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  • 1
    Electronic Resource
    Electronic Resource
    Zur Imaginärgeometrie des Raumes (1931)
    Springer
    Monatshefte für Mathematik 38 (1931), S. 291-300 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700700
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  • 2
    Electronic Resource
    Electronic Resource
    Zur Theorie ebener Dreiecksnetze aus Kegelschnitten (1933)
    Springer
    Monatshefte für Mathematik 40 (1933), S. 411-417 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01708878
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  • 3
    Electronic Resource
    Electronic Resource
    Imaginärgeometrie und die Residuen Cauchys (1931)
    Springer
    Monatshefte für Mathematik 38 (1931), S. 167-172 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700691
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  • 4
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    Unknown
    Socratic Moderation and Self-Knowledge (1983)
    Berkeley, Calif. : Periodicals Archive Online (PAO)
    Journal of the history of philosophy. 21:3 (1983:July) 339 
    Details
    ISSN: 0022-5053
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b151-1983-021-03-000004
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  • 5
    Electronic Resource
    Electronic Resource
    Der Widerstand des menschlichen Körpers gegen Hochfrequenzströme bei Diathermiebehandlung (1930)
    Springer
    Electrical engineering 24 (1930), S. 202-215 
    Details
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung 1. Die Frage nach der bei Diathermiebehandlung zugeführten Leistung wird an Hand der von Gildemeister aufgestellten Theorie der elektrischen Leitung im Organismus erörtert. 2. Die meßtechnische Aufgabe wird aus den Ergebnissen früherer Messungen entwickelt. 3. Als geeignetes Meßverfahren wird eine Differentialanordnung gewählt, die sich für den vorliegenden Zweck vor allem durch eine sehr geringe Empfindlichkeit gegen Erdkapazität des Meßobjektes auszeichnet. 4. Die verschiedenen Fehlerquellen werden geprüft und entsprechende Korrekturen eingeführt. Es wird gezeigt, wie sich aus den Messungen gleichzeitig ein Anhalt über die Wirkung der Erdkapazität der Versuchsperson gewinnen läßt. 5. Eine Reihe von Messungen bei verschiedenen Behandlungsarten ergibt, daß der menschliche Körper bei Hochfrequenz mit einer für die Praxis der Diathermie ausreichenden Genauigkeit als reiner Widerstand betrachtet werden darf.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01656725
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  • 6
    Electronic Resource
    Electronic Resource
    Glucocorticoid receptors and sensitivity in leukemias (1981)
    Springer
    Annals of hematology 42 (1981), S. 183-190 
    Details
    ISSN: 1432-0584
    Keywords: Glucocorticoid-Rezeptoren ; Sensitivität ; Leukämie ; Glucocorticoid receptors ; Sensitivity ; Leukemias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In an attempt to investigate the utility of glucocorticoid receptor determination to predict clinical responsiveness in human leukemias we have studied glucocorticoid receptors in the leukemic cells from 46 patients and in the lymphocytes from 18 normal donors. In the normal lymphocytes there were 3,875 (Median) specific binding sites per cell. The blasts from 17 patients with ANLL had on average higher levels of binding sites per cell (Median = 7,250, range: 0 to 15,295) than the other leukemias. Of the 15 patients with CLL, six had received glucocorticoid treatment for 3 to 5 years. Their lymphocytes had lower number of receptors (Median = 2,000) than the other cases which were newly diagnosed (Median = 4,500). Four patients had ALL/AUL, three patients had blast crisis as terminal phase of CML, and seven had leukemic Non-Hodgkin lymphomas (Median = 3,500 sites/cell). In 24 patients we have also studied the in vitro sensitivity of the leukemic cells to dexamethasone. There was no marked correlation between glucocorticoid receptor levels and in vitro sensitivity. An attempt to correlate receptor levels with clinical responsiveness demonstrated that glucocorticoid receptor determination might be of value in patients with lymphoid malignancies but probably not in patients with other leukemias.
    Notes: Zusammenfassung Zur Prüfung der Frage, ob eine positive Korrelation zwischen dem Steroid-Rezeptorgehalt von Leukämiezellen und dem Erfolg einer Steroid-Therapie besteht, haben wir Glucocorticoid-Rezeptoren bei Leukämien und Lymphomen untersucht. Die Bestimmung erfolgte nach Baxter und Tomkins. Untersucht wurden 46 Patienten mit Leukämien und 18 Kontrollpersonen. Normale Lymphozyten haben durchschnittlich 3875 spezifische Bindungsstellen pro Zelle. Die Anzahl der Glucocorticoid-Rezeptoren in den Blasten von 17 Patienten mit akuter myeloischer Leukämie zeigten starke Schwankungen (Bereich 0 bis 15295 Rezeptoren pro Zelle). Sechs von 15 Patienten mit chronischer lymphatischer Leukämie wurden seit Jahren mit Glucocorticoiden behandelt und sprachen zur Zeit der Steroid-Rezeptor-Bestimmung auf diese Therapie nicht mehr an. Die Anzahl der Steroid-Bindungsstellen der Lymphozyten dieser Patienten erwies sich im Mittel als niedriger (2000 je Zelle) als bei den unbehandelten Patienten (4500 je Zelle). Bei 24 Patienten haben wir auch die In-Vitro-Sensitivität der Leukämiezellen gegenüber Dexamethason untersucht. Es konnte keine eindeutige Korrelation zwischen Rezeptorengehalt und In-Vitro-Sensitivität festgestellt werden. Weitere Analysen mit klinischen Daten weisen darauf hin, da\ die Bestimmung von Glucocorticoid-Rezeptoren für die Planung und Durchführung einer Therapie bei den lymphatischen Leukämien Bedeutung erlangen kann, jedoch wahrscheinlich nicht bei den myeloischen Leukämien.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01026388
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  • 7
    Electronic Resource
    Electronic Resource
    The delivery of genetic counseling services in Europe (1980)
    Springer
    Human genetics 〈Berlin〉 56 (1980), S. 1-5 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Oranizational forms and the current status of genetic counseling within the health care system of 15 European countries were evaluated by questionnaire and at a symposium, with individuals present from Austria, Belgium, Czechoslovakia, Denmark, the Federal Republic of Germany, the German Democratic Republic, Finland, France, Hungary, Italy, the Netherlands, Norway, Switzerland, the United Kingdom, and the Soviet Union. In spite of wide differences between these countries, certain similarities with respect to the delivery of genetic counseling services could be observed: (i) most genetic counseling is done within university institutions or closely linked to it; (ii) governmental support of genetic counseling is developing slowly, and genetic counseling is usually not yet fully integrated into the health care system; (iii) there is lack of qualified personnel; (iv) no guide lines for formal education have been developed, but a postgraduate training period of no less than four years is considered a minimum; (v) without appropriate support, genetic counseling is a burden for research in human genetics; yet, a strict separation of genetic counseling and research activities is not recommended; (vi) on the average, a team providing genetic counseling for about 1–2 million people should consist of 3–4 physicians, 5–10 technicians, 2–3 secretaries, and other supportive personnel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281565
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  • 8
    Electronic Resource
    Electronic Resource
    The “Cat Eye syndrome”: Dicentric small marker chromosome probably derived from a No. 22 (Tetrasomy 22pter→q11) associated with a characteristic phenotype (1981)
    Springer
    Human genetics 〈Berlin〉 57 (1981), S. 148-158 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Eleven patients with the so-called Cat Eye syndrome are reported including a more detailed description of the original cases reported by Schnid and Fraccaro. All cases had, in addition to a normal karyotype, a small extra G-like chromosome which appeared to be an isochromosome for the juxtacentromeric region (pter→q11) of an acrocentric chromosome. None were mosaics. Clinical findings and further cytogenetic studies in a few cases suggest that these markers probably derive from a No. 22 chromosome. Characteristic features of the Cat Eye syndrome in these 11 patients and those reviewed from the literature are: ocular coloboma which may involve the iris, choroid and/or optic nerve, preauricular skin tags and/or pits which are probably the most consistent feature, congenital heart defect, anal atresia with a fistula, renal malformations such as unilateral absence, unilateral or bilateral hypoplasia, and cystic dysplasia, and antimongoloid position of eyes. Intelligence is usually low-normal, although moderate retardation is also seen. There is great variability in the clinical findings ranging from near normal to lethal malformations. Less frequent, but also characteristic findings are: microphthalmia, microtia with atresia of the external auditory canal, intrahepatic or extrahepatic biliary atresia and malrotation of the gut. Direct transmission of the marker from one generation to the other was observed in both sexes. In those families, there was considerable variability in the clinical findings between affected family members. Theses cases show that there is a bias of ascertainment for patients who have the more striking malformation, especially those with ocular coloboma and anal atresia, a combination which appears to be present in only a minority of cases. Many mildly affected patients probably remain undetected. It is proposed that the term Cat Eye syndrome should be applied only to cases with trisomy or tetrasomy of not more than 22pter→q11 and without additional duplication or deletion of another autosomal segment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282012
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  • 9
    Electronic Resource
    Electronic Resource
    Incomplete trisomy 22 (1981)
    Springer
    Human genetics 〈Berlin〉 56 (1981), S. 249-262 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A syndrome due to 3:1 meiotic segregation of balanced 11/22 translocation is defined from nine personally observed patients and 22 cases from the literature with apparently the same aberration. Frequent findings include a characteristic face with deepset eyes, flat nose, prominent upper lip, receding mandible and preauricular pits or tags, male genital hypoplasia, anal atresia or other anomalies of the anus, cleft palate, and congenital heart defect. Less frequent are severe reduction of the auricles, an additional pair of ribs, and hypoplasia of the diaphragm. Perinatal mortality is high. Growth is usually and psychomotor development is invariably and severely delayed. Balanced 11/22 translocations are apparently disproportionally frequent; as the balanced rearrangement is not easy to detect, it is important to be aware of it at the family investigation of cases with extra chromosomes similar to a No.22 or 22q-.The unbalanced products are most probably trisomic for both a segment of 22 (22q-) and a distal segment of 11q; the exact determination of the breakpoints is not possible at present due to the similar banding characteristics of the two segments involved in the translocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274675
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  • 10
    Electronic Resource
    Electronic Resource
    Letters to the Editors (1982)
    Springer
    Human genetics 〈Berlin〉 62 (1982), S. 180-180 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282312
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