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  • missense mutation  (4)
  • Leguminosae  (2)
  • Lower uterine segment  (2)
  • Nuclear Reactions  (2)
  • (Diptera)  (1)
  • Binding mechanism  (1)
Datenquelle
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    d-Alanine in germinating Pisum sativum seedlings
    Amsterdam : Elsevier
    Phytochemistry 12 (1973), S. 2593-2595 
    Details
    ISSN: 0031-9422
    Schlagwort(e): Leguminosae ; N-malonyl-d-alanine. ; Pisum sativum ; d-alanine ; pea ; γ-l-glutamyl-d-alanine
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(73)85061-7
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  • 2
    Digitale Medien
    Digitale Medien
    Improved isolation method and some properties of soybean gamma-conglycinin
    Amsterdam : Elsevier
    Phytochemistry 23 (1984), S. 1523-1526 
    Details
    ISSN: 0031-9422
    Schlagwort(e): Glycine max ; Leguminosae ; MW ; electrophoresis ; gamma-conglycinin ; soybean protein
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)83431-7
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  • 3
    Digitale Medien
    Digitale Medien
    In-beam γ-Ray study of ^2^1^2Po
    Amsterdam : Elsevier
    Nuclear Physics, Section A 443 (1985), S. 461-471 
    Details
    ISSN: 0375-9474
    Schlagwort(e): Nuclear Reactions
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(85)90412-9
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  • 4
    Digitale Medien
    Digitale Medien
    Spin-flip magnetic quadrupole transitions in ^1^1^5Sn and ^1^1^7Sn
    Amsterdam : Elsevier
    Nuclear Physics, Section A 470 (1987), S. 1-12 
    Details
    ISSN: 0375-9474
    Schlagwort(e): Nuclear Reactions ; Radioactivity
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(87)90118-7
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  • 5
    Digitale Medien
    Digitale Medien
    The pH-dependent swinging-out of the distal histidine residue in ferric hemoglobin of a midge larva (Tokunagayusurika akamusi)
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1208 (1994), S. 306-309 
    Details
    ISSN: 0167-4838
    Schlagwort(e): (Diptera) ; (T. akamusi) ; CD Soret magnetic ; Distal histidine ; Hemoglobin ; Midge larva ; Pentacoordination
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(94)90117-1
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  • 6
    Digitale Medien
    Digitale Medien
    Examination of previous caesarean section scars by ultrasound (1988)
    Springer
    Archives of gynecology and obstetrics 243 (1988), S. 221-224 
    Details
    ISSN: 1432-0711
    Schlagwort(e): Vaginal delivery ; Caesarean section ; Previous caesarean section scar ; Ultrasonography ; Lower uterine segment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We examined 84 lower segment caesarean section scars by ultrasonography near term. Seventy scars showed good healing with a thickness of the lower uterine segment of more than 3 mm; 14 scars showed poor healing with a thickness of less than 2 mm and loss of continuity. Among 70 patients with good healing, 24 patients delivered vaginally but the remaining 46 patients have had repeat caesarean sections for other obstetric indications. Intraoperative findings in these 46 patients were as follows: Grade I (no thinning of the lower uterine segment), 42; Grade II (thinning and loss of continuity of the lower uterine segment but fetal hair not visible), 4; Grade III (thinning of the lower uterine segment and fetal hair visible), 0. Fourteen patients with poor healing had repeat caesarean sections. Intraoperative findings in these 14 patients were as follows: Grade I, 0; Grade II, 9; Grade III, 5. These results indicate that ultrasound examination detect thinning of the lower uterine segment and may help to determine management.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932271
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  • 7
    Digitale Medien
    Digitale Medien
    Studies on the binding mechanism of fluoroquinolones to melanin (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 72-76 
    Details
    ISSN: 1437-7780
    Schlagwort(e): Key words Ocular melanin ; Melanin affinity ; Fluoroquinolones ; Metal ions ; Binding mechanism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In order to elucidate the binding mechanism of melanin and fluoroquinolones (ofloxacin, norfloxacin, ciprofloxacin, lomefloxacin, levofloxacin), we investigated the interaction of fluoroquinolones with compounds such as l-β-(3,4-dihydroxyphenyl) alanine (l-DOPA), l-tyrosine, 5-hydroxy-l-tryptophan, l-tryptophan, and l-phenylalanine, which possess the kind of functional groups that melanin does and are closely related to melanin. The recovery of drugs from the melanin-drug complexes by metal ions of Li, Na, Ka, Mg, Ca, Ba, Cu, Ni, and Fe was demonstrated. Smaller and highly charged cations were found to be more effective for this recovery, and magnesium ions were the most effective of all the ions investigated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00012154
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  • 8
    Digitale Medien
    Digitale Medien
    Association of Trp64Arg mutation of the β3-adrenergic-receptor with NIDDM and body weight gain (1996)
    Springer
    Diabetologia 39 (1996), S. 349-352 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Β3-adrenergic-receptor gene ; susceptibility ; missense mutation ; non-insulin-dependent diabetes mellitus ; insulin resistance syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A possible pathogenic mutation in the Β3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects. Since marked heterogeneity has been reported in the association of mutations of candidate genes with NIDDM between Japanese and other ethnic groups, we investigated the association of Trp64Arg with NIDDM in Japanese subjects. The allele frequency of the mutation (Arg) was slightly, but not significantly, higher in NIDDM than in control subjects (70 out of 342 alleles [20.5%] vs 40 out of 248 [16.1%], respectively, p〉0.2). When our data were combined with those of Pima Indian and Finnish subjects, however, the Arg/Arg genotype was significantly associated with NIDDM as compared with the other two genotypes (p〈0.005, relative risk [RR] 2.13, 95% confidence interval [CI] 1.28–3.55). The Arg allele was also associated with NIDDM (p〈0.05, RR 1.27, 95% CI 1.06–1.52). Japanese subjects homozygous for the mutation had a significantly higher body mass index (mean ± SD∶25.5±3.9 kg/ m2) than heterozygotes (22.6±4.1, p〈0.05) and normal homozygotes (22.8±3.8, p〈0.05). NIDDM patients homozygous for the mutation tended to have an earlier age of onset of NIDDM than those with other genotypes. These data suggest that the Trp64Arg mutation not only contributes to weight gain and age-at-onset of NIDDM but is also associated with susceptibility to NIDDM.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00418352
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  • 9
    Digitale Medien
    Digitale Medien
    A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus (1995)
    Springer
    Diabetologia 38 (1995), S. 983-985 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Glucagon receptor gene ; susceptibility ; missense mutation ; non-insulin-dependent diabetes mellitus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A possible pathogenic mutation in the glucagon receptor gene causing a Gly to Ser change at codon 40 (Gly40Ser) was reported to be associated and linked with non-insulin-dependent diabetes mellitus (NIDDM), in France and Sardinia, Since the frequency of the mutation (Gly40Ser), about 5% in the French population of familial NIDDM and 8% in randomly chosen diabetic patients in Sardinia, was much higher than that of any of the previously reported mutations in candidate genes, it is important to clarify whether the contribution of this mutation to NIDDM is universal. In this study, we investigated the association of this mutation with diabetes mellitus in a large number of Japanese diabetic patients (383 NIDDM and 53 insulin-dependent diabetic patients) by polymerase chain reaction-restriction fragment length polymorphism analysis. None of the Japanese diabetic patients showed Gly40Ser mutation and the association of this mutation with NIDDM was significantly different (p〈4·10−5 vs French, p〈3·10−6 vs Sardinian by Fisher's exact test). The results not only indicate that the mutation plays little, if any, role in susceptibility to diabetes in Japan, but also indicate the genetic heterogeneity in NIDDM and further emphasize the importance of studies on genetic susceptibility to NIDDM and other complex traits in different ethnic groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00400589
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  • 10
    Digitale Medien
    Digitale Medien
    A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus (1995)
    Springer
    Diabetologia 38 (1995), S. 983-985 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Key words Glucagon receptor gene ; susceptibility ; missense mutation ; non-insulin-dependent diabetes mellitus.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A possible pathogenic mutation in the glucagon receptor gene causing a Gly to Ser change at codon 40 (Gly40Ser) was reported to be associated and linked with non-insulin-dependent diabetes mellitus (NIDDM), in France and Sardinia. Since the frequency of the mutation (Gly40Ser), about 5 % in the French population of familial NIDDM and 8 % in randomly chosen diabetic patients in Sardinia, was much higher than that of any of the previously reported mutations in candidate genes, it is important to clarify whether the contribution of this mutation to NIDDM is universal. In this study, we investigated the association of this mutation with diabetes mellitus in a large number of Japanese diabetic patients (383 NIDDM and 53 insulin-dependent diabetic patients) by polymerase chain reaction-restriction fragment length polymorphism analysis. None of the Japanese diabetic patients showed Gly40Ser mutation and the association of this mutation with NIDDM was significantly different (p 〈 4 · 10−5 vs French, p 〈 3 · 10−6 vs Sardinian by Fisher's exact test). The results not only indicate that the mutation plays little, if any, role in susceptibility to diabetes in Japan, but also indicate the genetic heterogeneity in NIDDM and further emphasize the importance of studies on genetic susceptibility to NIDDM and other complex traits in different ethnic groups. [Diabetologia (1995) 38: 983–985]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00400589
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