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  • 1970-1974  (2,138)
  • Analytical Chemistry and Spectroscopy  (2,128)
  • Biochemistry
  • 1
    Electronic Resource
    Electronic Resource
    Neuropathological and biochemical studies in Fabry's disease (1974)
    Springer
    Acta neuropathologica 30 (1974), S. 345-354 
    Details
    ISSN: 1432-0533
    Keywords: Fabry's Disease ; Autopsy ; Histochemistry ; Biochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pathological and biochemical studies were performed on a patient with Fabry's disease. Abnormal deposits in the nervous system were restricted mainly to neurons of the autonomic nervous system. Affected neurons were found in the supraoptic and paraventricular nuclei, the midline nucleus, substriatal grey, nucleus amygdalae, presubiculum of hippocampus, fifth and sixth cortical layers of the parahippocampus and inferior temporal gyrus, dorsal motor nucleus of the vagus, superior and inferior salivatory nuclei, Edinger-Westphal nucleus, reticular formation of the pons and medulla oblongata, trigeminal ganglia, non-pigmented cells of the substantia nigra, intermediolateral column, spinal dorsal root ganglia, sympathetic ganglia and the submucous and myenteric plexuses. Abnormal deposits were found also in the periventricular glial cells, perineurium, the endothelial and smooth muscle cells of blood vessels throughout the body, the heart, kidneys and reticuloendothelial cells of many organs. The histogram of the sural nerve showed a decrease in the smaller myelinated and unmyelinated fibers. The abnormal deposits were glycolipids, CTH and CDH. Although there were two distinct staining characteristics of the deposited material with Luxol fast blue and PAS in paraffin section, these differently stained deposits could not be differentiated by histochemical and biochemical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697017
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  • 2
    Electronic Resource
    Electronic Resource
    Pierre Robin Syndrome (1974)
    Springer
    Acta neuropathologica 30 (1974), S. 91-107 
    Details
    ISSN: 1432-0533
    Keywords: Pierre Robin Syndrome ; Neuropathology ; Biochemistry ; Undernutrition ; Cerebral Hypoxia ; Cerebral Development ; Mental Retardation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical, light and electron-microscopic, and biochemical observations are presented in an 11 years old boy with Pierre Robin Syndrome; micrognathia, cleft palate and glossoptosis. Respiratory distress and feeding difficulties were early and serious complications of the glossoptosis. “Cachexia”, a striking physical underdevelopment, profound psychomotor retardation and epilepsy constituted the prominent clinical features. The neuropathology of the syndrome was characterized by the following: 1. Arrest in cerebral growth and maturation; 2. Mild diffuse and laminar cortical neuronal losses and astrocytic fibrosis; and 3. Minor histogenetic anomaly in the cerebellar cortex. The arrest in cerebral development was reflected grossly by microencephaly and, histologically by “immaturity” of numerous cortical neurons, poverty of intracortical fibrillary plexuses, poor establishment of cytoarchitectonic characteristics and hypoplasia of hemispheric white matter. At subcellular level, there was diminution of cytoplasmic organelles, particularly the rough endoplasmic reticulum. A marked deficiency in myelin lipids and severe diminution of total ganglioside concentration in the cerebral cortex were the major biochemical findings. In the pathogenesis of cerebral alterations congenital factors and the complications of “glossoptosis” were considered. It was suggested that the early undernutrition played an important role in the impediment of cerebral growth and maturation. The cerebral hypoxic insults further curtailed the development of already compromised neurons and depressed their functional activities, particularly in the more susceptible cerebral cortex. It was proposed that the arrested brain development provided a substantial structural basis for the psychomotor retardation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685436
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  • 3
    Electronic Resource
    Electronic Resource
    Juvenile GM2-Gangliosidose mit veränderter Substratspezifität der Hexosaminidase A (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 225-232 
    Details
    ISSN: 1432-0533
    Keywords: GM2 Gangliosidosis ; Juvenile Type ; Biochemistry ; Hexosaminidase A ; Altered Substrate Specifity ; Galactosaminidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The N-acetyl-β-d-hexosaminidases A and B were extracted from the liver tissue of a patient who died from juvenile GM2-gangliosidosis at the age of $$14{1 \mathord{\left/ {\vphantom {1 2}} \right. \kern-\nulldelimiterspace} 2}$$ years. The enzymes were separated from each other and studied in comparison to enzyme preparations from normal tissue. The kinetic parameters studied (pH profiles, Michaelis constants, heat lability) and the substrate specificity of the B-enzyme appeared normal. The activity of the A-enzyme against two artificial substrates was lowered in the pathological tissue to 53% and 41% of the control and to 27% of the control against the storage compound trihexosylceramide (ceramide-glucose-galactose-N-acetylgalactosamine). Furthermore, using the main storage compound ganglioside GM2 (ceramide-glucose-galactose-[N-acetylneuraminic acid]-N-acetylgalactosamine) as substrate, no N-acetyl-β-d-galactosaminidase activity was found in the extracts from pathological liver tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687632
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  • 4
    Electronic Resource
    Electronic Resource
    Estimations histophotométriques et dosages biochimiques des orthophosphorique-monoester-phosphohydrolases acides du système hypothalamo-neurohypophysaire du rat soumis à une épreuve de déshydratation (1974)
    Springer
    Experimental brain research 19 (1974), S. 314-325 
    Details
    ISSN: 1432-1106
    Keywords: Hypothalamo-neurohypophyseal system ; Dehydration ; Acid phosphatases ; Biochemistry ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activities of acid orthophosphoric-monoester-phosphohydrolases in the supra-opticus nucleus and the neurohypophysis of the rat were measured at pH 4.1 and 5.3 by biochemical assay and by histospectrophotometric method after a thirsting period of 1–12 days. For the neurohypophysis the biochemical and histophotometrical results are convergent. These enzymatic activities increase during the entire experimental period but if the biochemical results are expressed for 100 μg of proteins the elevation is only significant at pH 4.1. For the supra-optic nucleus, changes in enzymatic activities are different by histophotometric and biochemical methods. It is assumed that in the rat hypothalamo-neurohypophyseal system the acid phosphatases are distributed between two separate pools: (1) one strongly bound to cytoplasmic membrane structures, particulary abundant in the perikarya of the supra-optic nucleus, and (2) another pool of “free” or easily discharged enzyme, the major component in the neurohypophysis; our biochemical assay measures only this “free pool”. The role of these pools in the synthesis and release of vasopressin is presumably different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233237
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Enzyminduktion in der Leber nach oraler Lindanapplikation (1974)
    Springer
    Archives of toxicology 32 (1974), S. 115-130 
    Details
    ISSN: 1432-0738
    Keywords: Enzyme Induction ; Lindane ; Functional Tests ; Biochemistry ; Morphology ; Enzyminduktion ; Lindan ; Funktionelle Tests ; Biochemie ; Morphologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach kurzzeitiger oraler Lindanapplikation (5 mg/kg, 20 mg/kg) wurden an männlichen Ratten verschiedene funktionelle, biochemische, histochemische und elektronenmikroskopische Untersuchungen angestellt. Dabei wurde keine Beeinflussung der Motilität und Exploration (open field-Test), der Lebergewichte und der histochemisch dargestellten Enzyme durch die Lindanmedikation gefunden. Die Schlafzeit, gemessen nach Pentobarbital i.p., war dosisund zeitabhängig reduziert. Der Leberglykogengehalt von behandelten und Kontrolltieren unterschied sich nicht, wenn die Tiere Futter ad libitum aufnehmen konnten. Nach 24 Std Futterentzug wurde bei den behandelten Tieren eine Tendenz zur Glykogenverminderung in der Leber festgestellt. Die Ascorbinsäureausscheidung im Urin war um ein Vielfaches erhöht, während das Blutserum eine Verdoppelung der Ascorbinsäurekonzentration aufwies (als Transporteffekt gedeutet). Elektronenmikroskopisch fand sich eine deutliche Vermehrung des glatten, endoplasmatischen Reticulum, besonders in Hepatocyten der Intermediärzone. Die gefundene Zunahme freier Ribosomen wird mit der verstärkten Bildung von mikrosomalem Protein in Verbindung gebracht. Die auch elektronenoptisch dargestellte Glykogenverminderung einzelner Zellen läßt sich als Folge des unter der Enzyminduktion veränderten Metabolismus (erhöhte Glucuronsäurebildung, verstärkte Ascorbinsäuresynthese) erklären. Insgesamt konnte mit der gegebenen Versuchsanstellung kein Hinweis auf hepatotoxische Wirkungen der Prüfsubstanz gefunden werden, so daß sich die funktionellen und morphologischen Äquivalente der Enzyminduktion als adaptative Veränderungen interpretieren lassen.
    Notes: Abstract Following short-term oral administration of Lindane (5 mg/kg, 20 mg/ kg) to male rats, various functional, biochemical, histochemical and electronmicroscope investigations were performed. No effects of the Lindane medication were found in movement and exploration (open-field test), liver weight, and the histochemically presented enzymes. A dose-dependent and time-dependent reduction in the duration of sleep was measured after i.p. pentobarbital. There were no differences in the liver glycogen levels of treated and control animals when food was available to the animals ad libitum. After food had been withdrawn for 24 h, a tendency to reduced liver glycogen was observed in the treated animals. The excretion of ascorbic acid in the urine was several times higher than normal, while the ascorbic acid concentration in blood serum was doubled (attributed to transport effect). The electron microscope revealed a distinct increase in the smooth endoplasmic reticulum, particularly in hepatocytes of the intermediary zone. The observed increase in free ribosomes was thought to be connected with the intensified formation of microsomal protein. The reduced glycogen of individual cells, also observed with the electron microscope, was explained as a result of the change in metabolism caused by enzyme induction (increase in formation of glucuronic acid, increased ascorbic acid synthesis). In all, no hepatotoxic effects of the test substance were found with the given experimental procedure, so the functional and morphological equivalents of enzyme induction can be interpreted as adaptive changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316232
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  • 6
    Electronic Resource
    Electronic Resource
    Die Leber bei der progressiven Myoklonusepilepsie (Lafora's disease) (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 559-567 
    Details
    ISSN: 1432-1440
    Keywords: Progressive myoclonus epilepsy (Lafora's disease) ; Type I (Unverricht, Lundborg) ; Type II ; Liver findings ; Clinical aspects ; Histology ; Ultrastructure ; Histochemistry ; Biochemistry ; Glycogenosis type IV ; Progressive Myoklonusepilepsie (Laforasche Erkrankung) ; Typ I (Unverricht, Lundborg) ; Typ II ; Leberbefunde ; Klinik ; Histologie ; Ultrastruktur ; Histochemie ; Biochemie ; Glykogenose Typ IV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dem klinischen Bild der progressiven Myoklonusepilepsie (Lafora's disease) liegt eine kongenitale Stoffwechselanomalie mit Ablagerung pathologischer Stoffwechselprodukte vorwiegend im Zentralnervensystem zugrunde. Der häufigere Typ I (Typ Unverricht, Typ Lundborg) zeigt eine regelmäßige Mitbeteiligung von Leber und Myokard sowie teilweise der Muskulatur, der seltenere Typ II ist mit seiner Speicherung nur auf das Zentralnervensystem beschränkt. Die Kenntnis der charakteristischen Leberbefunde kann einmal eine Hilfe sein für die klinische Unterscheidung von Typ I und Typ II, unspezifisch degenerativen Formen der Myoklonusepilepsie sowie gegenüber der myoklonischen Variante der amaurotischen Idiotie. Als eine weitere Möglichkeit könnte das bisher unbekannte Speicherprodukt und der auslösende spezifische Enzymdefekt auf diesem Wege identifiziert werden. Lichtmikroskopisch zeigen die Leberzellen — vorwiegend der Läppchenperipherie — und gelegentlich auch die Kupfferschen Sternzellen eine PAS-positive homogene Speichersubstanz, die in Übereinstimmung mit den Befunden am Zentralnervensystem und am Myocard elektronenoptisch aus granulärem und filamentärem Material aufgebaut ist. Die Deutung der einzelnen Untersucher hinsichtlich der histochemischen und biochemischen Ergebnisse variiert: die Natur des Ablagerungsproduktes wird als Mucopolysaccharid aber auch als Polyglucosan angesprochen. Übereinstimmend sieht man aber die Hauptstörung im Bereich des Kohlenhydratstoffwechsels. Die hier demonstrierten bemerkenswerten licht- und elektronenmikroskopischen Übereinstimmungen mit der Glykogenose Typ IV lassen nach unserer Auffassung nahe Beziehungen zur Gruppe der Glykogenosen annehmen. Als Thesaurismose ist die Laforasche Erkrankung eine potentielle Vorstufe der Cirrhose. Es entwickelt sich eine mehr oder minder ausgeprägte Mesenchymbeteiligung im Sinne einer chronischen Hepatitis. Eine komplette Cirrhose ist jedoch selbst bei den Spätfällen nicht nachzuweisen. Eine Hepatomegalie als Folge der Speicherung fehlt. Spezifische Leberproben fallen negativ aus. Das klinische Bild wird nicht von Seiten der Leber, sondern ausschließlich von der progredienten neurologisch-psychiatrischen Symptomatik der Myoklonusepilepsie geprägt.
    Notes: Summary The cause of clinical manifestations of progressive myoclonus epilepsy (Lafora's disease) is an inborn error of metabolism characterised by deposition of pathologic metabolic products in the central nervous system. In the most common type I (Type Unverricht, Type Lundborg) these deposits are regularly located in liver and myocard, and in some cases also in sceletal muscle. In the less common type II they are found only in the central nervous system. The characteristic liver findings might help to distinguish type I, type II, unspecific degenerative forms of myoclonic epilepsy and the myoclonic form of amaurotic idiocy. They also might be valuable in identification of yet unknown specific enzyme defect leading to tissue deposits. Our light microscopy observations demonstrate deposits of a PAS-positive homogene substance in liver cells—especially in the periphery of lobule— and sometimes in Kupffer cells. By electron microscopy this substance is identified as granular and filamentary material. This corresponds to our findings in the central nervous system and myocard. The interpretation of existing histochemical and biochemical studies did not yet solve the question, if the mentioned deposits are mucopolysaccharides or polyglucosanes, however, it is recognized that the main disorder is an error in carbohydrate metabolism. The notable similarity of our light- and electronmicroscopic observations to results obtained in glycogenosis type IV suggest that Lafora's disease might be another form of glycogenosis. As a thesaurismosis Lafora's disease can predispose to cirrhosis. The activation of mesenchyme, less or more pronounced, corresponds to chronic hepatitis. And even in the late forms a complete cirrhosis is not found. This thesaurismosis does not lead to hepatomegaly. Specific liver function tests are negative. The clinical course is characterised not by liver symptoms but by the neurologic and psychiatric symptoms of progressive myoclonic epilepsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468496
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of 2-hydroxy fatty acids in complex mixtures of fatty acid methyl esters by mass chromatographyAbbreviations: Hydroxy fatty acids are identified by h preceding chain length. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 10-14 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Repetitive mass spectrometric scanning of gas-liquid chromatographic effuents at short (6 to 15 s) intervals, with a digital computer for data acquisition, reduction and display, allows plots (mass chromatograms) to be made of the intensities of specific ion fragments. Plotting of m/e values characteristic for certain classes of compounds and/or individual components reveals the location of constituents in the gas chromatogram. This technique was applied to the identification of trimethylsilyl derivatives of unsubstituted and 2-hydroxy fatty acid methyl esters in mixtures obtained from acid catalyzed methanolysis of cat brain galactocerebrosides. The plot of total ionization intensity vs scan number generated the gas-liquid chromatogram. Mass chromatograms of m/e 73 and [M - 59]+ gave the locations in the gas-liquid chromatogram of the hydroxy fatty acid derivatives, and mass chromatograms of m/e 74 and [M]+ located the unsubstituted fatty acid derivatives. Integrated ion intensities were used to determine the composition of the mixture of fatty acids.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010105
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  • 8
    Electronic Resource
    Electronic Resource
    The structural elucidation of polyene macrolide antibiotics by mass spectrometry. Nystatin, amphotericin B and pimaricin (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 20-28 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Complete mass spectra of the pertimethylsilylated derivatives of three high molecular weight polyene macrolide antibiotics are reported for the first time. The fragmentation pathways which are proposed have been corroborated by the stable isotope derivatives d9-TMS and d3-acetyl. Accurate mass measurements and metastable transitions confirm the proposed fragmentation mechanisms in the low mass range. Nystatin - the macrolide of highest molecular weight in this study - expels several TMSOH molecules and a TMS radical. Amphotericin B underwent extensive rearrangements preliminary to eliminating a series of TMSOH molecules. An apparent equilibrium between the keto and ketal forms of amphotericin B facilitated the rearrangements. Pimaricin fragmented in a manner parallel to that of the other two macrolides. The sugar portion of the molecules dominated the fragmentation in the low mass region in the spectra of all compounds. The transfer of a TMS group from the sugar amine to the glycosidic oxygen was observed when the amino sugar was eliminated from the intact molecule. The resulting sugar ion then expelled ammonia.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010107
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  • 9
    Electronic Resource
    Electronic Resource
    Sex-linked specificity of the hepatic metabolism of steroids in rats. Mass fragmentography as a method for the assay of hydrogenated metabolites of corticosterone in the liver (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 29-39 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the separation, identification and quantitation of endogenous hydrogenated metabolities of corticosterone in rat liver Corticosterone, 5α- and 5β-dihydrocorticosterone, 3α,11β,21-trihydroxy-5α-pregnane-3,20-dione, 3β,11β,21-trihydroxy-5α-pregnane-3,20-dione, 3α,11β,21-trihydroxy-5β-pregnane-3,20-dione, 3β,11β,21-trihydroxy-5α-pregnane-3,20-dione, 5α-pregnane-3α,11β,20α,21-tetrol, 5α-pregnane-3α,11β,20β,21-tetrol and 5α-pregnane-3β,11β,20β,21-tetrol are specifically quantitated in one analysis by mass fragmentography all as their O-methyloxime pertrimethylsilyl derivatives. A pronounced difference in the amounts of these nine metabolites between male and female adult rats was found, while in newborn rats only the two tetrahydro-compounds bearing a 5α-hydrogen were detected in both sexes. On the other hand 3α,11β,1 5α,21-tetrahydroxy-5α-pregnan-20-one was detected only in the adult female as its second prominent metabolite of corticosterone. Corticosterone metabolites being biochemical markers of the sex-linked differentiation of the hepatocytes, their mass fragmentographic assay is proposed as a tool for the quantitative analysis of this type of gene expression.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010108
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  • 10
    Electronic Resource
    Electronic Resource
    Determination of the structure of partially methylated sugars as O-trimethylsilyl ethers by gas chromatography-mass spectrometry (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 62-65 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The separation and structural determination of ten partially methylated methyl glucosides by gas chromatography and gas chromatography-mass spectrometry are described. These glucosides were four possible structures for methyl tri-O-methylglucosides and six for methyl di-O-methylglucosides. The positions of free hydroxyl groups in four isomers of methyl tri-O-methylglucosides could be fairly distinguished from each other by their mass spectra. Mass spectra of methyl di-O-methylglucosides were similar to each other, though their spectra were different from those of fully methylated or methyl tri-O-methylglucosides. After introduction of a trimethylsilyl group to the free hydroxyl group, mass spectra of methyl di-O-methylglucosides showed a characteristic pattern for the position of the trimethylsilylated hydroxyl group, and O-trimethylsilyl ethers of methyl tri-O-methylglucosides also showed distinguishable mass spectra. The structures of fragment ions of partially methylated methyl glucosides were confirmed by high resolution mass spectrometry.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010113
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  • 11
    Electronic Resource
    Electronic Resource
    Liquid chromatography-mass spectrometry. II - continuous monitoring (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 80-82 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Monitoring of solutes eluted from a liquid chromatograph is possible by continuous introduction of the effluent solution into the ion source of a chemical ionization mass spectrometer. Detection sensitivities in the nanogram range are possible for a wide variety of solutes and solvents. Auxiliary techniques which have proved valuable for g.c.-m.s. also appear to be applicable to l.c.m.s.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010117
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  • 12
    Electronic Resource
    Electronic Resource
    Study on drug metabolites by mass spectrometry. IVFor Part III, see Ref. 1. - metabolites of 2-(diethylamino) ethyltetrahydro-α-(1-naphthylmethyl)-2-furanpropionate oxalate in rats (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 66-72 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The determination of drug metabolites is very important in the biochemical field. However, the procedure for doing this has been very complicated in many cases. The major reason is because of the need for fairly large amounts of the samples. We have been studying procedures for the determination and identification by use of mass spectrometry, which usually gives a lot of information rapidly from very small amounts of the samples (below μg). In this paper, the metabolites excreted in urine and bile following oral administration of 2-(diethyamino)ethyl tetrahydro-α-(1-naphthylmethyl)-2-furanpropionate oxalate (1) in rats, were investigated by means of mass spectrometry and other techniques. The drug was not excreted unchanged in urine. Of the eight metabolites suspected to be present in urine and bile, the structures of three metabolites were elucidated to be tetrahydro-α-(1-naphthylmethyl)-2-furanpropionic acid (3) and α-(1-naphthylmethyl)-2-perhydro-5-oxofuranpropionic acid (4) in urine, and diethylaminoethanol (2) in bile. These metabolites might also be present as their structural isomers or conjugates.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010114
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  • 13
    Electronic Resource
    Electronic Resource
    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010201
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  • 14
    Electronic Resource
    Electronic Resource
    Interpretation of mass spectra, 2nd Edition, by F. W. McLafferty. W. A. Benjamin Inc., Reading, Massachusetts, 1973. $15.00 (cloth) $7.50 (paper) (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xiv 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010118
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  • 15
    Electronic Resource
    Electronic Resource
    Qualitative and quantitative mass spectrometry of some noncatecholic biogenic amines and related compounds as their dansyl derivatives (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 83-95 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of the integrated ion current technique for the analysis of biogenic amines and phenols as their 1-dimethylaminonaphthalene-5-sulphonyl (dansyl) derivatives is described, particularly as regards to the linearity and sensitivity of detection. The mono derivatized amines gave a linear response over the range 10-9 to 10-14 mol, with a few being detected in quantities as small as 5 × 10-15 mol. The bisdansyl derivatives have a lower sensitivity and the response is linear over a more restricted range, terminating at 10-13 mol. Deuterated analogues of some of the amines were prepared and the feasibility of their use as internal standards was investigated. In this way, the problems associated with quantitative biochemical analyses caused by losses during extractions, chromatographic separations and thermal decomposition in the mass spectrometer lon source are overcome. The differentiation of isomers of biogenic amines as their dansyl derivatives has been accomplished by fractional sublimation and by examination of differences in their fragmentation patterns.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010202
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  • 16
    Electronic Resource
    Electronic Resource
    Amino acid mixture analysis by mass spectrometry in the form of their dimethylaminomethylene methyl esters (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 115-119 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The amino acids, arginine, citrulline, cysteine, cystine, histidine, hydroxyproline, methionine, ornithine, proline, serine, threonine, tryptophan and tyrosine, have been analysed in the form of their N-(N′, N′-dimethylaminomethylene) methyl esters. formed in a single step by reaction of the free amino acid or its hydrochloride with N,N-dimethylformamide dimethylacetal in acetonitrile/methanol (2:1). A reaction time of 15 minutes at 100 °C ensures complete derivatization, the derivatives being volatile at source temperatures below 150 °C, and giving electron impact spectra characterized by abundant (or moderately abundant) peaks at or near the mass of the molecular ion.The analysis of amino acid mixtures by mass fragmentography on characteristic high mass peaks of their N-(N′,N′-dimethylaminoethylene) methyl ester derivatives, introduced on a direct insertion probe and volatilized during temperature programming of the source, is qescribed. The method is applied to the analysis of a mixture containing arginine, citrulline, cystine, histidine and tryptophan, traditionally difficult to analyse by other methods.
    Additional Material: 6 Ill.
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    Observations on the mechanism of hydroxylation of cyclophosphamide by rat liver microsomes: The metabolism of cyclophosphamide-4-d2 (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 130-136 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The metabolism of cyclophosphamide-4-d2 (2-[bis(2-chloroethyl)amino]-tetrahydro-4,4-dideuterio-2H-1,3,2-oxazaphosphorine 2-oxide), was studied. The first detectable metabolite was a hydroxy derivative which was trapped with ethanol. Mass spectrometry of the resulting two ethoxy derivatives and of the deuterated acrolein 2,4-dinitrophenylhydrazones formed therefrom via reaction with acidic 2,4-dinitrophenylhydrazine, afforded evidence that the ethoxy substituents were at C-4, which was therefore the position of the original hydroxy substituent. The mass spectrum of the deuterated acrolein 2,4-dinitrophenylhydrazone obtained from the total reactive metabolites was used to estimate the ratio of 4- to 6-hydroxylation. The rate of metabolism and the antitumour activity of cyclophosphamide and its 4-d2 analogue were compared.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010209
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  • 18
    Electronic Resource
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    Mass spectral studies of airborne particulates and possible pollution sourcesWork supported in part by EPA under Agreement No. EPA-IAG-0217(D) entitled ‘Correlation of Hazardous Compound Composition of Coal, Ash, Fly-Ash, and Other Emissions from Combustion’. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 137-141 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The organic material in airborne particulate matter is being studied by high resolution mass spectrometry to determine if hydrocarbons typical of major sources of pollution can be detected. Carbon number distributions and hydrogen-to-carbon ratios of components found in airborne particulate samples and the corresponding data for compounds detected in fuel combustion products show great similarity. Samples collected near large power stations and major airports were compared with typical urban particulate samples. Particulates collected from jet engine exhaust and a condensate from the stack effluent from a coal-fired combustion system were studied. Mass spectral data were obtained for an auto exhaust tar, a coal tar pitch and several fuels. The mass spectra of two total particulate samples, compared to the spectrum of an ether extract of the organic matter, indicate that direct vaporization can be used and extraction is not essential for qualitative mass spectral studies.
    Additional Material: 7 Ill.
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  • 19
    Electronic Resource
    Electronic Resource
    Analysis of intact phospholipids by field desorption mass spectrometry (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 154-155 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The first application of field desorption mass spectrometry to the analysis of intact diacyl glycerophosphorylcholines (lecithins) has led to the detection of prominent molecular ions. This technique enables positive identification of the components of a mixture of phosphatidylcholines, which will provide valuable information on the phospholipid composition of biological fluids.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010213
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  • 20
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    Mass spectrometry of pesticides and pollutants, by S. Safe and O. Hutzinger. CRC Press Inc., Cleveland, Ohio, 1973. pp. 220, $32.00 (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 157-157 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010215
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  • 21
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    News and events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xi 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010216
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  • 22
    Electronic Resource
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    Detection and quantitative analysis of amphetamine (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 159-162 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The high resolution mass spectrometric integrated ion current procedure has been used to identify and quantitate amphetamine, isolated as its dansyl derivative, as it is found after addition to urine and in tissues of the rat following intraperitoneal injection. A linear relationship between amphetamine and ion current response has been established at least in the range 5 × 10-12 to 5 × 10-7 g, and as little as 8 × 10-13 mol of amphetamine in urine may be detected.
    Additional Material: 3 Ill.
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  • 23
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    Thin-layer chromatography-mass spectrometry for the identification of sapogenins from Digitalis species (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 166-168 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the identification of the sapogenins of several Digitalis species. The steroids are separated by repeated development thin-layer chromatography and identified by means of high resolution mass spectrometry. The spectra of tigogenin, gitogenin, digalogenin and digitogenin are recorded. These spectra are of particular use in establishing the position of extra hydroxy moieties in the steroid nuclei. Several species of Digitalis were screened for their sapogenin content. D. purpurea, D. mertonensis and D. lutea were found to contain tigogenin and digitogenin in small amounts, the principal steroid being gitogenin, whilst D. ambigua and D. lanata contained all four steroids.
    Additional Material: 2 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010304
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  • 24
    Electronic Resource
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    Intramolecular isotopic order in biologically produced acetic acid (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 172-174 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Acetic acid isolated from cider vinegar and inorganically synthesized glacial acetic acid have markedly different intramolecular isotopic distributions of the stable carbon isotopes. Carbon-12 is concentrated in the methyl group relative to the carboxyl group in the biologically produced acid. The reverse distribution is observed in the particular sample of glacial acetic acid examined here.
    Additional Material: 1 Tab.
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  • 25
    Electronic Resource
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    Identification of some organic smog components based on rain water analysis (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 192-194 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An analysis has been made of a sample of rain water collected in Washington, D.C. following a sustained photo-oxidant smog alert which was accompanied by haze and low visibility. The analysis was effected by purging the organic content from the water with helium gas and identifying the constituents by means of gas chromatography - mass spectrometry. The predominant compound was found to be 3-methylfuran, a possible intermediate or end product of the atmospheric decomposition of terpenoid hydrocarbons. The analysis suggests that the smog resulted from the air oxidation of hydrocarbons evolved from Appalachian forestation rather than from manassociated activities.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010309
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  • 26
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    Source of the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of cambendazole (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 190-191 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined gas chromatography-mass spectrometry and isotope labeling techniques have been employed to demonstrate that the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of 2-thiazolyl-5-isopropoxycarbonylaminobenzimidazole (cambendazole), is derived wholly from the parent drug. [15N] Thiazole-labeled cambendazole was administered to a rat and the metabolite isolated from urine. Trideutero-2-carboxamido-5-isopropoxycarbonylaminobenzimidazole was employed as a carrier to isolate the metabolite in sufficient purity for isotope ratio measurements using multiple ion detection. The metabolite was converted to its tetramethyl derivative by on-column reaction with trimethylanilium hydroxide to permit satisfactory gas chromatography.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010308
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  • 27
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    Workshop reports (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 206-207 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010312
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  • 28
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    News and events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xiii 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010314
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  • 29
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    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010401
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  • 30
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    Evaluation of bilirubin derivatives for mass spectral analysis (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 219-222 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Twelve derivatives of bilirubin were evaluated from the point of view of providing intense molecular ion peaks on electron impact and unambiguous molecular weights. The tetrakis-(trimethylsilyl) derivative of bilirubin was judged to be the most suitable because its molecular ion carries 22% of the total ion current and is the base peak in the spectrum. Molecular ions were found to carry 10% of the total ion current in the spectrum of the trimethylsilylated methyl ester of the phenylazo derivative of bilirubin. Fragmentation patterns of these two compounds were studied using deuterium labeling.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010404
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    The use of Edman degradation in peptide mixture analysis by mass spectrometryA preliminary report including some of the data presented in this paper has been given at the 6th International Mass Spectrometry Conference, Edinburgh, Scotland, September 1973. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 231-236 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectrometric analysis of peptide mixtures may lead to ambiguous results when it is possible to change from one peptide chain to another during the interpretation of the spectra. This kind of ambiguity can be eliminated by submission of part of the sample to one cycle of Edman degradation, followed by comparison of the results obtained for this preparation with those obtained for the nondegraded sample. Combination of this procedure with the use of deuterated derivatives has allowed an unambiguous interpretation for two mixtures of synthetic peptides.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010406
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  • 32
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    Field desorption mass spectrometry of ten medicinal carbamates (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 256-262 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The field desorption mass spectra of ten medicinal carbamates - meprobamate, mebutamate, carisoprodol, emylcamate, bethanechol chloride, styramate, hydroxyphenamate, mephenesin carbamate, methocarbamol and chlorphenesin carbamate - were run and compared with their published electron impact spectra. Of the ten compounds run only emylcamate did not give a field desorption mass spectrum. All others gave abundant molecular ions, with the exception of bethanechol chloride which has a quarternary ammonium group and gave a field desorption spectrum characteristic of compounds possessing such a functional group. No general characteristic fragmentation was attributed to the carbamate function in the field desorption mode. However, the ease of obtaining abundant molecular ions or quasimolecular ions makes the field desorption method a valuable complementary technique to electron impact studies of carbamates.
    Additional Material: 9 Ill.
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  • 33
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    The determination of sequence information in homologously related proteins by mass spectrometry (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 269-273 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An azurin, a small respiratory copper protein from the bacterium Pseudomonas fluorescens biotype G, has been studied by mass spectrometry to determine sequence information. The study of homologously related proteins by mass spectiometry is particularly attractive, since the correct nature of major parts of the deduced sequences can be confirmed by comparison with the sequences of the protein from related organisms. An oxidized tryptohan residue has been identified amongst the products from a cyanogen bromide digest of this wild type azurin. In the same digest, a product is also found to arise from cleavage of the peptide chain at the C-terminal side of the same tryptophan residue. These results are rationalized.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010411
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  • 34
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    The mass spectral fragmentation of partially ethylated alditol acetates, a derivative used in determining the glycosly linkage composition of polysaccharidesSupported in part by AEC Contract No. AT(11-1)-1426.Abbreviations: PEGS = poly-(ethylene glycol succinate); PEGA = poly-(ethylene glycol adipate). (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 263-268 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectral data for the primary fragmentation of partially ethylated alditol acetates have been tabulated in order to allow easy reference for the identification of these polysaccharide derivatives. Sodium borodeuteride is used in all the aldose to alditol reductions, since the presence of a single deuterium label on C-1 greatly increases the information available in the mass spectrum and allows some identifications to be made which would not otherwise be possible. The primary fragmentations of these derivatives are analogous to those of the partially methylated alditol acetates, with each fragment shifted to a higher m/e value by fourteen mass units for each ether linkage contained in the fragment. The secondary fragmentation is also very similar, being characterized by the loss of acetic acid or ketene, or, less frequently, by the loss of ethanol or acetaldehyde. Coupled with the chromatographic retention time data for the partially ethylated alditol acetates tabulated elsewhere, the unambiguous mass spectral identification makes this derivative an excellent choice as a complementary derivative to the partially methylated alditol acetates for polysaccharide analysis. The utility of the partially ethylated alditol as a routine analytical derivative is further enhanced by the almost identical procedures required for synthesis of the ethyl and methyl derivatives. Through the combined use of these derivatives, most of the possible linkage isomers of the seven common aldoses of plant cell wall polysaccharides can be resolved, identified and quantitated.
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    Characterization of cytosine nucleosides by mass spectrometry (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 281-285 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of most nucleosides of cytosine exhibit molecular ions of low abundance, rearranged ions base + 2H in greater abundance than the companion species base + H, and a characteristic and abundant ion which corresponds to base + C2HO from the sugar. Deuterium, oxygen-18 and substituent labeling showed the presence of C-1′, 2′, H-2′ and O-4′ in the latter ion, which led to a proposed mechanism of formation involving opening of the sugar ring and recyclization between O2 and C-2′ with expulsion of water. Primary driving force for the reaction is due to resonance stabilization promoted by unshared electrons from N4, which results in diminished abundance in the case of imino isomers and derivatives which contain electron-withdrawing groups at N4, and enhanced abundance resulting from methylation at N4. Data for 24 nucleosides are presented and discussed in terms of the determination of nucleoside structure.
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    News and events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. ix 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010417
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    Metabolism of branched medium chain length fatty acid: I - ω-oxidation of sodium dipropylacetate in ratsAbbreviations: DPA = dipropylacetate; BSA = N,O-bis-(trimethylsil)acetamide; TMCS = trimethylchlorosilane. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 291-294 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The metabolism of sodium dipropylacetate (a newly developed anticonvulsant) was investigated in rats, and two metabolites were found in urine of rats which received dipropylacetate. The metabolites were identified as 2-n-propyl-5-hydroxypentanoic acid and 2-n-propylglutaric acid, respectively, by low and high resolution mass spectrometry. Synthetic 2-n-propylglutaric acid, when administered to rats, was not oxidized further and was excreted intact in urine. These data clearly show that ω-oxidation is involved in the metabolism of sodium dipropylacetate and that 2-n-propylglutaric acid, the end product of ω-oxidation, does not serve as a substrate for β-oxidation.
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  • 38
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    Limits of detection of carbon-13 labelled drugs and their metabolites in human urineAbbreviation used: PDB = Belemnitella americana (‘Peedee Belemnite’). (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 345-349 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The precise isotopic analysis of carbon by means of differential comparison of CO2 samples is applied to neutral, acid c and basic extract fractions of human urine. It is shown that the standard deviation of the analytical procedure, including sample preparation steps, is about 1% or 0.001 atom % excess carbon-13, but depends some what on the fraction considered. Day to day variations (expressed as standard deviations) in the isotopic composition of the urine fractions are generally less than 2.8%, 1.4% and 3.9% for the neutral, acidica and basic fractions, respectively, although the effect of unusual dietary inputs can be recognized. The ingestion of 23 μg excess carbon-13 in the form of isotopically labelled aspirin is shown to perturb significantly the isotopic composition of the acidic urine fraction which, for a 24 hour collection period, had a mass of 570 mg C. Because only 0.01% of the fraction was consumed by isotopic analysis, further extensive analysis would be possible. It is concluded that carbon-13 tracer experiments generally should be arranged to provide at least 5 × 10-5 g excess 13C/g carbon in any fraction which is to be used for lable detection.
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  • 39
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    A method of analysis of dansylamides in mixtures by mass spectrometryAbbreviation: Dansyl = dimethylaminonaphthalene-5-sulphonyl. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 363-364 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of a mixture twenty dansyl derivatives of biogenic amines were run using low energy electron impact. This method appears to be useful for the analysis of amines present in biological materials.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010514
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  • 40
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    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010601
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  • 41
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    Mass spectrometric studies of thyroxine and related compounds. Trimethylsilyl derivatives (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 374-380 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of the trimethylsilyl derivatives of thyroxine and sixteen related compounds are reported. In addition to deiodinated analogues and iodinated tyrosines, the latter include a series of thyroacetic and thyropropionic acids and one thyroformic acid compound. Their spectra are discussed in terms of their fragmentation and utility for qualitative and quantitative estimation by gas chromatography - mass spectrometry.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010603
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    Mass spectrometry of the methyl ethers of isomeric hydroxychlorobiphenyls - potential metabolites of chlorobiphenyls (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 386-392 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of synthetic methoxychlorobiphenyls have been investigated. These substances are of interest as reference compounds in studies of the metabolism of chlorobiphenyls. Some characteristic fragmentation patterns have been found, useful for differentiation between the 2-, 3- and 4-methoxychlorobiphenyl isomers. Thus, mass spectra of 2-methoxychlorobiphenyls show large fragments at [M - CH3Cl]+., while those of 4-methoxy compounds differ from 3-methoxy isomers by the presence of significant [M - CH3]+ fragments in the former.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010605
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  • 43
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    Identification of explosives by chemical ionization mass spectrometry using water as reagentAbbreviations: HMX (Octogen) = 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane; RDX (Hexogen, Cyclonite) = 1,3,5-Trinitro-1,3,5-triazacyclohexane; PETN = Pentaerythrytoltetranitrate. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 393-396 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical ionization mass spectra of four explosive compounds have been obtained by using water as reagent gas. The compounds are 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane, 1,3,5-trinitor-1,3,5-triazacyclohexane, pentaerythritol tetranitrate, and an explosive which has been used in letter bombs, containing the two latter compounds and a plasticizer. The chemical ionization H2O mass spectra were recorded at an ion source temperature range of 170 to 225°C, a probe temperature range of 160 to 265°C and a reagent gas (H2O) pressure range of 0.07 to 0.10 Torr. Unlike in chemical ionization using methane or isobutane, chemical ionization H2O spectrum of these compounds provides a method for obtaining quasimolecular peaks. Adduct ion peaks like [M + H3O]+, [M + H5O2]+, [M + NO]+ and [M + NO2]+ are also observed in the chemical ionization H2O mass spectra of these compounds. Chemical ionization H2O mass spectra provide thus a better means of explosive identification.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010606
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  • 44
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    Carbon isotopic fractionations associated with acetic acid production by Acetobacter suboxydans (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 412-414 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Acetobacter suboxydans, strain 8.3, was grown using ethanol, made by the hydration of ethylene, as the sole energy source. After the microorganism had oxidized some of the ethanol to acetic acid, the unassimilated alcohol and produced acetic acid were isolated from the supernatant. Carbon isotopic analyses of these compounds and the starting ethanol show: (1) the methyl carbon of the starting alcohol is enriched in carbon-13 by 4.6% relative to the hydroxyl carbon, (2) the starting alcohol contains 2% less carbon-13 than the unassimilated ethanol and (3) the carboxyl carbon of the acetic acid excreted by the A. suboxydans is enriched by 3.8% in carbon-13 relative to the methyl carbon. These results support earlier findings which indicate that organisms preferentially utilize compounds enriched in carbon-12 and tend to concentrate carbon-12 in the reduced carbons relative to the oxidized carbons of metabolic products.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010608
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  • 45
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    Comparison of the field desorption, chemical ionization and electron impact mass spectra of some steroids (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 423-424 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact, chemical ionization and field desorption mass spectra of seven steroids showing varying stability to electron impact have been compared.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010611
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  • 46
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    Letter to the editors (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 427-428 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010613
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  • 47
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    News (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. ix 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010615
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  • 48
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    Mass spectra of compounds of biological interest, Volume 1 to 3, edited and compiled by S. P. Markey, W. G. Urban and S. P. Levine. USAEC TID-26553-P1, 2, 3. National Technical Information Service, U.S. Department of Commerce, Springfield, Virginia, 22161. 1974. pp. 1226. $28.80 (paper), $6.75 (microfiche) (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 428-428 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010614
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  • 49
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    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010101
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  • 50
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    Editorial (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xi 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010102
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  • 51
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    Separation and characterization of isomeric substituted nucleosides by gas chromatography and mass spectrometryAbbreviations used: TMS (trimethylsilyl); TFA (trifluoroacetyl); TBDMS (t-butyldimethylsilyl). (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 78-79 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 3′- and 5′-O-t-butyldimethylsilyl derivatives of thymidine and deoxyadenosine have characteristically different mass spectra and can be separated by gas chromatography.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010116
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    The collection and analysis of volatile hydrocarbon air pollutants using a timed elution chromatographic technique linked to a computer controlled mass spectrometer (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 73-77 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The difficulty of collecting volatile hydrocarbons, such as benzene, from street air in a form suitable for subsequent analysis is overcome by the use of a time-based elution procedure. By linking this technique to a gas chromatograph-mass spectrometer-data system, a rapid analysis is possible for low concentrations of collected material. Among advantages of this novel sample introduction procedure are the facility for collecting organic materials without interference from water vapour and their subsequent introduction into the g.c.-m.s. system without the use of any auxiliary solvents. Consequently the mass spectrometer can be used continuously on-line enabling the more volatile materials, normally masked by solvents, to be examined. This procedure is illustrated by the measurement of benzene and other hydrocarbon levels in street air (London). Following gas chromatographic separation the hydrocarbons can be identified by library search facilities attached to the mass spectrometer.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010115
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  • 53
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    Forthcoming events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xiv 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010119
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  • 54
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    News and events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xv 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010120
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  • 55
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    Reagent gases for G.C.-M.S. analyses (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 96-102 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several reagent gases and mixed reagent gases for high pressure ion-molecule reaction ionization of samples have been investigated for use in gas chromatography-mass spectrometry analyses. The common g.c. carrier gases and their mixtures with other gases such as isobutane, ammonia, tetramethylsilane, hexafluoroacetone and nitric oxide, were studied. These reagents were used to enhance the molecular ion intensity and to simplify the spectra of steroidal alcohols and the trimethylsilyl ethers of biologically important compounds.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010203
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  • 56
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    Studies in organic mass spectrometry: XVSande, C. Van de; Vandewalle, M. Bull. Soc. Chim. Belges 1973, 82, 775. - mass fragmentographic identification of epinine in adrenal medulla and as a product of an in vitro enzymic methylation (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 103-108 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The presence of epinine in adrenal medulla and in reaction mixtures of enzymic in vitro experiments is proven by mass fragmentography. Derivatization of catecholamines, suitable for gas chromatographic analysis is discussed. The perfluoropropionates were selected for mass fragmentography.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010204
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  • 57
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    Mass spectrometry of 16,16′-O-permethylated 17-ketosteroidsAbbreviations used: A (androsterone); EA (epiandrosterone); E (etiocholanolone); DHA (dehydroandrosterone); DHEA (dehydroepiandrosterone); 11 OH-A (11 β-hydroxyandrosterone); 11 OH-E (11 β-hydroxyetiocholanolone). (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 109-114 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Using methylsulphinyl carbanion as base. methylation of 17-ketosteroids with methyl iodide not only converts hydroxy into methoxy groups, but also replaces both C-16 hydrogen atoms by methyl groups. These permethyl derivatives are very stable, have excellent properties for gas chromatographic separation and fragment characteristically upor electron impact. The mass spectra of a number of these derivatives are discussed.
    Additional Material: 11 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010205
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  • 58
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    High resolution field desorption mass spectrometry: II - glycosides (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 120-123 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The high resolution field desorption mass spectra of a number of glycosides are described. In all cases the spectra enabled molecular weights and elemental formulae to be established, and the presence of fragment ions due to cleavage of the sugar groups provides considerable assistance in the identification of sugar and aglycone moieties. The [M + 23Na]+ ion was the base peak in the spectrum of the sodium salt of testosterone glucuronide, and the presence [M + 39K]+, [M + 41K]+ and [M + 23Na]+ ions in the spectra of other glycosides are attributed to the presence of their sodium or potassium salts as impurities.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010207
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  • 59
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    Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical lonization mass spectrometry and stable isotope labeling: Quinidine and lidocaineAbbreviations: MEGX = monoethylglycinexylidide; GX = glycinexylidide. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 124-129 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Preliminary results are reported for the quantitative determination of the antiarrhythmic agents quinidine and lidocaine in human plasma by combined isobutane chemical ionization mass spectrometry and stable isotope labeling. The concentration of monoethylglycinexylidide, a known metabolite of lidocaine, was also determined using this method. In the procedure used, stable isotope analogs of the materials to be determined were added to serial plasma samples. The plasma was then made basic and extracted with benzene. The residue after evaporation of the solvent was placed directly into the mass spectrometer via the direct insertion probe and the spectrum determined. In this manner the above named compounds could readily be quantitated without recourse to either derivitization or further purification.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010208
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  • 60
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    Mass spectrometric determination of butobarbitone and its metabolites in man (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 142-144 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The urinary excretion of butobarbitone and its metabolites has been studied quantitatively using combined gas chromatography-mass fragmentography, tuned to ions at m/e 169 and 184. After a single oral dose (200 mg) to healthy male volunteers, unchanged drug (7 to 9%), 3′-hydroxybutobarbitone (22 to 27%), 3′-oxobutobarbitone (14 to 18%) and the 3′-carboxylic acid (4 to 8%), were found. In all cases, the maximum rate of excretion was in or near the third 12 hour urine.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010211
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    Letter to the editors (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 156-157 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010214
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    Chemical ionization and high resolution electron impact mass spectra of 1,6-anhydro-3,4-O-isopropylidene-β-D-talopyranosePart of a series Specific Isotropic Labeling of Sugars: Applications in Mass-Spectral Analysis. For the previous report in this series. see Ref. 1. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 145-153 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The high resolution, electron impact mass spectrum of 1,6-anhydro-3,4-O-isopropylidene-β-D-talopyranose, together with those of its derivatives having specific deuterium substitution at C-2, at C-3, at C-2 and C-3, and in the isopropylidene group, is considered in detail and compared with the ammonia and isobutane mediated chemical ionization spectra of these five compounds. From the elemental compositions of the fragment ions and mass number shifts upon deuterium incorporation, the origin of the hydrogen atoms in each of the fragments is traced, and a detailed scheme of the main fragmentation. pathways is presented.
    Additional Material: 2 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010212
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  • 63
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    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010301
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  • 64
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    High resolution mass spectroscopic analysis of methylated tolbutomide derivatives (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 163-165 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The methyl derivative of tolbutamide, obtained by the action of dimethyl sulfate, has been subjected to g.c.-m.s. at high resolution. From the mass spectrum it is deduced that methylation of the sulfonamide nitrogen atom has occurred. During the loss of SO2 from the molecular ion, aryl rearrangement to both oxygen and nitrogen occurs in the ratio of 1:2.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010303
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  • 65
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    Field desorption mass spectrometry of the B vitamins: Pyridoxal, pyridoxamine, their phosphates, and thiamine (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 169-171 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Characterization of the B vitamins. pyridoxal, pyridoxamine, their phosphates and thiamine salts by electron impact mass spectrometry is difficult. A new technique, field desorption, is applied in ionizing these molecules for mass spectrometric analysis Characterization of these compounds by field desorption has the advantage that in each case the most intense peak in the spectrum is formed without fragmentation.
    Additional Material: 4 Ill.
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    Mass spectrometry of synthetic oligopeptides N, O-permethylated, N-acetylated derivativesAbbreviation: DMF = dimethylformamide. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 175-189 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectra of a series of stable isotope derivatives aided a structure elucidation study of an amino acid amide (Tyr-NH2) and the following family of synthetic oligopeptides: Gly-Tyr-NH2, Gly-Gly-Tyr-NH2, Gln-Gly-Gly-Tyr-NH2, Gln-Gln-Gly-Gly-Tyr-NH2, Ala-Gln-Gln-Gly-Gly-Tyr-NH2, Ser-Ala-Gln-Gln-Gly-Gly-Tyr-NH2 and Lys-Ser-Ala-Gln-Gln-Gly-Gly-Tyr-NH2. This series of peptides was synthesized by classical methods. N,O-permethylated, N-acetylated derivatives were synthesized to provide sufficient volatility for mass spectrometry. Various combinations of stable isotope derivatives (CH3CO + CH3, CD3CO + CH3, CH3CO + CD3, CD3CO + CD3) confirmed proposed fragmentation pathways and corroborated hypothetical ion structures. This family of oligopeptides corresponds to the C-terminus of scotophobin.
    Additional Material: 8 Ill.
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    Phospholipids in pulmonary alveolar proteinosis (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 195-198 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Gas chromatography-mass spectrometry has been used to identify the phosphate diester backbones of two classes of phospholipids previously unrecognized in washings from human lungs. Washings were analyzed from two patients with pulmonary alveolar proteinosis and also from two pairs of normal lungs washed postmortem. α-Glycerophosphorylglycerol and α-glycerophosphorylinositol were identified in all four cases following hydrolysis of the fatty acid esters and treatment with trimethylsilylating reagent.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010310
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    Letter to the editors (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 207-208 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010313
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    Studies of O-substituted oxime-trimethylsilyl ester derivatives of some metabolically-important oxocarboxylic acidsAbbreviations: BO-TMS, EO-TMS and MO-TMS are respectively the benzyl, ethyl and methyl O-substituted oximes; BSA = N, O-(trimethylsilyl)acetamide. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 199-205 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of the methyl-, ethyl- and benzyl-oxime trimethylsilyl ester derivatives of sixteen oxocarboxylic acids are reported. They are discussed both in terms of their fragmentation and their utility for use in studies of inborn errors of metabolism. Several applications where these derivatives have proved of value are presented.
    Additional Material: 4 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010311
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    Organic contaminants in the District of Columbia water supply (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 209-211 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Thirty-two organic contaminants have been identified in District of Columbia drinking water. These contaminants include aliphatic and aromatic hydrocarbons, chlorocarbons, bromine-containing compounds, alcohols and ketones. The concentration of each constituent identified was less than one part per million. The organic contaminants were extracted from the water samples with a 1:1 mixture of carbon disulfide (CS2) and methylene chloride (CH2Cl2). Each constituent was identified by its gas chromatographic retention time and by its mass spectrum.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010402
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    Characterization of dipeptides by electron impact and chemical ionization mass spectrometryAbbreviation : ACA = acetylacetone. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 212-218 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The components of mixtures of dipeptides can be identified from the electron ionization and chemical ionization mass spectra of their N-acetylacetonyl methyl ester derivatives without prior separation. The pyrolytic conversion of peptide trimethylanilinium salts to their methyl esters in the direct insertion probe of a mass spectrometer was found to be most suitable for the derivatization of dipeptides in mixtures.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010403
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  • 72
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    Field desorption mass spectrometry of metabolites of the anticancer drug cyclophosphamide (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 223-230 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some of the known and important metabolites of cyclophosphamide and the parent drug itself were investigated by low and high resolution field desorption mass spectrometry. The potential of the relatively new analytical method for the determination of the molecular weight and elemental formulae of drugs and drug metabolites was exemplified. This holds for pure, synthetic compounds as well as for contaminated extracts from biological sources. In addition, by thermally-/field-induced fragmentation, diagnostic fragment ions could be produced, providing valuable structural information. Further, an indication on how to distinguish [M]+. and [M + H]+ ions in field desorption mass spectrometry is given. The ability to identify these ions unambiguously is critical for interpretation. Finally, the potential of the method as applied to drug and drug metabolite mixtures is evaluated. The results indicate that field desorption mass spectrometry is a promising tool in metabolism studies.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010405
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  • 73
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    Gas chromatographic and high resolution mass spectrometric determination of phenylbutazone in blood (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 252-255 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High resolution mass spectrometry has been used to identify phenylbutanone in plasma extracts. Concentrations of 5 μg/ml of the drug in plasma have been determined by a gas chromatographic method with a standard deviation of ±0.3%.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010408
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  • 74
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    The amino acid sequences of the tryptic peptides of the cowpea strain of tobacco mosaic virus proteinThe following abbreviations are used in the text: CPA = carboxypeptidase A; CPB = carboxypeptidase B-DFP.The following additional abbreviations and symbols are used in the diagrams: Th = thermolytic peptide; C = chymotryptic peptide; ⇀ = amino acids determined by the Edman degradation procedure; ⇁ = amino acids determined by mass spectrometry; ↽ = amino acids determined by carboxypeptidase A or B; → = amino acids determined by partial acid hydrolysis. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 237-251 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The amino acid sequences of the thirteen tryptic peptides of the cowpea strain of tobacco mosaic virus (Cowpea TMV) protein were determined by a combination of the mass spectrometric and Edman degradation procedures. In order to complete the amino acid sequences, a number of the tryptic peptides were further digested with chymotrypsin, thermolysin and carboxypeptidases A and B. The peptide fragments were separated and purified by the use of ion exchange chromatography. Sephadex chromatography and paper electrophoresis.The total number of amino acid residues in the Cowpea TMV protein was found to be 161 as opposed to the 158 found for the type TMV protein, and asparaginyl-arginine was the only tryptic peptide common to both proteins. All peptides used for mass spectrometry were first N-acetylated and then permethylated using methyl iodide and methyl sulphinyl carbanion or potassium t-butoxide dissolved in dimethyl sulphoxide.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010407
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  • 75
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    Gas phase analytical resolution of enantiomeric amines as diastereomeric amides. Gas chromatography-mass spectrometry of α-phenylbutyramides, α-phenylpropionamides and α-chlorophenylacetamides (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 274-280 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Representative phenylalkylamines (six enantiomeric pairs) and amino acid methyl esters (five enantiomeric pairs) have been examined by gas chromatography-mass spectrometry, in the form of their N-(R)-α-phenylbutyryl, N-(S)-α-phenylpropionyl- and N-(R)-α-chlorophenylacetyl derivatives. In most cases, satisfactory gas chromatographic resolution of the diastereomeric amides has been achieved on both SE-30 and OV-17 stationary phases. The phenylbutyramides and phenylpropionamides gave the more informative mass spectra (for characterization of the amines) but molecular ions were observed in all instances.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010412
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  • 76
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    Letter to the editors (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 295-295 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010416
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  • 77
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    Identification of nitrosophenols by mass spectrometryAbbreviations: SCOT = support-coated open tubular columns; BSTFA = N, O-bis-(trimethylsilyl) trifluroacetamide. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 286-290 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Characteristic mass spectroscopic data for the identification of ten nitrosophenols is presented. The use of TMS derivatives for gas chromatography-mass spectrometry of 4-nitrosophenols is discussed, together with the use of copper chelates for obtaining direct insertion spectra of 2-nitrosophenols. The fragmentations of nitrosopher ols also show ions derived from their quinonemonoxime tautomers, even under gas chromatography-mass spectrometry conditions, indicating that isomerization occurs in the mass spectrometer. An anomalous elimination of nitrogen from these nitrosophenols has been shown to be a facile reduction of the nitroso moiety which takes place in the ion source of the mass spectrometer.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010414
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  • 78
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    Masthead (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010501
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  • 79
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    Mass fragmentography of morphine and 6-monoacetylmorphine in blood with a stable isotope internal standardAbbreviations used: 6-MAM = 6-monoacetylmorphine; TFA = trifluoroacetyl; TFAA = trifluoroacetic anhydride. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 305-311 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A mass fragmentographic method for the estimation of the estimation of free and bound morphine and free 6-monoacetylmorphine in blood has been developed. It uses stable isotope internal standards and has a sensitivity of about 1 ng per ml or about 100 times better than ordinary gas chromatography. The focusing on specific high molecular fragments of the molecules gives high specificity to the assay and the stable isotope internal standards allow correction for losses occuring in the preparative steps of the analysis. A sensitive, specific method for monoacetylmorphine is particularly valuable since this compound seems to be a specific metabolite of heroin.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010503
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    Recent advances in pyrolysis mass spectrometry of complex biological materialsThe research reported in this paper is supported by the Foundation for Fundamental Research on Matter (F.O.M.) and the Ministry of Health and Environmental Hygiene in the Netherlands, and has been presented in part at the 2nd International Symposium on Mass Spectrometry in Biochemistry and Medicine, Milan, Italy, 24th to 26th June 1974. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 312-319 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Nonvolatile biological materials, such as biopolymers or even whole cells, can be made accessible to mass spectrometric analysis by pyrolysis techniques. In principle, this enables differentiation, classification and identification of these materials. Moreover, pyrolysis mass spectrometry can provide a general picture of the chemical composition and structure of the sample analysed. During the past few years we have investigated several pyrolysis techniques in combination with different mass spectrometric methods. These investigations included Curie point pyrolysis, infrared laser pyrolysis, low voltage electron impact ionization, field ionizationIn co-operation with Professor Dr H. D. Beckey and Dr H.-R. Schulten, University of Bonn, Germany. and pyrolysis field desorption. Pyrolysis reactions were performed either at the gas inlet or directly at the ion source. The relative merits of these different experimental approaches are discussed. Additionally, examples of various applications, such as computer identification of bacteria and qualitative analyses of biopolymers, are given.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010504
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    The use of solid probe chemical ionization mass spectrometry and gas chromatography-chemical ionization mass spectrometry in quantitation of drugs in biological fluids. Determination of tolbutamide and its metabolites in human plasmaAbbreviations used: T = tolbutamide; OHT = 1-p-hydroxymethylbenzenesulfonyl-3-butylurea; COOHT = 1-p-carboxyphenylsulfonyl-3-butylurea. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 323-328 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Quantitative methods based on chemical ionization mass spectrometry are described for the determination of tolbutamide, a sulfonylurea, and its metabolites from human plasma. The sulfonylureas are extracted from the acidified plasma and then N-1 methylated with diazomethane. The methylated compounds can be subjected to gas chromatography where they are partially cleaved to the corresponding N-1 methylated sulfonamides. Alternatively, the methylated compounds can be introduced into the ion source by means of a solid sampler. The sulfonylureas upon evaporation from the solid sampler or the formed sulfonamide and the parent sulfonylurea upon elution from the gas chromatographic column are subjected to chemical ionization with methane as the reactant gas. The [M + H]+ ions formed are measured quantitatively with respect to the deuterium substituted internal standards. It is suggested that the technique of introducing biological extracts into the ion source via a solid probe may be applied for the quantification of compounds that are unstable under gas-liquid chromatographic conditions. Both the gas chromatographic and the non gas chromatographic methods provided excellent and comparable results. The plasma level-time profile of tolbutamide and its metabolites in a diabetic patient following the administration of 1.0 g tolbutamide intravenously is presented.
    Additional Material: 11 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010506
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    Characterization of the isomeric dialkylbarbituric acids formed by the reaction of barbiturates with diazoalkanes (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 340-344 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction of barbituric acids with diazoalkanes (diazomethane and diazoethane) gives the N,N′-dialkylbarbituric acids as the major products. Gas chromatograms of the reaction products show up to four additional peaks. These have been shown by mass and proton magnetic resonance spectrometry to be produced by the two isomeric N,O-dialkylbarbituric acids (1,4- and 1,2-dialkylbarbituric acids) and the two O,O′-dialkyl isomers.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010509
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  • 83
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    Mass fragmentographic studies of sulfur compounds: The thienylthiaalkanes (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 297-304 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Fragmentation studies of the mass spectra of 24 high purity compounds of importance in a study of fossil fuels are described. The substances include eleven 1-(2-thienyl)-1-thia-, six1-(2-thienyl)-3-thia, and seven1-(2-thienyl)-4-thiaalkanes in the molecular weight range 158 to 270. Rearrangement peaks are prominent in all spectra and form the base peaks for the 1-thia- and 4-thia- compounds. The 3-thia- compounds are somewhat perverse in exhibiting weaker rearrangement peaks, and large ion intensities, including base peaks, at masses typical of alkyl fragments, alkenyl fragments, or ions more characteristic of the thiaalkanes (aliphatic sulfides). The major fragment ions are discussed and their use in differentiating subclasses is described. Low ionization voltage data is presented in support of suggested mechanisms of fragmentation.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010502
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    Determination of phenformin in biological fluids using chemical ionization mass spectrometryAbbreviations used: P = phenformin; PD2 = α-dideuteriophenethyl biguanide. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 320-322 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method for the quantification of phenformin, an oral hypoglycemic biguanide, from biological fluids based upon gas chromatography and chemical ionization mass spectrometry, is reported. Phenformin is quantitatively cyclized to the 2-substituted-4-trifluoremethyl-2,6-diamino-1,3,5-S-triazine when acylated with trifluoroacetic anhydride. This cyclized product was measured with respect to the deuterium substituted phenformin. The plasma levels achieved following the administration of a therapeutic dose of phenformin to a diabetic subject are reported.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010505
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  • 85
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    Mass spectrometric identification of an N-oxide formed by incubation of N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine with rat liver microsomes (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 329-331 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On incubation with rat liver microsomes, N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine is converted to the N-oxide. The identification of this metabolite has been achieved by the use of gas chromatography, mass spectrometry and thin-layer chromatography.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010507
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  • 86
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    Studies on the mass fragmentographic determination of plasma estriol (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 332-339 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three mass fragmentatographic methods for the determination of unconjugated estriol in pregnancy plasma and unconjugated and conjugated estriol in plasma of nonpregnant women after estriol administration were developed and tested as to their reliability and practicability. The methods were found to fulfil appropriate reliability criteria especially with regard to specificity. Unconjugated estriol could be assayed without prior chromatography in late pregnancy plasma, but a chromatographic step was needed for plasmas with a low estriol titre, and both a methylation step and chromatography is needed to achieve the required specificity if plasma conjugated estriol is determined or if assays are carried out following estriol administration. Unconjugated estriol in normal late pregnancy plasma was found in concentrations from 4.3 to 9.3 μg/l. The highest value recorded, 16.3 μg/l, was found in a prediabetic subject with mild hypertension, who delivered a child weighing 4150 g by Cesarean section in the 39th week. Low values were found in severe hypertension and in toxemia, and in general the results from the pathological material investigated seemed to correlate well with the clinical findings. However, only a few samples (five to ten) can be processed so rapidly that the results can be obtained the same day, which in addition to the expensive and complicated instrumentation limits the usefulness of the methods in routine clinical chemistry.
    Additional Material: 6 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200010508
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    Identification of an atypical constitutent of a clandestine opiate (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 350-351 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An unusual morphine analog was extracted and separated from an opium-like sample. The high resolution mass spectrum of the unknown substance confirmed the empirical formula as C17H18O2NCl. Mass spectra and retention factor values in thin-layer chromatography of both unknown and authentic standards were compared, which lead to the identification of the unknown as β-chloromorphide.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010511
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  • 88
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    Pyrolysis mass spectrometric studies on nucleic acids (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 352-357 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two different mass spectrometric techniques have been used to analyse the products resulting from Curie-point pyrolysis of nucleic acids: low voltage ionization quadrupole mass spectrometry and high resolution field ionization mass spectrometry. The spectra obtained with both techniques are in good agreement with one another. As already indicated by the low resolution spectra, the high resolution spectra proved that most of the peaks originate from the carbohydrate moiety of the nucleic acid. Micrograms of DNA/RNA can be distinguished very easily by use of these key fragments, although the bases themselves are not found. Some significant pyrolysis mechanisms are proposed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010512
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  • 89
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    A quantitative method of sample loading for field desorption mass spectrometry (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 358-362 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantitative method for loading nanogram samples onto field desorption emitter wires is described. Sample consumption is reduced and problems with emitter wettability are overcome by freezing microliter droplets onto the emitters. Using this technique, good spectral data are obtained from 10 to 50 ng of material. Field desorption sensitivity measurements are reported for neomycin B, adenosine and cholesterol. Evaluation of the nonquantitative dipping technique previously employed reveals poor and nonreproducible sample loading efficiency.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010513
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  • 90
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    News and events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. xv 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010516
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  • 91
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    The analysis of ashed mammalian blood by high resolution spark source mass spectroscopy (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 365-366 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Spark source mass spectrometry at a resolving power of up to 19 000 has been used to analyse an ashed human blood standard and an unknown animal blood for 28 elements.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010515
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  • 92
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    Gas-liquid chromatography and mass spectrometry of biologically active primary amines as their isothiocyanate derivativesAbbreviations: BSTFA = bis-trimethylsilyltrifluoroacetamide; TMCS = trimethylchlorosilane: PEA = phenylethylamine; PIA = phenylisopropylamines; DMPEA = 3,4-dimethoxyphenethyl-amine. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 367-373 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Biologically active primary amines (phenethylamines, amphetamines and tryptamines) form thermally stable isothiocyanate derivatives by reacting with carbon disulfide. Phenolic hydroxyl and indole (NH) nitrogens are further converted to their trimethylsilyl derivatives. The gas chromatographic and mass spectrometric properties of several amines are presented. It is shown that the combined use of gas chromatography and mass spectrometry of these derivatives is well suited for the differentiation of several structural isomers. Fragmentation mechanisms leading to the formation of structurally significant ions are discussed.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200010602
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  • 93
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    Estimation of picomole quantities of piperidine in tissuesAbbreviations: [3H]DNFB = tritium labelled 2,4-dinitrofluorobenzene; Dns-Cl = 5-dimethylaminonaphthalene-1-sulphonyl chloride; Bns-Cl = 5-di-n-butylaminonaphthalene-1-sulphonyl chloride. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 381-385 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Piperidine is a putative neurotransmitter. Its sensitive determination is one of the prerequisites for the evaluation of its assumed physiological role. For its derivatization 5-di-n-butylaminonaphthalene-1-sulphonyl chloride, a new reagent which improves methods applying 5-dimethylaminonaphthalene-1-sulphonyl chloride, is used. Reaction of the perchloric acid tissue extract with this reagent, thin-layer chromatographic separation of the fluorescent derivatives and mass spectrometric evaluation of the di-n-butylaminonaphthalenesulphonyl piperidine spot by a version of the integrated ion current technique allows the determination of piperidine in tissues in picomole quantities. Standard deviation of the determinations of 2 to 16 pmol of piperidine added to 50 mg of brain tissue was ±8%. The method was applied to the analysis of different tissues. Brain concentrations of piperidine in different species were found to be lower by a factor up to 100 in comparison with published data.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010604
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    Intramolecular carbon isotopic distribution in biologically produced acetoin (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 415-417 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The concentrations of carbon-13 in the individual carbon atoms of 3-hydroxy-2-butanone (acetoin) from apple cider vinegar decrease with decreasing oxidation level in the sequence .Because the distributions of isotopes within biological compounds are controlled by kinetic and equilibrium effects, intramolecular isotopic analyses may provide a means of defining the equilibria between metabolic pathways and of recognizing the molecular remnants of pre-existent organisms in geological samples.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010609
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    Computerized mass fragmentography and peak matchingAbbreviations: m.f. = mass fragmentography; a.v.a. = accelerating voltage alternator; m.i.d. = multiple ion detection; p.m. = peak matching; d.a.c. = digital to analogue converter; a.d.c. = analogue to digital converter; d.c. = direct current; t.i.c. = total ion current; PFK = perfluorokerosene. (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 397-411 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The minicomputer calculates and sets the required accelerating voltages by means of a 16 bit d.a.c. for maximum 8 masses within a 30% mass range. These, together with the t.i.c., are displayed in real time on a television screen and recorded on magnetic tape with a dynamic range of 1:32 000. Automatic fine adjustment of the mass focus and compensation for drifts in the magnetic field are some of the features in the mass fragmentographic package, which also allows data to be displayed, analysed, edited and plotted. Quantitative analyses can be handled entirely by the system if it is provided with the weight ratios of the compound to be determined and the standards to construct the standard curve. A table of the concentration per ml sample at the various times and/or a semi-log plot may be obtained by providing the amount of the standard added to the sample (e.g. blood), the extracted sample volume and the time at which the sample was drawn. Mass determinations of isolated or non-isolated compounds (nanogram amounts) can be performed within a few minutes with a precision usually better than 5 ppm employing a single focusing instrument at a resolution of 600-700. A maximum of seven unknown masses within a 30% range can be specified and determined simultaneously or in a preselected order. The shortest sweep time of the ion beam is 300 ms. The peak shapes can be analysed by displaying the data stored on magnetic tape on the television monitor.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010607
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    Multiple ion detection by accelerating voltage alternation in conjunction with voltage sweeping (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 418-422 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An analog multiple ion detection system has been developed for magnetic sector mass spectrometers based on accelerating voltage alternation in conjunction with the accurate maintenance of focusing by means of voltage sweeping, using a superimposed a.c. sine wave voltage. This multiple ion detector voltage sweep system is easily constructed, inexpensive and produces analytical data of much greater precision than that reported from conventional systems. The application of the multiple ion detector voltage sweep system to biomedical problems is illustrated by the development of a method for the determination of stable isotope enrichment in blood glucose and alanine in children infused with tetradeuterio-L-alanine and dideuterioglucose to study gluconeogenesis and glucose utilization in vivo.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010610
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  • 97
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    Beneficial effect of macrocyclic ligands on field desorption mass spectra of samples containing alkali metal ions (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 425-426 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Addition of a macrocyclic ligand, such as a crown ether or cryptate, to the solution of an organic compound containing alkali metal ions prior to field desorption mass spectral analysis, has been shown to result in a reproducible, smooth field desorption process at low anode temperature. Crystalline dibenzo-18-crown-6 ether complexes of NaI and KI give field desorption spectra in which free and complexed ligands are of comparable intensity. Cryptate complexes retain the metal ion even more strongly, as illustrated by the fact that the complex of LiCl with [2.1.1]-cryptate yields almost exclusively the complexed lithium peak on field desorption. Alkali metal salts with organic anions also desorb more smoothly after complexation, although in the case of simple carboxylates the anion is found only in a cluster peak.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010612
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    Forthcoming events (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. x 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010616
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  • 99
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    Metabolism of [14C]niflumic acid isolation and identification of metabolites from human urine (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 1-4 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The two major metabolites of [14C]niflumic acid, 2-(3′-[14C] trifluoromethylanilino)nicotinic acid have been isolated from human urine. Low and high resolution mass spectrometry indicate that both metabolites (M2a and M2b) are monohydroxylated derivatives of niflumic acid. The 100 MHz proton magnetic resonance spectrum of M2b demonstrates it to be 5-hydroxyniflumic acid, whereas M2a is either the 4′- or 6′-hydroxy derivative. The synthesis of 6′-methoxyniflumic acid methyl ester and comparison of its spectral data and melting point with that of the corresponding derivative of M2a reveal their non-identity. The structure of M2a is, therefore, 4′-hydroxyniflumic acid.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010103
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  • 100
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    The field ionization spectra of some natural coumarins (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 5-9 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The field ionization and electron impact mass spectra of eleven coumarins have been compared. In the field ion spectra the molecular ions were the base peaks and structurally diagnostic fragment ions formed by direct cleavage were present, whereas the molecular ions were weak in the electron impact spectra and fragment ions formed by rearrangement were dominant. Crude coumarin mixtures obtained from natural sources have been successfully examined using field ionization and gas chromatography + field ionization mass spectrometry.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010104
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