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  • 1
    Electronic Resource
    Electronic Resource
    Klinische Wertigkeit der Positronen-Emissions-Tomographie in der Neuromedizin Positionspapier zu den Ergebnissen einer interdisziplinären Konsensuskonferenz (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 1045-1060 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Positronen-Emissions-Tomographie (PET) ; Neurologie ; Neurochirurgie ; Psychiatrie ; Key words Positron emission tomography ; Neurology ; Neurosurgery ; Psychiatry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To date, positron emission tomography (PET) is the most powerful method for the in-vivo investigation of human brain metabolism. Besides extensive application of this technology in the neurosciences, PET is also being increasingly used as a clinical tool. However, despite its acceptance in clinical practice, a major obstacle is its high costs. The present article reviews the literature on the clinical use of PET in neurology, neurosurgery, and psychiatry in order to substantiate the clinical indications for PET in these specialties as established by an interdisciplinary conference.
    Notes: Zusammenfassung Die Positronen-Emissions-Tomographie (PET) ist das derzeit leistungsfähigste Verfahren zur In-vivo-Untersuchung des zerebralen Stoffwechsels. Neben einem breitgefächerten Einsatz von PET in der neuromedizinischen Forschung findet die PET zunehmend auch Eingang in die klinische Diagnostik. Dieser Entwicklung entgegen stehen die relativ hohen Kosten, die mit diesem Verfahren verbunden sind. Die vorliegende Arbeit begründet die, in einer interdisziplinären Konferenz erarbeiteten Konsensusindikationen für den klinischen Einsatz der PET in der Neurologie, Neurochirurgie und Psychiatrie durch Aufarbeitung der einschlägigen Literatur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050382
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  • 2
    Electronic Resource
    Electronic Resource
    Calculation of residence times and radiation doses using the standard PC software Excel (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 1514-1521 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Residence times ; Radiation dosimetry ; Excel ; MIRDOSE3Introduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We developed a program which aims to facilitate the calculation of radiation doses to single organs and the whole body. IMEDOSE uses Excel to include calculations, graphical displays, and interactions with the user in a single general-purpose PC software tool. To start the procedure the input data are copied into a spreadsheet. They must represent percentage uptake values of several organs derived from measurements in animals or humans. To extrapolate these data up to seven half-lives of the radionuclide, fitting to one or two exponentional functions is included and can be checked by the user. By means of the approximate time-activity information the cumulated activity or residence times are calculated. Finally these data are combined with the absorbed fraction doses (S-values) given by MIRD pamphlet No. 11 to yield radiation doses, the effective dose equivalent and the effective dose. These results are presented in a final table. Interactions are realized with push-buttons and drop-down menus. Calculations use the Visual Basic tool of Excel. In order to test our program, biodistribution data of fluorine-18 fluorodeoxyglucose were taken from the literature (Meija et al., J Nucl Med 1991; 32:699–706). For a 70-kg adult the resulting radiation doses of all target organs listed in MIRD 11 were different from the ICRP 53 values by 1%±18% on the average. When the residence times were introduced into MIRDOSE3 (Stabin, J Nucl Med 1996; 37:538–546) the mean difference between our results and those of MIRDOSE3 was –3%±6%. Both outcomes indicate the validity of the present approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050182
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  • 3
    Electronic Resource
    Electronic Resource
    Optimal scan time for fluorine-18 fluorodeoxyglucose positron emission tomography in breast cancer (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 226-230 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Breast cancer ; Fluorine-18 fluorodeoxyglucose ; Positron emission tomography ; Tumour-to-non-tumour ratio ; Contrast parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) has proven useful in the differentiation of various tumour entities, including breast cancer. In patients with primary breast cancer we performed a 3-h imaging protocol to examine possible improvements in tumour detectability and image contrast. Twenty-nine patients with primary breast cancer with a diameter of ≥2 cm that was demonstrated to be malignant by biopsy or surgery were injected with 370–740 MBq 18F-FDG and scanned in the prone position. Data were acquired 0–40 min, 1.5 h and 3.0 h after injection. After correction for measured attenuation, decay and scatter and iterative reconstruction, standardised uptake values (SUVs) and tumour-to-non-tumour and tumour-to-organ ratios were calculated. Visual analysis was performed using transverse, sagittal and coronal slices as well as 3D reprojection images. Tumour-to-non-tumour and tumour-to-organ ratios were significantly higher for the 3-h images than for the 1.5-h images. SUVs did not increase to the same extent. Lesion detectability was 83% in 1.5-h images compared to 93% in 3-h images. We conclude that tumour contrast in breast cancer is improved by starting the PET acquisition at 3 h p.i. rather than at 1.5 h p.i.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050381
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 1156-1161 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Cholinergic system ; Muscarinic receptors ; Epilepsy ; Emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254249
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    Paper (German National Licenses)
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