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  • Bone marrow transplantation  (2)
  • Pig  (2)
  • chemotaxis  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Granulocytendysfunktion (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 643-652 
    Details
    ISSN: 1432-1440
    Keywords: Granulocytes ; function ; inborn defects ; chemotaxis ; opsonisation ; phagocytosis ; intracellular microbicidal activity ; Granulocyten ; Funktion ; angeborene Defekte ; Chemotaxis ; Opsonierung ; Phagocytose ; intracelluläre Keimabtötung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Funktion der Granulocyten und deren Störungen findet zunehmend Beachtung. Die vorliegende Übersicht soll den augenblicklichen Stand des Wissens zusammenfassen. Im ersten von zwei Teilen wird ein Überblick über die molekulare Basis der Granulocytenfunktion gegeben und die wesentlichsten angeborenen Störungen der Chemotaxis, Opsonierung, Phagocytose und intracellulären Abtötung von Keimen werden referiert.
    Notes: Summary The insight in the function and dysfunction of granulocytes lately arouses more and more interest. This report summarises our present knowledge. In the first of two chapters the authors review the molecular basis of granulocyte function and the inborn defects of chemotaxis, opsonisation, phagocytosis and intracellular killing of bacteria and fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469293
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  • 2
    Electronic Resource
    Electronic Resource
    Granulocytendysfunktion (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 739-746 
    Details
    ISSN: 1432-1440
    Keywords: Granulocytes function ; secondary defects ; chemotaxis ; opsonisation ; phagocytosis ; intracellular microbicidal activity ; Granulocyten ; Funktion ; sekundäre Defekte ; Chemotaxis ; Opsonierung ; Phagocytose ; intrazelluläre Keimabtötung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im ersten Teil dieser Übersicht haben wir einen Überblick über die molekulare Basis der Granulocytenfunktion und deren wesentlichsten angeborenen Störungen gegeben. Der vorliegende zweite Teil soll das gegenwärtige Wissen über die sekundären Störungen der Chemotaxis, Opsonierung, Phagocytose und intracellulären Keimabtötung zusammenfassen.
    Notes: Summary In the first part we reviewed both the molecular basis of granulocyte function and the inborn defects. The present chapter summarizes our knowledge of the secondary defects of chemotaxis, opsonisation, phagocytosis and intracellular microbicidal activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614854
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Severe combined immunodeficiency: treatment by bone marrow transplantation in 15 infants using HLA-haploidentical donors (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 125-130 
    Details
    ISSN: 1432-1076
    Keywords: Severe combined immunodeficiency ; Bone marrow transplantation ; HLA-haploidentical donors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 15 infants with severe combined immunodeficiency (SCID), immunological reconstitution was attempted by bone marrow transplantation (BMT) from HLA-haploidentical parents. To prevent graft versus host disease (GvHD), marrow grafts were depleted of contaminating T-lymphocytes using lectin agglutination and rosette formation with sheep red blood cells. Thirteen patients received transplants without undergoing prior cytoreductive conditioning. Eleven of these developed donor-dependent T-cell functions, two failed to do this. One of these two as well as two further patients received cytoreductive treatment prior to repeat and to first transplants and in two, complete lymphohemopoietic reconstitution was observed. Of the 15 patients who received transplants, 11 are currently alive. Two recently treated patients remain in the hospital, nine are at home with stable T-cell functions. Normal humoral immune functions have developed upto now in three patients. In the others, gammaglobulins are regularly substituted. Complications of acute or chronic GvHD were not observed with the exception of one case who developed transient GvHD of the skin. These results suggest that in a majority of patients with SCID, T-cell functions can develop without GvHD following haploidentical, T-cell-depleted BMT. Exceptional patients require preconditioning to allow donor cell engraftment, an approach that also appears to facilitate reconstitution of humoral immune functions
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451897
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  • 4
    Electronic Resource
    Electronic Resource
    Knochenmarktransplantation bei Panmyelopathie, akuter Leukämie und chronisch myeloischer Leukämie: Ergebnisse der „Ulmer Transplantationsgruppe“ (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 577-585 
    Details
    ISSN: 1432-1440
    Keywords: Bone marrow transplantation ; Aplastic anaemia ; Acute leukaemia ; Chronic granulocytic leukaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 1972–1983 53 patients underwent bone marrow transplantation. The median age was 18 years (3–41). 27 patients suffered from severe aplastic anaemia, 22 patients had acute leukaemia and 4 patients had chronic granulocytic leukaemia in chronic phase. Out of 22 patients with acute leukaemia, 2 had florid leukaemia, 2 had an early relapse and 18 patients were in first or second remission of their disease. 2/53 patients received a syngeneic transplant, 51/53 patients an allogeneic transplant. 47/51 patients had a HLA-A, B, C-identical, MLC-negative sibling donor, 1/51 had a HLA-A, B-C-identical, MLC-positive sibling donor, 2/51 a HLA-phaenotypical identical parental donor and 1/51 a HLA-identical, MLC-negative unrelated donor. The comparison of the results obtained in patients with severe aplastic anaemia transplanted from 1972–1979 with those transplanted from 1980–1983 shows that the bone marrow transplantation has to be performed in an early stage of the disease before the patients become multiple transfused, sensitized and severely infected and that the conditioning regimen for polytransfused patients has to be more intensive than in untransfused patients. From the patient group transplanted 1972–1979, only 1/14 patients is a long-term survivor in contrast to 8/13 patients transplanted from 1980–1983. 11/22 patients with acute leukaemia are alive between more than 5 years and 14 days after bone marrow transplantation. Only 1/4 patients, who were transplanted not in remission, is alive. For patients with acute leukaemia the bone marrow transplantation should be performed in an early stage of their disease when the tumor burden is small and when the patients are in good clinical condition. 2/4 patients with CGL are alive between 12 months and 3 months after bone marrow transplantation. In our patient group graft versus host disease was the most important problem with a high mortality due to GvHD associated infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728176
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  • 5
    Electronic Resource
    Electronic Resource
    Gibt es ein fetales Hämoglobin beim Schwein? (1972)
    Springer
    Research in experimental medicine 158 (1972), S. 219-228 
    Details
    ISSN: 1433-8580
    Keywords: Fetal hemoglobin ; Pig ; Development ; Fetales Hämoglobin ; Schwein ; Ontogenese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter der Fragestellung, ob beim Schwein in Analogie zu anderen Species während der Ontogenese ein fetales Hämoglobin synthetisiert wird, wurden Eigenschaften des Blutfarbstoffs von Embryonen und Feten mit einer Kopf-Steiß-Länge von 20 bis 230 mm mit denen erwachsener Schweine verglichen. Weder mit elektrophoretischen und chromatographischen Methoden noch mit einer Reihe von Denaturierungstesten (Alkali, Säure, Hitze) und Spektralanalysen im sichtbaren und ultravioletten Bereich konnte bei Feten ein fetales Hämoglobin nachgewiesen werden. Ob sich der Prozeß der Synthese eines fetalen Blutfarbstoffs und sein Ersatz durch adultes Hämoglobin bereits in der Embryonalperiode abspielt, kann aus den bisher vorliegenden Daten nicht gefolgert werden.
    Notes: Summary The existence of a fetal hemoglobin synthesized in pigs during developmental stages is contested (Novyet al., 1968; Kleihauer, 1970; Glauser and Glauser, 1971). Comparative studies have been performed in hemolysates of adult pigs and fetuses resp. embryos with a crown-rump length ranging between 20 and 230 mm applying the following techniques: electrophoresis on starck block and cellulose acetate folie, chromatography on DEAE-sephadex, denaturation by alkali, acid and heat, and spectral analysis in the visible and ultraviolet range. The results give good evidence that no fetal hemoglobin is present in pigs during fetal life. However, whether a fetal hemoglobin is synthesized and fully replaced by an adult type hemoglobin already during embryonic stages remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852313
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  • 6
    Electronic Resource
    Electronic Resource
    Gibt es ein fetales Hämoglobin beim Schwein? (1972)
    Springer
    Research in experimental medicine 159 (1972), S. 44-49 
    Details
    ISSN: 1433-8580
    Keywords: Adult, fetal haemoglobin ; Globin ; Pig ; Development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vergleichende Untersuchungen an Polypeptidketten des Hämoglobins von erwachsenen Schweinen und Embryonen bzw. Feten verschiedener Entwicklungsstadien ließen keine Unterschiede in der Struktur derα-Ketten einerseits und der Nicht-α-Ketten andererseits erkennen. Diese Aussage bezieht sich auf Analysen des Globins mit chromatographischen und elektrophoretischen Methoden sowie mit der Fingerprinttechnik. Die Ergebnisse lassen den Schluß zu, daß beim Schwein während der Fetalzeit keine Synthese vonγ-Ketten (fetales Hämoglobin) stattfindet.
    Notes: Summary Studies on polypeptide chains of haemoglobin from adult pigs compared with those from fetuses respectively embryos revealed no differences in the structure of either theα-chains or the non-α-chains. The results were obtained by chromatographic, electrophoretic and fingerprint techniques. It is concluded that no γ-chains (fetal haemoglobin) are synthesized in red cells of pigs during developmental stages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852140
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    Paper (German National Licenses)
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