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  • Polymer and Materials Science  (5)
  • glucagon  (3)
  • Cyclic peptide  (2)
  • Inhalation  (2)
  • 36.00
  • 1
    Digitale Medien
    Digitale Medien
    Hemolytic activity of a cyclic peptide Ro09-0198 isolated from Streptoverticillium
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 940 (1988), S. 171-179 
    Details
    ISSN: 0005-2736
    Schlagwort(e): (Streptoverticillium) ; Cinnamycin ; Cyclic peptide ; Hemolysis ; Phospholipid ; Ro09-0198
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(88)90192-7
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  • 2
    Digitale Medien
    Digitale Medien
    Interaction of a cyclic peptide, Ro09-0198, with phosphatidylethanolamine in liposomal membranes
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 940 (1988), S. 180-187 
    Details
    ISSN: 0005-2736
    Schlagwort(e): Cyclic peptide ; Liposome permeability ; Phosphatidylethanolamine ; Ro09-0198 ; Streptoverticillium)
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(88)90193-9
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  • 3
    Digitale Medien
    Digitale Medien
    Direct write-out of particle size distribution of inhaled aerosol deposition using a laser scattering method
    Amsterdam : Elsevier
    Respiration Physiology 78 (1989), S. 107-121 
    Details
    ISSN: 0034-5687
    Schlagwort(e): Breathing ; Human, HeNe gas laser ; Inhalation ; Nebulizer
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(89)90146-1
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  • 4
    Digitale Medien
    Digitale Medien
    Response of gastric inhibitory polypeptide (GIP) to oral administration of nutrients in normal and pancreatectomized dogs
    Amsterdam : Elsevier
    Regulatory Peptides 5 (1983), S. 263-272 
    Details
    ISSN: 0167-0115
    Schlagwort(e): arginine ; fat ; glucagon ; glucose ; insulin
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(83)90257-4
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  • 5
    Digitale Medien
    Digitale Medien
    The application of incoherent light for the study of femtosecond-picosecond relaxation in condensed phase (1988)
    Springer
    Applied physics 47 (1988), S. 107-125 
    Details
    ISSN: 1432-0649
    Schlagwort(e): 36.00 ; 42.65 ; 42.80
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract A convenient technique for the ultrashort-relaxation-time measurement using temporally incoherent light instead of short pulses can be applied to the studies of relaxation processes. Theoretical studies on measuring various types of relaxation times by this method are summarized. We have applied this technique to the studies of the electronic dephasing in a polydiacetylene film, the vibrational dephasing in dimethylsulfoxide and the relaxation of optical Kerr effect in CS2 and nitrobenzene.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00684078
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of glicentin-related peptides on glucagon secretion in anaesthetized dogs (1986)
    Springer
    Diabetologia 29 (1986), S. 397-401 
    Details
    ISSN: 1432-0428
    Schlagwort(e): GLI ; glicentin-related peptide ; glucagon ; insulin ; dog pancreas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recent studies have demonstrated that glicentin is released during nutrient ingestion. However, the biological function of glicentin remains unclear. In order to clarify the role of glicentin in the enteroinsular axis, the effect of glicentin-related peptides was investigated using in vivo local circulation of canine pancreas. Peaks I and II of gut glucagon-like immunoreactivity, partially purified from porcine intestinal extract by affinity chromatography and gel filtration, synthesized hexadecapeptide of N-terminal glicentin (1–16) and synthesized octapeptide of C-terminal glicentin (62–69) were administered for 10 min into the pancreaticoduodenal artery of canine pancreas. Blood samples were then drawn from the pancreaticoduodenal vein. The administration of peak I of glucagon-like immunoreactivity during arginine infusion in a dosage of 20 ng reduced the glucagon secretion by 42 pmol/1 (p〈0.05), whereas peak 11 of glucagon-like immunoreactivity (20 ng) slightly increased the plasma level of insulin, although not significantly. The administration of glicentin (1–16) in a dosage of 400 ng during saline infusion did not alter the plasma insulin level, but reduced the plasma glucagon level in the pancreaticoduodenal vein by 29 pmol/1 (p〈0.05). In addition, glicentin [62–691 in a dosage of 400 ng exerted a decrease in both the plasma insulin (40 mU/1,p〈0.05) and glucagon level (27 pmol/l,p〈0.05). The present study demonstrates the suppression of pancreatic glucagon release during the infusion of peak I glucagon-like immunoreactivity and N- or C-terminal glicentin-related peptide. Therefore, it is suggested that glicentin released during nutrient intake might inhibit the secretion of glucagon.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00903352
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  • 7
    Digitale Medien
    Digitale Medien
    Insulin and glucagon in spontaneously diabetic non-obese mice (1984)
    Springer
    Diabetologia 27 (1984), S. 460-463 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Non-obese diabetic mice ; pancreas ; stomach ; insulin ; glucagon ; intestine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To investigate the rôle of glucagon in the development of diabetes mellitus, spontaneously diabetic non-obese mice were studied before (group 1) and after the onset of diabetes mellitus (group 2). In group 1, fasting blood glucose and insulin in plasma and pancreas did not differ significantly, while plasma glucagon was elevated (48.9±10.4 versus control 18.6±6.0pmol/l). In group 2, the insulin content of plasma and the pancreas were markedly reduced, whereas plasma glucagon was elevated (180.9±59.1 pmol/l). When diabetic mice were treated with insulin for 4 weeks (group 3), plasma glucagon was markedly reduced compared with that of group 2 (30.3±9.0 pmol/l). In group 1, glucagon and glucagon-like immunoreactivity of the intestine were reduced. The glucagon content of the intestine was elevated in group 2. Group 3 elicited increased contents of gastric glucagon as well as intestinal glucagon-like immunoreactivity. We conclude that, in addition to insulin deficiency, hypersecretion of glucagon might contribute to the development and clinical course of diabetes mellitus in the non-obese diabetic mouse.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00273911
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  • 8
    Digitale Medien
    Digitale Medien
    Mechanism of acute lung injury caused by inhalation of fabric protector and the effect of surfactant replacement (1998)
    Springer
    Intensive care medicine 24 (1998), S. 55-60 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Key words Acute lung injury ; Blood gas ; Fabric protector ; Inhalation ; Pulmonary surfactant ; Surface tension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To evaluate the role of surfactant in the mechanism and treatment of acute lung injury caused by inhalation of fabric protector. Design: Prospective, randomized study. Setting: University laboratory. Interventions: In vitro experiment: a porcine surfactant suspension (10 mg · ml−1) was exposed to a fabric protector aerosolized with an ultrasonic nebulizer for 1 min. Minimum surface tension (γ min) was sequentially measured using pulsating bubble equipment. Animal experiment: 14 adult rats were anesthetized with pentobarbital and mechanically ventilated with pure oxygen. Then, all rats inhaled fabric protector aerosolized with the nebulizer for five breaths. Three hours after inhalation, the rats were randomly assigned to two groups: a surfactant group (n = 7), in which surfactant (100 mg · kg−1) was replaced, and a control group (n = 7), in which no substance was given. Measurements and results: In vitro experiment: exposure to fabric protector aerosol increased the mean γ min of the surfactant from 1.7 to 19.2 mN · m−1 (n = 5, p 〈 0.05). Animal experiment: the mean partial pressure of oxygen in arterial blood (PaO2) in all rats decreased from 62.8 to 17.1 kPa at 3 h after inhalation. The PaO2 in the surfactant group increased to 49.8 ± 11.1 (SD) kPa at 30 min after surfactant replacement (p 〈 0.05), while the PaO2 in the control group remained below 20 kPa. Conclusions: Impairment of surfactant is a factor involved in the development of acute lung injury caused by inhalation of fabric protector. Surfactant replacement may be therapeutic for such injuries.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001340050515
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  • 9
    Digitale Medien
    Digitale Medien
    Fracture studies in rubber-modified acrylics. I. Experimental method: Design of sandwich-tapered double-cantilever beam cleavage specimens (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 17 (1973), S. 1909-1917 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Double-cantilever beam cleavage specimens are very useful in characterizing the fracture behavior of isotropic, homogeneous, brittle, and semibrittle polymers. However, until this time they have not been used for ductile materials such as rubber-modified polymers or polycarbonates because of excessive yielding or breakage of the specimen arms before crack propagation can occur. In order to make it possible to measure the fracture surface work of these materials, a new sandwich cleavage specimen was developed by bonding rigid reinforcement plates to both sides of the specimen sheet. With this sandwich-tapered double-cantilever beam cleavage specimen, one can create conditions under which controlled crack propagation through tough ductile materials and measurement of the fracture surface work-two previously unobtainable results-are readily determined. In this paper, the design and construction of the sandwich specimens, test procedure, and the data analysis will be discussed in detail.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1973.070170623
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  • 10
    Digitale Medien
    Digitale Medien
    Fracture studies in rubber-modified polymers. II. Experimental results: Fracture surface work of rubber-modified acrylics (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 17 (1973), S. 2053-2066 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: With the use of a sandwich-tapered double-cantilever beam cleavage specimen (described in part I of this series), the fracture surface work of several commercial and experimental acrylic multipolymers has been measured as a function of crack velocity and rubber content. The plots of fracture surface work versus crack velocity clearly exhibit the effects of rate (crack velocity) and rubber concentration on fracture behavior. Specifically, the fracture surface work of specimens with seven different rubber contents has been determined over a crack velocity range from 10-5 meters/sec to approximately 10 meters/sec. For each material, distinct maxima occur in the curves of fracture surface work versus crack velocity. The significance of these observations is discussed.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1973.070170708
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