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  • 2005-2009  (1)
  • 1985-1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Studies for the Development of a Simulation Basis for Numerically Controlled Driving of Sheet Metal (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 6-8 (May 2005), p. 517-524 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The manufacturing technique of driving is one of the oldest procedures for sheet metal forming and has been used in the ancient world for the production of copper pots and vases. This technique is still utilized for niche applications but today has lost its importance. The process of driving is almost completely carried out manually and thus is only appropriate for very small quantities or in case of failure of other production processes. Since individualization of products is strongly gaining in significance, forming processes have to be found, which are independent from expensive tools and equipment. Using driving as the process of choice to form sheet metal, the grade of automation of the forming process has to be increased. Numerically controlled driving, i.e. automated positioning and handling of the work piece during the production process, will need a conclusive simulation base. This paper provides results of the analysis of sheet steel angles formed by the driving sub groups of shrinking and stretching
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.6-8.517.pdf
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reversible Keimzelltoxizität nach aggressiver Chemotherapie bei Patienten mit Hodentumoren: Ergebnisse einer prospektiven Studie (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 367-378 
    Details
    ISSN: 1432-1440
    Keywords: Germ cell tumors ; Gonadal toxicity ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The impact of aggressive chemotherapy on reproductive and endocrine gonadal function was prospectively studied in 44 patients with germ cell tumors. Diagnostic procedures to determine gonadal toxicity consisted of hormone determinations, semen analyses, interviews with a standardized questionnaire, and gonadal histology. After chemotherapy all patients showed elevated serum levels of follicle-stimulating hormone (FSH) and azoospermia due to germ cell and stem cell loss. Recovery of spermatogenesis, as indicated by normalization of serum FSH levels and sperm density, occurred in 77% of the patients 25–60 months after cessation of chemotherapy. In all patients serum testosterone and luteinizing hormone (LH) values remained within normal limits after therapy indicating resistance of Leydig cells to cytotoxic drugs. Three patients fathered four healthy children after completion of chemotherapy. These data suggest significant reproductive dysfunction in all men treated for germ cell tumors. However, most patients showed late and complete recovery of spermatogenesis. In contrast, endocrine gonadal function was unaffected after chemotherapy in all patients. FSH and LH are feasible markers to assess drug-induced gonadal toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711264
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of advanced renal cell cancer with recombinant interferon alpha as a single agent and in combination with medroxyprogesterone acetate (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 95-100 
    Details
    ISSN: 1432-1335
    Keywords: Interferon plus MPA ; Advanced renal cell cancer ; Medroxyprogesterone acetate (MPA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFNα) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFNα 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFNα 2C (2MU) was given s.c. 5 times per week for 8–12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p. o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4%, corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390492
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment of distal ureteral calculi with ESWL: experience with more than 100 consecutive cases (1987)
    Springer
    World journal of urology 5 (1987), S. 259-261 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Until recently, the indications for extracorporeal shock wave lithotripsy (ESWL) have been limited to renal calculi and ureteral calculi above the pelvic brim. However, the distal ureter can be made available for shock wave treatment as well, by modifying the position of the patient on the support of the Dornier lithotripter HM-3. Using this “sitting position” technique, 133 patients with stones or stone fragments in the lower ureter were treated from January through November 1986. Treatment was successful in 125 patients (94%), 14 of whom required 2 sessions. In 8 patients, treatment failed and stone removal was accomplished using ureteroscopy or open surgery. No complications or adverse side effects were encountered in the entire series. We consider ESWL the treatment of choice in the management of distal ureteral calculi and Steinstrassen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327231
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    Paper (German National Licenses)
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