique ventromédial — sans destruction de la partie latérale du noyau — a mené, dans des rats comparés avec des animaux de contrôle, à une consommation augmentée de nourriture avec une forte augmentation du poids du corps. La destruction bilatérale au dedans de l'aire de l'hypothalamus latéral a causé une inhibition de la consommation de nourriture avec une perte considérable de poids et, en fin, au cours de 16 jours, à la mort. Moyennant l'irritation unilatérale dans l'hypothalamus latéral dorsal les animaux pouvaient être provoqués à reprendre la consommation de nourriture. C'était possible, pourtant, seulement quand les pointes des électrodes étaient localisées dans l'aire strictement limitée où les fibres du Fasciculus medialis telencephali passent au Nucleus lateralis hypothalami. Présumablement, cela déclenche des impulsions frayantes qui activent les reflexes-dirigeant la consommation de nourriture.
    Notes: Zusammenfassung Die bilaterale Zerstörung im Bereich des ventromedialen Hypothalamuskerns — ohne Beschädigung des lateralen Kernanteils — führte bei Ratten gegenüber Kontrolltieren zu einer gesteigerten Nahrungsaufnahme mit starker Zunahme des Körpergewichtes. Beidseitige Zerstörung im Bereich des lateralen Hypothalamus hatte ein Sistieren der Nahrungsaufnahme mit starkem Gewichtsverlust und schließlich im Verlauf von 16 Tagen den Exitus zur Folge. Durch elektrische Reizung im dorsalen lateralen Hypothalamus konnte bei einseitiger Reizung eine Futteraufnahme erzielt werden. Dies aber nur, wenn die Elektrodenspitzen in dem eng begrenzten Gebiet lokalisiert waren, in welchem die Fasern des Fasciculus medialis telencephali in den Nucleus lateralis hypothalami übergehen. Vermutlich werden dadurch bahnende Impulse ausgelöst, durch welche eine Aktivierung der die Nahrungsaufnahme steuernden Reflexe stattfindet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01233020
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  • 3
    Electronic Resource
    Electronic Resource
    Ca++-, Hypothermie- und pH-Effekte auf den mechanischen Systolenbeginn des isolierten Herzens (1966)
    Springer
    Naturwissenschaften 53 (1966), S. 585-586 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600540
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of respiratory acidosis on heart and circulation in cats, pigs, dogs and rabbits (1972)
    Springer
    Research in experimental medicine 158 (1972), S. 308-320 
    Details
    ISSN: 1433-8580
    Keywords: Respiratory Acidosis ; Cardiovascular Effects ; Sympathomimetic Amines ; Species Differences ; Respiratorische Acidose ; Kreislauf ; Sympathomimetica ; Speciesunterschiede
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Katzen, Hunden, Kaninchen und Hausschweinen wurden in Pentobarbitalnarkose nach Muskelrelaxation mit Alloferin® bei geschlossenem Thorax die Auswirkungen einer akuten respiratorischen Acidose auf den Kreislauf sowie dessen Reaktion auf Pharmaka untersucht. 1. BeiKatzen undSchweinen steigen in respiratorischer Acidose Herzfrequenz, dp/dtmax und Blutdruck an; beiKaninchen bleiben dp/dtmax und Blutdruck nahezu unverändert. BeiHunden hingegen sinken Schlagfrequenz, dp/dtmax und Blutdruck in Acidose ab. Untersuchungen an Katzen, die mit Reserpin vorbehandelt waren, zeigten, daß eine respiratorische Acidose einen negativ inotropen und blutdrucksenkenden Eigeneffekt besitzt. Nach Vorbehandlung mit Phenoxybenzamin verursacht eine respiratorische Acidose bei Katzen einen Blutdruckabfall sowie einen Anstieg von dp/dtmax. Nach Vorbehandlung mit Pindolol verursacht eine Acidose eine Abnahme von Frequenz und dp/dtmax, während der Blutdruck konstant bleibt. Am unvorbehandelten Tier wird der negativ inotrope Effekt einer Acidose offenbar durch eine Stimulierung des sympathischen Nervensystems überdeckt, die bei Katzen und Schweinen am ausgeprägtesten ist. 2. DieWirkung sympathomimetischer Amine auf Herz und Kreislauf ist bei allen 4 untersuchten Tierarten in Acidose abgeschwächt, wobei die Abschwächung bei den Tieren mit der stärksten sympathischen Stimulation am ausgeprägtesten ist. 3. Biochemische Untersuchungen an Hunden und Katzen ergaben, daß in Acidose K+, Mg2+, anorganisches Phosphat und Glucose im Serum ansteigen, während der Magnesiumgehalt des Herzmuskels abnimmt.
    Notes: Summary In closed chest cats, dogs, rabbits and pigs, anaesthetized with pentobarbital and relaxed with diallylnortoxiferinium dichloride the effects of a respiratory acidosis on heart and circulation as well as their reaction to sympathomimetic amines were studied. 1. Incats andpigs a respiratory acidosis causes a rise of frequency, dp/dtmax of the left ventricle and systolic blood-pressure. Inrabbits an acidosis causes no significant alteration of blood-pressure and dp/dtmax. Indogs frequency, dp/dtmax and blood-pressure decline in acidosis. In cats pretreated withreserpine a respiratory acidosis causes a negative inotropic effect and a declining of blood-pressure. After pretreating cats withphenoxybenzamine in acidosis there results a decrease of blood-pressure, but a rise of dp/dtmax and frequency; after pretreating withpindolol in acidosis dp/dtmax and frequency decline, but blood-pressure remains unaltered. 2. The effectiveness of sympathomimetic amines on heart and circulation is diminished in acidosis. This diminution is most significant in those animals (cat, pig) with the most augmented sympathetic tonus in acidosis, but experiments performed with reserpinized cats indicated that the augmented sympathetic tonus can not be the only cause for the diminished efficiency of adrenergic stimulant amines in acidosis. 3. Biochemical studies performed in acidosis showed a rise of K+, Mg2+, inorganic phosphate and glucose in serum and a decrease of Mg2+ in the heart muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852214
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Frage der Beziehungen zwischen enddiastolischem Ventrikeldruck unddp/dt bzw.d 2 p/dt 2 der Ventrikeldruckkurve des Herzens (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 261-262 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Correlations between left ventricular enddiastolic pressure of the heart and first and second derivation of left ventricular pressure curve (dp/dt, d 2 p/dt 2 respectively) were examined at various hemodynamic conditions. The results showed only a particular dependence ofdp/dt andd 2 p/dt 2 from enddiastolic pressure. Therefore, it is concluded, that enddiastolic pressure is not the most important factor, which influences the dynamics of ventricular contraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02034380
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  • 6
    Electronic Resource
    Electronic Resource
    Differences in acetylcholine- and bradykinin-induced vasorelaxation of the mesenteric vascular bed in spontaneously hypertensive rats of different ages (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 38-43 
    Details
    ISSN: 1432-1912
    Keywords: Key words SHR ; Endothelium-dependent relaxation ; Rat mesenteric vascular bed ; Rat thoracic aorta ; Bradykinin Acetylcholine ; Age dependency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study examined whether alterations of endothelium-dependent vasorelaxation in spontaneously hypertensive rats (SHR) in response to the endothelium-dependent vasodilators acetylcholine and bradykinin ran parallel. We tried to find out the age at which endothelium-dependent vasorelaxation in response to each agonist became impaired and compared three different groups of SHR aged 7, 21 and 51 weeks. To be able to separate hypertension-induced alterations from age-dependent changes age-matched normotensive Wistar rats were included. Endothelium-dependent vasorelaxation was studied in the mesenteric vascular bed precontracted with noradrenaline, a typical resistance vessel, which showed relaxation to both acetylcholine and bradykinin, and the precontracted thoracic aorta, which only responded to acetylcholine. There were major differences in the agonist-dependent vasorelaxation between bradykinin and acetylcholine in SHR as a function of age. A surprising finding was that acetylcholine-induced relaxation was preserved, even slightly improved not only in young SHR (7 weeks) with developing hypertension but also in adult SHR (21 weeks) with established hypertension, which can be interpreted as a compensatory mechanism. As expected, in old SHR (51 weeks) acetylcholine-induced vasorelaxation was impaired as a consequence of the detrimental effects of long-term hypertension on endothelium. The parallel changes observed with acetylcholine in the mesenteric vascular bed and thoracic aorta provided mutual confirmation. In clear contrast to acetylcholine bradykinin-induced vasorelaxation was already impaired in young SHR with developing hypertension suggesting that bradykinin-induced vasorelaxation is either much more sensitive to detrimental effects of (even slightly) increased blood pressure or, more likely, that there is a basic deficiency in the action of bradykinin in SHR. Thus, our study allows to conclude that impairment of acetylcholine-induced endothelium-dependent vasorelaxation in the mesenteric vascular bed of SHR is a secondary phenomenon developing as a consequence of long-term hypertension while the impaired bradykinin-induced vasorelaxation seems to be a primary phenomenon that could be closely related to the development of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168704
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  • 7
    Electronic Resource
    Electronic Resource
    Die Abhängigkeit vondv/dt unddp/dt des Ventrikeldruckes des Herzens von physikalischen Resultaten der Systole (1969)
    Springer
    Pflügers Archiv 306 (1969), S. 290-303 
    Details
    ISSN: 1432-2013
    Keywords: dv/dt of Ventricular Pressure Curve of the Heart ; dp/dt of Ventricular Pressure Curve ; Performance of the Heart ; Metabolic Alcalosis ; Pressure Load ; Increased Preload ; dv/dt der Ventrikeldruckkurve des Herzens ; dp/dt der Ventrikeldruckkurve ; Herzarbeit ; Herzleistung ; metabolische Alkalose ; Druckarbeit ; Füllungsdruckerhöhung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden Untersuchungen am isolierten Katzenherzen mit der Fragestellung durchgeführt, obdp/dt max unddv/dt max der Druckkurve des linken Ventrikels mit Parameters korrelieren, die sich nicht primär aus der Druckkurve ergeben. Besonders interessierten dabei mögliche Beziehungen zu Arbeit und Leistung des linken Ventrikels. Durch metabolische Alkalose (pH 7,8) erhöhte Druckbelastung und Füllungsdruckerhöhung wurden Dynamik und somit physikalisches Resultat der Systole verändert. Ohne Berücksichtigung dieser unterschiedlichen Versuchsbedingungen ergab sich für jeden Versuch eine gesicherte Korrelation zwischendv/dt max und Arbeit bzw. Leistung des linken Ventrikels. Dagegen ließen sich solche Korrelationen zum Schlag-bzw. Herzzeitvolumen und zur Beschleunigungsarbeit nicht nachweisen. Werden die entsprechenden Korrelationen für die genannten Versuchsbedingungen getrennt untersucht, so besteht teilweise eine Beziehung zwischendv/dt max und Schlag-, Herzzeitvolumen bzw. Beschleunigungsarbeit. dp/dt max hängt in ähnlicher Weise von Arbeit und Leistung des linken Ventrikels ab, es ergaben sich jedoch teilweise kleinere Korrelationskoeffizienten. Aus den Ergebnissen läßt sich eine Proportionalität zwischendv/dt max als wesentlichem dynamischen Parameter der Druckarbeit des Ventrikels und dem physikalischen Resultat seiner Systole ableiten.
    Notes: Summary Experiments were performed at isolated cat hearts to examine correlations betweendp/dt max ordv/dt max of the ventricular pressure curve and stroke volume, cardiac index, 1/2 mv2 and performance of the left ventricle. By metabolic alcalosis, pressure load and increased preload the dynamics of ventricular contraction and its physical result were varied. Each heart showed an exact correlation betweendv/dt max and the physical work of the left chamber per systole, respectively performance. Controversely, there could not be found correlations betweendv/dt max and stroke volume, cardiac index and 1/2 mv2. By separate examination of these correlations at metabolic alcalosis, pressure load or increased preload, there exists a particular dependence ofdv/dt max from these parameters. However, the dependence ofdv/dt max from left ventricular work per systole is unchanged. Similar correlations were found betweendp/dt max and the left ventricular work per systole. It is concluded that there exists a proportionality betweendv/dt max as the most important derivation of the ventricular pressure curve and the physical result of ventricular contraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589155
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  • 8
    Electronic Resource
    Electronic Resource
    Metabolism of digitoxin in man and its modification by spironolactone (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 345-354 
    Details
    ISSN: 1432-1041
    Keywords: 3H-digitoxin ; metabolism ; spironolactone ; enzyme induction ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of spironolactone on the metabolism of intravenously administered3H-digitoxin (80 µCi) was investigated in eight patients. In three of them the labelled glycoside was given on a second occasion after spironolactone treatment had been discontinued for at least 65 days. Of total urinary radioactivity 79 % was unaltered drug and 12 % consisted of water soluble compounds. No digitoxigenin or digoxigenin and only trace amounts (〈2 %) of digoxin and the bis- and monoglycosides of digoxigenin were found. After spironolactone total urinary radioactivity was unchanged but the fraction eliminated as unchanged digitoxin fell from 79 to 66 % and the water soluble compounds increased from 12 to 26 % (p〈0.05). In addition spironolactone caused a 20 % reduction in the half-life of serum radioactivity (p〈0.01) and a 16 % reduction in the volume of distribution (p〈0.05). Induction of hepatic enzymes by spironolactone is proposed to explain the alteration in the metabolism of digitoxin in man. Both the altered metabolic pattern and the reduction in the volume of distribution appear to contribute to the reduction in half-life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606547
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  • 9
    Electronic Resource
    Electronic Resource
    Analyse von Globulinen mit der Gelfiltration (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 528-532 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary By means of gel filtration technique plasma proteins can be fractionated according to their molecular weight. By this procedure disorders of plasma proteins (macroglobulinaemia, plasmocytome etc.) can simply and quickly be differentiated. The development and application of this method is reported.
    Notes: Zusammenfassung Durch Anwendung der Gelfiltrationstechnik lassen sich die Serumeiweißkörper einfach nach ihren Molekulargewichten sortieren und die Diagnose von Störungen der Serumeiweißzusammensetzung einfach und rasch im Hinblick auf Makroglobulinämien sowie Plasmocytomkrankheiten usw. differenzieren. Es wird über die Entwicklung und Anwendung der Technik berichtet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485114
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  • 10
    Electronic Resource
    Electronic Resource
    Elektrische Registrierung der Druckanstiegsbeschleunigung und ihre Beziehung zur isometrischen Kontraktion des linken Herzventrikels (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 1005-1006 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The first derivative of the pressure of the ventricle may be regarded as reflecting the contractility of the myocardium. The results reported here show that the second derivative of the pressure curve of the left ventricle offers further analysis of the dynamics of the contraction and may be indicative of the mechanical performance of the heart.
    Notes: Zusammenfassung Aus der zweimaligen Differentiation der Ventrikeldruckkurve nach der Zeit ergibt sich die Druckanstiegsbeschleunigung. Dieser Parameter wurde mittels RC-Glieder bei der Kontraktion des linken Ventrikels der Katze registriert. Sein Maximum lag in der Phase der isometrischen Kontraktion. Die maximale Druckanstiegsbeschleunigung nahm bei Erhöhung der isometrischen Kontraktion stärker zu als die maximale Druckanstiegsgeschwindigkeit. Es wird gefolgert, daß zwischen der Kraft der isometrischen Kontraktion und der maximalen Druckanstiegsbeschleunigung eine Proportionalität besteht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746134
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