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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 647-647 
    ISSN: 1435-2451
    Keywords: Breast cancer ; Diagnosis ; Treatment ; Mamma-Carcinom ; Diagnose ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Durch die Übereinstimmung der an Diagnostik, Therapie und Nachsorge des Mamma-Ca. beteiligten Disziplinen der Univ.-Kliniken Ulm gelang im Rahmen des Onkologischen Arbeitskreises der Univ. Ulm die Aufstellung einheitlicher Diagnostik und Therapierichtlinien. Die einzelnen Verfahren in derDiagnostik-obligat („Tripel-Diagnostik”) und fakultativ -undTherapie — chirurgische Primärtherapie, adjuvante Chemoimmunotherapie, Zusatztherapieformen, Netzplastik, Chemotherapieprotokolle beim metastasierenden M.C. - werden dargestellt und mit eigenen ErgebniBen belegt.
    Notes: Summary By agreement of the different divisions of the University Hospital in Ulm involved in the diagnosis, treatment, and postoperative follow-up program for breast cancer, it was poBible to establish a uniform regimen for diagnosis and treatment. The particular procedures indiagnosis-obligatory (“triple diagnosis”) and optional-and treatment-primary surgical therapy, adjuvant chemoimmunotherapy, additional treatment forms, omentum plastic, protocols of chemotherapy for advanced breast cancer-are demonstrated and documented with own results.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1335
    Keywords: Interferon plus MPA ; Advanced renal cell cancer ; Medroxyprogesterone acetate (MPA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFNα) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFNα 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFNα 2C (2MU) was given s.c. 5 times per week for 8–12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p. o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4%, corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
    Type of Medium: Electronic Resource
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